{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:48:24Z","timestamp":1791398904387,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":3097,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1074\/jbc.m111.329623","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T01:35:00Z","timestamp":1327455300000},"page":"12379-12386","source":"Crossref","is-referenced-by-count":90,"title":["Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility"],"prefix":"10.1016","volume":"287","author":[{"given":"Hsiang-Tsui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ru","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung-Lung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-shong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.329623_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200700412","article-title":"Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease","volume":"52","author":"Stevens","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1074\/jbc.M111.329623_bib2","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/carcin\/17.10.2105","article-title":"Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts","volume":"17","author":"Chung","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M111.329623_bib3","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/mnfr.201100279","article-title":"Acrolein, a pulmonary hazard","volume":"55","author":"Bein","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1074\/jbc.M111.329623_bib4","unstructured":"Comes, R. M., Eggleton, M., (2002) Concise International Chemical Assessment Document 43, World Health Organization, Geneva."},{"key":"10.1074\/jbc.M111.329623_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/57.1.6","article-title":"The molecular effects of acrolein","volume":"57","author":"Kehrer","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1074\/jbc.M111.329623_bib6","first-page":"95","article-title":"Fate and effects of acrolein","volume":"144","author":"Ghilarducci","year":"1995","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib7","first-page":"3577","article-title":"Acrolein initiates rat urinary bladder carcinogenesis","volume":"52","author":"Cohen","year":"1992","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.329623_bib8","first-page":"990","article-title":"Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde","volume":"44","author":"Chung","year":"1984","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.329623_bib9","doi-asserted-by":"crossref","first-page":"18257","DOI":"10.1074\/jbc.M112419200","article-title":"Error-prone translesion synthesis past \u03b3-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells","volume":"277","author":"Kanuri","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.329623_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5718(98)00093-X","article-title":"Molecular analysis of mutations induced by acrolein in human fibroblast cells using supF shuttle vector plasmids","volume":"417","author":"Kawanishi","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.M111.329623_bib11","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1074\/jbc.M207774200","article-title":"Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase \u03b7","volume":"278","author":"Minko","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.329623_bib12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx034066u","article-title":"Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived \u03b1-HOPdG and \u03b3-HOPdG regioisomeric deoxyguanosine adducts","volume":"16","author":"Sanchez","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib13","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1074\/jbc.M008900200","article-title":"Evaluation of the mutagenic potential of the principal DNA adduct of acrolein","volume":"276","author":"VanderVeen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.329623_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/tx800369y","article-title":"Mutagenicity and sequence specificity of acrolein-DNA adducts","volume":"22","author":"Wang","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib15","doi-asserted-by":"crossref","first-page":"13826","DOI":"10.1021\/bi0264723","article-title":"Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells","volume":"41","author":"Yang","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.329623_bib16","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1074\/jbc.M008918200","article-title":"Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli","volume":"276","author":"Yang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.329623_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/tx010123c","article-title":"Genotoxic mechanism for the major acrolein-derived deoxyguanosine adduct in human cells","volume":"15","author":"Yang","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib18","doi-asserted-by":"crossref","first-page":"13989","DOI":"10.1074\/jbc.M212535200","article-title":"Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase \u03b7 in error-prone synthesis in human cells","volume":"278","author":"Yang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.329623_bib19","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1073\/pnas.0607031103","article-title":"Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair","volume":"103","author":"Feng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.329623_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/tox.20153","article-title":"Determination of toxic carbonyl compounds in cigarette smoke","volume":"21","author":"Fujioka","year":"2006","journal-title":"Environ. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib21","series-title":"Handbook of Experimental Pharmacology","first-page":"70","author":"Hoffmann","year":"1990"},{"key":"10.1074\/jbc.M111.329623_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ijc.2910400505","article-title":"Lung cancer among Chinese women","volume":"40","author":"Gao","year":"1987","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M111.329623_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ije\/26.1.24","article-title":"Risk factors for primary lung cancer among non-smoking women in Taiwan","volume":"26","author":"Ko","year":"1997","journal-title":"Int. J. Epidemiol."},{"key":"10.1074\/jbc.M111.329623_bib24","first-page":"1215","article-title":"Fumes from meat cooking and lung cancer risk in Chinese women","volume":"9","author":"Seow","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1074\/jbc.M111.329623_bib25","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1093\/ije\/19.Supplement_1.S14","article-title":"Worldwide epidemiological patterns of lung cancer in nonsmokers","volume":"19","author":"Koo","year":"1990","journal-title":"Int. J. Epidemiol."},{"key":"10.1074\/jbc.M111.329623_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1470-2045(01)00457-0","article-title":"Women and lung cancer: Does oestrogen play a role?","volume":"2","author":"Siegfried","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1074\/jbc.M111.329623_bib27","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/mnfr.201100148","article-title":"Acrolein induced DNA damage, mutagenicity, and effect on DNA repair","volume":"55","author":"Tang","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1074\/jbc.M111.329623_bib28","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1073\/pnas.87.15.5837","article-title":"Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines","volume":"87","author":"Holmes","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.329623_bib29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2005.06.027","article-title":"Reconstitution of 5\u2032-directed human mismatch repair in a purified system","volume":"122","author":"Zhang","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.329623_bib30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1021\/tx700023z","article-title":"Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"20","author":"Zhang","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.M111.329623_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mrgentox.2008.08.015","article-title":"Particulate matter inhibits DNA repair and enhances mutagenesis","volume":"657","author":"Mehta","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.M111.329623_bib32","doi-asserted-by":"crossref","first-page":"8598","DOI":"10.1073\/pnas.0402794101","article-title":"Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis","volume":"101","author":"Feng","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.329623_bib33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nchembio.250","article-title":"Targeting proteins for degradation","volume":"5","author":"Schrader","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M111.329623_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0009-2797(01)00295-2","article-title":"Acrolein-induced cell death: A caspase-influenced decision between apoptosis and oncosis\/necrosis","volume":"139","author":"Kern","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1074\/jbc.M111.329623_bib35","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.freeradbiomed.2008.01.004","article-title":"Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction","volume":"44","author":"Li","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M111.329623_bib36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.neuint.2005.07.002","article-title":"Acrolein-induced cell death in PC12 cells: Role of mitochondria-mediated oxidative stress","volume":"47","author":"Luo","year":"2005","journal-title":"Neurochem. Int."},{"key":"10.1074\/jbc.M111.329623_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1139\/Y09-134","article-title":"Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: Role of p53","volume":"88","author":"Roy","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1074\/jbc.M111.329623_bib38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cbi.2009.07.001","article-title":"Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells","volume":"181","author":"Roy","year":"2009","journal-title":"Chem. Biol. Interact"},{"key":"10.1074\/jbc.M111.329623_bib39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mito.2006.04.003","article-title":"Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria","volume":"6","author":"Sun","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1074\/jbc.M111.329623_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbamcr.2004.11.007","article-title":"The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway","volume":"1743","author":"Tanel","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.329623_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0165-7992(88)90104-2","article-title":"Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein","volume":"209","author":"Curren","year":"1988","journal-title":"Mutat. Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820531657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820531657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.329623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:13:37Z","timestamp":1641341617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820531657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":41,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0021925820531657"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.329623","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}