{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:01:44Z","timestamp":1792450904380,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":3088,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1074\/jbc.m112.343996","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T06:20:51Z","timestamp":1329891651000},"page":"13813-13821","source":"Crossref","is-referenced-by-count":124,"title":["Hg1, Novel Peptide Inhibitor Specific for Kv1.3 Channels from First Scorpion Kunitz-type Potassium Channel Toxin Family"],"prefix":"10.1016","volume":"287","author":[{"given":"Zong-Yun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Tian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Shan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Ping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.343996_bib1","first-page":"640","article-title":"Potassium channels as therapeutic targets for autoimmune disorders","volume":"6","author":"Wulff","year":"2003","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1074\/jbc.M112.343996_bib2","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.343996_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.imlet.2010.06.009","article-title":"Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels","volume":"133","author":"Toldi","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1074\/jbc.M112.343996_bib4","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","article-title":"Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases","volume":"67","author":"Beeton","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M112.343996_bib5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2008.07.015","article-title":"Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block","volume":"29","author":"Matheu","year":"2008","journal-title":"Immunity"},{"key":"10.1074\/jbc.M112.343996_bib6","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0501770102","article-title":"The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain","volume":"102","author":"Rus","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.343996_bib7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/1097-0282(20010405)58:4<422::AID-BIP1018>3.0.CO;2-T","article-title":"A helical capping motif in ShK toxin and its role in helix stabilization","volume":"58","author":"Lanigan","year":"2001","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M112.343996_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/mol.105.017210","article-title":"Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain","volume":"69","author":"Mouhat","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M112.343996_bib9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.toxicon.2009.11.010","article-title":"Mining on scorpion venom biodiversity","volume":"56","author":"Rodr\u00edguez de la Vega","year":"2010","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M112.343996_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3280321","article-title":"A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom","volume":"328","author":"Lebrun","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M112.343996_bib11","article-title":"Molecular diversity and functional evolution of scorpion potassium channel toxins","volume":"10","author":"Zhu","year":"2010","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M112.343996_bib12","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1073\/pnas.0910123106","article-title":"A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library","volume":"106","author":"Takacs","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.343996_bib13","doi-asserted-by":"crossref","first-page":"19058","DOI":"10.1074\/jbc.M802054200","article-title":"Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease","volume":"283","author":"Han","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib14","doi-asserted-by":"crossref","first-page":"23914","DOI":"10.1074\/jbc.M800776200","article-title":"Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1)","volume":"283","author":"Andreev","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature10607","article-title":"A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain","volume":"479","author":"Bohlen","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.343996_bib16","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1073\/pnas.91.3.878","article-title":"Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons","volume":"91","author":"Schweitz","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.343996_bib17","doi-asserted-by":"crossref","first-page":"22079","DOI":"10.1074\/jbc.M109.013276","article-title":"The first gene-encoded amphibian neurotoxin","volume":"284","author":"You","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","article-title":"The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms","volume":"10","author":"Fry","year":"2009","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1074\/jbc.M112.343996_bib19","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1107\/S0907444906021123","article-title":"Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail","volume":"62","author":"Dy","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M112.343996_bib20","doi-asserted-by":"crossref","first-page":"e3414","DOI":"10.1371\/journal.pone.0003414","article-title":"Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas","volume":"3","author":"Yuan","year":"2008","journal-title":"PloS One"},{"key":"10.1074\/jbc.M112.343996_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-3623(96)00173-5","article-title":"Recent studies on dendrotoxins and potassium ion channels","volume":"28","author":"Harvey","year":"1997","journal-title":"Gen. Pharmacol."},{"key":"10.1074\/jbc.M112.343996_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.peptides.2007.11.013","article-title":"A novel serine protease inhibitor from Bungarus fasciatus venom","volume":"29","author":"Lu","year":"2008","journal-title":"Peptides"},{"key":"10.1074\/jbc.M112.343996_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2011.03.023","article-title":"A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties","volume":"82","author":"Peigneur","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M112.343996_bib24","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.1074\/jbc.270.42.25121","article-title":"Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage-sensitive K+ channels","volume":"270","author":"Schweitz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib25","doi-asserted-by":"crossref","first-page":"23766","DOI":"10.1074\/jbc.C500064200","article-title":"Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization","volume":"280","author":"Bayrhuber","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib26","doi-asserted-by":"crossref","first-page":"e27548","DOI":"10.1371\/journal.pone.0027548","article-title":"SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.343996_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2164-8-119","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)","volume":"8","author":"Schwartz","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1074\/jbc.M112.343996_bib28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/pr060368g","article-title":"Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: Insights into the selectivity of molecular recognition","volume":"6","author":"Yi","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1074\/jbc.M112.343996_bib29","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/pr100027k","article-title":"Protein-protein recognition control by modulating electrostatic interactions","volume":"9","author":"Han","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1074\/jbc.M112.343996_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/prot.10389","article-title":"ZDOCK: An initial stage protein-docking algorithm","volume":"52","author":"Chen","year":"2003","journal-title":"Proteins"},{"key":"10.1074\/jbc.M112.343996_bib31","doi-asserted-by":"crossref","first-page":"24177","DOI":"10.1074\/jbc.M800179200","article-title":"Structural basis for toxin resistance of \u03b24-associated calcium-activated potassium (BK) channels","volume":"283","author":"Gan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.343996_bib32","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1021\/bi00072a026","article-title":"Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker","volume":"32","author":"Smith","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M112.343996_bib33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nsb0494-246","article-title":"Proteinase inhibitor homologues as potassium channel blockers","volume":"1","author":"Lancelin","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M112.343996_bib34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jmr.1031","article-title":"Molecular mechanism of \u03b4-dendrotoxin-potassium channel recognition explored by docking and molecular dynamic simulations","volume":"24","author":"Jin","year":"2011","journal-title":"J. Mol. Recognit."},{"key":"10.1074\/jbc.M112.343996_bib35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0165-6147(03)00080-4","article-title":"Novel interactions between K+ channels and scorpion toxins","volume":"24","author":"Rodr\u00edguez de la Vega","year":"2003","journal-title":"Trends Pharm. Sci."},{"key":"10.1074\/jbc.M112.343996_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/bj20030115","article-title":"The \u201cfunctional\u201d dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels","volume":"377","author":"Mouhat","year":"2004","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M112.343996_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/psc.630","article-title":"Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels","volume":"11","author":"Mouhat","year":"2005","journal-title":"J. Pept. Sci."},{"key":"10.1074\/jbc.M112.343996_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/187152811797200641","article-title":"Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases","volume":"10","author":"Beeton","year":"2011","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1074\/jbc.M112.343996_bib39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2011.07.016","article-title":"Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases","volume":"59","author":"Chi","year":"2012","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M112.343996_bib40","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1006\/jmbi.2000.3522","article-title":"Energetic and structural interactions between \u03b4-dendrotoxin and a voltage-gated potassium channel","volume":"296","author":"Imredy","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.343996_bib41","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxicon.2008.05.020","article-title":"A rational nomenclature for naming peptide toxins from spiders and other venomous animals","volume":"52","author":"King","year":"2008","journal-title":"Toxicon"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820529530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820529530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.343996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T12:26:09Z","timestamp":1624623969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820529530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":41,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0021925820529530"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.343996","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}