{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T22:36:54Z","timestamp":1779057414972,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":2599,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1074\/jbc.m113.491654","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T04:37:21Z","timestamp":1371789441000},"page":"23128-23140","source":"Crossref","is-referenced-by-count":25,"title":["Control of Voltage-gated Potassium Channel Kv2.2 Expression by Pyruvate-Isocitrate Cycling Regulates Glucose-stimulated Insulin Secretion"],"prefix":"10.1016","volume":"288","author":[{"given":"Mette V.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Haldeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark O.","family":"Huising","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wylie W.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans E.","family":"Hohmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Newgard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.491654_bib1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft","year":"2005","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.M113.491654_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-90-481-3271-3_7","article-title":"Electrophysiology of islet cells","volume":"654","author":"Drews","year":"2010","journal-title":"Adv Exp. Med. Biol"},{"key":"10.1074\/jbc.M113.491654_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1507\/endocrj.48.275","article-title":"KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic \u03b2-cell","volume":"48","author":"Komatsu","year":"2001","journal-title":"Endocr. J"},{"key":"10.1074\/jbc.M113.491654_bib4","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1210\/endo.140.5.6729","article-title":"Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in \u03b2 cells","volume":"140","author":"Sato","year":"1999","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M113.491654_bib5","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1172\/JCI115714","article-title":"Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells","volume":"89","author":"Gembal","year":"1992","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.M113.491654_bib6","doi-asserted-by":"crossref","first-page":"27263","DOI":"10.1074\/jbc.M401167200","article-title":"Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue","volume":"279","author":"Boucher","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib7","doi-asserted-by":"crossref","first-page":"22342","DOI":"10.1074\/jbc.M604350200","article-title":"Compensatory responses to pyruvate carboxylase suppression in islet \u03b2-cells. Preservation of glucose-stimulated insulin secretion","volume":"281","author":"Jensen","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib8","doi-asserted-by":"crossref","first-page":"E1287","DOI":"10.1152\/ajpendo.90604.2008","article-title":"Metabolic cycling in control of glucose-stimulated insulin secretion","volume":"295","author":"Jensen","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M113.491654_bib9","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1073\/pnas.052005699","article-title":"13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)","volume":"99","author":"Lu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.491654_bib10","doi-asserted-by":"crossref","first-page":"16530","DOI":"10.1074\/jbc.M109.092593","article-title":"The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion","volume":"285","author":"Odegaard","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib11","doi-asserted-by":"crossref","first-page":"30593","DOI":"10.1074\/jbc.M511908200","article-title":"A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion","volume":"281","author":"Ronnebaum","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib12","doi-asserted-by":"crossref","first-page":"28909","DOI":"10.1074\/jbc.M804665200","article-title":"Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets","volume":"283","author":"Ronnebaum","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib13","doi-asserted-by":"crossref","first-page":"31592","DOI":"10.1074\/jbc.M706080200","article-title":"Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion","volume":"282","author":"Joseph","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00125-010-1923-5","article-title":"The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic \u03b2 cells","volume":"54","author":"Huypens","year":"2011","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M113.491654_bib15","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/diabetes.49.5.718","article-title":"Glucose-regulated anaplerosis and cataplerosis in pancreatic \u03b2-cells: possible implication of a pyruvate\/citrate shuttle in insulin secretion","volume":"49","author":"Farfari","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1074\/jbc.M602954200","article-title":"Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion","volume":"282","author":"Pongratz","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib17","doi-asserted-by":"crossref","first-page":"44370","DOI":"10.1074\/jbc.M311842200","article-title":"13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells","volume":"279","author":"Cline","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib18","doi-asserted-by":"crossref","first-page":"35657","DOI":"10.1074\/jbc.M707294200","article-title":"A role for ATP-citrate lyase, malic enzyme, and pyruvate\/citrate cycling in glucose-induced insulin secretion","volume":"282","author":"Guay","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1007\/s00125-006-0263-y","article-title":"Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets","volume":"49","author":"Fransson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M113.491654_bib20","doi-asserted-by":"crossref","first-page":"18572","DOI":"10.1074\/jbc.272.30.18572","article-title":"Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in \u03b2 cells","volume":"272","author":"Schuit","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2337\/diab.45.2.190","article-title":"Evidence for an anaplerotic\/malonyl-CoA pathway in pancreatic \u03b2-cell nutrient signaling","volume":"45","author":"Brun","year":"1996","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib22","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.00218.2004","article-title":"Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion","volume":"288","author":"MacDonald","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M113.491654_bib23","doi-asserted-by":"crossref","first-page":"35624","DOI":"10.1074\/jbc.M602606200","article-title":"The mitochondrial citrate\/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion","volume":"281","author":"Joseph","year":"2006","journal-title":"J. Biol. Chem"},{"issue":"Suppl. 2","key":"10.1074\/jbc.M113.491654_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1463-1326.2007.00784.x","article-title":"Action potentials and insulin secretion: new insights into the role of Kv channels","volume":"9","author":"Jacobson","year":"2007","journal-title":"Diabetes Obes. Metab"},{"key":"10.1074\/jbc.M113.491654_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-3495(99)76886-4","article-title":"Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation","volume":"77","author":"Kerschensteiner","year":"1999","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M113.491654_bib26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0014-5793(02)02267-6","article-title":"Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K+ channel Kv2.1","volume":"512","author":"Sano","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M113.491654_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/369289a0","article-title":"Inactivation properties of voltage-gated K+ channels altered by presence of \u03b2-subunit","volume":"369","author":"Rettig","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.491654_bib28","first-page":"237","article-title":"Evidence for voltage-gated potassium channel \u03b2-subunits with oxidoreductase motifs in human and rodent pancreatic \u03b2 cells","volume":"7","author":"Chouinard","year":"2000","journal-title":"Receptors Channels"},{"key":"10.1074\/jbc.M113.491654_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1749-6632.1999.tb11296.x","article-title":"Functional and molecular aspects of voltage-gated K+ channel \u03b2 subunits","volume":"868","author":"Pongs","year":"1999","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.M113.491654_bib30","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1002\/cne.22457","article-title":"Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice","volume":"518","author":"Hermanstyne","year":"2010","journal-title":"J. Comp. Neurol"},{"key":"10.1074\/jbc.M113.491654_bib31","doi-asserted-by":"crossref","first-page":"H2012","DOI":"10.1152\/ajpheart.01374.2007","article-title":"Posttranslational modification of voltage-dependent potassium channel Kv1.5: COOH-terminal palmitoylation modulates its biological properties","volume":"294","author":"Jindal","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M113.491654_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1159\/000185543","article-title":"Modulation of the voltage-gated potassium channel Kv1.5 by the SGK1 protein kinase involves inhibition of channel ubiquitination","volume":"22","author":"Boehmer","year":"2008","journal-title":"Cell. Physiol. Biochem"},{"key":"10.1074\/jbc.M113.491654_bib33","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1523\/JNEUROSCI.22-18-07913.2002","article-title":"Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases","volume":"22","author":"Nitabach","year":"2002","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.491654_bib34","doi-asserted-by":"crossref","first-page":"32241","DOI":"10.1074\/jbc.271.50.32241","article-title":"Expression and function of pancreatic \u03b2-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling","volume":"271","author":"Roe","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib35","doi-asserted-by":"crossref","first-page":"44938","DOI":"10.1074\/jbc.M205532200","article-title":"Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic \u03b2-cells enhances glucose-dependent insulin secretion","volume":"277","author":"MacDonald","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib36","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.2337\/diabetes.55.04.06.db05-0788","article-title":"Blockers of the delayed-rectifier potassium current in pancreatic \u03b2-cells enhance glucose-dependent insulin secretion","volume":"55","author":"Herrington","year":"2006","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib37","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1152\/ajpendo.00054.2005","article-title":"Delayed-rectifier (KV2.1) regulation of pancreatic \u03b2-cell calcium responses to glucose: inhibitor specificity and modeling","volume":"289","author":"Tamarina","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M113.491654_bib38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cmet.2007.07.010","article-title":"Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion","volume":"6","author":"Jacobson","year":"2007","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M113.491654_bib39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1113\/jphysiol.2005.089375","article-title":"Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic \u03b2-cells","volume":"567","author":"Herrington","year":"2005","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M113.491654_bib40","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.2337\/db07-0991","article-title":"Voltage-gated ion channels in human pancreatic \u03b2-cells: electrophysiological characterization and role in insulin secretion","volume":"57","author":"Braun","year":"2008","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib41","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1016\/j.bpj.2010.09.004","article-title":"A biophysical model of electrical activity in human \u03b2-cells","volume":"99","author":"Pedersen","year":"2010","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M113.491654_bib42","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1124\/mol.105.021717","article-title":"Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels","volume":"70","author":"Wolf-Goldberg","year":"2006","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M113.491654_bib43","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.2337\/diabetes.54.7.2132","article-title":"Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin","volume":"54","author":"Ivarsson","year":"2005","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/jphysiol.2002.035709","article-title":"Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic \u03b2-cells","volume":"546","author":"MacDonald","year":"2003","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M113.491654_bib45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/endo.130.1.1370150","article-title":"Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines","volume":"130","author":"Asfari","year":"1992","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M113.491654_bib46","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/diabetes.49.3.424","article-title":"Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion","volume":"49","author":"Hohmeier","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib47","doi-asserted-by":"crossref","first-page":"E177","DOI":"10.1152\/ajpendo.00321.2002","article-title":"Transgenic mice with green fluorescent protein-labeled pancreatic \u03b2-cells","volume":"284","author":"Hara","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M113.491654_bib48","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1089\/hum.1997.8.13-1625","article-title":"Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: normal \u03b2-cell function despite induction of an anti-adenovirus immune response","volume":"8","author":"Sigalla","year":"1997","journal-title":"Hum. Gene Ther"},{"key":"10.1074\/jbc.M113.491654_bib49","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1242\/dev.127.11.2317","article-title":"Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages","volume":"127","author":"Herrera","year":"2000","journal-title":"Development"},{"key":"10.1074\/jbc.M113.491654_bib50","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1073\/pnas.0913610107","article-title":"CRFR1 is expressed on pancreatic \u03b2 cells, promotes \u03b2 cell proliferation, and potentiates insulin secretion in a glucose-dependent manner","volume":"107","author":"Huising","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.491654_bib51","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.2337\/diabetes.53.9.2190","article-title":"An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of Langerhans","volume":"53","author":"Bain","year":"2004","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib52","doi-asserted-by":"crossref","first-page":"21234","DOI":"10.1016\/S0021-9258(17)31953-1","article-title":"Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels","volume":"269","author":"Becker","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib53","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1074\/jbc.270.3.1295","article-title":"Pancreatic \u03b2-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids","volume":"270","author":"Milburn","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib54","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI117042","article-title":"Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle","volume":"93","author":"Zhou","year":"1994","journal-title":"J. Clin. Investig"},{"issue":"Suppl. 3","key":"10.1074\/jbc.M113.491654_bib55","doi-asserted-by":"crossref","first-page":"S405","DOI":"10.2337\/diabetes.51.2007.S405","article-title":"Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in \u03b2-cell adaptation and failure in the etiology of diabetes","volume":"51","author":"Prentki","year":"2002","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/endo.143.2.8623","article-title":"Minireview: secondary \u03b2-cell failure in type 2 diabetes\u2014a convergence of glucotoxicity and lipotoxicity","volume":"143","author":"Poitout","year":"2002","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M113.491654_bib57","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2337\/diabetes.53.3.597","article-title":"Expression of voltage-gated potassium channels in human and rhesus pancreatic islets","volume":"53","author":"Yan","year":"2004","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib58","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1210\/me.2009-0144","article-title":"The transcriptional response of the islet to pregnancy in mice","volume":"23","author":"Rieck","year":"2009","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M113.491654_bib59","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/mol.62.1.48","article-title":"Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies","volume":"62","author":"Escoubas","year":"2002","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M113.491654_bib60","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1523\/JNEUROSCI.18-23-09585.1998","article-title":"Heteromultimeric potassium channels formed by members of the Kv2 subfamily","volume":"18","author":"Blaine","year":"1998","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.491654_bib61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.00003.2010","article-title":"Type 1 diabetes: etiology, immunology, and therapeutic strategies","volume":"91","author":"van Belle","year":"2011","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M113.491654_bib62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrm2327","article-title":"Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and \u03b2-cell failure in type 2 diabetes","volume":"9","author":"Muoio","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.491654_bib63","doi-asserted-by":"crossref","first-page":"15048","DOI":"10.1074\/jbc.M109.074260","article-title":"Formation of heteromeric Kv2 channels in mammalian brain neurons","volume":"285","author":"Kihira","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib64","doi-asserted-by":"crossref","first-page":"26341","DOI":"10.1074\/jbc.271.42.26341","article-title":"A new K+ channel \u03b2 subunit to specifically enhance Kv2.2 (CDRK) expression","volume":"271","author":"Fink","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.491654_bib65","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00125-012-2512-6","article-title":"The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function","volume":"55","author":"Dai","year":"2012","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M113.491654_bib66","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2337\/db10-0440","article-title":"SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans","volume":"60","author":"Dai","year":"2011","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M113.491654_bib67","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1242\/jcs.036632","article-title":"SUMOylation regulates Kv2.1 and modulates pancreatic \u03b2-cell excitability","volume":"122","author":"Dai","year":"2009","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M113.491654_bib68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1124\/jpet.112.199083","article-title":"The roles of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets","volume":"344","author":"Li","year":"2013","journal-title":"J. Pharmacol. Exp. Ther"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820453372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820453372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.491654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T14:23:22Z","timestamp":1641306202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820453372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":68,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0021925820453372"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.491654","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}