{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:25:38Z","timestamp":1791419138121,"version":"4.3.3"},"reference-count":102,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":2471,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1074\/jbc.m113.497909","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T03:28:02Z","timestamp":1386646082000},"page":"2946-2959","source":"Crossref","is-referenced-by-count":43,"title":["Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction"],"prefix":"10.1016","volume":"289","author":[{"given":"Samuel O.","family":"Adeosun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Stockmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Weisgraber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.497909_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E. Far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu. Rev. Genomics Hum. Genet"},{"key":"10.1074\/jbc.M113.497909_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E. Cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M113.497909_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer's disease. Pathways, pathogenesis, and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease. Risk, mechanisms, and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0065-3233(08)60642-7","article-title":"Apolipoprotein E. Structure-function relationships","volume":"45","author":"Weisgraber","year":"1994","journal-title":"Adv. Protein Chem"},{"key":"10.1074\/jbc.M113.497909_bib6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1074\/jbc.M113.497909_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M113.497909_bib8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer's disease. Allelic variation and receptor interactions","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"key":"10.1074\/jbc.M113.497909_bib9","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archneur.1994.00540240033012","article-title":"Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E \u03f54 allele","volume":"51","author":"Reed","year":"1994","journal-title":"Arch. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/1533317511421921","article-title":"Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults","volume":"26","author":"Ready","year":"2011","journal-title":"Am. J. Alzheimers Dis. Other Demen"},{"key":"10.1074\/jbc.M113.497909_bib11","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.neurobiolaging.2006.07.001","article-title":"Predicting memory decline in normal elderly. Genetics, MRI, and cognitive reserve","volume":"28","author":"Tupler","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M113.497909_bib12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0197-4580(01)00223-8","article-title":"Memory performance in healthy elderly without Alzheimer's disease. Effects of time and apolipoprotein-E","volume":"22","author":"Mayeux","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M113.497909_bib13","doi-asserted-by":"crossref","first-page":"726197","DOI":"10.4061\/2011\/726197","article-title":"The apolipoprotein E antagonistic pleiotropy hypothesis. Review and recommendations","volume":"2011","author":"Tuminello","year":"2011","journal-title":"Int. J. Alzheimers Dis"},{"key":"10.1074\/jbc.M113.497909_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0022-2275(20)42621-5","article-title":"Apolipoprotein E distribution among human plasma lipoproteins. Role of the cysteine-arginine interchange at residue 112","volume":"31","author":"Weisgraber","year":"1990","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.497909_bib15","doi-asserted-by":"crossref","first-page":"19053","DOI":"10.1074\/jbc.271.32.19053","article-title":"Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins","volume":"271","author":"Dong","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.497909_bib16","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1523\/JNEUROSCI.1972-08.2008","article-title":"Impact of apolipoprotein E (ApoE) polymorphism on brain apoE Levels","volume":"28","author":"Riddell","year":"2008","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib17","doi-asserted-by":"crossref","first-page":"11587","DOI":"10.1073\/pnas.201279298","article-title":"Introduction of human apolipoprotein E4 \u201cdomain interaction\u201d into mouse apolipoprotein E","volume":"98","author":"Raffa\u00ef","year":"2001","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M113.497909_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jalz.2008.01.006","article-title":"Apolipoprotein E4 domain interaction. Synaptic and cognitive deficits in mice","volume":"4","author":"Zhong","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1074\/jbc.M113.497909_bib19","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1038\/nprot.2006.275","article-title":"Two-day radial-arm water maze learning and memory task. Robust resolution of amyloid-related memory deficits in transgenic mice","volume":"1","author":"Alamed","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M113.497909_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(92)91352-F","article-title":"A two-trial memory task with automated recording. Study in young and aged rats","volume":"588","author":"Dellu","year":"1992","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1601-183X.2011.00698.x","article-title":"Schizophrenia-relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency","volume":"10","author":"Vuillermot","year":"2011","journal-title":"Genes Brain Behav"},{"key":"10.1074\/jbc.M113.497909_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/10253890500156663","article-title":"Chronic stress leaves novelty-seeking behavior intact while impairing spatial recognition memory in the Y-maze","volume":"8","author":"Wright","year":"2005","journal-title":"Stress"},{"key":"10.1074\/jbc.M113.497909_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbr.2007.05.006","article-title":"Neuropharmacological effects of oleamide in male and female mice","volume":"182","author":"Akanmu","year":"2007","journal-title":"Behav. Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1021691918517","article-title":"Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations. Lack of association with amyloid deposits","volume":"29","author":"Holcomb","year":"1999","journal-title":"Behav. Genet"},{"key":"10.1074\/jbc.M113.497909_bib25","doi-asserted-by":"crossref","first-page":"e18568","DOI":"10.1371\/journal.pone.0018568","article-title":"Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2","volume":"6","author":"Ramonet","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.497909_bib26","doi-asserted-by":"crossref","first-page":"e50040","DOI":"10.1371\/journal.pone.0050040","article-title":"Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease","volume":"7","author":"Adeosun","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.497909_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/jbc.M113.497909_bib28","doi-asserted-by":"crossref","first-page":"D805","DOI":"10.1093\/nar\/gkl767","article-title":"qPrimerDepot. A primer database for quantitative real time PCR","volume":"35","author":"Cui","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.497909_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-8993(98)01075-0","article-title":"Quantitative analysis of GABAergic neurons in the mouse hippocampus, with optical dissector using confocal laser scanning microscope","volume":"814","author":"Jinno","year":"1998","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib30","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/j.1528-1167.2011.03086.x","article-title":"Stereologic estimation of hippocampal GluR2\/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy","volume":"52","author":"Volz","year":"2011","journal-title":"Epilepsia"},{"key":"10.1074\/jbc.M113.497909_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2202-7-77","article-title":"Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation","volume":"7","author":"Pl\u00fcmpe","year":"2006","journal-title":"BMC Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib32","doi-asserted-by":"crossref","first-page":"e53569","DOI":"10.1371\/journal.pone.0053569","article-title":"Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice","volume":"7","author":"Leung","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.497909_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2012.12.024","article-title":"Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice","volume":"1497","author":"Paus","year":"2013","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.expneurol.2004.11.016","article-title":"Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats","volume":"192","author":"Scharfman","year":"2005","journal-title":"Exp. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib35","doi-asserted-by":"crossref","first-page":"14318","DOI":"10.1523\/JNEUROSCI.0709-12.2012","article-title":"BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission","volume":"32","author":"Waterhouse","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2008.03.002","article-title":"Early age-related changes in adult hippocampal neurogenesis in C57 mice","volume":"31","author":"Ben Abdallah","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M113.497909_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.expneurol.2006.09.018","article-title":"Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease","volume":"204","author":"Zhang","year":"2007","journal-title":"Exp. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2011.03.039","article-title":"Limited hippocampal neurogenesis in SAMP8 mouse model of Alzheimer's disease","volume":"1389","author":"Gang","year":"2011","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib39","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s11064-007-9366-1","article-title":"Differences in doublecortin immunoreactivity and protein levels in the hippocampal dentate gyrus between adult and aged dogs","volume":"32","author":"Hwang","year":"2007","journal-title":"Neurochem. Res"},{"key":"10.1074\/jbc.M113.497909_bib40","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.0403678101","article-title":"Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw, Ind) mice","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.497909_bib41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbr.2008.05.008","article-title":"Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks","volume":"193","author":"Bour","year":"2008","journal-title":"Behav. Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/exnr.2001.7715","article-title":"Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice. ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology","volume":"170","author":"Hartman","year":"2001","journal-title":"Exp. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib43","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease. Genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M113.497909_bib44","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/hipo.22013","article-title":"Adult-born hippocampal neurons promote cognitive flexibility in mice","volume":"22","author":"Burghardt","year":"2012","journal-title":"Hippocampus"},{"key":"10.1074\/jbc.M113.497909_bib45","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1212\/WNL.44.8.1513","article-title":"Reduced apolipoprotein \u03f54 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals","volume":"44","author":"Rebeck","year":"1994","journal-title":"Neurology"},{"key":"10.1074\/jbc.M113.497909_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archneur.1996.00550050048022","article-title":"Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition","volume":"53","author":"Corder","year":"1996","journal-title":"Arch. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1037\/a0014014","article-title":"The influence of apolipoprotein E genotype on visuospatial attention dissipates after age 80","volume":"23","author":"Negash","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1074\/jbc.M113.497909_bib48","doi-asserted-by":"crossref","first-page":"15181","DOI":"10.1523\/JNEUROSCI.1542-12.2012","article-title":"Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid \u03b2 peptide","volume":"32","author":"Hashimoto","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib49","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1096\/fj.10-175976","article-title":"High ability of apolipoprotein E4 to stabilize amyloid-\u03b2 peptide oligomers, the pathological entities responsible for Alzheimer's disease","volume":"25","author":"Cerf","year":"2011","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M113.497909_bib50","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid \u03b2-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M113.497909_bib51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/nbdi.2002.0483","article-title":"Human and murine apoE markedly alters A\u03b2 metabolism before and after plaque formation in a mouse model of Alzheimer's disease","volume":"9","author":"Fagan","year":"2002","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M113.497909_bib52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0169-328X(99)00073-X","article-title":"Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures","volume":"68","author":"Beffert","year":"1999","journal-title":"Mol. Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib53","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1073\/pnas.0409072102","article-title":"Gene delivery of human apolipoprotein E alters brain A\u03b2 burden in a mouse model of Alzheimer's disease","volume":"102","author":"Dodart","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.497909_bib54","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1046\/j.1471-4159.2003.02088.x","article-title":"Apolipoprotein E and \u03b2-amyloid (1\u201342) regulation of glycogen synthase kinase-3\u03b2","volume":"87","author":"Cedazo-M\u00ednguez","year":"2003","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.M113.497909_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-5793(00)02196-7","article-title":"Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3\u03b2 identified by nano-electrospray mass spectrometry","volume":"485","author":"Gibb","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M113.497909_bib56","doi-asserted-by":"crossref","first-page":"25326","DOI":"10.1074\/jbc.272.40.25326","article-title":"Lithium reduces Tau phosphorylation by inhibition of glycogen synthase kinase-3","volume":"272","author":"Hong","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.497909_bib57","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0306-4522(96)00126-1","article-title":"Phosphorylation of Tau by glycogen synthase kinase-3\u03b2 in intact mammalian cells. the effects on the organization and stability of microtubules","volume":"73","author":"Lovestone","year":"1996","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M113.497909_bib58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000283477","article-title":"Possible role of Tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade","volume":"7","author":"Inbar","year":"2010","journal-title":"Neurodegener. Dis"},{"key":"10.1074\/jbc.M113.497909_bib59","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0002-9440(10)64963-2","article-title":"Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein Tau in the brains of transgenic mice","volume":"156","author":"Tesseur","year":"2000","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M113.497909_bib60","doi-asserted-by":"crossref","first-page":"44795","DOI":"10.1074\/jbc.M408127200","article-title":"Increased Tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase. Modulation by zinc","volume":"279","author":"Harris","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.497909_bib61","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein E4 proteolysis is associated with increased Tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib62","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/glia.22289","article-title":"APOE genotype alters glial activation and loss of synaptic markers in mice","volume":"60","author":"Zhu","year":"2012","journal-title":"Glia"},{"key":"10.1074\/jbc.M113.497909_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2004.09.019","article-title":"Human apoE targeted replacement mouse lines. h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior","volume":"159","author":"Grootendorst","year":"2005","journal-title":"Behav. Brain Res"},{"key":"10.1074\/jbc.M113.497909_bib64","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1073\/pnas.95.18.10914","article-title":"Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice. Increased susceptibility of females","volume":"95","author":"Raber","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.497909_bib65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2005.11.070","article-title":"Reduced hippocampal volume in non-demented carriers of the apolipoprotein E \u03f54. Relation to chronological age and recognition memory","volume":"396","author":"Lind","year":"2006","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M113.497909_bib66","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exger.2008.11.005","article-title":"APOE polymorphism affects episodic memory among non demented elderly subjects","volume":"44","author":"De Blasi","year":"2009","journal-title":"Exp. Gerontol"},{"key":"10.1074\/jbc.M113.497909_bib67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jalz.2008.10.005","article-title":"Additional evidence for antagonistic pleiotropic effects of APOE","volume":"5","author":"Zetterberg","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.1074\/jbc.M113.497909_bib68","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0149-7634(02)00070-2","article-title":"Genetic variation in memory functioning","volume":"26","author":"Nilsson","year":"2002","journal-title":"Neurosci. Biobehav. Rev"},{"key":"10.1074\/jbc.M113.497909_bib69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1037\/0894-4105.19.2.199","article-title":"Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults. Results from the National Institute of Mental Health's BIOCARD Study","volume":"19","author":"Greenwood","year":"2005","journal-title":"Neuropsychology"},{"key":"10.1074\/jbc.M113.497909_bib70","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archpsyc.62.2.209","article-title":"Apolipoprotein e \u03f54 allele and lorazepam effects on memory in high-functioning older adults","volume":"62","author":"Pomara","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1074\/jbc.M113.497909_bib71","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1101\/lm.030031.112","article-title":"Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex","volume":"20","author":"Rodriguez","year":"2013","journal-title":"Learn. Mem"},{"key":"10.1074\/jbc.M113.497909_bib72","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1203\/PDR.0b013e3181cb8e68","article-title":"Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children","volume":"67","author":"Acevedo","year":"2010","journal-title":"Pediatr. Res"},{"key":"10.1074\/jbc.M113.497909_bib73","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.0953-816X.2003.03123.x","article-title":"Efficacy of doublecortin as a marker to analyze the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus","volume":"19","author":"Rao","year":"2004","journal-title":"Eur. J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib74","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1523\/JNEUROSCI.5060-06.2007","article-title":"The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells","volume":"27","author":"Walker","year":"2007","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.28.051804.101459","article-title":"Adult neurogenesis in the mammalian central nervous system","volume":"28","author":"Ming","year":"2005","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib76","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1523\/JNEUROSCI.20-22-08401.2000","article-title":"Neuronal apoptosis by apolipoprotein E4 through low density lipoprotein receptor-related protein and heterotrimeric GTPases","volume":"20","author":"Hashimoto","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib77","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-4547(19981001)54:1<58::AID-JNR7>3.0.CO;2-G","article-title":"Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis","volume":"54","author":"Michikawa","year":"1998","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M113.497909_bib78","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis. A Review of Programmed Cell Death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol"},{"key":"10.1074\/jbc.M113.497909_bib79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(00)01368-9","article-title":"Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain","volume":"291","author":"Biebl","year":"2000","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M113.497909_bib80","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1523\/JNEUROSCI.3064-12.2013","article-title":"Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering","volume":"33","author":"Vukovic","year":"2013","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib81","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.497909_bib82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nn.2709","article-title":"Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease","volume":"14","author":"D'Amelio","year":"2011","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib83","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/archneurol.2011.70","article-title":"Amyloid-dependent and amyloid-independent stages of Alzheimer disease","volume":"68","author":"Hyman","year":"2011","journal-title":"Arch. Neurol"},{"key":"10.1074\/jbc.M113.497909_bib84","doi-asserted-by":"crossref","first-page":"792070","DOI":"10.4061\/2011\/792070","article-title":"ApoE4-driven accumulation of intraneuronal oligomerized A\u03b242 following activation of the amyloid cascade in vivo is mediated by a gain of function","volume":"2011","author":"Zepa","year":"2011","journal-title":"Int. J. Alzheimers Dis"},{"key":"10.1074\/jbc.M113.497909_bib85","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener"},{"key":"10.1074\/jbc.M113.497909_bib86","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1073\/pnas.1001422107","article-title":"Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M113.497909_bib87","doi-asserted-by":"crossref","first-page":"e2935","DOI":"10.1371\/journal.pone.0002935","article-title":"Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease","volume":"3","author":"Rodr\u00edguez","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.497909_bib88","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer's disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.497909_bib89","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/hipo.20587","article-title":"Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP\/PS1 double transgenic mouse model","volume":"19","author":"Yu","year":"2009","journal-title":"Hippocampus"},{"key":"10.1074\/jbc.M113.497909_bib90","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nbd.2007.09.005","article-title":"Adult neurogenesis is functionally associated with AD-like neurodegeneration","volume":"29","author":"Chen","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M113.497909_bib91","doi-asserted-by":"crossref","first-page":"14385","DOI":"10.1073\/pnas.2334169100","article-title":"Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis","volume":"100","author":"Drapeau","year":"2003","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M113.497909_bib92","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3233\/JAD-121714","article-title":"Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe\/PS1\u0394E9 mice","volume":"34","author":"Abbott","year":"2013","journal-title":"J. Alzheimers Dis"},{"key":"10.1074\/jbc.M113.497909_bib93","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1460-9568.2005.03875.x","article-title":"New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment","volume":"21","author":"Bruel-Jungerman","year":"2005","journal-title":"Eur. J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib94","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1731-05.2005","article-title":"Exercise enhances learning and hippocampal neurogenesis in aged mice","volume":"25","author":"van Praag","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib95","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/lm.1172609","article-title":"Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats","volume":"16","author":"Jessberger","year":"2009","journal-title":"Learn. Mem"},{"key":"10.1074\/jbc.M113.497909_bib96","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The aging systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.497909_bib97","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/brain\/awq215","article-title":"Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans","volume":"133","author":"Coras","year":"2010","journal-title":"Brain"},{"key":"10.1074\/jbc.M113.497909_bib98","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","article-title":"New neurons and new memories. How does adult hippocampal neurogenesis affect learning and memory?","volume":"11","author":"Deng","year":"2010","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.M113.497909_bib99","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.stem.2009.10.015","article-title":"GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knock-in mice","volume":"5","author":"Li","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1074\/jbc.M113.497909_bib100","doi-asserted-by":"crossref","first-page":"27273","DOI":"10.1074\/jbc.M109.014464","article-title":"Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function","volume":"284","author":"Zhong","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.497909_bib101","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3233\/JAD-2010-1388","article-title":"Adult neurogenesis. A potential tool for early diagnosis in Alzheimer's disease?","volume":"20","author":"Lopez-Toledano","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"10.1074\/jbc.M113.497909_bib102","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jalz.2008.02.006","article-title":"Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis","volume":"4","author":"Han","year":"2008","journal-title":"Alzheimers Dement"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819748145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819748145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.497909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T03:51:18Z","timestamp":1746071478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819748145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":102,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0021925819748145"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.497909","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}