{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:05:53Z","timestamp":1791173153592,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"43","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":2906,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1074\/jbc.m112.401075","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T06:38:31Z","timestamp":1346827111000},"page":"36096-36104","source":"Crossref","is-referenced-by-count":16,"title":["Constant Domain-regulated Antibody Catalysis"],"prefix":"10.1016","volume":"287","author":[{"given":"Gopal","family":"Sapparapu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Planque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Mitsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.401075_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.cellbio.12.1.181","article-title":"Fc receptors and their interactions with immunoglobulins","volume":"12","author":"Raghavan","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.401075_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.it.2007.11.004","article-title":"The immunoglobulin constant region contributes to affinity and specificity","volume":"29","author":"Torres","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1074\/jbc.M112.401075_bib3","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.4049\/jimmunol.174.4.2132","article-title":"Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype","volume":"174","author":"Torres","year":"2005","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.molimm.2010.02.018","article-title":"Circular dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure","volume":"47","author":"Janda","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib5","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/eji.1830270635","article-title":"The repertoire of serum IgM in normal mice is largely independent of external antigenic contact","volume":"27","author":"Haury","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.gde.2007.08.006","article-title":"Epigenetics of antigen-receptor gene assembly","volume":"17","author":"Murre","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1074\/jbc.M112.401075_bib7","doi-asserted-by":"crossref","first-page":"20436","DOI":"10.1074\/jbc.M301468200","article-title":"Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity","volume":"278","author":"Planque","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1006\/jmbi.1995.0580","article-title":"Site-directed mutagenesis of proteolytic antibody light chain","volume":"253","author":"Gao","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.401075_bib9","doi-asserted-by":"crossref","first-page":"33079","DOI":"10.1074\/jbc.M109.036087","article-title":"A human germ line antibody light chain with hydrolytic properties associated with multimerization status","volume":"284","author":"Sharma","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/BJ20051739","article-title":"Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody","volume":"395","author":"Ramsland","year":"2006","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M112.401075_bib11","doi-asserted-by":"crossref","first-page":"15954","DOI":"10.1073\/pnas.1108460108","article-title":"Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics","volume":"108","author":"Smirnov","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.401075_bib12","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0161-5890(99)00141-8","article-title":"Innate antibody catalysis","volume":"36","author":"Gololobov","year":"1999","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.molimm.2012.01.004","article-title":"A novel molecular analysis of genes encoding catalytic antibodies","volume":"50","author":"Le Minoux","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib14","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.4049\/jimmunol.155.5.2695","article-title":"Unexpected presence of polyreactive catalytic antibodies in IgG from unimmunized donors and decreased levels in rheumatoid arthritis","volume":"155","author":"Kalaga","year":"1995","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jmr.1035","article-title":"Proteolysis activity of IgM antibodies from rheumatoid arthritis patients' sera: evidence of atypical catalytic site","volume":"23","author":"Kamalanathan","year":"2010","journal-title":"J. Mol. Recognit."},{"key":"10.1074\/jbc.M112.401075_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/bbrc.1994.2425","article-title":"Amidase activity of human Bence Jones proteins","volume":"204","author":"Matsuura","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M112.401075_bib17","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1074\/jbc.270.25.15257","article-title":"Natural catalytic antibodies: peptide-hydrolyzing activities of Bence Jones proteins and VL fragment","volume":"270","author":"Paul","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib18","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1126\/science.7690497","article-title":"Immunoglobulin VH3 gene products: natural ligands for HIV gp120","volume":"261","author":"Berberian","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M112.401075_bib19","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1074\/jbc.M312152200","article-title":"Ontogeny of proteolytic immunity: IgM serine proteases","volume":"279","author":"Planque","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib20","doi-asserted-by":"crossref","first-page":"9940","DOI":"10.1074\/jbc.M111.330043","article-title":"Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection","volume":"287","author":"Brown","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/jmr.734","article-title":"Broadly distributed nucleophilic reactivity of proteins coordinated with specific ligand binding activity","volume":"18","author":"Nishiyama","year":"2005","journal-title":"J. Mol. Recognit."},{"key":"10.1074\/jbc.M112.401075_bib22","doi-asserted-by":"crossref","first-page":"20429","DOI":"10.1074\/jbc.M300870200","article-title":"Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120","volume":"278","author":"Paul","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib23","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0264-410X(02)00504-2","article-title":"Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120","volume":"21","author":"Karle","year":"2003","journal-title":"Vaccine"},{"key":"10.1074\/jbc.M112.401075_bib24","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1074\/jbc.M310950200","article-title":"Toward selective covalent inactivation of pathogenic antibodies: a phosphate diester analog of vasoactive intestinal peptide that inactivates catalytic autoantibodies","volume":"279","author":"Nishiyama","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0003-9861(02)00087-5","article-title":"Covalent reactivity of phosphonate monophenyl esters with serine proteinases: an overlooked feature of presumed transition state analogs","volume":"402","author":"Nishiyama","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M112.401075_bib26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0076-6879(94)44032-8","article-title":"Amino acid and peptide phosphonate derivatives as specific inhibitors of serine peptidases","volume":"244","author":"Oleksyszyn","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M112.401075_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12033-007-0003-7","article-title":"Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodies","volume":"36","author":"Mitsuda","year":"2007","journal-title":"Mol. Biotechnol."},{"key":"10.1074\/jbc.M112.401075_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00002030-200401230-00026","article-title":"Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library","volume":"18","author":"Karle","year":"2004","journal-title":"AIDS"},{"key":"10.1074\/jbc.M112.401075_bib29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0161-5890(00)00101-2","article-title":"Human and murine immunoglobulin expression vector cassettes","volume":"37","author":"McLean","year":"2000","journal-title":"Mol. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib30","doi-asserted-by":"crossref","first-page":"24622","DOI":"10.1074\/jbc.M109.011858","article-title":"Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain","volume":"284","author":"Sapparapu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib31","doi-asserted-by":"crossref","first-page":"36724","DOI":"10.1074\/jbc.M806766200","article-title":"Exceptional amyloid \u03b2 peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds","volume":"283","author":"Taguchi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/pro.757","article-title":"Signal peptidase I: cleaving the way to mature proteins","volume":"21","author":"Auclair","year":"2012","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M112.401075_bib33","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1073\/pnas.0601910103","article-title":"Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates","volume":"103","author":"Radisky","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.401075_bib34","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1089\/aid.2007.0081","article-title":"Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infection","volume":"23","author":"Planque","year":"2007","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M112.401075_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jmr.2159","article-title":"Anti-integrase abzymes from the sera of HIV-infected patients specifically hydrolyze integrase but nonspecifically cleave short oligopeptides","volume":"25","author":"Odintsova","year":"2012","journal-title":"J. Mol. Recognit."},{"key":"10.1074\/jbc.M112.401075_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02900358","article-title":"Natural catalytic antibodies","volume":"5","author":"Paul","year":"1996","journal-title":"Mol. Biotechnol."},{"key":"10.1074\/jbc.M112.401075_bib37","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1158\/1078-0432.CCR-06-2788","article-title":"Molecular characterization of Waldenstrom's macroglobulinemia reveals frequent occurrence of two B-cell clones having distinct IgH VDJ sequences","volume":"13","author":"Kriangkum","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M112.401075_bib38","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1182\/blood.V100.4.1505.h81602001505_1505_1507","article-title":"Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events","volume":"100","author":"Sahota","year":"2002","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.401075_bib39","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.leukres.2004.12.008","article-title":"Lymphoplasmacytic lymphoma\/Waldenstr\u00f6m's macroglobulinemia derives from an extensively hypermutated B cell that lacks ongoing somatic hypermutation","volume":"29","author":"Walsh","year":"2005","journal-title":"Leuk. Res."},{"key":"10.1074\/jbc.M112.401075_bib40","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3816\/CLM.2006.n.042","article-title":"Immunoglobulin heavy chain sequence analysis in Waldenstrom's macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance","volume":"7","author":"Rollett","year":"2006","journal-title":"Clin. Lymphoma Myeloma"},{"key":"10.1074\/jbc.M112.401075_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2567.2005.02208.x","article-title":"Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection","volume":"116","author":"Bose","year":"2005","journal-title":"Immunology"},{"key":"10.1074\/jbc.M112.401075_bib42","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1074\/jbc.M102530200","article-title":"Phosphonate ester probes for proteolytic antibodies","volume":"276","author":"Paul","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1538-7836.2007.02496.x","article-title":"Exosites in the substrate specificity of blood coagulation reactions","volume":"5","author":"Bock","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1074\/jbc.M112.401075_bib44","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1006\/jmbi.1998.2439","article-title":"The atomic structure of protein-protein recognition sites","volume":"285","author":"Lo Conte","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M112.401075_bib45","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ajh.2830440411","article-title":"Hemostatic molecular markers in nephrotic syndrome","volume":"44","author":"Chen","year":"1993","journal-title":"Am. J. Hematol."},{"key":"10.1074\/jbc.M112.401075_bib46","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1398-9995.2012.02812.x","article-title":"Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis","volume":"67","author":"Alvarez-Twose","year":"2012","journal-title":"Allergy"},{"key":"10.1074\/jbc.M112.401075_bib47","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1074\/jbc.M707983200","article-title":"Autoantibody-catalyzed hydrolysis of amyloid \u03b2 peptide","volume":"283","author":"Taguchi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib48","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1074\/jbc.M705674200","article-title":"Catalytic features and eradication ability of antibody light-chain UA15-L against Helicobacter pylori","volume":"283","author":"Hifumi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1096\/fj.11-195339","article-title":"Highly efficient method of preparing human catalytic antibody light chains and their biological characteristics","volume":"26","author":"Hifumi","year":"2012","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M112.401075_bib50","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.2727702","article-title":"Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody","volume":"244","author":"Paul","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M112.401075_bib51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1585181","article-title":"DNA hydrolyzing autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M112.401075_bib52","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1582-4934.2004.tb00325.x","article-title":"Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis","volume":"8","author":"Polosukhina","year":"2004","journal-title":"J. Cell Mol. Med."},{"key":"10.1074\/jbc.M112.401075_bib53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1073\/pnas.0509849103","article-title":"Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.401075_bib54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/rheumatology\/kep328","article-title":"Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity","volume":"49","author":"Yang","year":"2010","journal-title":"Rheumatology"},{"key":"10.1074\/jbc.M112.401075_bib55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaut.2011.05.007","article-title":"Autoantibodies with enzymatic properties in human autoimmune diseases","volume":"37","author":"Wootla","year":"2011","journal-title":"J. Autoimmun."},{"key":"10.1074\/jbc.M112.401075_bib56","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1182\/blood-2010-07-296103","article-title":"Proteolytic antibodies activate factor IX in patients with acquired hemophilia","volume":"117","author":"Wootla","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.401075_bib57","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1073\/pnas.0500586102","article-title":"High levels of catalytic antibodies correlate with favorable outcome in sepsis","volume":"102","author":"Lacroix-Desmazes","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.401075_bib58","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.4049\/jimmunol.180.12.8455","article-title":"Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients","volume":"180","author":"Wootla","year":"2008","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib59","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.4049\/jimmunol.159.3.1530","article-title":"Characterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease","volume":"159","author":"Paul","year":"1997","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib60","doi-asserted-by":"crossref","first-page":"39611","DOI":"10.1074\/jbc.M406719200","article-title":"Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120","volume":"279","author":"Paul","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.401075_bib61","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.4049\/jimmunol.161.8.4083","article-title":"Comparisons of the ability of human IgG3 hinge mutants, IgM, IgE, and IgA2, to form small immune complexes: a role for flexibility and geometry","volume":"161","author":"Roux","year":"1998","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.401075_bib62","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1380-2933(98)00025-6","article-title":"Structural aspects of human IgM antibodies expressed in chronic B lymphocytic leukemia","volume":"4","author":"Ramsland","year":"1999","journal-title":"Immunotechnology"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820625856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820625856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.401075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T15:30:59Z","timestamp":1687707059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820625856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":62,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0021925820625856"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.401075","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}