{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:12:31Z","timestamp":1789395151256,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":2937,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1074\/jbc.m112.352534","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:19:57Z","timestamp":1343261997000},"page":"32578-32587","source":"Crossref","is-referenced-by-count":28,"title":["A Disintegrin and Metalloproteinase 17 (ADAM17) and Epidermal Growth Factor Receptor (EGFR) Signaling Drive the Epithelial Response to Staphylococcus aureus Toxic Shock Syndrome Toxin-1 (TSST-1)"],"prefix":"10.1016","volume":"287","author":[{"given":"Laura M.","family":"Breshears","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Schlievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie L.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.352534_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.352534_bib2","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0002-9378(03)00873-1","article-title":"Penetration of toxic shock syndrome toxin-1 across porcine vaginal mucosa ex vivo: permeability characteristics, toxin distribution, and tissue damage","volume":"189","author":"Davis","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1074\/jbc.M112.352534_bib3","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/IAI.68.6.3630-3634.2000","article-title":"Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals","volume":"68","author":"Schlievert","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1128\/iai.45.3.566-571.1984","article-title":"Staphylococcal toxic shock toxin specifically binds to cultured human epithelial cells and is rapidly internalized","volume":"45","author":"Kushnaryov","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib5","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1128\/IAI.70.4.2178-2186.2002","article-title":"Identification of a transcytosis epitope on staphylococcal enterotoxins","volume":"70","author":"Shupp","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib6","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/IAI.73.4.2164-2174.2005","article-title":"The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1","volume":"73","author":"Peterson","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib7","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.4049\/jimmunol.0803283","article-title":"Cytolysins augment superantigen penetration of stratified mucosa","volume":"182","author":"Brosnahan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.352534_bib8","doi-asserted-by":"crossref","first-page":"12995","DOI":"10.1021\/bi801468w","article-title":"Novel toxic shock syndrome toxin-1 amino acids required for biological activity","volume":"47","author":"Brosnahan","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M112.352534_bib9","doi-asserted-by":"crossref","first-page":"e32813","DOI":"10.1371\/journal.pone.0032813","article-title":"Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1","volume":"7","author":"Schaefers","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M112.352534_bib10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.semcdb.2008.09.005","article-title":"The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer","volume":"20","author":"Pruessmeyer","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.352534_bib11","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/emboj\/cdg111","article-title":"TACE is required for the activation of the EGFR by TGF-alpha in tumors","volume":"22","author":"Borrell-Pages","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.352534_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tibs.2005.05.006","article-title":"Shedding light on ADAM metalloproteinases","volume":"30","author":"Huovila","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M112.352534_bib13","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M112.352534_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.gastro.2004.05.017","article-title":"The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells","volume":"127","author":"Tanida","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M112.352534_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1074\/jbc.M109.059394","article-title":"A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells","volume":"285","author":"Pruessmeyer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.352534_bib16","doi-asserted-by":"crossref","first-page":"pe18","DOI":"10.1126\/scisignal.264pe18","article-title":"Syndecans shed their reputation as inert molecules","volume":"2","author":"Bass","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1074\/jbc.M112.352534_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1100\/tsw.2003.118","article-title":"Syndecan-1 as a regulator of chemokine function","volume":"3","author":"G\u00f6tte","year":"2003","journal-title":"Sci. World J."},{"key":"10.1074\/jbc.M112.352534_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/scdb.2000.0239","article-title":"Molecular interactions of syndecans during development","volume":"12","author":"Rapraeger","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.352534_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0076-6879(88)65009-9","article-title":"Preparation of toxic shock syndrome toxin-1","volume":"165","author":"Blomster-Hautamaa","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M112.352534_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/iai.64.1.371-374.1996","article-title":"Localization of biologically important regions on toxic shock syndrome toxin 1","volume":"64","author":"Murray","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1095\/biolreprod57.4.847","article-title":"Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins","volume":"57","author":"Fichorova","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1074\/jbc.M112.352534_bib22","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/sj.jid.5701184","article-title":"The epidermal growth factor receptor system in skin repair and inflammation","volume":"128","author":"Pastore","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.M112.352534_bib23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/328817a0","article-title":"Production and auto-induction of transforming growth factor-\u03b1 in human keratinocytes","volume":"328","author":"Coffey","year":"1987","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.352534_bib24","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1210\/me.2005-0504","article-title":"Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor","volume":"20","author":"Shimada","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M112.352534_bib25","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.biocel.2008.04.009","article-title":"The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells","volume":"40","author":"Ramos","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1074\/jbc.M112.352534_bib26","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1091\/mbc.01-11-0561","article-title":"Extracellular signal-regulated kinase phosphorylates tumor necrosis factor \u03b1-converting enzyme at threonine 735: a potential role in regulated shedding","volume":"13","author":"D\u00edaz-Rodr\u00edguez","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M112.352534_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/sj.emboj.7601554","article-title":"Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling","volume":"26","author":"G\u00f3mez","year":"2007","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.352534_bib28","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00620.2005","article-title":"ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors","volume":"291","author":"Ohtsu","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1074\/jbc.M112.352534_bib29","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus \u03b1-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.352534_bib30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.68.1.120-124.2000","article-title":"Induction of tumor necrosis factor \u03b1 and interleukin-8 gene expression in bronchial epithelial cells by toxic shock syndrome toxin 1","volume":"68","author":"Aubert","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.352534_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.otohns.2005.11.016","article-title":"Proinflammatory effects of Staphylococcus aureus exotoxin B on nasal epithelial cells","volume":"134","author":"Damm","year":"2006","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1074\/jbc.M112.352534_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1465-9921-7-115","article-title":"Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells","volume":"7","author":"O'Brien","year":"2006","journal-title":"Respiratory Research"},{"key":"10.1074\/jbc.M112.352534_bib33","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/150.4.535","article-title":"Study of staphylococcal toxic shock syndrome toxin in human epithelial cell culture","volume":"150","author":"Kushnaryov","year":"1984","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.352534_bib34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/74672","article-title":"Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation","volume":"6","author":"Arad","year":"2000","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M112.352534_bib35","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ejps.2009.09.016","article-title":"Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-\u03b4 and PKC-\u03f5 in the shedding of epidermal growth factor receptor ligands","volume":"38","author":"Uchiyama","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1074\/jbc.M112.352534_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/BJ20091611","article-title":"The cytoplasmic domains of TNF\u03b1-converting enzyme (TACE\/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding","volume":"428","author":"Killock","year":"2010","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M112.352534_bib37","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1002\/pmic.200800204","article-title":"Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network","volume":"8","author":"Morandell","year":"2008","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M112.352534_bib38","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1074\/jbc.M109.078170","article-title":"P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells","volume":"285","author":"Ratchford","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.352534_bib39","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1128\/MCB.26.10.3917-3934.2006","article-title":"Furin-, ADAM10-, and \u03b3-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of \u03b2-catenin's transcriptional activity","volume":"26","author":"Anders","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.352534_bib40","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(02)01079-6","article-title":"Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury","volume":"111","author":"Li","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.352534_bib41","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1074\/jbc.M110.185165","article-title":"Syndecan-1 promotes Staphylococcus aureus corneal infection by counteracting neutrophil-mediated host defense","volume":"286","author":"Hayashida","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.352534_bib42","doi-asserted-by":"crossref","first-page":"e1000405","DOI":"10.1371\/journal.ppat.1000405","article-title":"Differential modulation of TNF-\u03b1-induced apoptosis by Neisseria meningitidis","volume":"5","author":"Deghmane","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M112.352534_bib43","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1074\/jbc.M708422200","article-title":"Reduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis","volume":"283","author":"Paland","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.352534_bib44","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nm1079","article-title":"Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1","volume":"10","author":"G\u00f3mez","year":"2004","journal-title":"Nat. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820629180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820629180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.352534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:00:24Z","timestamp":1641366024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820629180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":44,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0021925820629180"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.352534","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}