{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:14:37Z","timestamp":1789928077372,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":3097,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1074\/jbc.m111.320465","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T01:34:20Z","timestamp":1328060060000},"page":"12309-12320","source":"Crossref","is-referenced-by-count":36,"title":["G-protein-coupled Receptor Kinase Interactor-1 (GIT1) Is a New Endothelial Nitric-oxide Synthase (eNOS) Interactor with Functional Effects on Vascular Homeostasis"],"prefix":"10.1016","volume":"287","author":[{"given":"Songling","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Premont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C.","family":"Rockey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.320465_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium-derived nitric oxide production by the protein kinase Akt","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.320465_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric-oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.320465_bib3","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.1016\/S0021-9258(18)52889-1","article-title":"Endothelial nitric-oxide synthase. N-terminal myristoylation determines subcellular localization","volume":"268","author":"Busconi","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib4","doi-asserted-by":"crossref","first-page":"27237","DOI":"10.1074\/jbc.271.44.27237","article-title":"Endothelial nitric-oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1","volume":"271","author":"Garc\u00eda-Carde\u00f1a","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib5","doi-asserted-by":"crossref","first-page":"14249","DOI":"10.1074\/jbc.M006258200","article-title":"Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function","volume":"276","author":"Cao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/33934","article-title":"Dynamic activation of endothelial nitric-oxide synthase by Hsp90","volume":"392","author":"Garc\u00eda-Carde\u00f1a","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.320465_bib7","doi-asserted-by":"crossref","first-page":"17734","DOI":"10.1074\/jbc.272.28.17734","article-title":"Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity","volume":"272","author":"Freedman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cardiores.2007.03.023","article-title":"Life history of eNOS. Partners and pathways","volume":"75","author":"Dudzinski","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1074\/jbc.M111.320465_bib9","doi-asserted-by":"crossref","first-page":"15583","DOI":"10.1074\/jbc.272.25.15583","article-title":"Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin","volume":"272","author":"Michel","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib10","doi-asserted-by":"crossref","first-page":"27383","DOI":"10.1074\/jbc.273.42.27383","article-title":"Receptor-regulated translocation of endothelial nitric-oxide synthase","volume":"273","author":"Prabhakar","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib11","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1161\/01.CIR.101.20.2342","article-title":"Estrogen-induced vasoprotection is estrogen receptor dependent. Evidence from the balloon-injured rat carotid artery model","volume":"101","author":"Bakir","year":"2000","journal-title":"Circulation"},{"key":"10.1074\/jbc.M111.320465_bib12","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1056\/NEJM199512143332416","article-title":"Endothelial nitric-oxide synthase in the lungs of patients with pulmonary hypertension","volume":"333","author":"Xue","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.320465_bib13","doi-asserted-by":"crossref","first-page":"E68","DOI":"10.1161\/hh1101.092677","article-title":"Phosphorylation of Thr495 regulates Ca2+\/calmodulin-dependent endothelial nitric-oxide synthase activity","volume":"88","author":"Fleming","year":"2001","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M111.320465_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0016-5085(98)70487-1","article-title":"Reduced nitric oxide production by endothelial cells in cirrhotic rat liver. Endothelial dysfunction in portal hypertension","volume":"114","author":"Rockey","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M111.320465_bib15","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0016-5085(99)70408-7","article-title":"Impaired endothelial nitric-oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat","volume":"117","author":"Shah","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M111.320465_bib16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1289","article-title":"A crucial role for GRK2 in regulation of endothelial cell nitric-oxide synthase function in portal hypertension","volume":"11","author":"Liu","year":"2005","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.320465_bib17","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1093\/emboj\/19.16.4272","article-title":"Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling","volume":"19","author":"Dessy","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M111.320465_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.pharmtox.44.101802.121844","article-title":"The regulation and pharmacology of endothelial nitric-oxide synthase","volume":"46","author":"Dudzinski","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M111.320465_bib19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cell.2007.02.046","article-title":"Regulation of \u03b2-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2","volume":"129","author":"Whalen","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.320465_bib20","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1073\/pnas.96.6.2788","article-title":"Estradiol induces the calcium-dependent translocation of endothelial nitric-oxide synthase","volume":"96","author":"Goetz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.320465_bib21","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1073\/pnas.95.9.5009","article-title":"Endothelial Ca2+ waves preferentially originate at specific loci in caveolin-rich cell edges","volume":"95","author":"Isshiki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.320465_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0033-0620(05)80001-5","article-title":"Nitric oxide and its role in the cardiovascular system","volume":"38","author":"Loscalzo","year":"1995","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1074\/jbc.M111.320465_bib23","doi-asserted-by":"crossref","first-page":"49929","DOI":"10.1074\/jbc.M306930200","article-title":"Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein \u03b2\u03b3 subunit signaling to protein kinase B\/Akt","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib24","doi-asserted-by":"crossref","first-page":"18953","DOI":"10.1074\/jbc.M102376200","article-title":"Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by \u03b2-adrenergic receptor kinase 1. A role in receptor sequestration","volume":"276","author":"Naga Prasad","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0898-6568(04)00023-3","article-title":"The GIT\/PIX complex. An oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1\/Cdc42 guanine nucleotide exchange factors","volume":"16","author":"Premont","year":"2004","journal-title":"Cell Signal."},{"key":"10.1074\/jbc.M111.320465_bib26","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1242\/jcs.115.7.1497","article-title":"GIT1 functions in a motile, multimolecular signaling complex that regulates protrusive activity and cell migration","volume":"115","author":"Manabe","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.320465_bib27","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1074\/jbc.M600081200","article-title":"Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1","volume":"281","author":"Meyer","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib28","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1074\/jbc.M212287200","article-title":"The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo","volume":"278","author":"Kim","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ceb.2003.11.007","article-title":"Talin. An emerging focal point of adhesion dynamics","volume":"16","author":"Nayal","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M111.320465_bib30","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1523\/JNEUROSCI.23-05-01667.2003","article-title":"Interaction between liprin-\u03b1 and GIT1 is required for AMPA receptor targeting","volume":"23","author":"Ko","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.320465_bib31","doi-asserted-by":"crossref","first-page":"14082","DOI":"10.1073\/pnas.95.24.14082","article-title":"\u03b22-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein","volume":"95","author":"Premont","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.320465_bib32","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1523\/JNEUROSCI.3553-04.2005","article-title":"A GIT1\/PIX\/Rac\/PAK signaling module regulates spine morphogenesis and synapse formation through MLC","volume":"25","author":"Zhang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.320465_bib33","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1096\/fj.03-0198com","article-title":"Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling. Role of Src and GIT","volume":"17","author":"Shikata","year":"2003","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M111.320465_bib34","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1128\/MCB.20.17.6354-6363.2000","article-title":"Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly","volume":"20","author":"Zhao","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.320465_bib35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/MCB.24.2.875-885.2004","article-title":"GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor","volume":"24","author":"Yin","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.320465_bib36","doi-asserted-by":"crossref","first-page":"49936","DOI":"10.1074\/jbc.M307317200","article-title":"GIT1 mediates Src-dependent activation of phospholipase C\u03b3 by angiotensin II and epidermal growth factor","volume":"278","author":"Haendeler","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3171\/jns.2006.105.1.103","article-title":"Functions of G-protein-coupled receptor kinase interacting protein 1 in human neuronal (N2TN) cells","volume":"105","author":"Lieu","year":"2006","journal-title":"J. Neurosurg."},{"key":"10.1074\/jbc.M111.320465_bib38","doi-asserted-by":"crossref","first-page":"G565","DOI":"10.1152\/ajpgi.00512.2000","article-title":"Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver","volume":"282","author":"Yu","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1074\/jbc.M111.320465_bib39","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.cellsig.2007.03.010","article-title":"GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin","volume":"19","author":"Schmalzigaug","year":"2007","journal-title":"Cell Signal."},{"key":"10.1074\/jbc.M111.320465_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2005.04.109","article-title":"Akt1 contains a functional leucine-rich nuclear export sequence","volume":"332","author":"Saji","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.320465_bib41","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1074\/jbc.M411991200","article-title":"Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice. A proinflammatory role for eNOS-derived NO in vivo","volume":"280","author":"Connelly","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-5793(90)80902-U","article-title":"Calcium-dependent nitric-oxide synthesis in endothelial cytosol is mediated by calmodulin","volume":"265","author":"Busse","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M111.320465_bib43","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.1074\/jbc.273.10.5566","article-title":"Electron transfer and catalytic activity of nitric-oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoforms","volume":"273","author":"Nishida","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib44","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1242\/jcs.02925","article-title":"The multifunctional GIT family of proteins","volume":"119","author":"Hoefen","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.320465_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1083\/jcb.200601051","article-title":"Identification of Golgi-localized acyltransferases that palmitoylate and regulate endothelial nitric-oxide synthase","volume":"174","author":"Fern\u00e1ndez-Hernando","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M111.320465_bib46","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/002215540205000604","article-title":"Endothelial nitric-oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles","volume":"50","author":"Govers","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"10.1074\/jbc.M111.320465_bib47","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1242\/jcs.03044","article-title":"Identification of phosphorylation sites in GIT1","volume":"119","author":"Webb","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.320465_bib48","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/MCB.19.1.714","article-title":"RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to G\u03b111","volume":"19","author":"Dulin","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.320465_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1006827007251","article-title":"Absence of endothelin receptors and receptor mRNA in mammalian fibroblasts transformed with SV40 or ras oncogene","volume":"175","author":"Nambi","year":"1997","journal-title":"Mol. Cell Biochem."},{"key":"10.1074\/jbc.M111.320465_bib50","doi-asserted-by":"crossref","first-page":"18522","DOI":"10.1074\/jbc.272.30.18522","article-title":"Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity","volume":"272","author":"Ju","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1096\/fj.00-0078com","article-title":"NOSIP, a novel modulator of endothelial nitric-oxide synthase activity","volume":"15","author":"Dedio","year":"2001","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M111.320465_bib52","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.physiol.64.081501.155952","article-title":"Regulation of endothelial nitric-oxide synthase. Location, location, location","volume":"64","author":"Shaul","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M111.320465_bib53","doi-asserted-by":"crossref","first-page":"19416","DOI":"10.1074\/jbc.M001952200","article-title":"A chimeric transmembrane domain directs endothelial nitric-oxide synthase palmitoylation and targeting to plasmalemmal caveolae","volume":"275","author":"Prabhakar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib54","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1074\/jbc.271.11.6518","article-title":"Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae","volume":"271","author":"Shaul","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib55","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1113\/jphysiol.2002.021972","article-title":"ACh-induced endothelial NO synthase translocation, NO release and vasodilatation in the hamster microcirculation in vivo","volume":"544","author":"Figueroa","year":"2002","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M111.320465_bib56","doi-asserted-by":"crossref","first-page":"C1437","DOI":"10.1152\/ajpcell.00005.2005","article-title":"eNOS translocation but not eNOS phosphorylation is dependent on intracellular Ca2+ in human atrial myocardium","volume":"290","author":"Pott","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1074\/jbc.M111.320465_bib57","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1074\/jbc.M106302200","article-title":"Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme","volume":"277","author":"Fulton","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib58","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1074\/jbc.274.42.30101","article-title":"Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002","volume":"274","author":"Gallis","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib59","doi-asserted-by":"crossref","first-page":"13901","DOI":"10.1074\/jbc.275.18.13901","article-title":"GIT proteins. A novel family of phosphatidylinositol 3,4,5-trisphosphate-stimulated GTPase-activating proteins for ARF6","volume":"275","author":"Vitale","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.320465_bib60","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.yjmcc.2011.06.020","article-title":"G protein-coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart","volume":"51","author":"Pang","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1074\/jbc.M111.320465_bib61","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.108.823997","article-title":"G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development","volume":"119","author":"Pang","year":"2009","journal-title":"Circulation"},{"key":"10.1074\/jbc.M111.320465_bib62","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/japplphysiol.00690.2002","article-title":"S1P induces FA remodeling in human pulmonary endothelial cells. Role of Rac, GIT1, FAK, and paxillin","volume":"94","author":"Shikata","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M111.320465_bib63","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/ncb1976","article-title":"Slit2-Robo4 signaling promotes vascular stability by blocking Arf6 activity","volume":"11","author":"Jones","year":"2009","journal-title":"Nat. Cell Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582053158X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582053158X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.320465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T07:03:41Z","timestamp":1625295821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582053158X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":63,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S002192582053158X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.320465","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}