{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:09:35Z","timestamp":1789978175066,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":2775,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1074\/jbc.m113.449918","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T07:27:57Z","timestamp":1358494077000},"page":"8691-8701","source":"Crossref","is-referenced-by-count":32,"title":["Membrane Microdomains and Cytoskeleton Organization Shape and Regulate the IL-7 Receptor Signalosome in Human CD4 T-cells"],"prefix":"10.1016","volume":"288","author":[{"given":"Blanche","family":"Tamarit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bugault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-H\u00e9l\u00e8ne","family":"Pillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lavergne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bochet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Garin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Th\u00e8ze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.449918_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nri2970","article-title":"Harnessing the biology of IL-7 for therapeutic application","volume":"11","author":"Mackall","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by \u03b3c family cytokines","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1073\/pnas.86.1.302","article-title":"Human interleukin 7. Molecular cloning and growth factor activity on human and murine B-lineage cells","volume":"86","author":"Goodwin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M113.449918_bib4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0092-8674(90)90342-C","article-title":"Cloning of the human and murine interleukin-7 receptors. Demonstration of a soluble form and homology to a new receptor superfamily","volume":"60","author":"Goodwin","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.449918_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1084\/jem.192.5.659","article-title":"Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor. Formation of a functional heteromeric complex requires interleukin 7 receptor","volume":"192","author":"Park","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M113.449918_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-065X.2012.01160.x","article-title":"Structural insights into the common \u03b3-chain family of cytokines and receptors from the interleukin-7 pathway","volume":"250","author":"Walsh","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M113.449918_bib7","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.4049\/jimmunol.180.8.5201","article-title":"Differential regulation of human IL-7 receptor \u03b1 expression by IL-7 and TCR signaling","volume":"180","author":"Alves","year":"2008","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/QAD.0b013e3280115b6a","article-title":"The correlation between levels of IL-7R\u03b1 expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients","volume":"21","author":"Colle","year":"2007","journal-title":"AIDS"},{"key":"10.1074\/jbc.M113.449918_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2004.07.016","article-title":"Suppression of IL7R\u03b1 transcription by IL-7 and other prosurvival cytokines. A novel mechanism for maximizing IL-7-dependent T cell survival","volume":"21","author":"Park","year":"2004","journal-title":"Immunity"},{"key":"10.1074\/jbc.M113.449918_bib10","doi-asserted-by":"crossref","first-page":"14898","DOI":"10.1074\/jbc.M110.104232","article-title":"Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response","volume":"285","author":"Rose","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M113.449918_bib11","doi-asserted-by":"crossref","first-page":"7389","DOI":"10.4049\/jimmunol.0900190","article-title":"Identification and biochemical characterization of human plasma soluble IL-7R. Lower concentrations in HIV-1-infected patients","volume":"182","author":"Rose","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/sqb.1999.64.417","article-title":"Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus","volume":"64","author":"Leonard","year":"1999","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1074\/jbc.M113.449918_bib13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1364\/OL.19.000780","article-title":"Breaking the diffraction resolution limit by stimulated emission. Stimulated-emission-depletion fluorescence microscopy","volume":"19","author":"Hell","year":"1994","journal-title":"Opt. Lett."},{"key":"10.1074\/jbc.M113.449918_bib14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nmeth1108","article-title":"STED microscopy with continuous wave beams","volume":"4","author":"Willig","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M113.449918_bib15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/nature07596","article-title":"Direct observation of the nanoscale dynamics of membrane lipids in a living cell","volume":"457","author":"Eggeling","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.449918_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-physchem-032210-103402","article-title":"Detecting nanodomains in living cell membrane by fluorescence correlation microscopy","volume":"62","author":"He","year":"2011","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1074\/jbc.M113.449918_bib17","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1038\/sj.emboj.7601214","article-title":"Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork","volume":"25","author":"Lenne","year":"2006","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M113.449918_bib18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nature01601","article-title":"Molecular motors","volume":"422","author":"Schliwa","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.449918_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2011.01.029","article-title":"Signaling from the living plasma membrane","volume":"144","author":"Grecco","year":"2011","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.449918_bib20","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.4049\/jimmunol.0801933","article-title":"A programmed switch from IL-15- to IL-2-dependent activation in human NK cells","volume":"182","author":"Pillet","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib21","first-page":"49","article-title":"Human IL-R\u03b2 chains form IL-2 binding homodimers","volume":"19","author":"Pillet","year":"2008","journal-title":"Eur. Cytokine Netw."},{"key":"10.1074\/jbc.M113.449918_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jmb.2010.08.056","article-title":"IL-2 induces conformational changes in its preassembled receptor core which then migrates in lipid raft and binds to cytoskeleton meshwork","volume":"403","author":"Pillet","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M113.449918_bib23","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1073\/pnas.1116582109","article-title":"Structural reorganization of the interleukin-7 signaling complex","volume":"109","author":"McElroy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M113.449918_bib24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1126\/science.1117893","article-title":"Structure of the quaternary complex of interleukin-2 with its \u03b1, \u03b2, and \u03b3c receptors","volume":"310","author":"Wang","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M113.449918_bib25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri2193","article-title":"Tether and trap. Regulation of membrane-raft dynamics by actin-binding proteins","volume":"7","author":"Viola","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib26","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.4049\/jimmunol.159.5.2259","article-title":"IL-7 activates \u03b14\u03b21 integrin in murine thymocytes","volume":"159","author":"Kitazawa","year":"1997","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M113.449918_bib27","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/emboj.2010.127","article-title":"Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse","volume":"29","author":"Lasserre","year":"2010","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M113.449918_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrm2369","article-title":"Tracking the ends: a dynamic protein network controls the fate of microtubule tips","volume":"9","author":"Akhmanova","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M113.449918_bib29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ceb.2010.08.008","article-title":"Microtubule tip-interacting proteins. A view from both ends","volume":"23","author":"Jiang","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M113.449918_bib30","doi-asserted-by":"crossref","first-page":"16447","DOI":"10.1074\/jbc.M008821200","article-title":"Arginine\/lysine-rich structural element is involved in interferon-induced nuclear import of STATs","volume":"276","author":"Melen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M113.449918_bib31","doi-asserted-by":"crossref","first-page":"30072","DOI":"10.1074\/jbc.M202943200","article-title":"Arginine\/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin \u03b15","volume":"277","author":"Fagerlund","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M113.449918_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev.biochem.67.1.265","article-title":"Nucleocytoplasmic transport. The soluble phase","volume":"67","author":"Mattaj","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M113.449918_bib33","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s00018-009-0022-6","article-title":"Cytoskeleton-membrane interactions in membrane raft structure","volume":"66","author":"Chichili","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"10.1074\/jbc.M113.449918_bib34","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.febslet.2010.09.001","article-title":"Cytoskeletal cross-talk in the control of T cell antigen receptor signaling","volume":"584","author":"Lasserre","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M113.449918_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/jcs.00855","article-title":"A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation","volume":"117","author":"Zoubiane","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M113.449918_bib36","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1074\/jbc.M409918200","article-title":"STAT5B-mediated growth hormone signaling is organized by highly dynamic microtubules in hepatic cells","volume":"280","author":"Phung-Koskas","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M113.449918_bib37","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.biocel.2006.04.001","article-title":"A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF","volume":"38","author":"Lopez-Perez","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1074\/jbc.M113.449918_bib38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jtbi.2010.08.017","article-title":"A spatial model of cellular molecular trafficking including active transport along microtubules","volume":"267","author":"Cangiani","year":"2010","journal-title":"J. Theor. Biol."}],"updated-by":[{"DOI":"10.1074\/jbc.aac119.008288","type":"correction","label":"Correction","source":"retraction-watch","updated":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"record-id":"20211"},{"DOI":"10.1074\/jbc.aac119.008288","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000}}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819335185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819335185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.449918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T19:49:04Z","timestamp":1687981744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819335185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0021925819335185"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.449918","relation":{"erratum":[{"id-type":"doi","id":"10.1074\/jbc.AAC119.008288","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}