{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:19:32Z","timestamp":1791303572046,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2625,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1074\/jbc.m113.482992","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T05:18:17Z","timestamp":1370063897000},"page":"20558-20567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum"],"prefix":"10.1016","volume":"288","author":[{"given":"Yoann","family":"Augagneur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Jaubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Schiavoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niseema","family":"Pachikara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aprajita","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Usmani-Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Wesolowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhisek","family":"Ghosal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Cornillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid M.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Altman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choukri","family":"Ben Mamoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.482992_bib1","unstructured":"World Malaria Report (2011) World Health Organization, Geneva,"},{"key":"10.1074\/jbc.M113.482992_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(04)15836-4","article-title":"A large focus of naturally acquired Plasmodium knowlesi infections in human beings","volume":"363","author":"Singh","year":"2004","journal-title":"Lancet"},{"key":"10.1074\/jbc.M113.482992_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(12)60034-8","article-title":"Global malaria mortality between 1980 and 2010. A systematic analysis","volume":"379","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1074\/jbc.M113.482992_bib4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0020-7519(01)00258-2","article-title":"Nutrient acquisition by intracellular apicomplexan parasites. Staying in for dinner","volume":"31","author":"Saliba","year":"2001","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/jbc.M113.482992_bib5","doi-asserted-by":"crossref","first-page":"20827","DOI":"10.1074\/jbc.M110.118489","article-title":"PfNT2, a permease of the equilibrative nucleoside transporter family in the endoplasmic reticulum of Plasmodium falciparum","volume":"285","author":"Downie","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijpara.2007.07.005","article-title":"Purine nucleobase transport in the intraerythrocytic malaria parasite","volume":"38","author":"Downie","year":"2008","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/jbc.M113.482992_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.molbiopara.2008.06.012","article-title":"Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine, and adenine by Plasmodium falciparum","volume":"161","author":"El Bissati","year":"2008","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/jbc.M113.482992_bib8","doi-asserted-by":"crossref","first-page":"9286","DOI":"10.1073\/pnas.0602590103","article-title":"The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum","volume":"103","author":"El Bissati","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.482992_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/138945007779315560","article-title":"Targeting nutrient uptake mechanisms in Plasmodium","volume":"8","author":"Kirk","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M113.482992_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2958.2009.06863.x","article-title":"Membrane transport proteins of the malaria parasite","volume":"74","author":"Martin","year":"2009","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.M113.482992_bib11","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/gb-2005-6-3-r26","article-title":"The \u201cpermeome\u201d of the malaria parasite. An overview of the membrane transport proteins of Plasmodium falciparum","volume":"6","author":"Martin","year":"2005","journal-title":"Genome Biol"},{"key":"10.1074\/jbc.M113.482992_bib12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1365-2958.2010.07060.x","article-title":"Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality","volume":"75","author":"Slavic","year":"2010","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.M113.482992_bib13","doi-asserted-by":"crossref","first-page":"9931","DOI":"10.1073\/pnas.170153097","article-title":"Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes","volume":"97","author":"Woodrow","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.482992_bib14","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1074\/jbc.274.11.7272","article-title":"Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter","volume":"274","author":"Woodrow","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1574-6976.2007.00093.x","article-title":"Coenzyme A biosynthesis. An antimicrobial drug target","volume":"32","author":"Spry","year":"2008","journal-title":"FEMS Microbiol. Rev"},{"key":"10.1074\/jbc.M113.482992_bib16","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1074\/jbc.273.17.10190","article-title":"Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum","volume":"273","author":"Saliba","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib17","doi-asserted-by":"crossref","first-page":"18115","DOI":"10.1074\/jbc.M010942200","article-title":"H+-coupled pantothenate transport in the intracellular malaria parasite","volume":"276","author":"Saliba","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/EC.3.2.406-412.2004","article-title":"Cell division defects of Schizosaccharomyces pombe liz1-mutants are caused by defects in pantothenate uptake","volume":"3","author":"Stolz","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"10.1074\/jbc.M113.482992_bib19","doi-asserted-by":"crossref","first-page":"18747","DOI":"10.1074\/jbc.274.26.18747","article-title":"The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter","volume":"274","author":"Stolz","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/(SICI)1097-0061(199605)12:6<531::AID-YEA934>3.0.CO;2-E","article-title":"FEN2. A gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast","volume":"12","author":"Marcireau","year":"1996","journal-title":"Yeast"},{"key":"10.1074\/jbc.M113.482992_bib21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1074\/jbc.M113.482992_bib22","doi-asserted-by":"crossref","first-page":"27636","DOI":"10.1074\/jbc.M804360200","article-title":"Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects","volume":"283","author":"Witola","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib23","doi-asserted-by":"crossref","first-page":"21305","DOI":"10.1074\/jbc.M603260200","article-title":"Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus","volume":"281","author":"Witola","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.1078599","article-title":"Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum","volume":"299","author":"Foth","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M113.482992_bib25","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.1073\/pnas.96.15.8716","article-title":"A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum","volume":"96","author":"Mamoun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.482992_bib26","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1093\/nar\/26.15.3577","article-title":"Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids. Expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae","volume":"26","author":"Miller","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.482992_bib27","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/nar\/20.6.1425","article-title":"Improved method for high efficiency transformation of intact yeast cells","volume":"20","author":"Gietz","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.482992_bib28","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1074\/jbc.M310502200","article-title":"The Plasmodium falciparum PfGatp is an endoplasmic reticulum membrane protein important for the initial step of malarial glycerolipid synthesis","volume":"279","author":"Santiago","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib29","doi-asserted-by":"crossref","first-page":"41095","DOI":"10.1074\/jbc.M107037200","article-title":"Localization of the Plasmodium falciparum PfNT1 nucleoside transporter to the parasite plasma membrane","volume":"276","author":"Rager","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib30","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1073\/pnas.1203516109","article-title":"Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum","volume":"109","author":"Augagneur","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.482992_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1550-7408.1985.tb03013.x","article-title":"Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth","volume":"32","author":"Divo","year":"1985","journal-title":"J. Protozool"},{"key":"10.1074\/jbc.M113.482992_bib32","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1128\/AAC.49.2.632-637.2005","article-title":"Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite","volume":"49","author":"Saliba","year":"2005","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1074\/jbc.M113.482992_bib33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1074\/jbc.M111.313676","article-title":"Identification of gene encoding Plasmodium knowlesi phosphatidylserine decarboxylase by genetic complementation in yeast and characterization of in vitro maturation of encoded enzyme","volume":"287","author":"Choi","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib34","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr. Robust phylogenetic analysis for the non-specialist","volume":"36","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.482992_bib35","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1074\/jbc.M414626200","article-title":"In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway","volume":"280","author":"Pessi","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib36","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.1074\/jbc.M709869200","article-title":"Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum","volume":"283","author":"Reynolds","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.482992_bib37","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/319689a0","article-title":"Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases","volume":"319","author":"Serrano","year":"1986","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.482992_bib38","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1128\/AAC.49.11.4649-4657.2005","article-title":"A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites","volume":"49","author":"Spry","year":"2005","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1074\/jbc.M113.482992_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molbiopara.2005.02.003","article-title":"CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation","volume":"141","author":"Saliba","year":"2005","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/jbc.M113.482992_bib40","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/AAC.01607-06","article-title":"Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening","volume":"51","author":"Johnson","year":"2007","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1074\/jbc.M113.482992_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1475-2875-7-19","article-title":"Characterization of two putative potassium channels in Plasmodium falciparum","volume":"7","author":"Waller","year":"2008","journal-title":"Malar. J"},{"key":"10.1074\/jbc.M113.482992_bib42","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1021\/bi200922g","article-title":"Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in S. cerevisiae yeast","volume":"50","author":"Baro","year":"2011","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.482992_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.trstmh.2008.01.021","article-title":"Performance and reliability of the SYBR Green I based assay for the routine monitoring of susceptibility of Plasmodium falciparum clinical isolates","volume":"102","author":"Rason","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820456248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820456248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.482992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T23:33:38Z","timestamp":1699054418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820456248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":43,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0021925820456248"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.482992","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M113.482992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}