{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:22Z","timestamp":1791326122527,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":2875,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1074\/jbc.m112.380204","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T08:01:08Z","timestamp":1348992068000},"page":"38970-38979","source":"Crossref","is-referenced-by-count":28,"title":["Aberrant Gene Expression Profiles in Pluripotent Stem Cells Induced from Fibroblasts of a Klinefelter Syndrome Patient"],"prefix":"10.1016","volume":"287","author":[{"given":"Yu","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.380204_bib1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1586\/erm.10.63","article-title":"Klinefelter syndrome. Clinical and molecular aspects","volume":"10","author":"Giltay","year":"2010","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1074\/jbc.M112.380204_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000316604","article-title":"Klinefelter syndrome. A clinical and therapeutical update","volume":"4","author":"Forti","year":"2010","journal-title":"Sex Dev."},{"key":"10.1074\/jbc.M112.380204_bib3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00198-010-1354-7","article-title":"Bone mineral density in Klinefelter syndrome is reduced and primarily determined by muscle strength and resorptive markers, but not directly by testosterone","volume":"22","author":"Bojesen","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1074\/jbc.M112.380204_bib4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1651-2227.2011.02233.x","article-title":"Body composition, metabolic syndrome, and type 2 diabetes in Klinefelter syndrome","volume":"100","author":"Gravholt","year":"2011","journal-title":"Acta Paediatr."},{"key":"10.1074\/jbc.M112.380204_bib5","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1651-2227.2010.02131.x","article-title":"Breast cancer risk among patients with Klinefelter syndrome","volume":"100","author":"Brinton","year":"2011","journal-title":"Acta Paediatr."},{"key":"10.1074\/jbc.M112.380204_bib6","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/ajmg.a.32232","article-title":"Cognitive and motor development during childhood in boys with Klinefelter syndrome","volume":"146","author":"Ross","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1074\/jbc.M112.380204_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.380204_bib8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.380204_bib9","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1101\/gad.1963910","article-title":"Induced pluripotency: history, mechanisms, and applications","volume":"24","author":"Stadtfeld","year":"2010","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.380204_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrd3577","article-title":"Induced pluripotent stem cells\u2013opportunities for disease modeling and drug discovery","volume":"10","author":"Grskovic","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M112.380204_bib11","doi-asserted-by":"crossref","first-page":"e6724","DOI":"10.1371\/journal.pone.0006724","article-title":"Germ line-competent mouse-induced pluripotent stem cell lines generated on human fibroblasts without exogenous leukemia inhibitory factor","volume":"4","author":"Li","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M112.380204_bib12","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1093\/hmg\/ddp386","article-title":"Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells","volume":"18","author":"Li","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M112.380204_bib13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0301-472X(03)00260-1","article-title":"Retrovirus-mediated gene transfer and expression cloning. Powerful tools in functional genomics","volume":"31","author":"Kitamura","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1074\/jbc.M112.380204_bib14","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1073\/pnas.0905657107","article-title":"Stk40 links the pluripotency factor Oct4 to the Erk\/MAPK pathway and controls extraembryonic endoderm differentiation","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.380204_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11626-010-9304-4","article-title":"Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos","volume":"46","author":"Li","year":"2010","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"10.1074\/jbc.M112.380204_bib16","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/hmg\/ddr093","article-title":"Isolation of MECP2-null Rett syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation","volume":"20","author":"Cheung","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M112.380204_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1634\/stemcells.2007-1018","article-title":"A novel approach for the derivation of putative primordial germ cells and Sertoli cells from human embryonic stem cells","volume":"27","author":"Bucay","year":"2009","journal-title":"Stem Cells"},{"key":"10.1074\/jbc.M112.380204_bib18","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.leu.2402880","article-title":"Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies","volume":"17","author":"Lossos","year":"2003","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M112.380204_bib19","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1101\/gad.1422906","article-title":"Dosage compensation in mammals. Fine-tuning the expression of the X chromosome","volume":"20","author":"Heard","year":"2006","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.380204_bib20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2010.06.024","article-title":"Female human iPSCs retain an inactive X chromosome","volume":"7","author":"Tchieu","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1074\/jbc.M112.380204_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/molehr\/gaq019","article-title":"Novel genetic aspects of Klinefelter syndrome","volume":"16","author":"T\u00fcttelmann","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"10.1074\/jbc.M112.380204_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature03440","article-title":"The DNA sequence of the human X chromosome","volume":"434","author":"Ross","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.380204_bib23","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/art.23701","article-title":"Klinefelter syndrome (47,XXY) in male systemic lupus erythematosus patients. Support for the notion of a gene-dose effect from the X chromosome","volume":"58","author":"Scofield","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M112.380204_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jnr.10160","article-title":"The MAGE proteins. Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease","volume":"67","author":"Barker","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M112.380204_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jmb.2007.04.033","article-title":"The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription","volume":"369","author":"Al-Kandari","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.380204_bib26","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/stem.672","article-title":"Complete meiosis from human-induced pluripotent stem cells","volume":"29","author":"Eguizabal","year":"2011","journal-title":"Stem Cells"},{"key":"10.1074\/jbc.M112.380204_bib27","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1073\/pnas.160274797","article-title":"The human VASA gene is specifically expressed in the germ cell lineage","volume":"97","author":"Castrillon","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.380204_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature08562","article-title":"Human DAZL, DAZ, and BOULE genes modulate primordial germ-cell and haploid gamete formation","volume":"462","author":"Kee","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.380204_bib29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/hmg\/ddq520","article-title":"Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells","volume":"20","author":"Panula","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M112.380204_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/1096-8628(20010101)98:1<25::AID-AJMG1015>3.0.CO;2-X","article-title":"Evidence of skewed X-chromosome inactivation in 47,XXY and 48,XXYY Klinefelter patients","volume":"98","author":"Iitsuka","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1074\/jbc.M112.380204_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1530\/EJE-09-0768","article-title":"Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome","volume":"162","author":"Poplinski","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"10.1074\/jbc.M112.380204_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nbt1102","article-title":"Characterization and culture of human embryonic stem cells","volume":"23","author":"Hoffman","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M112.380204_bib33","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1073\/pnas.0712136105","article-title":"X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells","volume":"105","author":"Silva","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.380204_bib34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/ajmg.b.30454","article-title":"Dysregulation of X-linked gene expression in Klinefelter syndrome and association with verbal cognition","volume":"144B","author":"Vawter","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1074\/jbc.M112.380204_bib35","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1038\/sj.onc.1207808","article-title":"Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells","volume":"23","author":"Kawakami","year":"2004","journal-title":"Oncogene"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820623596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820623596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.380204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:34:46Z","timestamp":1641364486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820623596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":35,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0021925820623596"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.380204","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}