{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:55:07Z","timestamp":1782514507506,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"34","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":2968,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1074\/jbc.m112.351379","type":"journal-article","created":{"date-parts":[[2012,7,7]],"date-time":"2012-07-07T04:30:35Z","timestamp":1341635435000},"page":"28745-28754","source":"Crossref","is-referenced-by-count":40,"title":["Diindolylmethane-mediated Gli1 Protein Suppression Induces Anoikis in Ovarian Cancer Cells in Vitro and Blocks Tumor Formation Ability in Vivo"],"prefix":"10.1016","volume":"287","author":[{"given":"Prabodh K.","family":"Kandala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.351379_bib1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/sj.cdd.4401723","article-title":"Anoikis","volume":"12","author":"Gilmore","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M112.351379_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0955-0674(00)00251-9","article-title":"Anoikis mechanisms","volume":"13","author":"Frisch","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M112.351379_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ijc.25725","article-title":"The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors","volume":"128","author":"Nagaprashantha","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M112.351379_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1015312119693","article-title":"Molecular mechanisms of \u201cdetachment-induced apoptosis: anoikis.\u201d","volume":"7","author":"Grossmann","year":"2002","journal-title":"Apoptosis"},{"key":"10.1074\/jbc.M112.351379_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.canlet.2008.05.029","article-title":"Anoikis resistance and tumor metastasis","volume":"272","author":"Simpson","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1074\/jbc.M112.351379_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jss.2009.07.011","article-title":"Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death","volume":"164","author":"Coates","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1074\/jbc.M112.351379_bib7","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","article-title":"Mutations affecting segment number and polarity in Drosophila","volume":"287","author":"N\u00fcsslein-Volhard","year":"1980","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.351379_bib8","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.351379_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0092-8674(00)00129-X","article-title":"Transducing the hedgehog signal","volume":"103","author":"Kalderon","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.351379_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nrc1229","article-title":"Hedgehog signalling in cancer formation and maintenance","volume":"3","author":"Pasca di Magliano","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M112.351379_bib11","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1158\/1078-0432.CCR-08-1414","article-title":"Role of hedgehog signaling in ovarian cancer","volume":"14","author":"Bhattacharya","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/carcin\/bgn230","article-title":"Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion, and differentiation","volume":"30","author":"Liao","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M112.351379_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/dna.2007.0625","article-title":"GLI1 is involved in cell cycle regulation and proliferation of NT2 embryonal carcinoma stem cells","volume":"27","author":"Vestergaard","year":"2008","journal-title":"DNA Cell Biol."},{"key":"10.1074\/jbc.M112.351379_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/417299a","article-title":"Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E","volume":"417","author":"Duman-Scheel","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.351379_bib15","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1745-7254.2007.00620.x","article-title":"Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells","volume":"28","author":"Hu","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1074\/jbc.M112.351379_bib16","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1158\/0008-5472.CAN-11-1338","article-title":"Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer","volume":"71","author":"Yoo","year":"2011","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib17","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.gt.3302748","article-title":"Gene therapy, angiogenesis, sonic hedgehog: sonic the hedgehog to the rescue?","volume":"13","author":"Donahue","year":"2006","journal-title":"Gene Ther."},{"key":"10.1074\/jbc.M112.351379_bib18","first-page":"pt9","article-title":"Hedgehog signaling and the Gli code in stem cells, cancer, and metastases","volume":"4","author":"Ruiz i Altaba","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1074\/jbc.M112.351379_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3322\/caac.20121","article-title":"Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths","volume":"61","author":"Siegel","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1074\/jbc.M112.351379_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: integrating insights from disparate model organisms","volume":"5","author":"Naora","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M112.351379_bib21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrclinonc.2010.47","article-title":"Imaging ovarian cancer and peritoneal metastases: current and emerging techniques","volume":"7","author":"Kyriazi","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1074\/jbc.M112.351379_bib22","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1158\/0008-5472.CAN-09-3557","article-title":"Down-regulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells","volume":"70","author":"He","year":"2010","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib23","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1172\/JCI40802","article-title":"Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis","volume":"120","author":"Sood","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M112.351379_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/mc.20698","article-title":"3,3\u2032-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model","volume":"50","author":"Cho","year":"2011","journal-title":"Mol. Carcinog."},{"key":"10.1074\/jbc.M112.351379_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11010-011-0985-0","article-title":"3,3\u2032-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation","volume":"358","author":"Jin","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M112.351379_bib26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1158\/1940-6207.CAPR-08-0142","article-title":"3,3\u2032-Diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin","volume":"2","author":"Bhatnagar","year":"2009","journal-title":"Cancer Prevent. Res."},{"key":"10.1074\/jbc.M112.351379_bib27","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1158\/0008-5472.CAN-09-0838","article-title":"3,3\u2032-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer","volume":"69","author":"Banerjee","year":"2009","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1124\/mol.110.063750","article-title":"Activation of checkpoint kinase 2 by 3,3\u2032-diindolylmethane is required for causing G2\/M cell cycle arrest in human ovarian cancer cells","volume":"78","author":"Kandala","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M112.351379_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.111.188706","article-title":"Blocking epidermal growth factor receptor activation by 3,3\u2032-diindolylmethane suppresses ovarian tumor growth in vitro in vivo","volume":"341","author":"Kandala","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M112.351379_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.18632\/oncotarget.483","article-title":"Regulation of macroautophagy in ovarian cancer cells in vitro in vivo by controlling glucose regulatory protein 78 and AMPK","volume":"3","author":"Kandala","year":"2012","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.M112.351379_bib31","first-page":"94","article-title":"Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro in vivo","volume":"6","author":"Kandala","year":"2012","journal-title":"Drug Discoveries Therapeutics"},{"key":"10.1074\/jbc.M112.351379_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1741-7015-10-9","article-title":"Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)","volume":"10","author":"Kandala","year":"2012","journal-title":"BMC Med."},{"key":"10.1074\/jbc.M112.351379_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2121-9-49","article-title":"Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines","volume":"9","author":"Lipinski","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1074\/jbc.M112.351379_bib34","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1172\/JCI27698","article-title":"Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity","volume":"116","author":"Chien","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M112.351379_bib35","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/carcin\/bgp253","article-title":"Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells","volume":"30","author":"Lui","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M112.351379_bib36","first-page":"811","article-title":"Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation","volume":"99","author":"Mawji","year":"2007","journal-title":"J.N.C.I."},{"key":"10.1074\/jbc.M112.351379_bib37","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1158\/1078-0432.CCR-10-1891","article-title":"Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K\/AKT\/FOXO pathway","volume":"17","author":"Boreddy","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M112.351379_bib39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0955-0674(99)00076-9","article-title":"Cholesterol in signal transduction","volume":"12","author":"Incardona","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M112.351379_bib40","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/S0140-6736(07)60781-8","article-title":"Metastasis: recent discoveries and novel treatment strategies","volume":"369","author":"Eccles","year":"2007","journal-title":"Lancet"},{"key":"10.1074\/jbc.M112.351379_bib41","first-page":"3181","article-title":"Walker 256 tumor implantation in normal and injured peritoneum studied by electron microscopy, scanning electron microscopy, and autoradiography","volume":"33","author":"Buck","year":"1973","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1349-7006.2006.00353.x","article-title":"Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: its inhibition leads to growth suppression and apoptosis","volume":"98","author":"Chen","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1074\/jbc.M112.351379_bib43","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1158\/1535-7163.MCT-06-0014","article-title":"Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation","volume":"5","author":"Kaur","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M112.351379_bib44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3748\/wjg.14.582","article-title":"Gli-1 siRNA induced apoptosis in Huh7 cells","volume":"14","author":"Chen","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1074\/jbc.M112.351379_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mrrev.2011.06.001","article-title":"Attenuation of multi-targeted proliferation-linked signaling by 3,3\u2032-diindolylmethane (DIM): from bench to clinic","volume":"728","author":"Banerjee","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.M112.351379_bib46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/mc.20604","article-title":"Curcumin inhibits the sonic hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells","volume":"49","author":"Elamin","year":"2010","journal-title":"Mol. Carcinog."},{"key":"10.1074\/jbc.M112.351379_bib47","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1158\/0008-5472.CAN-09-3012","article-title":"Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer","volume":"70","author":"Slusarz","year":"2010","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.351379_bib48","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1200\/JCO.2010.27.9943","article-title":"Clinical experience with hedgehog pathway inhibitors","volume":"28","author":"Low","year":"2010","journal-title":"J. Clin. Oncol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820684101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820684101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.351379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T11:17:39Z","timestamp":1641381459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820684101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":48,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0021925820684101"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.351379","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}