{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:50:09Z","timestamp":1791078609124,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":3023,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1074\/jbc.m111.321661","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:54:33Z","timestamp":1334624073000},"page":"21204-21213","source":"Crossref","is-referenced-by-count":28,"title":["Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase \u03f5 Attenuates Mutant Huntingtin Toxicity"],"prefix":"10.1016","volume":"287","author":[{"given":"Ningzhe","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bensheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Al-Ramahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Botas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford W.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.321661_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington disease chromosomes. The Huntington Disease Collaborative Research Group","volume":"72","author":"The Huntington's Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.321661_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20071040","article-title":"Diacylglycerol kinases: At the hub of cell signaling","volume":"409","author":"M\u00e9rida","year":"2008","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.321661_bib3","doi-asserted-by":"crossref","first-page":"19093","DOI":"10.1073\/pnas.0606728103","article-title":"Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange","volume":"103","author":"Weissmann","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.321661_bib4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbalip.2007.04.006","article-title":"Diacylglycerol kinases: Why so many of them?","volume":"1771","author":"Sakane","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.321661_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chembiol.2011.04.012","article-title":"Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington disease treatment","volume":"18","author":"Wu","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M111.321661_bib6","doi-asserted-by":"crossref","first-page":"31062","DOI":"10.1074\/jbc.M109.050617","article-title":"Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol","volume":"284","author":"Lung","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.321661_bib7","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1073\/pnas.081536298","article-title":"Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling","volume":"98","author":"Rodriguez de Turco","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.321661_bib8","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1021\/bi800492c","article-title":"Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase","volume":"47","author":"Milne","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.321661_bib9","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/j.1471-4159.2009.06255.x","article-title":"Polyglutamine expansion in huntingtin alters its interaction with phospholipids","volume":"110","author":"Kegel","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.321661_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol (1,4,5)-triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.321661_bib11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1523\/JNEUROSCI.4411-08.2009","article-title":"Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington disease mouse model","volume":"29","author":"Tang","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.321661_bib12","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","author":"Trettel","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M111.321661_bib13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.chembiol.2010.08.014","article-title":"Identification and evaluation of small molecule pan-caspase inhibitors in Huntington disease models","volume":"17","author":"Leyva","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M111.321661_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3858\/emm.2010.42.1.001","article-title":"Mass spectrometry-based cellular phosphoinositides profiling and phospholipid analysis: A brief review","volume":"42","author":"Kim","year":"2010","journal-title":"Exp. Mol. Med."},{"key":"10.1074\/jbc.M111.321661_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nbt837","article-title":"Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry","volume":"21","author":"Wenk","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M111.321661_bib16","doi-asserted-by":"crossref","first-page":"26714","DOI":"10.1074\/jbc.M601603200","article-title":"CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation","volume":"281","author":"Al-Ramahi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.321661_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuron.2010.06.021","article-title":"Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease","volume":"67","author":"Miller","year":"2010","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.321661_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.321661_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0009-3084(99)00023-7","article-title":"Diacylglycerol kinase in the central nervous system\u2013molecular heterogeneity and gene expression","volume":"98","author":"Goto","year":"1999","journal-title":"Chem. Phys. Lipids"},{"key":"10.1074\/jbc.M111.321661_bib20","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1021\/bi6024726","article-title":"Role of the hydrophobic segment of diacylglycerol kinase epsilon","volume":"46","author":"Dicu","year":"2007","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.321661_bib21","doi-asserted-by":"crossref","first-page":"21155","DOI":"10.1016\/S0021-9258(17)31943-9","article-title":"Arachidonoyl-diacylglycerol kinase from bovine testis. Purification and properties","volume":"269","author":"Walsh","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.321661_bib22","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1074\/jbc.271.17.10237","article-title":"Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates","volume":"271","author":"Tang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.321661_bib23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tins.2011.06.005","article-title":"Emerging roles for cholesterol in Huntington disease","volume":"34","author":"Valenza","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M111.321661_bib24","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1523\/JNEUROSCI.6348-09.2010","article-title":"Impaired ganglioside metabolism in Huntington disease and neuroprotective role of GM1","volume":"30","author":"Maglione","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.321661_bib25","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1073\/pnas.1114502109","article-title":"Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice","volume":"109","author":"Di Pardo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.321661_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/chan.3914","article-title":"PIP2 regulates the ionic current of P2X receptors and P2X7 receptor-mediated cell death","volume":"1","author":"Zhao","year":"2007","journal-title":"Channels"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820498126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820498126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.321661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T13:36:42Z","timestamp":1641303402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820498126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":26,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0021925820498126"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.321661","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714447811.790002814","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}