{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:11:04Z","timestamp":1791119464771,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2656,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1074\/jbc.m112.434787","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T03:50:43Z","timestamp":1367466643000},"page":"17579-17588","source":"Crossref","is-referenced-by-count":105,"title":["A Blood-Brain Barrier (BBB) Disrupter Is Also a Potent \u03b1-Synuclein (\u03b1-syn) Aggregation Inhibitor"],"prefix":"10.1016","volume":"288","author":[{"given":"Ronit","family":"Shaltiel-Karyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Frenkel-Pinter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Rockenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Levy-Sakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirit","family":"Egoz-Matia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.434787_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pharmthera.2004.08.001","article-title":"Delivery of therapeutic agents to the central nervous system: the problems and the possibilities","volume":"104","author":"Begley","year":"2004","journal-title":"Pharmacol. Ther"},{"key":"10.1074\/jbc.M112.434787_bib2","first-page":"505","article-title":"Strategies to optimize brain penetration in drug discovery","volume":"8","author":"Liu","year":"2005","journal-title":"Curr. Opin. Drug Discov. Devel"},{"key":"10.1074\/jbc.M112.434787_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nbd.2009.07.028","article-title":"Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases","volume":"37","author":"Gabathuler","year":"2010","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M112.434787_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.47.120505.105237","article-title":"Drug targeting to the brain","volume":"47","author":"de Boer","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1074\/jbc.M112.434787_bib5","first-page":"613","article-title":"Intracarotid infusion of hypertonic mannitol changes permeability of blood-brain barrier to methotrexate in rats","volume":"21","author":"Pan","year":"2000","journal-title":"Acta Pharmacol. Sin"},{"key":"10.1074\/jbc.M112.434787_bib6","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.STR.29.12.2631","article-title":"Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells","volume":"29","author":"Malek","year":"1998","journal-title":"Stroke"},{"key":"10.1074\/jbc.M112.434787_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1161\/01.STR.16.4.695","article-title":"Chemiluminescence in hypoxic brain\u2013the second report: cerebral protective effect of mannitol, vitamin E, and glucocorticoid","volume":"16","author":"Suzuki","year":"1985","journal-title":"Stroke"},{"key":"10.1074\/jbc.M112.434787_bib8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1128\/EC.2.4.690-698.2003","article-title":"Mannitol is required for stress tolerance in Aspergillus niger conidiospores","volume":"2","author":"Ruijter","year":"2003","journal-title":"Eukaryot Cell"},{"key":"10.1074\/jbc.M112.434787_bib9","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1529\/biophysj.105.071761","article-title":"Structural transitions of confined model proteins: molecular dynamics simulation and experimental validation","volume":"90","author":"Lu","year":"2006","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M112.434787_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0895-4356(01)00425-5","article-title":"Risk tables for parkinsonism and Parkinson's disease","volume":"55","author":"Elbaz","year":"2002","journal-title":"J. Clin. Epidemiol"},{"key":"10.1074\/jbc.M112.434787_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00005072-199603000-00001","article-title":"Neuropathology of Parkinson's disease","volume":"55","author":"Forno","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1074\/jbc.M112.434787_bib12","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.434787_bib13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S1474-4422(11)70213-7","article-title":"Pathological roles of \u03b1-synuclein in neurological disorders","volume":"10","author":"Vekrellis","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1074\/jbc.M112.434787_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1385\/JMN:24:3:343","article-title":"The role of \u03b1-synuclein assembly and metabolism in the pathogenesis of Lewy body disease","volume":"24","author":"Hashimoto","year":"2004","journal-title":"J. Mol. Neurosci"},{"issue":"Suppl. 12","key":"10.1074\/jbc.M112.434787_bib15","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1002\/mds.20538","article-title":"\u03b1-Synuclein dysfunction in Lewy body diseases","volume":"20","author":"Tofaris","year":"2005","journal-title":"Mov. Disord"},{"key":"10.1074\/jbc.M112.434787_bib16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1146\/annurev.bi.61.070192.004503","article-title":"Amyloidosis","volume":"61","author":"Sipe","year":"1992","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M112.434787_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0167-7799(94)90082-5","article-title":"Mutations and off-pathway aggregation of proteins","volume":"12","author":"Wetzel","year":"1994","journal-title":"Trends Biotechnol"},{"key":"10.1074\/jbc.M112.434787_bib18","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1007\/s11064-009-9986-8","article-title":"Modulation of \u03b1-synuclein aggregation by dopamine: a review","volume":"34","author":"Leong","year":"2009","journal-title":"Neurochem. Res"},{"key":"10.1074\/jbc.M112.434787_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1110\/ps.062610407","article-title":"Mixed osmolytes: the degree to which one osmolyte affects the protein stabilizing ability of another","volume":"16","author":"Holthauzen","year":"2007","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M112.434787_bib20","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1203\/00006450-200212000-00004","article-title":"Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking","volume":"52","author":"Perlmutter","year":"2002","journal-title":"Pediatr. Res"},{"key":"10.1074\/jbc.M112.434787_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/092986711793979698","article-title":"Chemical and pharmacological chaperones: application for recombinant protein production and protein folding diseases","volume":"18","author":"Rajan","year":"2011","journal-title":"Curr. Med. Chem"},{"key":"10.1074\/jbc.M112.434787_bib22","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1742-4658.2006.05181.x","article-title":"Protein-misfolding diseases and chaperone-based therapeutic approaches","volume":"273","author":"Chaudhuri","year":"2006","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M112.434787_bib23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/ijms10020572","article-title":"Folding, stability and shape of proteins in crowded environments: experimental and computational approaches","volume":"10","author":"Samiotakis","year":"2009","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.M112.434787_bib24","doi-asserted-by":"crossref","first-page":"8993","DOI":"10.1021\/bi8008399","article-title":"Guiding protein aggregation with macromolecular crowding","volume":"47","author":"Munishkina","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M112.434787_bib25","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jnr.10231","article-title":"Differential neuropathological alterations in transgenic mice expressing \u03b1-synuclein from the platelet-derived growth factor and Thy-1 promoters","volume":"68","author":"Rockenstein","year":"2002","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M112.434787_bib26","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jmb.2006.12.044","article-title":"Relationships between the sequence of \u03b1-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity","volume":"366","author":"Volles","year":"2007","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M112.434787_bib27","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/j.1742-4658.2007.05733.x","article-title":"Dynamics of \u03b1-synuclein aggregation and inhibition of pore-like oligomer development by \u03b2-synuclein","volume":"274","author":"Tsigelny","year":"2007","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M112.434787_bib28","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.neuroscience.2006.07.005","article-title":"Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype \u03b1-synuclein","volume":"142","author":"Fleming","year":"2006","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M112.434787_bib29","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1523\/JNEUROSCI.3080-04.2004","article-title":"Early and progressive sensorimotor anomalies in mice overexpressing wild-type human \u03b1-synuclein","volume":"24","author":"Fleming","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M112.434787_bib30","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1523\/JNEUROSCI.3527-05.2005","article-title":"Neurological and neurodegenerative alterations in a transgenic mouse model expressing human \u03b1-synuclein under oligodendrocyte promoter: implications for multiple system atrophy","volume":"25","author":"Shults","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M112.434787_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuroscience.2004.12.025","article-title":"Intraneuronal A\u03b2, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease","volume":"132","author":"Crowther","year":"2005","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M112.434787_bib32","doi-asserted-by":"crossref","first-page":"e16564","DOI":"10.1371\/journal.pone.0016564","article-title":"Orally administrated cinnamon extract reduces \u03b2-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models","volume":"6","author":"Frydman-Marom","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.434787_bib33","doi-asserted-by":"crossref","first-page":"e11101","DOI":"10.1371\/journal.pone.0011101","article-title":"Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor","volume":"5","author":"Scherzer-Attali","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.434787_bib34","doi-asserted-by":"crossref","first-page":"e13863","DOI":"10.1371\/journal.pone.0013863","article-title":"Inhibiting \u03b1-synuclein oligomerization by stable cell-penetrating \u03b2-synuclein fragments recovers phenotype of Parkinson's disease model flies","volume":"5","author":"Shaltiel-Karyo","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M112.434787_bib35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A Drosophila model of Parkinson's disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.434787_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(95)12208-7","article-title":"Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat","volume":"202","author":"Richmon","year":"1995","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M112.434787_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1326-4-9","article-title":"\u03b1-Synuclein and neuronal cell death","volume":"4","author":"Cookson","year":"2009","journal-title":"Mol. Neurodegener"},{"key":"10.1074\/jbc.M112.434787_bib38","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1093\/brain\/awm119","article-title":"Complexities in the association of human blood brain barrier disruption with seizures: importance of patient population and method of disruption","volume":"130","author":"Butler","year":"2007","journal-title":"Brain"},{"key":"10.1074\/jbc.M112.434787_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2003.12.011","article-title":"Role of quality control pathways in human diseases involving protein misfolding","volume":"15","author":"Welch","year":"2004","journal-title":"Semin. Cell Dev. Biol"},{"key":"10.1074\/jbc.M112.434787_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcdb.2003.12.010","article-title":"Roles of molecular chaperones in protein misfolding diseases","volume":"15","author":"Barral","year":"2004","journal-title":"Semin. Cell Dev. Biol"},{"key":"10.1074\/jbc.M112.434787_bib41","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/bbrc.2002.6495","article-title":"Synergistic effect of cold mannitol and Na+\/Ca2+ exchange blocker on blood-brain barrier opening","volume":"291","author":"Ikeda","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820458983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820458983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.434787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T09:52:13Z","timestamp":1641289933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820458983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":41,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0021925820458983"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.434787","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718011329.793476971","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}