{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:06:09Z","timestamp":1790867169416,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":3004,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1074\/jbc.m112.364075","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T02:42:09Z","timestamp":1338345729000},"page":"25203-25215","source":"Crossref","is-referenced-by-count":57,"title":["Synthetic Human Monoclonal Antibodies toward Staphylococcal Enterotoxin B (SEB) Protective against Toxic Shock Syndrome"],"prefix":"10.1016","volume":"287","author":[{"given":"Hatice","family":"Karauzum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Abaandou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahta","family":"Mahmoudieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh R.","family":"Boroun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Shulenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Sathya","family":"Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Stavale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Warfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Zeitlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachdev S.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Javad","family":"Aman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.364075_bib1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M112.364075_bib2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tim.2005.10.002","article-title":"Staphylococcal innate immune evasion","volume":"13","author":"Rooijakkers","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M112.364075_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaci.2007.06.005","article-title":"Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets","volume":"120","author":"Nizet","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M112.364075_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0065-2776(08)60534-9","article-title":"Superantigens and their potential role in human disease","volume":"54","author":"Kotzin","year":"1993","journal-title":"Adv. Immunol."},{"key":"10.1074\/jbc.M112.364075_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1074\/jbc.M112.364075_bib6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/infdis\/167.5.997","article-title":"Role of superantigens in human disease","volume":"167","author":"Schlievert","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.364075_bib7","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(86)91859-3","article-title":"Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 are significantly associated with non-menstrual TSS","volume":"1","author":"Schlievert","year":"1986","journal-title":"Lancet."},{"key":"10.1074\/jbc.M112.364075_bib8","series-title":"Textbook of Military Medicine. Part I. Warfare, Weaponry, and the Casualty","first-page":"621","article-title":"Staphylococcal enterotoxin B and related pyrogeni c toxins","author":"Ulrich","year":"1997"},{"key":"10.1074\/jbc.M112.364075_bib9","first-page":"1","article-title":"Streptococcal superantigens","volume":"93","author":"Proft","year":"2007","journal-title":"Chem. Immunol. Allergy."},{"key":"10.1074\/jbc.M112.364075_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrd1694","article-title":"The evolving field of biodefence. Therapeutic developments and diagnostics","volume":"4","author":"Burnett","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M112.364075_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/376630","article-title":"Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome. A European randomized, double-blind, placebo-controlled trial","volume":"37","author":"Darenberg","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1074\/jbc.M112.364075_bib12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1086\/381979","article-title":"Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens. Implications for therapy of toxic shock syndrome","volume":"38","author":"Darenberg","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1074\/jbc.M112.364075_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nbt.1791","article-title":"Beyond natural antibodies. The power of in vitro display technologies","volume":"29","author":"Bradbury","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M112.364075_bib14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio843","article-title":"Synthetic therapeutic antibodies","volume":"2","author":"Sidhu","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M112.364075_bib15","series-title":"Phage Display in Biotechnology and Drug Discovery","first-page":"709","article-title":"Synthetic antibody libraries","author":"Fellouse","year":"2006"},{"key":"10.1074\/jbc.M112.364075_bib16","series-title":"Making and Using Antibodies","first-page":"157","article-title":"Making antibodies in bacteria","author":"Fellouse","year":"2007"},{"key":"10.1074\/jbc.M112.364075_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jim.2007.01.008","article-title":"Antibody internalization studied using a novel IgG binding toxin fusion","volume":"321","author":"Mazor","year":"2007","journal-title":"J. Immunol. Methods."},{"key":"10.1074\/jbc.M112.364075_bib18","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1093\/annonc\/mdq256","article-title":"Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma","volume":"21","author":"Bendandi","year":"2010","journal-title":"Ann. Oncol."},{"key":"10.1074\/jbc.M112.364075_bib19","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nbt1094","volume":"23","author":"Marillonnet","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M112.364075_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1467-7652.2008.00330.x","volume":"6","author":"Strasser","year":"2008","journal-title":"Plant Biotechnol. J."},{"key":"10.1074\/jbc.M112.364075_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00320315","article-title":"Isolation of human monocytes by Ficoll density gradient centrifugation","volume":"43","author":"Berthold","year":"1981","journal-title":"Blut."},{"key":"10.1074\/jbc.M112.364075_bib22","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jmb.2007.08.005","article-title":"High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries","volume":"373","author":"Fellouse","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.364075_bib23","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/nprot.2007.151","article-title":"Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries","volume":"2","author":"Tonikian","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1074\/jbc.M112.364075_bib24","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1128\/IAI.61.12.5333-5338.1993","article-title":"Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide. Major histocompatibility complex class II molecule dependency and cytokine release","volume":"61","author":"Stiles","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.364075_bib25","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrmicro1289","article-title":"Immune evasion by staphylococci","volume":"3","author":"Foster","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.364075_bib26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/prep.2001.1556","article-title":"Production and purification of a recombinant Staphylococcal enterotoxin B vaccine candidate expressed in Escherichia coli","volume":"24","author":"Coffman","year":"2002","journal-title":"Protein Expr. Purif."},{"key":"10.1074\/jbc.M112.364075_bib27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jmr.659","article-title":"Identification of differences in the specificity-determining residues of antibodies that recognize antigens of different size. Implications for the rational design of antibody repertoires","volume":"17","author":"Almagro","year":"2004","journal-title":"J. Mol. Recognit."},{"key":"10.1074\/jbc.M112.364075_bib28","doi-asserted-by":"crossref","first-page":"e17887","DOI":"10.1371\/journal.pone.0017887","article-title":"High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity","volume":"6","author":"Bostrom","year":"2011","journal-title":"PLoS One."},{"key":"10.1074\/jbc.M112.364075_bib29","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.4049\/jimmunol.147.5.1709","article-title":"Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites","volume":"147","author":"Kabat","year":"1991","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.364075_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0161-5890(94)90001-9","article-title":"Anatomy of the antibody molecule","volume":"31","author":"Padlan","year":"1994","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.364075_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1074-7613(00)00006-6","article-title":"Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities","volume":"13","author":"Xu","year":"2000","journal-title":"Immunity."},{"key":"10.1074\/jbc.M112.364075_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-2836(02)00264-4","article-title":"Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis","volume":"320","author":"Vajdos","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.364075_bib33","doi-asserted-by":"crossref","first-page":"e13253","DOI":"10.1371\/journal.pone.0013253","article-title":"Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B","volume":"5","author":"Larkin","year":"2010","journal-title":"PLoS One."},{"key":"10.1074\/jbc.M112.364075_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-8518-8-9","article-title":"Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B","volume":"8","author":"Drozdowski","year":"2010","journal-title":"J. Immune Based Ther. Vaccines."},{"key":"10.1074\/jbc.M112.364075_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens. An update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.364075_bib36","doi-asserted-by":"crossref","first-page":"14645","DOI":"10.1073\/pnas.0607089103","article-title":"Monoclonal antibodies from plants. A new speed record","volume":"103","author":"Hiatt","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.364075_bib37","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1467-7652.2009.00495.x","article-title":"Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems","volume":"8","author":"Pogue","year":"2010","journal-title":"Plant Biotechnol. J."},{"key":"10.1074\/jbc.M112.364075_bib38","series-title":"Sequences of Proteins of Immunological Interest","author":"Kabat","year":"1991"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820736872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820736872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.364075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:28:29Z","timestamp":1687480109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820736872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":38,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0021925820736872"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.364075","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}