{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:09:36Z","timestamp":1768716576709,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":2986,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1074\/jbc.m112.353979","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:13:00Z","timestamp":1338163980000},"page":"24216-24227","source":"Crossref","is-referenced-by-count":86,"title":["Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein"],"prefix":"10.1016","volume":"287","author":[{"given":"Jaume","family":"Amengual","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Golczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"von Lintig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.353979_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.75.103004.142743","article-title":"G protein-coupled receptor rhodopsin","volume":"75","author":"Palczewski","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M112.353979_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M112.353979_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/nu3010063","article-title":"Vitamin A metabolism. An update","volume":"3","author":"D'Ambrosio","year":"2011","journal-title":"Nutrients"},{"key":"10.1074\/jbc.M112.353979_bib4","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1074\/jbc.M800777200","article-title":"The molecular basis of retinoid absorption. A genetic dissection","volume":"283","author":"Wongsiriroj","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib5","doi-asserted-by":"crossref","first-page":"276S","DOI":"10.1093\/jn\/134.1.276S","article-title":"Vitamin A. Overlapping delivery pathways to tissues from the circulation","volume":"134","author":"Paik","year":"2004","journal-title":"J. Nutr."},{"key":"10.1074\/jbc.M112.353979_bib6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-2275(20)32461-5","article-title":"Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester","volume":"40","author":"van Bennekum","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M112.353979_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0022-2275(20)39309-3","article-title":"Tissue Distribution and Metabolism of Newly Absorbed Vitamin A in the Rat","volume":"6","author":"Goodman","year":"1965","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M112.353979_bib8","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.M507924200","article-title":"Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)","volume":"280","author":"O'Byrne","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib9","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1093\/emboj\/18.17.4633","article-title":"Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein","volume":"18","author":"Quadro","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.353979_bib10","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1073\/pnas.90.6.2375","article-title":"Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone","volume":"90","author":"Episkopou","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.353979_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cmet.2007.02.006","article-title":"STRA6, a cell surface receptor for retinol-binding protein. The plot thickens","volume":"5","author":"Blaner","year":"2007","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M112.353979_bib12","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.1136244","article-title":"A membrane receptor for retinol-binding protein mediates cellular uptake of vitamin A","volume":"315","author":"Kawaguchi","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M112.353979_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0925-4773(97)00039-7","article-title":"Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein","volume":"63","author":"Bouillet","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1074\/jbc.M112.353979_bib14","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1167\/iovs.11-8476","article-title":"Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6","volume":"53","author":"Ruiz","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M112.353979_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmet.2008.01.009","article-title":"RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome","volume":"7","author":"Isken","year":"2008","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M112.353979_bib16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1021\/cb200178w","article-title":"Receptor-mediated cellular uptake mechanism that couples to intracellular storage","volume":"6","author":"Kawaguchi","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1074\/jbc.M112.353979_bib17","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1074\/jbc.274.6.3834","article-title":"Molecular and biochemical characterization of lecithin retinol acyltransferase","volume":"274","author":"Ruiz","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib18","doi-asserted-by":"crossref","first-page":"40226","DOI":"10.1074\/jbc.M509643200","article-title":"Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency","volume":"280","author":"Liu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib19","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1074\/jbc.M312410200","article-title":"Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver","volume":"279","author":"Batten","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/jn\/127.2.218","article-title":"Lecithin:retinol acyltransferase and retinyl ester hydrolase activities are differentially regulated by retinoids and have distinct distributions between hepatocyte and nonparenchymal cell fractions of rat liver","volume":"127","author":"Matsuura","year":"1997","journal-title":"J. Nutr."},{"key":"10.1074\/jbc.M112.353979_bib21","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1074\/jbc.M708982200","article-title":"Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina","volume":"283","author":"Golczak","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib22","doi-asserted-by":"crossref","first-page":"33553","DOI":"10.1074\/jbc.M706763200","article-title":"CMO1 deficiency abolishes vitamin A production from \u03b2-carotene and alters lipid metabolism in mice","volume":"282","author":"Hessel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib23","doi-asserted-by":"crossref","first-page":"30191","DOI":"10.1074\/jbc.M205046200","article-title":"Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice","volume":"277","author":"Quadro","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib24","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1074\/jbc.273.4.2409","article-title":"Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor \u03b3 and retinoid X receptor \u03b1","volume":"273","author":"Abu-Abed","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1432-1033.1976.tb10390.x","article-title":"Binding affinities of retinol and related compounds to retinol-binding proteins","volume":"65","author":"Cogan","year":"1976","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M112.353979_bib26","doi-asserted-by":"crossref","first-page":"22188","DOI":"10.1016\/S0021-9258(20)80666-8","article-title":"Unfolding of newly made retinol-binding protein by dithiothreitol. Sensitivity to retinoids","volume":"268","author":"Kaji","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib27","doi-asserted-by":"crossref","first-page":"E1420","DOI":"10.1152\/ajpendo.00362.2009","article-title":"Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis","volume":"297","author":"Preitner","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1074\/jbc.M112.353979_bib28","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1167\/iovs.05-0820","article-title":"Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores. A potential therapy for treatment of lipofuscin-based retinal diseases","volume":"46","author":"Radu","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M112.353979_bib29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature03711","article-title":"Serum retinol-binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes","volume":"436","author":"Yang","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.353979_bib30","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1074\/jbc.M809654200","article-title":"Identification and characterization of a non-retinoid ligand for retinol-binding protein 4, which lowers serum retinol-binding protein 4 levels in vivo","volume":"284","author":"Motani","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.353979_bib31","first-page":"280","article-title":"Effects of N-(4-hydroxyphenyl)-retinamide on the number and cytotoxicity of natural killer cells in vitamin A-sufficient and -deficient rats","volume":"13","author":"Zhao","year":"1994","journal-title":"Nat. Immun."},{"key":"10.1074\/jbc.M112.353979_bib32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1083\/jcb.200405110","article-title":"Retinosomes. New insights into intracellular managing of hydrophobic substances in lipid bodies","volume":"166","author":"Imanishi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.353979_bib33","first-page":"1730","article-title":"Analysis of the visual cycle in cellular retinol-binding protein type I (CRBPI) knockout mice","volume":"43","author":"Saari","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M112.353979_bib34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1194\/jlr.M001222","article-title":"Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung","volume":"51","author":"Wu","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M112.353979_bib35","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1476-5381.2011.01310.x","article-title":"Fenretinide metabolism in humans and mice. Utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure","volume":"163","author":"Cooper","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M112.353979_bib36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/jn\/132.6.1160","article-title":"Lecithin:retinol acyltransferase expression is regulated by dietary vitamin A and exogenous retinoic acid in the lung of adult rats","volume":"132","author":"Zolfaghari","year":"2002","journal-title":"J. Nutr."},{"key":"10.1074\/jbc.M112.353979_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-5793(92)81046-O","article-title":"In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences","volume":"308","author":"Berni","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M112.353979_bib38","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2337\/diabetes.53.4.882","article-title":"Modulation of resistin expression by retinoic acid and vitamin A status","volume":"53","author":"Felipe","year":"2004","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M112.353979_bib39","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/oby.2001.65","article-title":"Changes of adiposity in response to vitamin A status correlate with changes of PPAR\u03b32 expression","volume":"9","author":"Ribot","year":"2001","journal-title":"Obes. Res."},{"key":"10.1074\/jbc.M112.353979_bib40","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/MCB.01742-08","article-title":"All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor \u03b2\/\u03b4 and retinoic acid receptor","volume":"29","author":"Berry","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M112.353979_bib41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/archopht.1986.01050130079024","article-title":"Abnormal retinal function associated with fenretinide, a synthetic retinoid","volume":"104","author":"Kaiser-Kupfer","year":"1986","journal-title":"Arch. Ophthalmol."},{"key":"10.1074\/jbc.M112.353979_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/jnci\/86.2.105","article-title":"Effect of the synthetic retinoid fenretinide on dark adaptation and the ocular surface","volume":"86","author":"Decensi","year":"1994","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820432727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820432727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.353979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:37:36Z","timestamp":1641299856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820432727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":42,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0021925820432727"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.353979","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}