{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:30:16Z","timestamp":1770150616040,"version":"3.49.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":2808,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1074\/jbc.m112.402933","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T03:43:09Z","timestamp":1355197389000},"page":"2485-2500","source":"Crossref","is-referenced-by-count":31,"title":["The LIM Homeodomain Transcription Factor LHX6"],"prefix":"10.1016","volume":"288","author":[{"given":"Zichao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitas","family":"Bidlack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huojun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad A.","family":"Amendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.402933_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/384270a0","article-title":"Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins","volume":"384","author":"Agulnick","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.402933_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0925-4773(99)00314-7","article-title":"The LIM domain. Regulation by association","volume":"91","author":"Bach","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1074\/jbc.M112.402933_bib3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0896-6273(01)00283-5","article-title":"Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish","volume":"30","author":"Segawa","year":"2001","journal-title":"Neuron"},{"key":"10.1074\/jbc.M112.402933_bib4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/mcne.1996.0061","article-title":"Differential expression of LIM homeobox genes among motor neuron subpopulations in the developing chick brain stem","volume":"8","author":"Varela-Echavarr\u00eda","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.M112.402933_bib5","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1242\/dev.02322","article-title":"Isl1Cre reveals a common Bmp pathway in heart and limb development","volume":"133","author":"Yang","year":"2006","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib6","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/sj.embor.7400030","article-title":"LIM-domain-binding protein 1. A multifunctional cofactor that interacts with diverse proteins","volume":"4","author":"Matthews","year":"2003","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M112.402933_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0168-9525(99)01883-1","article-title":"Functions of LIM-homeobox genes","volume":"16","author":"Hobert","year":"2000","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M112.402933_bib8","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1038\/emboj.2008.123","article-title":"Implementing the LIM code. The structural basis for cell type-specific assembly of LIM-homeodomain complexes","volume":"27","author":"Bhati","year":"2008","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.402933_bib9","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1242\/dev.125.11.2063","article-title":"Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development","volume":"125","author":"Grigoriou","year":"1998","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib10","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1210\/me.2005-0184","article-title":"The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter","volume":"20","author":"Granger","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M112.402933_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ydbio.2009.07.001","article-title":"The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition","volume":"333","author":"Denaxa","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M112.402933_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1034\/j.1600-0544.2002.02198.x","article-title":"Comparison of the expression patterns of two LIM-homeodomain genes, Lhx6 and L3\/Lhx8, in the developing palate","volume":"5","author":"Zhang","year":"2002","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1074\/jbc.M112.402933_bib13","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1523\/JNEUROSCI.1245-04.2004","article-title":"Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype","volume":"24","author":"Alifragis","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M112.402933_bib14","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1523\/JNEUROSCI.3055-06.2007","article-title":"Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes","volume":"27","author":"Liodis","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M112.402933_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2005.04.011","article-title":"Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus","volume":"46","author":"Choi","year":"2005","journal-title":"Neuron"},{"key":"10.1074\/jbc.M112.402933_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/cne.21772","article-title":"Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants","volume":"510","author":"Zhao","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.M112.402933_bib17","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1073\/pnas.96.26.15002","article-title":"Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8","volume":"96","author":"Zhao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.402933_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1679\/aohc.66.95","article-title":"Expression and role of Lhx8 in murine tooth development","volume":"66","author":"Shibaguchi","year":"2003","journal-title":"Arch. Histol. Cytol."},{"key":"10.1074\/jbc.M112.402933_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng1296-392","article-title":"Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome","volume":"14","author":"Semina","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.402933_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/mcne.1996.0062","article-title":"Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain","volume":"8","author":"Mucchielli","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.M112.402933_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1097-0177(200005)218:1<195::AID-DVDY17>3.0.CO;2-C","article-title":"The Pitx2 protein in mouse development","volume":"218","author":"Hjalt","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1074\/jbc.M112.402933_bib22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/hmg\/ddl008","article-title":"Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis","volume":"15","author":"Berry","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M112.402933_bib23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/nar\/gkm1047","article-title":"Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt\/\u03b2-catenin signaling","volume":"36","author":"Amen","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M112.402933_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1101\/gad.11.11.1370","article-title":"A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins","volume":"11","author":"Bach","year":"1997","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.402933_bib25","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1128\/MCB.17.10.5688","article-title":"Functional analysis of the nuclear LIM domain interactor NLI","volume":"17","author":"Jurata","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.402933_bib26","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1074\/jbc.273.6.3152","article-title":"The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors","volume":"273","author":"Jurata","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.402933_bib27","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1074\/jbc.273.8.4712","article-title":"Interactions between LIM domains and the LIM domain-binding protein Ldb1","volume":"273","author":"Breen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.402933_bib28","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1128\/MCB.19.10.7001","article-title":"Multifunctional role of the Pitx2 homeodomain protein C-terminal tail","volume":"19","author":"Amendt","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.402933_bib29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/jcs.01706","article-title":"PITX2, \u03b2-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter","volume":"118","author":"Vadlamudi","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M112.402933_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3727\/000000001783992515","article-title":"Antagonistic regulation of Dlx2 expression by PITX2 and Msx2. Implications for tooth development","volume":"9","author":"Green","year":"2001","journal-title":"Gene Expr."},{"key":"10.1074\/jbc.M112.402933_bib31","doi-asserted-by":"crossref","first-page":"22437","DOI":"10.1074\/jbc.M210163200","article-title":"PITX2 isoform-specific regulation of atrial natriuretic factor expression. Synergism and repression with Nkx2.5","volume":"278","author":"Ganga","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.402933_bib32","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1021\/bi048362x","article-title":"Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein","volume":"44","author":"Espinoza","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M112.402933_bib33","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1128\/MCB.00315-07","article-title":"PITX2 and \u03b2-catenin interactions regulate Lef-1 isoform expression","volume":"27","author":"Amen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.402933_bib34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)01084-X","article-title":"Identification of a Wnt\/Dvl\/\u03b2-catenin \u2192 Pitx2 pathway mediating cell-type-specific proliferation during development","volume":"111","author":"Kioussi","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.402933_bib35","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1093\/nar\/gkl689","article-title":"Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2","volume":"34","author":"Diamond","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M112.402933_bib36","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0003-9969(92)90110-T","article-title":"Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ","volume":"37","author":"Chen","year":"1992","journal-title":"Arch. Oral Biol."},{"key":"10.1074\/jbc.M112.402933_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ydbio.2010.08.031","article-title":"Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21","volume":"347","author":"Cao","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M112.402933_bib38","first-page":"789","article-title":"Visualization of molecular interactions by fluorescence complementation","volume":"9","author":"Hu","year":"2002","journal-title":"Nat. Rev."},{"key":"10.1074\/jbc.M112.402933_bib39","first-page":"449","volume":"7","author":"Kerppola","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.402933_bib40","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1242\/dev.00849","article-title":"Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration","volume":"130","author":"Liu","year":"2003","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/dbio.1997.8672","article-title":"Mouse Otlx2\/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance","volume":"189","author":"Mucchielli","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M112.402933_bib42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000102683","article-title":"Enamel formation and amelogenesis imperfecta","volume":"186","author":"Hu","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"10.1074\/jbc.M112.402933_bib43","doi-asserted-by":"crossref","first-page":"19447","DOI":"10.1074\/jbc.M300445200","article-title":"A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression","volume":"278","author":"Paine","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.402933_bib44","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.200409077","article-title":"Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts","volume":"167","author":"Fukumoto","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.402933_bib45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neuron.2011.04.020","article-title":"Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors","volume":"70","author":"Flandin","year":"2011","journal-title":"Neuron"},{"key":"10.1074\/jbc.M112.402933_bib46","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1242\/dev.038083","article-title":"LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons","volume":"136","author":"Fragkouli","year":"2009","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/dvdy.22532","article-title":"GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons","volume":"240","author":"Waite","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1074\/jbc.M112.402933_bib48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1083\/jcb.147.1.105","article-title":"Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling","volume":"147","author":"Harada","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.402933_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1242\/dev.015081","article-title":"An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors","volume":"135","author":"Klein","year":"2008","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib50","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1371\/journal.pbio.0050159","article-title":"An integrated gene regulatory network controls stem cell proliferation in teeth","volume":"5","author":"Wang","year":"2007","journal-title":"Plos Biol."},{"key":"10.1074\/jbc.M112.402933_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/10454411980090020101","article-title":"Cellular and chemical events during enamel maturation","volume":"9","author":"Smith","year":"1998","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"10.1074\/jbc.M112.402933_bib52","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1242\/dev.00100","article-title":"Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization","volume":"129","author":"Gritli-Linde","year":"2002","journal-title":"Development"},{"key":"10.1074\/jbc.M112.402933_bib53","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.devcel.2004.09.012","article-title":"Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation","volume":"7","author":"Wang","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M112.402933_bib54","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1242\/dev.00332","article-title":"Root or crown. A developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species","volume":"130","author":"Tummers","year":"2003","journal-title":"Development"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820465184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820465184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.402933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T15:28:11Z","timestamp":1641310091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820465184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0021925820465184"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.402933","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}