{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:26:23Z","timestamp":1791591983599,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":2480,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1074\/jbc.m113.489237","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T20:34:26Z","timestamp":1382214866000},"page":"35387-35395","source":"Crossref","is-referenced-by-count":66,"title":["Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism"],"prefix":"10.1016","volume":"288","author":[{"given":"Vishal M.","family":"Gohil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charli D.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Cracan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Yaseen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Bakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamsi K.","family":"Mootha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.489237_bib1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature11707","article-title":"Mitochondrial disorders as windows into an ancient organelle","volume":"491","author":"Vafai","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.489237_bib2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/sj.bjp.0707288","article-title":"Mitochondrial medicine: pharmacological targeting of mitochondria in disease","volume":"151","author":"Armstrong","year":"2007","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.M113.489237_bib3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.drudis.2007.07.013","article-title":"The significance of mitochondrial toxicity testing in drug development","volume":"12","author":"Dykens","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1074\/jbc.M113.489237_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nbt.1606","article-title":"Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis","volume":"28","author":"Gohil","year":"2010","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.M113.489237_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/hmg\/ddq464","article-title":"Meclizine is neuroprotective in models of Huntington's disease","volume":"20","author":"Gohil","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M113.489237_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archneur.1972.00490140033006","article-title":"Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study","volume":"27","author":"Cohen","year":"1972","journal-title":"Arch. Neurol"},{"key":"10.1074\/jbc.M113.489237_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-5198(19)43508-7","article-title":"Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay","volume":"43","author":"Kubo","year":"1987","journal-title":"Jpn. J. Pharmacol"},{"key":"10.1074\/jbc.M113.489237_bib8","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/me.2004-0046","article-title":"Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR","volume":"18","author":"Huang","year":"2004","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M113.489237_bib9","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1073\/pnas.0906039107","article-title":"A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells","volume":"107","author":"Shaham","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.489237_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb3002s98","article-title":"Targeted metabolomics","author":"Roberts","year":"2012","journal-title":"Curr. Protoc. Mol. Biol"},{"key":"10.1074\/jbc.M113.489237_bib11","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1194\/jlr.M800259-JLR200","article-title":"Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1","volume":"49","author":"Zhu","year":"2008","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.489237_bib12","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol"},{"key":"10.1074\/jbc.M113.489237_bib13","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1194\/jlr.M600536-JLR200","article-title":"Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties","volume":"48","author":"Tie","year":"2007","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.489237_bib14","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.489237_bib15","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1074\/jbc.M109.098400","article-title":"Mitochondrial and nuclear genomic responses to loss of LRPPRC expression","volume":"285","author":"Gohil","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib16","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1038\/nprot.2006.351","article-title":"Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes","volume":"1","author":"Will","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M113.489237_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Bartlett","year":"1959","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib19","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1038\/tp.2011.56","article-title":"Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation","volume":"1","author":"Webhofer","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1074\/jbc.M113.489237_bib20","first-page":"224","article-title":"Metabolomics and biochemical profiling in drug discovery and development","volume":"4","author":"Watkins","year":"2002","journal-title":"Curr. Opin. Mol. Ther"},{"key":"10.1074\/jbc.M113.489237_bib21","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1194\/jlr.R700020-JLR200","article-title":"Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids","volume":"49","author":"Vance","year":"2008","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.489237_bib22","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3390\/ijms14022529","article-title":"Regulation of phosphatidylethanolamine homeostasis\u2014the critical role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)","volume":"14","author":"Pavlovic","year":"2013","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.M113.489237_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-3223(03)00784-4","article-title":"Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder","volume":"55","author":"Modica-Napolitano","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1074\/jbc.M113.489237_bib24","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1074\/jbc.M112.434183","article-title":"Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology","volume":"288","author":"Tasseva","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib25","doi-asserted-by":"crossref","first-page":"25704","DOI":"10.1074\/jbc.M109.023846","article-title":"The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice","volume":"284","author":"Fullerton","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib26","doi-asserted-by":"crossref","first-page":"35410","DOI":"10.1074\/jbc.M505478200","article-title":"Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae","volume":"280","author":"Gohil","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib27","doi-asserted-by":"crossref","first-page":"22387","DOI":"10.1074\/jbc.M909868199","article-title":"Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib28","doi-asserted-by":"crossref","first-page":"40032","DOI":"10.1074\/jbc.M506510200","article-title":"Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects","volume":"280","author":"Steenbergen","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib29","doi-asserted-by":"crossref","first-page":"28362","DOI":"10.1074\/jbc.M703786200","article-title":"The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species","volume":"282","author":"Bleijerveld","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.489237_bib30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jmb.2012.09.001","article-title":"Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes","volume":"423","author":"B\u00f6ttinger","year":"2012","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.489237_bib31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nchembio1207-739","article-title":"Recognizing and exploiting differences between RNAi and small-molecule inhibitors","volume":"3","author":"Weiss","year":"2007","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.M113.489237_bib32","first-page":"95","article-title":"Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: an experimental study","volume":"32","author":"Ferreira","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1074\/jbc.M113.489237_bib33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00395-010-0125-0","article-title":"Ethanolamine is a novel STAT-3 dependent cardioprotective agent","volume":"105","author":"Kelly","year":"2010","journal-title":"Basic Res. Cardiol"},{"key":"10.1074\/jbc.M113.489237_bib34","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-2958.2009.06764.x","article-title":"The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei","volume":"73","author":"Gibellini","year":"2009","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.M113.489237_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BJ20121480","article-title":"Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active","volume":"450","author":"Maheshwari","year":"2013","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M113.489237_bib36","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1177\/0091270011414575","article-title":"Meclizine metabolism and pharmacokinetics: formulation on its absorption","volume":"52","author":"Wang","year":"2012","journal-title":"J. Clin. Pharmacol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820554033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820554033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.489237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T20:51:35Z","timestamp":1641329495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820554033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":36,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0021925820554033"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.489237","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}