{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:14:21Z","timestamp":1791137661520,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":2968,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1074\/jbc.m112.376822","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T15:23:40Z","timestamp":1342538620000},"page":"30861-30873","source":"Crossref","is-referenced-by-count":64,"title":["Correlation between NS5A Dimerization and Hepatitis C Virus Replication"],"prefix":"10.1016","volume":"287","author":[{"given":"Precious J.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayan","family":"Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cordek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh D.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Garcia-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Targett-Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe A.","family":"Gallay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.376822_bib1","first-page":"S21","article-title":"Course and outcome of hepatitis C","volume":"36","author":"Hoofnagle","year":"2002","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.376822_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2000-9505","article-title":"Recovery, persistence, and sequelae in hepatitis C virus infection. A perspective on long-term outcome","volume":"20","author":"Alter","year":"2000","journal-title":"Semin. Liver Dis."},{"key":"10.1074\/jbc.M112.376822_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/jhep.2002.30531","article-title":"New therapeutic strategies for hepatitis C","volume":"35","author":"Di Bisceglie","year":"2002","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.376822_bib4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nrd937","article-title":"Hepatitis C therapeutics. Current status and emerging strategies","volume":"1","author":"Tan","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M112.376822_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature08960","article-title":"Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect","volume":"465","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.376822_bib6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1128\/JVI.01360-09","article-title":"Identification of hepatitis C virus NS5A inhibitors","volume":"84","author":"Lemm","year":"2010","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib7","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1128\/AAC.00146-11","article-title":"Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures","volume":"55","author":"Lemm","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M112.376822_bib8","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.290.5498.1972","article-title":"Efficient initiation of HCV RNA replication in cell culture","volume":"290","author":"Blight","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M112.376822_bib9","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/JVI.75.3.1252-1264.2001","article-title":"Characterization of cell lines carrying self-replicating hepatitis C virus RNAs","volume":"75","author":"Pietschmann","year":"2001","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib10","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1128\/JVI.75.10.4614-4624.2001","article-title":"Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations","volume":"75","author":"Krieger","year":"2001","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib11","doi-asserted-by":"crossref","first-page":"e1000035","DOI":"10.1371\/journal.ppat.1000035","article-title":"Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly","volume":"4","author":"Appel","year":"2008","journal-title":"PLoS Pathogens"},{"key":"10.1074\/jbc.M112.376822_bib12","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1128\/JVI.00826-08","article-title":"Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles","volume":"82","author":"Masaki","year":"2008","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1099\/vir.0.009332-0","article-title":"Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles","volume":"90","author":"Hughes","year":"2009","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M112.376822_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/hep.23278","article-title":"Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles","volume":"51","author":"Benga","year":"2010","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.376822_bib15","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1074\/jbc.M809244200","article-title":"Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis\/trans isomerase activity of cyclophilins A and B","volume":"284","author":"Hanoulle","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jviromet.2010.01.020","article-title":"The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A","volume":"165","author":"Waller","year":"2010","journal-title":"J. Virol. Methods"},{"key":"10.1074\/jbc.M112.376822_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jhep.2010.01.041","article-title":"HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors","volume":"53","author":"Chatterji","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1074\/jbc.M112.376822_bib18","doi-asserted-by":"crossref","first-page":"e13687","DOI":"10.1371\/journal.pone.0013687","article-title":"DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A","volume":"5","author":"Coelmont","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.376822_bib19","doi-asserted-by":"crossref","first-page":"e9815","DOI":"10.1371\/journal.pone.0009815","article-title":"Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A","volume":"5","author":"Fernandes","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.376822_bib20","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1128\/JVI.00393-11","article-title":"Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner","volume":"85","author":"Foster","year":"2011","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib21","doi-asserted-by":"crossref","first-page":"20441","DOI":"10.1074\/jbc.M110.182436","article-title":"Domain 3 of NS5A protein from the hepatitis C virus has intrinsic \u03b1-helical propensity and is a substrate of cyclophilin A","volume":"286","author":"Verdegem","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib22","doi-asserted-by":"crossref","first-page":"e1001118","DOI":"10.1371\/journal.ppat.1001118","article-title":"A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Pathogens"},{"key":"10.1074\/jbc.M112.376822_bib23","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.1074\/jbc.M111289200","article-title":"An amino-terminal amphipathic \u03b1-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A","volume":"277","author":"Brass","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib24","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/JVI.01279-06","article-title":"Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses","volume":"81","author":"Brass","year":"2007","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib25","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1128\/JVI.77.10.6055-6061.2003","article-title":"Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication","volume":"77","author":"Elazar","year":"2003","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib26","doi-asserted-by":"crossref","first-page":"40835","DOI":"10.1074\/jbc.M404761200","article-title":"Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A","volume":"279","author":"Penin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib27","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1021\/bi0517685","article-title":"NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus","volume":"45","author":"Sapay","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M112.376822_bib28","doi-asserted-by":"crossref","first-page":"48576","DOI":"10.1074\/jbc.M407787200","article-title":"The NS5A protein of hepatitis C virus is a zinc metalloprotein","volume":"279","author":"Tellinghuisen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature03580","article-title":"Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase","volume":"435","author":"Tellinghuisen","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.376822_bib30","doi-asserted-by":"crossref","first-page":"36417","DOI":"10.1074\/jbc.M508175200","article-title":"Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein","volume":"280","author":"Huang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib31","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1128\/JVI.02352-08","article-title":"Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus","volume":"83","author":"Love","year":"2009","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib32","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1128\/AAC.00556-10","article-title":"Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system","volume":"54","author":"Fridell","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M112.376822_bib33","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1128\/JVI.00215-11","article-title":"Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target. Insights into compound modes of action","volume":"85","author":"Targett-Adams","year":"2011","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib34","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1128\/JVI.01319-10","article-title":"Hepatitis C virus nonstructural protein 5A. Biochemical characterization of a novel structural class of RNA-binding proteins","volume":"84","author":"Hwang","year":"2010","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib35","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/hep.21809","article-title":"Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B","volume":"46","author":"Fernandes","year":"2007","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.376822_bib36","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1128\/JVI.80.9.4510-4520.2006","article-title":"Diverse effects of cyclosporine on hepatitis C virus strain replication","volume":"80","author":"Ishii","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib37","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/jhep.2003.50449","article-title":"Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes","volume":"38","author":"Watashi","year":"2003","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M112.376822_bib38","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1099\/vir.0.034801-0","article-title":"The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization","volume":"92","author":"Qiu","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M112.376822_bib39","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1128\/JVI.00616-10","article-title":"All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding","volume":"84","author":"Foster","year":"2010","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib40","doi-asserted-by":"crossref","first-page":"11149","DOI":"10.1074\/jbc.M111392200","article-title":"Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity","volume":"277","author":"Shirota","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.376822_bib41","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1128\/JVI.75.3.1437-1449.2001","article-title":"Mutations in hepatitis C virus RNAs conferring cell culture adaptation","volume":"75","author":"Lohmann","year":"2001","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.376822_bib42","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","article-title":"The galvanization of biology. A growing appreciation for the roles of zinc","volume":"271","author":"Berg","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M112.376822_bib43","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1128\/JVI.77.9.5401-5414.2003","article-title":"Protein-protein interactions between hepatitis C virus nonstructural proteins","volume":"77","author":"Dimitrova","year":"2003","journal-title":"J. Virol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820631842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820631842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.376822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:13:02Z","timestamp":1641366782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820631842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":43,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0021925820631842"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.376822","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}