{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:23:47Z","timestamp":1790004227700,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"51","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":2836,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1074\/jbc.m112.422568","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T05:29:37Z","timestamp":1351574977000},"page":"43083-43093","source":"Crossref","is-referenced-by-count":31,"title":["Listeria monocytogenes Triggers the Cell Surface Expression of Gp96 Protein and Interacts with Its N Terminus to Support Cellular Infection"],"prefix":"10.1016","volume":"287","author":[{"given":"Mariana","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cust\u00f3dio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Camejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Cabanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.422568_bib1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.micinf.2007.05.011","article-title":"The epidemiology of human listeriosis","volume":"9","author":"Swaminathan","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1074\/jbc.M112.422568_bib2","doi-asserted-by":"crossref","first-page":"19484","DOI":"10.1073\/pnas.1112371108","article-title":"Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes","volume":"108","author":"Cossart","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.422568_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4161\/viru.2.5.17703","article-title":"The arsenal of virulence factors deployed by Listeria monocytogenes to promote its cell infection cycle","volume":"2","author":"Camejo","year":"2011","journal-title":"Virulence"},{"key":"10.1074\/jbc.M112.422568_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/MMBR.00039-06","article-title":"Listeria monocytogenes surface proteins: from genome predictions to function","volume":"71","author":"Bierne","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1074\/jbc.M112.422568_bib5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0966-842X(02)02342-9","article-title":"Surface proteins and the pathogenic potential of Listeria monocytogenes","volume":"10","author":"Cabanes","year":"2002","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M112.422568_bib6","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1038\/sj.emboj.7600750","article-title":"Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein","volume":"24","author":"Cabanes","year":"2005","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.422568_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1016-8478(23)13214-6","article-title":"Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?","volume":"20","author":"Yang","year":"2005","journal-title":"Mol. Cells"},{"key":"10.1074\/jbc.M112.422568_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/scdb.1999.0320","article-title":"GRP94, an ER chaperone with protein and peptide binding properties","volume":"10","author":"Argon","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.422568_bib9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bbamcr.2011.10.013","article-title":"GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum","volume":"1823","author":"Marzec","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M112.422568_bib10","doi-asserted-by":"crossref","first-page":"48330","DOI":"10.1074\/jbc.M308661200","article-title":"Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation","volume":"278","author":"Soldano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.422568_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.immuni.2006.12.005","article-title":"Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages","volume":"26","author":"Yang","year":"2007","journal-title":"Immunity"},{"key":"10.1074\/jbc.M112.422568_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/02656730210166177","article-title":"The heat shock protein Gp96 links innate and specific immunity","volume":"18","author":"Hilf","year":"2002","journal-title":"Int. J. Hyperthermia"},{"key":"10.1074\/jbc.M112.422568_bib13","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1182\/blood.V99.10.3676","article-title":"Human platelets express heat shock protein receptors and regulate dendritic cell maturation","volume":"99","author":"Hilf","year":"2002","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.422568_bib14","doi-asserted-by":"crossref","first-page":"20847","DOI":"10.1074\/jbc.M200425200","article-title":"The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2\/4 pathway","volume":"277","author":"Vabulas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.422568_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ncomms1070","article-title":"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone","volume":"1","author":"Liu","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1074\/jbc.M112.422568_bib16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/(SICI)1097-0215(19960822)69:4<340::AID-IJC18>3.0.CO;2-9","article-title":"Tumor-specific cell surface expression of the-KDEL containing, endoplasmic reticular heat shock protein gp96","volume":"69","author":"Altmeyer","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M112.422568_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.chom.2007.11.002","article-title":"Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway","volume":"2","author":"Rechner","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1074\/jbc.M112.422568_bib18","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1128\/IAI.00326-08","article-title":"gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A","volume":"76","author":"Na","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2567.2007.02764.x","article-title":"Effects of complement regulators bound to Escherichia coli K1 and Group B Streptococcus on the interaction with host cells","volume":"124","author":"Maruvada","year":"2008","journal-title":"Immunology"},{"key":"10.1074\/jbc.M112.422568_bib20","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.4049\/jimmunol.169.11.6352","article-title":"A novel interaction of outer membrane protein A with C4b binding protein mediates serum resistance of Escherichia coli K1","volume":"169","author":"Prasadarao","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.422568_bib21","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/IAI.71.4.1680-1688.2003","article-title":"Cloning and expression of the Escherichia coli K1 outer membrane protein A receptor, a gp96 homologue","volume":"71","author":"Prasadarao","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib22","doi-asserted-by":"crossref","first-page":"e1002305","DOI":"10.1371\/journal.ppat.1002305","article-title":"Mechanisms of Candida albicans trafficking to the brain","volume":"7","author":"Liu","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M112.422568_bib23","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ncomms1554","article-title":"gp96 expression in neutrophils is critical for the onset of Escherichia coli K1 (RS218) meningitis","volume":"2","author":"Mittal","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1074\/jbc.M112.422568_bib24","doi-asserted-by":"crossref","first-page":"e1002843","DOI":"10.1371\/journal.ppat.1002843","article-title":"Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor","volume":"8","author":"Valle","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M112.422568_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1348-0421.2004.tb03510.x","article-title":"Down-regulation of gp96 by Orientia tsutsugamushi","volume":"48","author":"Cho","year":"2004","journal-title":"Microbiol. Immunol."},{"key":"10.1074\/jbc.M112.422568_bib26","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1053\/j.gastro.2009.02.076","article-title":"Rotaviruses: from pathogenesis to vaccination","volume":"136","author":"Greenberg","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M112.422568_bib27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.1200120","article-title":"A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response","volume":"331","author":"Lebreton","year":"2011","journal-title":"Science"},{"key":"10.1074\/jbc.M112.422568_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212\u0394\u0394CT) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/jbc.M112.422568_bib29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1086\/654880","article-title":"LapB, a novel Listeria monocytogenes LPXTG surface adhesin, required for entry into eukaryotic cells and virulence","volume":"202","author":"Reis","year":"2010","journal-title":"J. Infect Dis."},{"key":"10.1074\/jbc.M112.422568_bib30","doi-asserted-by":"crossref","first-page":"9865","DOI":"10.1128\/JVI.72.12.9865-9872.1998","article-title":"BiP (GRP78) and endoplasmin (GRP94) are induced following rotavirus infection and bind transiently to an endoplasmic reticulum-localized virion component","volume":"72","author":"Xu","year":"1998","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M112.422568_bib31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gut.2010.207456","article-title":"Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion","volume":"59","author":"Rolhion","year":"2010","journal-title":"Gut"},{"key":"10.1074\/jbc.M112.422568_bib32","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1128\/IAI.70.8.4556-4563.2002","article-title":"Identification of Escherichia coli outer membrane protein A receptor on human brain microvascular endothelial cells","volume":"70","author":"Prasadarao","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1462-5822.2009.01379.x","article-title":"Nitric oxide\/cGMP signalling induces Escherichia coli K1 receptor expression and modulates the permeability in human brain endothelial cell monolayers during invasion","volume":"12","author":"Mittal","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1074\/jbc.M112.422568_bib34","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1128\/IAI.72.2.931-936.2004","article-title":"Heat shock protein 60 acts as a receptor for the Listeria adhesion protein in Caco-2 cells","volume":"72","author":"Wampler","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib35","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1128\/IAI.00516-10","article-title":"Listeria monocytogenes uses Listeria adhesion protein (LAP) to promote bacterial transepithelial translocation and induces expression of LAP receptor Hsp60","volume":"78","author":"Burkholder","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib36","article-title":"Regulation of Toll-like receptor 2 interaction with Ecgp96 controls Escherichia coli K1 invasion of brain endothelial cells","author":"Krishnan","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1074\/jbc.M112.422568_bib37","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1462-5822.2012.01805.x","article-title":"IQGAP1 mediates the disruption of adherens junctions to promote Escherichia coli K1 invasion of brain endothelial cells","volume":"14","author":"Krishnan","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1074\/jbc.M112.422568_bib38","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/j.1462-5822.2008.01214.x","article-title":"Escherichia coli interaction with human brain microvascular endothelial cells induces signal transducer and activator of transcription 3 association with the C-terminal domain of Ec-gp96, the outer membrane protein A receptor for invasion","volume":"10","author":"Maruvada","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1074\/jbc.M112.422568_bib39","doi-asserted-by":"crossref","first-page":"36769","DOI":"10.1074\/jbc.M007382200","article-title":"Phosphatidylinositol 3-kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"275","author":"Reddy","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.422568_bib40","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1128\/IAI.68.11.6423-6430.2000","article-title":"Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells","volume":"68","author":"Reddy","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.422568_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ceb.2005.08.013","article-title":"Microbial strategies to target, cross or disrupt epithelia","volume":"17","author":"Sousa","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M112.422568_bib42","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood-2002-07-2261","article-title":"The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions","volume":"101","author":"Radsak","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.422568_bib43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2010.00993.x","article-title":"Cell biology and immunology of Listeria monocytogenes infections: novel insights","volume":"240","author":"Stavru","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M112.422568_bib44","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.181.3.2028","article-title":"Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation","volume":"181","author":"Machata","year":"2008","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.422568_bib45","doi-asserted-by":"crossref","first-page":"e33299","DOI":"10.1371\/journal.pone.0033299","article-title":"Both TLR2 and TRIF contribute to interferon-beta production during Listeria infection","volume":"7","author":"Aubry","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.422568_bib46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2010.05.075","article-title":"Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation","volume":"397","author":"Kim","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.422568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T21:44:06Z","timestamp":1714513446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820437974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":46,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0021925820437974"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.422568","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}