{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:19:56Z","timestamp":1781583596574,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":2875,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1074\/jbc.m112.394932","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T08:01:08Z","timestamp":1348992068000},"page":"39742-39752","source":"Crossref","is-referenced-by-count":57,"title":["Activation of Cholera Toxin Production by Anaerobic Respiration of Trimethylamine N-oxide in Vibrio cholerae"],"prefix":"10.1016","volume":"287","author":[{"given":"Kang-Mu","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasimul","family":"Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyeok","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Cheol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Sun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.394932_bib1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/MMBR.62.4.1301-1314.1998","article-title":"Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae","volume":"62","author":"Faruque","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1074\/jbc.M112.394932_bib2","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3201\/eid1707.110059","article-title":"Understanding the cholera epidemic, Haiti","volume":"17","author":"Piarroux","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1074\/jbc.M112.394932_bib3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1172\/JCI24684","article-title":"Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions","volume":"116","author":"Yoon","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M112.394932_bib4","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1128\/IAI.01094-07","article-title":"Regulatory networks controlling Vibrio cholerae virulence gene expression","volume":"75","author":"Matson","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib5","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1128\/mr.56.4.622-647.1992","article-title":"Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin","volume":"56","author":"Spangler","year":"1992","journal-title":"Microbiol. Rev."},{"key":"10.1074\/jbc.M112.394932_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0966-842X(94)90109-I","article-title":"The toxin-co-regulated pilus of Vibrio cholerae O1. A model for type 4 pilus biogenesis?","volume":"2","author":"Iredell","year":"1994","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib7","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M112.394932_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.resmic.2008.10.005","article-title":"Anaerobic growth promotes synthesis of colonization factors encoded at the Vibrio pathogenicity island in Vibrio cholerae El Tor","volume":"160","author":"Marrero","year":"2009","journal-title":"Res. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1073\/pnas.95.2.730","article-title":"TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae","volume":"95","author":"H\u00e4se","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.394932_bib10","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1073\/pnas.1014640108","article-title":"Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB","volume":"108","author":"Liu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.394932_bib11","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1128\/JB.00193-10","article-title":"The LysR-type virulence activator AphB regulates the expression of genes in Vibrio cholerae in response to low pH and anaerobiosis","volume":"192","author":"Kovacikova","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/jb.10.3.197-215.1925","article-title":"Contributions to the knowledge of Vibrio cholerae I. Fermentation of carbohydrates and polyatomic alcohols by Vibrio cholerae","volume":"10","author":"Nobechi","year":"1925","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1348-0421.1981.tb00132.x","article-title":"A Halophilic vibrio isolated from a case of chronic cholecystitis","volume":"25","author":"Konishi","year":"1981","journal-title":"Microbiol. Immunol."},{"key":"10.1074\/jbc.M112.394932_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2672.1976.tb00629.x","article-title":"An evaluation of commercial thiosulfate citrate bile salt sucrose agar (TCBS)","volume":"41","author":"Nicholls","year":"1976","journal-title":"J. Appl. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib15","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1128\/JB.187.17.5996-6004.2005","article-title":"Cytochrome c maturation and the physiological role of c-type cytochromes in Vibrio cholerae","volume":"187","author":"Braun","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib16","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/IAI.06161-11","article-title":"Vitamin B12-mediated restoration of defective anaerobic growth leads to reduced biofilm formation in Pseudomonas aeruginosa","volume":"80","author":"Lee","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0076-6879(94)35167-8","article-title":"Regulation of cholera toxin by temperature, pH, and osmolarity","volume":"235","author":"Gardel","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M112.394932_bib18","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1128\/IAI.01266-10","article-title":"Vibrio cholerae requires the type VI secretion system virulence factor VasX to kill Dictyostelium discoideum","volume":"79","author":"Miyata","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib19","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1128\/IAI.01361-10","article-title":"Anaerobiosis-induced loss of cytotoxicity is due to inactivation of quorum sensing in Pseudomonas aeruginosa","volume":"79","author":"Lee","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.plasmid.2004.02.003","article-title":"Improvement of pCVD442, a suicide plasmid for gene allele exchange in bacteria","volume":"51","author":"Philippe","year":"2004","journal-title":"Plasmid"},{"key":"10.1074\/jbc.M112.394932_bib21","doi-asserted-by":"crossref","first-page":"e16105","DOI":"10.1371\/journal.pone.0016105","article-title":"Contribution of cell elongation to the biofilm formation of Pseudomonas aeruginosa during anaerobic respiration","volume":"6","author":"Yoon","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M112.394932_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2180-9-114","article-title":"Pleiotropic effects of the twin arginine translocation system on biofilm formation, colonization, and virulence in Vibrio cholerae","volume":"9","author":"Zhang","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/35020000","article-title":"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae","volume":"406","author":"Heidelberg","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.394932_bib24","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1128\/iai.61.10.4462-4468.1993","article-title":"CVD110, an attenuated Vibrio cholerae O1 El Tor live oral vaccine strain","volume":"61","author":"Michalski","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib25","doi-asserted-by":"crossref","first-page":"16615","DOI":"10.1074\/jbc.273.26.16615","article-title":"TorD, a cytoplasmic chaperone that interacts with the unfolded trimethylamine N-oxide reductase enzyme (TorA) in Escherichia coli","volume":"273","author":"Pommier","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.394932_bib26","doi-asserted-by":"crossref","first-page":"34136","DOI":"10.1074\/jbc.M205247200","article-title":"Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli","volume":"277","author":"Layer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.394932_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.anaerobe.2011.06.008","article-title":"Identification and analysis of the Shewanella oneidensis major oxygen-independent coproporphyrinogen III oxidase gene","volume":"17","author":"Al-Sheboul","year":"2011","journal-title":"Anaerobe"},{"key":"10.1074\/jbc.M112.394932_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/jmbi.1998.2155","article-title":"Molecular analysis of the trimethylamine N-oxide (TMAO) reductase respiratory system from a Shewanella species","volume":"284","author":"Dos Santos","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.394932_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/emboj\/17.1.101","article-title":"A novel sec-independent periplasmic protein translocation pathway in Escherichia coli","volume":"17","author":"Santini","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.394932_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.micro.60.080805.142212","article-title":"The bacterial twin arginine translocation pathway","volume":"60","author":"Lee","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib31","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/j.1365-2958.1994.tb00393.x","article-title":"TMAO anaerobic respiration in Escherichia coli. Involvement of the tor operon","volume":"11","author":"M\u00e9jean","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib32","doi-asserted-by":"crossref","first-page":"11545","DOI":"10.1074\/jbc.M008875200","article-title":"Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli","volume":"276","author":"Gon","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.394932_bib33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1574-6968.2006.00102.x","article-title":"Type II secretion. From structure to function","volume":"255","author":"Johnson","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.M112.394932_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.tim.2005.09.005","article-title":"Type II secretion. A protein secretion system for all seasons","volume":"13","author":"Cianciotto","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1438-4221(00)80038-7","article-title":"Characterization of the multimeric Eps complex required for cholera toxin secretion","volume":"290","author":"Sandkvist","year":"2000","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib36","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1128\/jb.179.22.6994-7003.1997","article-title":"General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae","volume":"179","author":"Sandkvist","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.mi.39.100185.001023","article-title":"Bacterial reduction of trimethylamine oxide","volume":"39","author":"Barrett","year":"1985","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0065-2911(05)50004-3","article-title":"Microbial dimethylsulfoxide and trimethylamine N-oxide respiration","volume":"50","author":"McCrindle","year":"2005","journal-title":"Adv. Microb. Physiol."},{"key":"10.1074\/jbc.M112.394932_bib39","doi-asserted-by":"crossref","first-page":"28787","DOI":"10.1074\/jbc.M302730200","article-title":"Involvement of a mate chaperone (TorD) in the maturation pathway of molybdoenzyme TorA","volume":"278","author":"Ilbert","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.394932_bib40","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.165.2.1013","article-title":"Role of oxidants in NF-\u03baB activation and TNF-\u03b1 gene transcription induced by hypoxia and endotoxin","volume":"165","author":"Chandel","year":"2000","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.394932_bib41","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00109-007-0277-z","article-title":"Hypoxia and gastrointestinal disease","volume":"85","author":"Taylor","year":"2007","journal-title":"J. Mol. Med."},{"key":"10.1074\/jbc.M112.394932_bib42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2958.1992.tb01489.x","article-title":"Coordinate expression of virulence genes by ToxR in Vibrio cholerae","volume":"6","author":"DiRita","year":"1992","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1078\/1438-4221-00104","article-title":"Regulation of virulence in Vibrio cholerae","volume":"291","author":"Klose","year":"2001","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib44","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1348-0421.1986.tb03037.x","article-title":"Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor","volume":"30","author":"Iwanaga","year":"1986","journal-title":"Microbiol. Immunol."},{"key":"10.1074\/jbc.M112.394932_bib45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/jcm.22.3.405-408.1985","article-title":"New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor","volume":"22","author":"Iwanaga","year":"1985","journal-title":"J. Clin. Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib46","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1128\/JB.186.5.1355-1361.2004","article-title":"Expression of cholera toxin under non-AKI conditions in Vibrio cholerae El Tor induced by increasing the exposed surface of cultures","volume":"186","author":"S\u00e1nchez","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0006-2952(98)00218-4","article-title":"Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes. Selective catalysis by FMO3","volume":"56","author":"Lang","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M112.394932_bib48","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1021\/jf0507902","article-title":"Bioactive compounds in cod (Gadus morhua) products and suitability of 1H NMR metabolite profiling for classification of the products using multivariate data analyses","volume":"53","author":"Martinez","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1074\/jbc.M112.394932_bib49","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1128\/JB.186.14.4502-4509.2004","article-title":"Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis","volume":"186","author":"Bordi","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M112.394932_bib50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/mr.57.1.50-108.1993","article-title":"The complete general secretory pathway in Gram-negative bacteria","volume":"57","author":"Pugsley","year":"1993","journal-title":"Microbiol. Rev."},{"key":"10.1074\/jbc.M112.394932_bib51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tim.2004.05.002","article-title":"The general secretory pathway. A general misnomer?","volume":"12","author":"Desvaux","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M112.394932_bib52","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1093\/emboj\/20.23.6735","article-title":"Involvement of the twin arginine translocation system in protein secretion via the type II pathway","volume":"20","author":"Voulhoux","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.394932_bib53","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.00929-08","article-title":"Role of melanin pigment in expression of Vibrio cholerae virulence factors","volume":"77","author":"Valeru","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.394932_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820622694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820622694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.394932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:30:00Z","timestamp":1641364200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820622694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":54,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0021925820622694"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.394932","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}