{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:08:23Z","timestamp":1791349703496,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":3021,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1074\/jbc.m112.372425","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:18:19Z","timestamp":1337127499000},"page":"23769-23778","source":"Crossref","is-referenced-by-count":66,"title":["Tyrosine Kinase Btk Is Required for NK Cell Activation"],"prefix":"10.1016","volume":"287","author":[{"given":"Yan","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lung","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.372425_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-065X.2008.00741.x","article-title":"Bruton tyrosine kinase (Btk). Function, regulation, and transformation with special emphasis on the PH domain","volume":"228","author":"Mohamed","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M112.372425_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s10875-011-9639-y","article-title":"Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia","author":"Liu","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib3","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood-2010-11-317016","article-title":"Btk is a positive regulator in the TREM-1\/DAP12 signaling pathway","volume":"118","author":"Ormsby","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.372425_bib4","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1073\/pnas.050583597","article-title":"Post-transcriptional regulation of Bruton tyrosine kinase expression in antigen receptor-stimulated splenic B cells","volume":"97","author":"Nisitani","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.372425_bib5","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.molimm.2006.11.023","article-title":"Btk regulates multiple stages in the development and survival of B-1 cells","volume":"44","author":"Contreras","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4049\/jimmunol.182.1.329","article-title":"Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells","volume":"182","author":"Sharma","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib7","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/leu.2010.140","article-title":"Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK","volume":"24","author":"Ng","year":"2010","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M112.372425_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s10495-010-0569-6","article-title":"Role of Bruton tyrosine kinase in macrophage apoptosis","volume":"16","author":"Khare","year":"2011","journal-title":"Apoptosis"},{"key":"10.1074\/jbc.M112.372425_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nchembio.481","article-title":"Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis","volume":"7","author":"Di Paolo","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M112.372425_bib10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1160\/TH07-01-0061","article-title":"Tyrosine phosphorylation\/dephosphorylation balance is involved in thrombin-evoked microtubular reorganization in human platelets","volume":"98","author":"Bouaziz","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1074\/jbc.M112.372425_bib11","doi-asserted-by":"crossref","first-page":"11526","DOI":"10.1074\/jbc.M708935200","article-title":"The tec family tyrosine kinase Btk regulates RANKL-induced osteoclast maturation","volume":"283","author":"Lee","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.372425_bib12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1084\/jem.20082392","article-title":"Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity","volume":"206","author":"Kubo","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M112.372425_bib13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4049\/jimmunol.1003631","article-title":"Bruton tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages","volume":"187","author":"Vijayan","year":"2011","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/eji.201040840","article-title":"IFN-\u03b1-producing PDCA-1+ Siglec-H-B cells mediate innate immune defense by activating NK cells","volume":"41","author":"Bao","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni.2015","article-title":"Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk","volume":"12","author":"Liu","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis, and function. Parallels with CD8+ T cells","volume":"11","author":"Sun","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib17","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.4049\/jimmunol.1001974","article-title":"Cutting edge. The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL\/6 mouse","volume":"185","author":"Wang","year":"2010","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib18","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/hep.23168","article-title":"The \u03b22 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions","volume":"50","author":"Zhang","year":"2009","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.372425_bib19","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1073\/pnas.0712182105","article-title":"ATF3 regulates MCMV infection in mice by modulating IFN-\u03b3 expression in natural killer cells","volume":"105","author":"Rosenberger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.372425_bib20","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1182\/blood-2006-10-050096","article-title":"Hlx homeobox transcription factor negatively regulates interferon-\u03b3 production in monokine-activated natural killer cells","volume":"109","author":"Becknell","year":"2007","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.372425_bib21","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.4049\/jimmunol.1001682","article-title":"PRDM1\/Blimp-1 controls effector cytokine production in human NK cells","volume":"185","author":"Smith","year":"2010","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib22","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.20110226","article-title":"The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a \u03b3\u03b4 T cell population in humanized mice","volume":"208","author":"Tu","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M112.372425_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/eji.201040724","article-title":"Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-\u03b3- and T-bet-dependent pathway","volume":"41","author":"Zheng","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib24","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1086\/605413","article-title":"Phosphoantigen-expanded \u03b3\u03b4 T cells display potent cytotoxicity against human and avian influenza virus-infected monocyte-derived macrophages","volume":"200","author":"Qin","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.372425_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.cellbio.23.090506.123521","article-title":"Secretory mechanisms in cell-mediated cytotoxicity","volume":"23","author":"Stinchcombe","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.372425_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.0105-2896.2010.00904.x","article-title":"Cytotoxic immunological synapses","volume":"235","author":"Dustin","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M112.372425_bib28","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.4049\/jimmunol.180.12.7785","article-title":"Noncytotoxic functions of NK cells. Direct pathogen restriction and assistance to adaptive immunity","volume":"180","author":"Strowig","year":"2008","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or adaptive immunity? The example of natural killer cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"10.1074\/jbc.M112.372425_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ceb.2008.04.007","article-title":"New twists in X-chromosome inactivation","volume":"20","author":"Erwin","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M112.372425_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.genom.6.080604.162350","article-title":"Silencing of the mammalian X chromosome","volume":"6","author":"Chow","year":"2005","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1074\/jbc.M112.372425_bib32","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1073\/pnas.0712018105","article-title":"X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations","volume":"105","author":"Shen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.372425_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/intimm\/dxh391","article-title":"Opposing roles of NF-\u03baB family members in the regulation of NK cell proliferation and production of IFN-\u03b3","volume":"18","author":"Tato","year":"2006","journal-title":"Int. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib34","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1053\/j.gastro.2004.08.055","article-title":"Negative regulation of liver regeneration by innate immunity (natural killer cells\/interferon-\u03b3)","volume":"127","author":"Sun","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M112.372425_bib35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.clim.2007.10.005","article-title":"Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia","volume":"126","author":"Taneichi","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1074\/jbc.M112.372425_bib36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jhep.2004.08.021","article-title":"Involvement of natural killer cells in poly(I:C)-induced liver injury","volume":"41","author":"Dong","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1074\/jbc.M112.372425_bib37","first-page":"241","article-title":"The roles of innate immune cells in liver injury and regeneration","volume":"4","author":"Dong","year":"2007","journal-title":"Cell. Mol. Immunol."}],"updated-by":[{"DOI":"10.1074\/jbc.aac120.012994","type":"correction","label":"Correction","source":"retraction-watch","updated":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"record-id":"22830"},{"DOI":"10.1074\/jbc.aac120.012994","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000}}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820433848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820433848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.372425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:43:58Z","timestamp":1641300238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820433848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":37,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0021925820433848"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.372425","relation":{"erratum":[{"id-type":"doi","id":"10.1074\/jbc.AAC120.012994","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}