{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:38:07Z","timestamp":1787499487747,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":2599,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1074\/jbc.m113.487686","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T23:50:44Z","timestamp":1373068244000},"page":"23740-23750","source":"Crossref","is-referenced-by-count":85,"title":["Piceatannol Enhances Cisplatin Sensitivity in Ovarian Cancer via Modulation of p53, X-linked Inhibitor of Apoptosis Protein (XIAP), and Mitochondrial Fission"],"prefix":"10.1016","volume":"288","author":[{"given":"Lee","family":"Farrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanguine","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akechai","family":"Im-Aram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semi","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Yong","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyong Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.487686_bib1","unstructured":"Cancer Facts & Figures (2012) American Cancer Society, Atlanta,"},{"key":"10.1074\/jbc.M113.487686_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1470-2045(02)00847-1","article-title":"Part II: Chemotherapy for epithelial ovarian cancer-treatment of recurrent disease","volume":"3","author":"Harries","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1074\/jbc.M113.487686_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/gyno.2001.6552","article-title":"Systematic review of first-line chemotherapy for newly diagnosed postoperative patients with stage II, III, or IV epithelial ovarian cancer","volume":"85","author":"Covens","year":"2002","journal-title":"Gynecol. Oncol"},{"key":"10.1074\/jbc.M113.487686_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.7326\/0003-4819-100-5-704","article-title":"Drugs five years later. Cisplatin","volume":"100","author":"Loehrer","year":"1984","journal-title":"Ann. Intern. Med"},{"key":"10.1074\/jbc.M113.487686_bib5","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1002\/1097-0142(19941201)74:11<3059::AID-CNCR2820741125>3.0.CO;2-Z","article-title":"Cisplatin-associated hemolytic uremic syndrome","volume":"74","author":"Canpolat","year":"1994","journal-title":"Cancer"},{"key":"10.1074\/jbc.M113.487686_bib6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-1-66","article-title":"Chemoresistance in human ovarian cancer. The role of apoptotic regulators","volume":"1","author":"Fraser","year":"2003","journal-title":"Reprod. Biol. Endocrinol"},{"key":"10.1074\/jbc.M113.487686_bib7","first-page":"5659","article-title":"Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells","volume":"60","author":"Sasaki","year":"2000","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib8","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1158\/0008-5472.CAN-05-0425","article-title":"Akt-mediated cisplatin resistance in ovarian cancer. Modulation of p53 action on caspase-dependent mitochondrial death pathway","volume":"66","author":"Yang","year":"2006","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib9","first-page":"1391","article-title":"Apoptosis, p53, and tumor cell sensitivity to anticancer agents","volume":"59","author":"Brown","year":"1999","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib10","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1038\/sj.onc.1207925","article-title":"Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro","volume":"23","author":"Abedini","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.487686_bib11","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1074\/jbc.M111.314765","article-title":"Calpain-mediated processing of p53-associated Parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking","volume":"287","author":"Woo","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.487686_bib12","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","article-title":"Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis","volume":"288","author":"Oda","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M113.487686_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/35022514","article-title":"Structural and biochemical basis of apoptotic activation by Smac\/DIABLO","volume":"406","author":"Chai","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.487686_bib14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of Apoptosis by Bcl-2. Release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M113.487686_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrm1697","article-title":"Mitochondrial fission in apoptosis","volume":"6","author":"Youle","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.487686_bib16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M113.487686_bib17","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.487686_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M113.487686_bib19","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.ajog.2005.11.030","article-title":"Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin. Study in human gynecologic cancer cell lines and in rodent heart","volume":"194","author":"Rezk","year":"2006","journal-title":"Am. J. Obstet. Gynecol"},{"key":"10.1074\/jbc.M113.487686_bib20","first-page":"2783","article-title":"Role of resveratrol in prevention and therapy of cancer. Preclinical and clinical studies","volume":"24","author":"Aggarwal","year":"2004","journal-title":"Anticancer Res"},{"key":"10.1074\/jbc.M113.487686_bib21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.bjc.6600197","article-title":"The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1","volume":"86","author":"Potter","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M113.487686_bib22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/cvr\/cvp359","article-title":"Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells","volume":"85","author":"Choi","year":"2010","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M113.487686_bib23","doi-asserted-by":"crossref","first-page":"11566","DOI":"10.1074\/jbc.M111.259721","article-title":"Piceatannol, a natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in the early phase of differentiation","volume":"287","author":"Kwon","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.487686_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jn\/132.2.298","article-title":"Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines","volume":"132","author":"Wolter","year":"2002","journal-title":"J. Nutr"},{"key":"10.1074\/jbc.M113.487686_bib25","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1158\/0008-5472.CAN-08-0673","article-title":"Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells","volume":"68","author":"Abedini","year":"2008","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib26","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ymthe.2004.08.013","article-title":"Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer","volume":"10","author":"Shaw","year":"2004","journal-title":"Mol. Ther"},{"key":"10.1074\/jbc.M113.487686_bib27","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/onc.2011.399","article-title":"The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation","volume":"31","author":"Ali","year":"2012","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.487686_bib28","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1210\/endo.142.6.8080","article-title":"X-linked inhibitor of apoptosis protein activates the phosphatidylinositol 3-kinase\/Akt pathway in rat granulosa cells during follicular development","volume":"142","author":"Asselin","year":"2001","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M113.487686_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/onc.2009.300","article-title":"Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein","volume":"29","author":"Abedini","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.487686_bib30","doi-asserted-by":"crossref","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","article-title":"Loss of Parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation","volume":"284","author":"Lutz","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.487686_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships. The combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzyme Regul"},{"key":"10.1074\/jbc.M113.487686_bib32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tcb.2007.08.006","article-title":"Regulation of mitochondrial fusion and division","volume":"17","author":"Cerveny","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M113.487686_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.M113.487686_bib34","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"Detmer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.487686_bib35","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1091\/mbc.e04-04-0294","article-title":"Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis","volume":"15","author":"Lee","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.487686_bib36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.molcel.2008.08.002","article-title":"Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome c release","volume":"31","author":"Sheridan","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M113.487686_bib37","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1091\/mbc.e06-05-0377","article-title":"The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis","volume":"17","author":"Alirol","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.487686_bib38","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1242\/jcs.02537","article-title":"Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1","volume":"118","author":"Yu","year":"2005","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M113.487686_bib39","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1128\/MCB.02116-06","article-title":"Drp1 mediates caspase-independent type III cell death in normal and leukemic cells","volume":"27","author":"Bras","year":"2007","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M113.487686_bib40","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1017\/S0007114511003588","article-title":"Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells","volume":"107","author":"Takahashi","year":"2012","journal-title":"Br. J. Nutr"},{"key":"10.1074\/jbc.M113.487686_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1017\/S0029665108006009","article-title":"Effects of dietary polyphenols on gene expression in human vascular endothelial cells","volume":"67","author":"Nicholson","year":"2008","journal-title":"Proc. Nutr. Soc"},{"key":"10.1074\/jbc.M113.487686_bib42","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.biochi.2013.01.008","article-title":"Optimization of trans-resveratrol bioavailability for human therapy","volume":"95","author":"Amiot","year":"2013","journal-title":"Biochimie"},{"key":"10.1074\/jbc.M113.487686_bib43","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin. Mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.487686_bib44","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ijc.23086","article-title":"Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function","volume":"122","author":"Fraser","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M113.487686_bib45","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1101\/gad.1103603","article-title":"Integral role of Noxa in p53-mediated apoptotic response","volume":"17","author":"Shibue","year":"2003","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M113.487686_bib46","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1093\/emboj\/17.8.2215","article-title":"IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases","volume":"17","author":"Deveraux","year":"1998","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M113.487686_bib47","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/cdd.2010.44","article-title":"Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-\u03b1-dependent manner","volume":"17","author":"Probst","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M113.487686_bib48","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.1074\/jbc.M102415200","article-title":"X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes","volume":"276","author":"Suzuki","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.487686_bib49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1097-2765(03)00054-6","article-title":"Mechanism of XIAP-mediated inhibition of caspase-9","volume":"11","author":"Shiozaki","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M113.487686_bib50","first-page":"5137","volume":"61","author":"Alas","year":"2001","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature10167","article-title":"Selective killing of cancer cells by a small molecule targeting the stress response to ROS","volume":"475","author":"Raj","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.487686_bib52","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00520-003-0562-5","article-title":"Chemotherapy-induced alopeci. Psychosocial impact and therapeutic approaches","volume":"12","author":"Hesketh","year":"2004","journal-title":"Support. Care Cancer"},{"key":"10.1074\/jbc.M113.487686_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","article-title":"Cisplatin. A review of toxicities and therapeutic applications","volume":"6","author":"Barabas","year":"2008","journal-title":"Vet. Comp. Oncol"},{"key":"10.1074\/jbc.M113.487686_bib54","first-page":"7556","article-title":"Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin","volume":"61","author":"Ghamande","year":"2001","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib55","first-page":"6039","article-title":"Reversal of drug resistance in human tumor xenografts by 2\u2032-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter","volume":"60","author":"Plumb","year":"2000","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib56","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0006-291X(89)91060-7","article-title":"Piceatannol (3,4,3\u2032,5\u2032-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor","volume":"165","author":"Geahlen","year":"1989","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M113.487686_bib57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1677\/jme.1.01783","article-title":"The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor \u03b1 in human breast cancer cells","volume":"35","author":"Maggiolini","year":"2005","journal-title":"J. Mol. Endocrinol"},{"key":"10.1074\/jbc.M113.487686_bib58","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1158\/1078-0432.CCR-11-1389","article-title":"Molecular pathways. Digoxin use and estrogen-sensitive cancers. Risks and possible therapeutic implications","volume":"18","author":"Biggar","year":"2012","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/jbc.M113.487686_bib59","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/1097-0142(19861201)58:11<2363::AID-CNCR2820581102>3.0.CO;2-#","article-title":"International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption","volume":"58","author":"Rose","year":"1986","journal-title":"Cancer"},{"key":"10.1074\/jbc.M113.487686_bib60","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820452652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820452652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.487686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T08:59:54Z","timestamp":1639817994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820452652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":60,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0021925820452652"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.487686","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}