{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:05:03Z","timestamp":1789643103879,"version":"4.0.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2775,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1074\/jbc.m112.425728","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T12:04:46Z","timestamp":1354622686000},"page":"4023-4034","source":"Crossref","is-referenced-by-count":48,"title":["Role of Pilus Proteins in Adherence and Invasion of Streptococcus agalactiae to the Lung and Cervical Epithelial Cells"],"prefix":"10.1016","volume":"288","author":[{"given":"Puja","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hem","family":"Lata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul Kumar","family":"Johri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.425728_bib1","first-page":"820","author":"Baker","year":"1991"},{"key":"10.1074\/jbc.M112.425728_bib2","first-page":"271","article-title":"Group B streptococcal disease. Its importance in the developing world and prospect for prevention with vaccines","volume":"8","author":"Walsh","year":"1989","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1074\/jbc.M112.425728_bib3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1442-200X.1997.tb03638.x","article-title":"Minimization of the number of pregnant women to be treated with preventive procedure against GBS infection by means of antibody measurement. GBS Infection Group","volume":"39","author":"Hoshina","year":"1997","journal-title":"Acta Paediatr. Jpn."},{"key":"10.1074\/jbc.M112.425728_bib4","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1086\/314666","article-title":"Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese women","volume":"179","author":"Lachenauer","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.425728_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00006454-200004000-00022","article-title":"Early onset neonatal sepsis caused by serotype VIII group B streptococci","volume":"19","author":"Matsubara","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1074\/jbc.M112.425728_bib6","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1128\/IAI.72.8.4716-4722.2004","article-title":"Adherence to, invasion by, and cytokine production in response to serotype VIII group B streptococci","volume":"72","author":"Mikamo","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrmicro1552","article-title":"Group B Streptococcus. Global incidence and vaccine development","volume":"4","author":"Johri","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib8","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1084\/jem.177.6.1593","article-title":"Protein rib. A novel group B streptococcal cell surface protein that confers protective immunity and is expressed by most strains causing invasive infections","volume":"177","author":"St\u00e5lhammar-Carlemalm","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M112.425728_bib9","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1128\/IAI.68.10.5610-5618.2000","article-title":"Identification of group B streptococcal Sip protein, which elicits cross-protective immunity","volume":"68","author":"Brodeur","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib10","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1128\/IAI.69.4.2302-2308.2001","article-title":"Antibody against surface-bound C5a peptidase is opsonic and initiates macrophage killing of group B streptococci","volume":"69","author":"Cheng","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib11","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/IAI.00638-06","article-title":"Transcriptional and proteomic profiles of group B Streptococcus type V reveal potential adherence proteins associated with high-level invasion","volume":"75","author":"Johri","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1586\/14760584.5.5.687","article-title":"Towards a universal group B Streptococcus vaccine using multistrain genome analysis","volume":"5","author":"Tettelin","year":"2006","journal-title":"Expert Rev. Vaccines"},{"key":"10.1074\/jbc.M112.425728_bib13","doi-asserted-by":"crossref","first-page":"13950","DOI":"10.1073\/pnas.0506758102","article-title":"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae. Implications for the microbial \u201cpan-genome\u201d","volume":"102","author":"Tettelin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.425728_bib14","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1046\/j.1365-2958.2002.03126.x","article-title":"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease","volume":"45","author":"Glaser","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib15","doi-asserted-by":"crossref","first-page":"12391","DOI":"10.1073\/pnas.182380799","article-title":"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae","volume":"99","author":"Tettelin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.425728_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1126\/science.1109869","article-title":"Identification of a universal Group B Streptococcus vaccine by multiple genome screen","volume":"309","author":"Maione","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M112.425728_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1111563","article-title":"Genome analysis reveals pili in Group B Streptococcus","volume":"309","author":"Lauer","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M112.425728_bib18","doi-asserted-by":"crossref","first-page":"15641","DOI":"10.1073\/pnas.0507808102","article-title":"Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens","volume":"102","author":"Mora","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.425728_bib19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2958.2006.05225.x","article-title":"Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae","volume":"61","author":"Rosini","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib20","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1073\/pnas.0511017103","article-title":"A pneumococcal pilus influences virulence and host inflammatory responses","volume":"103","author":"Barocchi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.425728_bib21","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1128\/IAI.71.12.6707-6711.2003","article-title":"Oxygen regulates invasiveness and virulence of group B Streptococcus","volume":"71","author":"Johri","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib22","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1365-2958.2006.05190.x","article-title":"Assembly and role of pili in group B streptococci","volume":"60","author":"Dramsi","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib23","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1128\/iai.64.4.1220-1226.1996","article-title":"Cell growth rate regulates expression of group B Streptococcus type III capsular polysaccharide","volume":"64","author":"Paoletti","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1099\/mic.0.025213-0","article-title":"Impact of lgt mutation on lipoprotein biosynthesis and in vitro phenotypes of Streptococcus agalactiae","volume":"155","author":"Bray","year":"2009","journal-title":"Microbiology"},{"key":"10.1074\/jbc.M112.425728_bib25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2958.1993.tb01628.x","article-title":"An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes. Use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes","volume":"8","author":"Perez-Casal","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib26","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1128\/aem.63.9.3539-3547.1997","article-title":"New genetic techniques for group B streptococci. High-efficiency transformation, maintenance of temperature-sensitive pWV01 plasmids, and mutagenesis with Tn917","volume":"63","author":"Framson","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib27","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1017\/S1462399408000811","article-title":"Recent advances in understanding the molecular basis of group B Streptococcus virulence","volume":"10","author":"Maisey","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1074\/jbc.M112.425728_bib28","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4049\/jimmunol.178.3.1379","article-title":"Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein","volume":"178","author":"Madureira","year":"2007","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M112.425728_bib29","doi-asserted-by":"crossref","first-page":"39860","DOI":"10.1074\/jbc.M006928200","article-title":"Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340","volume":"275","author":"Prakobphol","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.425728_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1074\/jbc.M005702200","article-title":"Functional analysis in type Ia group B Streptococcus of a cluster of genes involved in extracellular polysaccharide production by diverse species of streptococci","volume":"276","author":"Cieslewicz","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.425728_bib31","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1128\/IAI.67.2.871-878.1999","article-title":"Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin","volume":"67","author":"Spellerberg","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bj2730635","article-title":"Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus","volume":"273","author":"Bohnsack","year":"1991","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M112.425728_bib33","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1371\/journal.pone.0002446","article-title":"Group B streptococcal b hemolysin\/cytolysin directly impairs cardiomyocyte viability and function","volume":"3","author":"Hensler","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.425728_bib34","doi-asserted-by":"crossref","first-page":"24714","DOI":"10.1074\/jbc.M402164200","article-title":"\u03b1 C protein of group B Streptococcus binds host cell surface glycosaminoglycan and enters cells by an actin-dependent mechanism","volume":"279","author":"Baron","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.425728_bib35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/CMR.18.1.102-127.2005","article-title":"Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens","volume":"18","author":"Lindahl","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1074\/jbc.M112.425728_bib36","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/iai.60.11.4801-4808.1992","article-title":"Opsonization of Streptococcus agalactiae of bovine origin by complement and antibodies against group B polysaccharide","volume":"60","author":"Rainard","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrmicro1443","article-title":"Pili in gram-positive pathogens","volume":"4","author":"Telford","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1074\/jbc.M112.425728_bib38","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1086\/595564","article-title":"Preventing bacterial infections with pilus-based vaccines. The group B streptococcus paradigm","volume":"199","author":"Margarit","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.425728_bib39","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1086\/591182","article-title":"Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells","volume":"198","author":"Pezzicoli","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M112.425728_bib40","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1128\/IAI.71.12.6857-6863.2003","article-title":"Subtractive hybridization identifies a novel predicted protein mediating epithelial cell invasion by virulent serotype III group B Streptococcus agalactiae","volume":"71","author":"Adderson","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M112.425728_bib41","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/JB.01153-06","article-title":"Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells","volume":"189","author":"Maisey","year":"2007","journal-title":"J. Bacteriol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820463604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820463604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.425728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T15:17:22Z","timestamp":1641309442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820463604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0021925820463604"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.425728","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}