{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:47:41Z","timestamp":1789152461714,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":2775,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1074\/jbc.m112.435388","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T20:43:00Z","timestamp":1358973780000},"page":"7451-7466","source":"Crossref","is-referenced-by-count":33,"title":["Depletion of Molecular Chaperones from the Endoplasmic Reticulum and Fragmentation of the Golgi Apparatus Associated with Pathogenesis in Pelizaeus-Merzbacher Disease"],"prefix":"10.1016","volume":"288","author":[{"given":"Yurika","family":"Numata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Morimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Kure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ich","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.435388_bib1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","article-title":"Orchestrating the unfolded protein response in health and disease","volume":"110","author":"Kaufman","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M112.435388_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.cdd.4401778","article-title":"ER stress and neurodegenerative diseases","volume":"13","author":"Lindholm","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M112.435388_bib3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M112.435388_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6\u03b1 and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M112.435388_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"Calfon","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.435388_bib6","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.435388_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10048-004-0207-y","article-title":"PLP1-related inherited dysmyelinating disorders. Pelizaeus-Merzbacher disease and spastic paraplegia type 2","volume":"6","author":"Inoue","year":"2005","journal-title":"Neurogenetics"},{"key":"10.1074\/jbc.M112.435388_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0896-6273(02)01045-0","article-title":"The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease","volume":"36","author":"Southwood","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M112.435388_bib9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1083\/jcb.140.4.925","article-title":"Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease","volume":"140","author":"Gow","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.435388_bib10","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng0896-422","article-title":"A cellular mechanism governing the severity of Pelizaeus-Merzbacher disease","volume":"13","author":"Gow","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.435388_bib11","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1242\/jcs.055160","article-title":"Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein","volume":"122","author":"Roboti","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M112.435388_bib12","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/emboj\/cdg300","article-title":"Role of calnexin in the glycan-independent quality control of proteolipid protein","volume":"22","author":"Swanton","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.435388_bib13","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1523\/JNEUROSCI.5431-11.2012","article-title":"Reduced calreticulin levels link endoplasmic reticulum stress and Fas-triggered cell death in motoneurons vulnerable to ALS","volume":"32","author":"Bernard-Marissal","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M112.435388_bib14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/hmg\/dds472","article-title":"Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production","volume":"22","author":"Jaronen","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M112.435388_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1523\/JNEUROSCI.10-01-00117.1990","article-title":"Conservative amino acid substitution in the myelin proteolipid protein of jimpy(msd) mice","volume":"10","author":"Gencic","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M112.435388_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/(SICI)1096-8628(19980203)75:4<439::AID-AJMG19>3.0.CO;2-P","article-title":"Jimpy(msd) mouse mutation and connatal Pelizaeus-Merzbacher disease","volume":"75","author":"Yamamoto","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1074\/jbc.M112.435388_bib17","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.neuroscience.2006.05.067","article-title":"Aberrant trafficking of a proteolipid protein in a mild Pelizaeus-Merzbacher disease","volume":"141","author":"Koizume","year":"2006","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M112.435388_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ng0794-351","article-title":"The rumpshaker mutation in spastic paraplegia","volume":"7","author":"Kobayashi","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.435388_bib19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/358758a0","article-title":"Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene","volume":"358","author":"Schneider","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.435388_bib20","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1086\/497541","article-title":"Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants","volume":"77","author":"Khajavi","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M112.435388_bib21","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1002\/jnr.22066","article-title":"Myelin under stress","volume":"87","author":"D'Antonio","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M112.435388_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/NMM:4:1-2:73","article-title":"The unfolded protein response in protein aggregating diseases","volume":"4","author":"Gow","year":"2003","journal-title":"Neuromolecular Med."},{"key":"10.1074\/jbc.M112.435388_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.med.50.1.263","article-title":"Hereditary peripheral neuropathies. Clinical forms, genetics, and molecular mechanisms","volume":"50","author":"Warner","year":"1999","journal-title":"Annu. Rev. Med."},{"key":"10.1074\/jbc.M112.435388_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ymgme.2012.02.016","article-title":"Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease","volume":"106","author":"Yu","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M112.435388_bib25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2009.09.087","article-title":"Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling","volume":"1304","author":"Morimura","year":"2009","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M112.435388_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jnr.20762","article-title":"Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not \u03b3-aminobutyric acidergic neurons","volume":"83","author":"Abematsu","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M112.435388_bib27","doi-asserted-by":"crossref","first-page":"16901","DOI":"10.1074\/jbc.M409048200","article-title":"Disabled1 regulates the intracellular trafficking of reelin receptors","volume":"280","author":"Morimura","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.435388_bib28","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum. Coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.435388_bib29","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1074\/jbc.M109.087445","article-title":"Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78\/BiP","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M112.435388_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrn1196","article-title":"Disease mechanisms in inherited neuropathies","volume":"4","author":"Suter","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M112.435388_bib31","doi-asserted-by":"crossref","first-page":"9852","DOI":"10.1073\/pnas.152621799","article-title":"Association of calnexin with mutant peripheral myelin protein-22 ex vivo. A basis for \u201cgain-of-function\u201d ER diseases","volume":"99","author":"Dickson","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.435388_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ng1292-288","article-title":"Identical point mutations of PMP-22 in Trembler-J mouse and Charcot-Marie-Tooth disease type 1A","volume":"2","author":"Valentijn","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M112.435388_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1097-4598(199701)20:1<97::AID-MUS13>3.0.CO;2-Z","article-title":"Dejerine-Sottas neuropathy in mother and son with same point mutation of PMP22 gene","volume":"20","author":"Ionasescu","year":"1997","journal-title":"Muscle Nerve"},{"key":"10.1074\/jbc.M112.435388_bib34","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1073\/pnas.89.10.4382","article-title":"A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse","volume":"89","author":"Suter","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.435388_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/356241a0","article-title":"Trembler mouse carries a point mutation in a myelin gene","volume":"356","author":"Suter","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.435388_bib36","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M112.435388_bib37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(02)00720-1","article-title":"Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells","volume":"109","author":"S\u00fctterlin","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.435388_bib38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.200110007","article-title":"Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis","volume":"156","author":"Lane","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.435388_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.20.010403.105307","article-title":"Bi-directional protein transport between the ER and Golgi","volume":"20","author":"Lee","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M112.435388_bib40","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1007\/s00018-008-8355-0","article-title":"Take the \u201cA\u201d train. On fast tracks to the cell surface","volume":"65","author":"Marie","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M112.435388_bib41","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/PL00012510","article-title":"Myelin sheaths. Glycoproteins involved in their formation, maintenance and degeneration","volume":"59","author":"Quarles","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M112.435388_bib42","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0092-8674(87)90086-9","article-title":"A C-terminal signal prevents secretion of luminal ER proteins","volume":"48","author":"Munro","year":"1987","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.435388_bib43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrm1910","article-title":"ARF proteins. Roles in membrane traffic and beyond","volume":"7","author":"D'Souza-Schorey","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M112.435388_bib44","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1083\/jcb.127.6.1557","article-title":"Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells","volume":"127","author":"Griffiths","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M112.435388_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(95)90240-6","article-title":"Degradation of CFTR by the ubiquitin-proteasome pathway","volume":"83","author":"Ward","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.435388_bib46","doi-asserted-by":"crossref","first-page":"e33266","DOI":"10.1371\/journal.pone.0033266","article-title":"ER stress in retinal degeneration in S334ter Rho rats","volume":"7","author":"Shinde","year":"2012","journal-title":"PloS One"},{"key":"10.1074\/jbc.M112.435388_bib47","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.cellsig.2012.03.011","article-title":"Redox signaling loops in the unfolded protein response","volume":"24","author":"Higa","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M112.435388_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1385\/CBB:39:3:223","article-title":"Calnexin, calreticulin, and ERp57. Teammates in glycoprotein folding","volume":"39","author":"Ellgaard","year":"2003","journal-title":"Cell Biochem. Biophys."},{"key":"10.1074\/jbc.M112.435388_bib49","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"Bertolotti","year":"2000","journal-title":"Nat. cell Biol."},{"key":"10.1074\/jbc.M112.435388_bib50","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1093\/emboj\/20.12.3082","article-title":"The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum","volume":"20","author":"Yamamoto","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M112.435388_bib51","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1007\/s00018-008-8227-7","article-title":"Large ARF guanine nucleotide exchange factors in membrane trafficking","volume":"65","author":"Anders","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1074\/jbc.M112.435388_bib52","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1073\/pnas.0712224105","article-title":"Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1","volume":"105","author":"Citterio","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M112.435388_bib53","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.nbd.2007.08.015","article-title":"A Golgi fragmentation pathway in neurodegeneration","volume":"29","author":"Nakagomi","year":"2008","journal-title":"Neurobiol. Dis."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819335318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819335318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.435388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T07:48:01Z","timestamp":1641109681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819335318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0021925819335318"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.435388","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}