{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:13:37Z","timestamp":1791278017749,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":2751,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1074\/jbc.m112.416446","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T13:55:45Z","timestamp":1357739745000},"page":"6034-6044","source":"Crossref","is-referenced-by-count":42,"title":["Reprogramming of the MicroRNA Transcriptome Mediates Resistance to Rapamycin"],"prefix":"10.1016","volume":"288","author":[{"given":"Hana","family":"Totary-Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Sanoudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iddo Z.","family":"Ben-Dov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cula N.","family":"Dautriche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven O.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.416446_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.416446_bib2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sarbassov","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M112.416446_bib3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrc1974","article-title":"mTOR and cancer: insights into a complex relationship","volume":"6","author":"Sabatini","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M112.416446_bib4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sarbassov","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M112.416446_bib5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M112.416446_bib6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/372570a0","article-title":"Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin","volume":"372","author":"Nourse","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.416446_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"Sarbassov","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M112.416446_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M112.416446_bib9","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1158\/1078-0432.CCR-04-0174","article-title":"Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage","volume":"10","author":"David","year":"2004","journal-title":"Clin Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib10","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1038\/sj.onc.1207545","article-title":"eIF-4E expression and its role in malignancies and metastases","volume":"23","author":"De Benedetti","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.416446_bib11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrd2062","article-title":"Current development of mTOR inhibitors as anticancer agents","volume":"5","author":"Faivre","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M112.416446_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrc1362","article-title":"The TOR pathway: a target for cancer therapy","volume":"4","author":"Bjornsti","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M112.416446_bib13","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/sj.bjc.6602162","article-title":"Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer","volume":"91","author":"Chan","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M112.416446_bib14","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1158\/0008-5472.CAN-11-2195","article-title":"Rapamycin resistance is linked to defective regulation of Skp2","volume":"72","author":"Totary-Jain","year":"2012","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/00063030-200923020-00002","article-title":"Current status and challenges associated with targeting mTOR for cancer therapy","volume":"23","author":"Dowling","year":"2009","journal-title":"BioDrugs"},{"key":"10.1074\/jbc.M112.416446_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1586\/erm.09.8","article-title":"mTOR in renal cell cancer: modulator of tumor biology and therapeutic target","volume":"9","author":"Wysocki","year":"2009","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1074\/jbc.M112.416446_bib17","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1517\/13543780802556485","article-title":"Deforolimus (AP23573) a novel mTOR inhibitor in clinical development","volume":"17","author":"Mita","year":"2008","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1074\/jbc.M112.416446_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1634\/theoncologist.2007-0171","article-title":"The potential role of mTOR inhibitors in non-small cell lung cancer","volume":"13","author":"Gridelli","year":"2008","journal-title":"Oncologist"},{"key":"10.1074\/jbc.M112.416446_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11912-009-0028-0","article-title":"Progress in the treatment of neuroendocrine tumors","volume":"11","author":"Chan","year":"2009","journal-title":"Curr. Oncol. Rep"},{"key":"10.1074\/jbc.M112.416446_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1586\/14737140.9.2.247","article-title":"mTOR inhibitors for hepatocellular cancer: a forward-moving target","volume":"9","author":"Treiber","year":"2009","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"Suppl. 5","key":"10.1074\/jbc.M112.416446_bib21","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.6004\/jnccn.2008.2005","article-title":"NCCN task force report: mTOR inhibition in solid tumors","volume":"6","author":"Figlin","year":"2008","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1074\/jbc.M112.416446_bib22","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1200\/JCO.2008.21.3033","article-title":"Randomized phase II study comparing two schedules of everolimus in patients with recurrent\/metastatic breast cancer: NCIC Clinical Trials Group IND. 163","volume":"27","author":"Ellard","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1074\/jbc.M112.416446_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrd2924","article-title":"Everolimus","volume":"8","author":"Atkins","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M112.416446_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1073\/pnas.98.1.136","article-title":"A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt","volume":"98","author":"Aoki","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.416446_bib25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/1535-7163.MCT-08-0668","article-title":"Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor-dependent and does not predict tumor cell response to PI3K\/mTOR inhibition","volume":"8","author":"Breuleux","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M112.416446_bib26","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.416446_bib27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nsmb1167","article-title":"RNA polymerase III transcribes human microRNAs","volume":"13","author":"Borchert","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M112.416446_bib28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M112.416446_bib29","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1200\/JCO.2008.19.4134","article-title":"Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma","volume":"27","author":"Lebanony","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1074\/jbc.M112.416446_bib30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1080\/13547500802646572","article-title":"MicroRNAs as biomarkers and therapeutic drugs in human cancer","volume":"13","author":"Osaki","year":"2008","journal-title":"Biomarkers"},{"key":"10.1074\/jbc.M112.416446_bib31","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1038\/sj.onc.1209883","article-title":"Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases","volume":"25","author":"Mayer","year":"2006","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.416446_bib32","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1128\/MCB.16.12.6744","article-title":"Rapamycin resistance tied to defective regulation of p27Kip1","volume":"16","author":"Luo","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.416446_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1023\/A:1016357510143","article-title":"Isolation of vascular smooth muscle cells from a single murine aorta","volume":"23","author":"Ray","year":"2001","journal-title":"Methods Cell Sci."},{"key":"10.1074\/jbc.M112.416446_bib34","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1074\/jbc.M112.416446_bib35","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1093\/bioinformatics\/btm412","article-title":"A comparison of background correction methods for two-colour microarrays","volume":"23","author":"Ritchie","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M112.416446_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/biostatistics\/kxn042","article-title":"Microarray background correction: maximum likelihood estimation for the normal-exponential convolution","volume":"10","author":"Silver","year":"2009","journal-title":"Biostatistics"},{"key":"10.1074\/jbc.M112.416446_bib37","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","article-title":"Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation","volume":"30","author":"Yang","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M112.416446_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.1074\/jbc.M112.416446_bib39","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1089\/cmb.2005.12.882","article-title":"Stochastic models inspired by hybridization theory for short oligonucleotide arrays","volume":"12","author":"Wu","year":"2005","journal-title":"J. Comput. Biol."},{"key":"10.1074\/jbc.M112.416446_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.416446_bib41","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1128\/MCB.19.9.6041","article-title":"Cell cycle progression and proliferation despite 4BP-1 dephosphorylation","volume":"19","author":"Marx","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.416446_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/MCB.24.1.200-216.2004","article-title":"mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1\/eukaryotic translation initiation factor 4E","volume":"24","author":"Fingar","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M112.416446_bib43","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.4049\/jimmunol.166.5.3201","article-title":"Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes","volume":"166","author":"Slavik","year":"2001","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.416446_bib44","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"O'Reilly","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib45","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.416446_bib46","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1101\/gad.1861409","article-title":"miR-19 is a key oncogenic component of mir-17\u201392","volume":"23","author":"Olive","year":"2009","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.416446_bib47","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.4161\/cc.10.17.16959","article-title":"Cooperative control of tumor suppressor genes by a network of oncogenic microRNAs","volume":"10","author":"Mavrakis","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M112.416446_bib48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","article-title":"A microRNA polycistron as a potential human oncogene","volume":"435","author":"He","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.416446_bib49","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/onc.2008.474","article-title":"Role of miR-143 targeting KRAS in colorectal tumorigenesis","volume":"28","author":"Chen","year":"2009","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.416446_bib50","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1038\/onc.2010.241","article-title":"Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein","volume":"29","author":"Xiong","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.416446_bib51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/sj.bjc.6605232","article-title":"MicroRNAs: new players in acute myeloid leukaemia","volume":"101","author":"Havelange","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M112.416446_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","article-title":"Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP","volume":"141","author":"Hafner","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.416446_bib53","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"O'Donnell","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.416446_bib54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng.2007.30","article-title":"Widespread microRNA repression by Myc contributes to tumorigenesis","volume":"40","author":"Chang","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.416446_bib55","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng1855","article-title":"Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster","volume":"38","author":"Dews","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.416446_bib56","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.molcel.2010.11.038","article-title":"The miR-17\u201392 microRNA cluster regulates multiple components of the TGF-\u03b2 pathway in neuroblastoma","volume":"40","author":"Mestdagh","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M112.416446_bib57","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.416446_bib58","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human MicroRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M112.416446_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2105-8-69","article-title":"Inference of miRNA targets using evolutionary conservation and pathway analysis","volume":"8","author":"Gaidatzis","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M112.416446_bib60","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1158\/0008-5472.CAN-09-0910","article-title":"MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy","volume":"69","author":"Balakumaran","year":"2009","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib61","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nature08025","article-title":"The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs","volume":"459","author":"Trabucchi","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.416446_bib62","doi-asserted-by":"crossref","unstructured":".Briata, P., Lin, W. J., Giovarelli, M., Pasero, M., Chou, C. F., Trabucchi, M., Rosenfeld, M. G., Chen, C. Y., Gherzi, R., PI3K\/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis. Cell Death Differ. 19, 478\u2013487,","DOI":"10.1038\/cdd.2011.117"},{"key":"10.1074\/jbc.M112.416446_bib63","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.pbio.0050005","article-title":"The RNA-binding protein KSRP promotes decay of \u03b2-catenin mRNA and is inactivated by PI3K-AKT signaling","volume":"5","author":"Gherzi","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M112.416446_bib64","doi-asserted-by":"crossref","first-page":"9762","DOI":"10.1158\/0008-5472.CAN-07-2462","article-title":"MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells","volume":"67","author":"Sampson","year":"2007","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib65","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1074\/jbc.M111.278705","article-title":"MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells","volume":"287","author":"Nadiminty","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.416446_bib66","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4161\/cc.7.6.5834","article-title":"The let-7 microRNA reduces tumor growth in mouse models of lung cancer","volume":"7","author":"Esquela-Kerscher","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M112.416446_bib67","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1158\/0008-5472.CAN-07-1083","article-title":"The let-7 microRNA represses cell proliferation pathways in human cells","volume":"67","author":"Johnson","year":"2007","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M112.416446_bib68","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","article-title":"RAS is regulated by the let-7 microRNA family","volume":"120","author":"Johnson","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.416446_bib69","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820434982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820434982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.416446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T13:47:50Z","timestamp":1714830470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820434982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0021925820434982"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.416446","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}