{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:51:42Z","timestamp":1791071502807,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":2711,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1074\/jbc.m112.446369","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:54:20Z","timestamp":1364518460000},"page":"13620-13630","source":"Crossref","is-referenced-by-count":60,"title":["Death Domain-associated Protein DAXX Promotes Ovarian Cancer Development and Chemoresistance"],"prefix":"10.1016","volume":"288","author":[{"given":"Wei-Wei","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Man","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng-Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M112.446369_bib1","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1158\/0008-5472.CAN-08-0673","article-title":"Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells","volume":"68","author":"Abedini","year":"2008","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M112.446369_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/onc.2009.300","article-title":"Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein","volume":"29","author":"Abedini","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib3","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1038\/sj.onc.1207925","article-title":"Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro","volume":"23","author":"Abedini","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0092-8674(00)80294-9","article-title":"Daxx, a novel Fas-binding protein that activates JNK and apoptosis","volume":"89","author":"Yang","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M112.446369_bib5","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1128\/MCB.23.20.7108-7121.2003","article-title":"Daxx silencing sensitizes cells to multiple apoptotic pathways","volume":"23","author":"Chen","year":"2003","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M112.446369_bib6","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1101\/gad.13.15.1918","article-title":"Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development","volume":"13","author":"Michaelson","year":"1999","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M112.446369_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tcb.2005.12.002","article-title":"Daxx: death or survival protein?","volume":"16","author":"Salomoni","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M112.446369_bib8","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/sj.onc.1210865","article-title":"Regulation of c-met expression by transcription repressor Daxx","volume":"27","author":"Morozov","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib9","doi-asserted-by":"crossref","first-page":"28783","DOI":"10.1074\/jbc.M109.041186","article-title":"Daxx is a transcriptional repressor of CCAAT\/enhancer-binding protein \u03b2","volume":"284","author":"Wethkamp","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.446369_bib10","doi-asserted-by":"crossref","first-page":"15958","DOI":"10.1074\/jbc.M300387200","article-title":"Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential","volume":"278","author":"Lin","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.446369_bib11","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1074\/jbc.M409161200","article-title":"Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4","volume":"280","author":"Chang","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.446369_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcb.21408","article-title":"Daxx contains two nuclear localization signals and interacts with importin \u03b13","volume":"103","author":"Yeung","year":"2008","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M112.446369_bib13","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1038\/sj.onc.1207533","article-title":"PML nuclear bodies and apoptosis","volume":"23","author":"Takahashi","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/sj.cdd.4401313","article-title":"Body language: the function of PML nuclear bodies in apoptosis regulation","volume":"10","author":"Hofmann","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M112.446369_bib15","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.4161\/cc.21196","article-title":"Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells","volume":"11","author":"Lv","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M112.446369_bib16","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1038\/onc.2011.70","article-title":"Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo","volume":"30","author":"Mullany","year":"2011","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib17","first-page":"1577","article-title":"Colony-forming ability of human ovarian carcinomas in the Courtenay soft agar assay","volume":"9","author":"Tveit","year":"1989","journal-title":"Anticancer Res"},{"key":"10.1074\/jbc.M112.446369_bib18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ncb1442","article-title":"Critical role for Daxx in regulating Mdm2","volume":"8","author":"Tang","year":"2006","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M112.446369_bib19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/er.2009-0012","article-title":"The mammalian ovary from genesis to revelation","volume":"30","author":"Edson","year":"2009","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M112.446369_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/0008-5472.CAN-08-0587","article-title":"Expression and functions of transmembrane mucin MUC13 in ovarian cancer","volume":"69","author":"Chauhan","year":"2009","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M112.446369_bib21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1083\/jcb.200305142","article-title":"Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions","volume":"164","author":"Wang","year":"2004","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M112.446369_bib22","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1128\/MCB.00636-06","article-title":"Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies","volume":"26","author":"Block","year":"2006","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M112.446369_bib23","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nature05029","article-title":"PML inhibits HIF-1\u03b1 translation and neoangiogenesis through repression of mTOR","volume":"442","author":"Bernardi","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M112.446369_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4161\/cc.11.1.18430","article-title":"Daxx interacts with and modulates the activity of CREB","volume":"11","author":"Huang","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M112.446369_bib25","doi-asserted-by":"crossref","first-page":"26645","DOI":"10.1074\/jbc.M604391200","article-title":"Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation","volume":"281","author":"Yang","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.446369_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1083\/jcb.200604009","article-title":"Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR","volume":"175","author":"Dellaire","year":"2006","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M112.446369_bib27","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1093\/emboj\/cdf341","article-title":"Deconstructing PML-induced premature senescence","volume":"21","author":"Bischof","year":"2002","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M112.446369_bib28","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1038\/onc.2008.305","article-title":"Regulation of apoptosis by PML and the PML-NBs","volume":"27","author":"Bernardi","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M112.446369_bib29","doi-asserted-by":"crossref","first-page":"28764","DOI":"10.1074\/jbc.M604392200","article-title":"ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis","volume":"281","author":"Joe","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M112.446369_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molcel.2011.02.022","article-title":"Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation","volume":"42","author":"Chang","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M112.446369_bib31","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nrm2277","article-title":"Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies","volume":"8","author":"Bernardi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M112.446369_bib32","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1242\/jcs.02816","article-title":"The number of PML nuclear bodies increases in early S phase by a fission mechanism","volume":"119","author":"Dellaire","year":"2006","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M112.446369_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.molcel.2006.10.019","article-title":"Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors","volume":"24","author":"Lin","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M112.446369_bib34","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.2741\/3216","article-title":"PML NBs (ND10) and Daxx: from nuclear structure to protein function","volume":"13","author":"Lindsay","year":"2008","journal-title":"Front. Biosci"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819545896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819545896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M112.446369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T23:43:35Z","timestamp":1619567015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819545896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":34,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0021925819545896"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m112.446369","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}