{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:14:00Z","timestamp":1790806440977,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2625,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1074\/jbc.m112.441360","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:08:27Z","timestamp":1370218107000},"page":"20122-20134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":154,"title":["Parathyroid Hormone (PTH)\/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH"],"prefix":"10.1016","volume":"288","author":[{"given":"Vaibhav","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Marengi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keertik S.","family":"Fulzele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Heiden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dedic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutada","family":"Lotinun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Divieti","family":"Pajevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.441360_bib1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.1658941","article-title":"A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide","volume":"254","author":"J\u00fcppner","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M112.441360_bib2","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1056\/NEJM199412153312404","article-title":"Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency","volume":"331","author":"Finkelstein","year":"1994","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M112.441360_bib3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2217\/pgs.12.50","article-title":"Pharmacogenomics of osteoporosis: a pathway approach","volume":"13","author":"Riancho","year":"2012","journal-title":"Pharmacogenomics"},{"key":"10.1074\/jbc.M112.441360_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/JOE-10-0308","article-title":"Targeted ablation of the PTH\/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses","volume":"209","author":"Powell","year":"2011","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M112.441360_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11914-012-0105-4","article-title":"Osteocyte signaling in bone","volume":"10","author":"Schaffler","year":"2012","journal-title":"Curr. Osteoporos. Rep"},{"key":"10.1074\/jbc.M112.441360_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jbmr.1567","article-title":"Demonstration of osteocytic perilacunar\/canalicular remodeling in mice during lactation","volume":"27","author":"Qing","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib8","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/jbmr.304","article-title":"PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling","volume":"26","author":"Rhee","year":"2011","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib9","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbmr.1492","article-title":"Mef2c deletion in osteocytes results in increased bone mass","volume":"27","author":"Kramer","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcb.22559","article-title":"Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts","volume":"110","author":"Genetos","year":"2010","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M112.441360_bib12","doi-asserted-by":"crossref","first-page":"14092","DOI":"10.1073\/pnas.1207188109","article-title":"Targeted deletion of SOST distal enhancer increases bone formation and bone mass","volume":"109","author":"Collette","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M112.441360_bib13","doi-asserted-by":"crossref","first-page":"26770","DOI":"10.1074\/jbc.M504308200","article-title":"SOST is a ligand for LRP5\/LRP6 and a Wnt signaling inhibitor","volume":"280","author":"Sem\u00ebnov","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.441360_bib14","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.441360_bib15","doi-asserted-by":"crossref","first-page":"38276","DOI":"10.1074\/jbc.M609509200","article-title":"LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST","volume":"281","author":"Semenov","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.441360_bib16","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2007-0270","article-title":"Targeting the Wnt\/\u03b2-catenin pathway to regulate bone formation in the adult skeleton","volume":"148","author":"Baron","year":"2007","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M112.441360_bib17","doi-asserted-by":"crossref","first-page":"48868","DOI":"10.1074\/jbc.M208494200","article-title":"Parathyroid hormone stimulates receptor activator of NF\u03baB ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein","volume":"277","author":"Fu","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.441360_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1359\/JBMR.0301226","article-title":"PTH differentially regulates expression of RANKL and OPG","volume":"19","author":"Huang","year":"2004","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib19","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M112.441360_bib20","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M112.441360_bib21","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M112.441360_bib22","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.129.12.2977","article-title":"PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps","volume":"129","author":"Kobayashi","year":"2002","journal-title":"Development"},{"key":"10.1074\/jbc.M112.441360_bib23","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF02556360","article-title":"Bone histomorphometry: proposed system for standardization of nomenclature, symbols, and units","volume":"42","author":"Parfitt","year":"1988","journal-title":"Calcif. Tissue Int"},{"key":"10.1074\/jbc.M112.441360_bib24","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib25","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/blood-2012-06-437160","article-title":"Myelopoiesis is regulated by osteocytes through Gs\u03b1-dependent signaling","volume":"121","author":"Fulzele","year":"2013","journal-title":"Blood"},{"key":"10.1074\/jbc.M112.441360_bib26","doi-asserted-by":"crossref","first-page":"15048","DOI":"10.1073\/pnas.1203085109","article-title":"Regulation of \u03b2-catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin","volume":"109","author":"Bonnet","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M112.441360_bib27","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1210\/en.2005-0239","article-title":"Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis","volume":"146","author":"Bellido","year":"2005","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M112.441360_bib28","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbmr.1665","article-title":"Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts","volume":"27","author":"Kim","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M112.441360_bib29","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/endo.136.8.7628403","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells","volume":"136","author":"Dobnig","year":"1995","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M112.441360_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI6610","article-title":"Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone","volume":"104","author":"Jilka","year":"1999","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M112.441360_bib31","doi-asserted-by":"crossref","first-page":"e2942","DOI":"10.1371\/journal.pone.0002942","article-title":"Control of bone mass and remodeling by PTH receptor signaling in osteocytes","volume":"3","author":"O'Brien","year":"2008","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820455851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820455851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.441360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T23:32:03Z","timestamp":1699054323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820455851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":31,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0021925820455851"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.441360","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid Hormone (PTH)\/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M112.441360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}