{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:00:57Z","timestamp":1782802857544,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1074\/jbc.m113.513291","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T09:03:58Z","timestamp":1379581438000},"page":"31952-31962","source":"Crossref","is-referenced-by-count":36,"title":["Cardiomyopathy Mutations in the Tail of \u03b2-Cardiac Myosin Modify the Coiled-coil Structure and Affect Integration into Thick Filaments in Muscle Sarcomeres in Adult Cardiomyocytes"],"prefix":"10.1016","volume":"288","author":[{"given":"Marcin","family":"Wolny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Colegrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Colman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Peckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.513291_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jsb.2008.01.016","article-title":"Fifty years of coiled-coils and \u03b1-helical bundles: a close relationship between sequence and structure","volume":"163","author":"Parry","year":"2008","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.M113.513291_bib2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1006\/jmbi.1995.0352","article-title":"Computer modelling of the \u03b1-helical coiled coil: packing of side-chains in the inner core","volume":"249","author":"Offer","year":"1995","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0022-2836(05)80309-2","article-title":"Skip residues correlate with bends in the myosin tail","volume":"216","author":"Offer","year":"1990","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0022-2836(92)90118-4","article-title":"Molecular interactions in myosin assembly. Role of the 28-residue charge repeat in the rod","volume":"226","author":"Atkinson","year":"1992","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/jsbi.1998.3983","article-title":"A conserved C-terminal assembly region in paramyosin and myosin rods","volume":"122","author":"Cohen","year":"1998","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.M113.513291_bib6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90274-I","article-title":"A molecular basis for familial hypertrophic cardiomyopathy: a \u03b2 cardiac myosin heavy chain gene missense mutation","volume":"62","author":"Geisterfer-Lowrance","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.513291_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/CIRCGENETICS.108.788703","article-title":"How should hypertrophic cardiomyopathy be classified? What's in a name? Dilemmas in nomenclature characterizing hypertrophic cardiomyopathy and left ventricular hypertrophy","volume":"2","author":"Maron","year":"2009","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/jbc.M113.513291_bib8","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1161\/01.CIR.0000128363.85581.E1","article-title":"Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases","volume":"109","author":"Maron","year":"2004","journal-title":"Circulation"},{"key":"10.1074\/jbc.M113.513291_bib9","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.amjcard.2009.12.021","article-title":"The 2009 international hypertrophic cardiomyopathy summit","volume":"105","author":"Maron","year":"2010","journal-title":"Am. J. Cardiol"},{"key":"10.1074\/jbc.M113.513291_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/res.90.3.246","article-title":"\u03b2-Myosin heavy chain gene mutations in familial hypertrophic cardiomyopathy: the usual suspect?","volume":"90","author":"McNally","year":"2002","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.513291_bib11","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/CIRCULATIONAHA.110.017277","article-title":"Hypertrophic cardiomyopathy in 2012","volume":"125","author":"Ho","year":"2012","journal-title":"Circulation"},{"key":"10.1074\/jbc.M113.513291_bib12","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy: a systematic review","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1074\/jbc.M113.513291_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-1172-1-27","article-title":"Cardiomyopathy, familial dilated","volume":"1","author":"Taylor","year":"2006","journal-title":"Orphanet. J. Rare Dis"},{"key":"10.1074\/jbc.M113.513291_bib14","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.yjmcc.2010.03.005","article-title":"Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes","volume":"48","author":"Xu","year":"2010","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M113.513291_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/hh0302.104532","article-title":"Mutations of the light meromyosin domain of the \u03b2-myosin heavy chain rod in hypertrophic cardiomyopathy","volume":"90","author":"Blair","year":"2002","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.513291_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.ejhg.5201310","article-title":"One third of Danish hypertrophic cardiomyopathy patients with MYH7 mutations have mutations (corrected) in MYH7 rod region","volume":"13","author":"Hougs","year":"2005","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/jbc.M113.513291_bib17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.ejheart.2004.04.017","article-title":"Two novel mutations in the \u03b2-myosin heavy chain gene associated with dilated cardiomyopathy","volume":"6","author":"K\u00e4rkk\u00e4inen","year":"2004","journal-title":"Eur. J. Heart Fail"},{"key":"10.1074\/jbc.M113.513291_bib18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00109-005-0635-7","article-title":"Prevalence of cardiac \u03b2-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy","volume":"83","author":"Perrot","year":"2005","journal-title":"J. Mol. Med"},{"key":"10.1074\/jbc.M113.513291_bib19","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.CIR.0000066323.15244.54","article-title":"Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy","volume":"107","author":"Richard","year":"2003","journal-title":"Circulation"},{"key":"10.1074\/jbc.M113.513291_bib20","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jacc.2004.04.039","article-title":"Comprehensive analysis of the \u03b2-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy","volume":"44","author":"Van Driest","year":"2004","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1074\/jbc.M113.513291_bib21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/humu.10074","article-title":"Low-density DNA microarrays are versatile tools to screen for known mutations in hypertrophic cardiomyopathy","volume":"19","author":"Waldm\u00fcller","year":"2002","journal-title":"Hum. Mutat"},{"key":"10.1074\/jbc.M113.513291_bib22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbrc.2009.11.062","article-title":"A mutation in the \u03b2-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype","volume":"391","author":"Armel","year":"2010","journal-title":"Biochem. Biophys. Res. Com"},{"key":"10.1074\/jbc.M113.513291_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.yjmcc.2009.10.011","article-title":"Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes","volume":"48","author":"Armel","year":"2010","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M113.513291_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1113\/jphysiol.2002.031922","article-title":"Heterologous expression of wild-type and mutant \u03b2-cardiac myosin changes the contractile kinetics of cultured mouse myotubes","volume":"548","author":"Miller","year":"2003","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M113.513291_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cardiores.2004.04.013","article-title":"Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy","volume":"63","author":"McCrossan","year":"2004","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M113.513291_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1023\/A:1005569225773","article-title":"Thick filament assembly occurs after the formation of a cytoskeletal scaffold","volume":"20","author":"Van der Ven","year":"1999","journal-title":"J. Muscle Res. Cell Motil"},{"key":"10.1074\/jbc.M113.513291_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1005639229497","article-title":"Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development","volume":"21","author":"Maggs","year":"2000","journal-title":"J. Muscle Res. Cell Motil"},{"key":"10.1074\/jbc.M113.513291_bib28","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/elps.201100118","article-title":"Protocol for high-resolution electrophoresis separation of myosin heavy chain isoforms in bovine skeletal muscle","volume":"32","author":"Picard","year":"2011","journal-title":"Electrophoresis"},{"key":"10.1074\/jbc.M113.513291_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ceca.2005.07.006","article-title":"Effect of cytoskeleton disruptors on L-type Ca channel distribution in rat ventricular myocytes","volume":"38","author":"Leach","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M113.513291_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb2101s19","article-title":"Measuring protein mobility by photobleaching GFP chimeras in living cells","author":"Snapp","year":"2003","journal-title":"Curr. Protoc. Cell Biol"},{"key":"10.1074\/jbc.M113.513291_bib31","first-page":"2493","article-title":"When a predicted coiled coil is really a single \u03b1-helix, in myosins and other proteins","volume":"5","author":"Peckham","year":"2009","journal-title":"Soft Matter"},{"key":"10.1074\/jbc.M113.513291_bib32","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/bi00838a031","article-title":"Computed circular dichroism spectra for the evaluation of protein conformation","volume":"8","author":"Greenfield","year":"1969","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.513291_bib33","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/nprot.2006.204","article-title":"Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions","volume":"1","author":"Greenfield","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M113.513291_bib34","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1083\/jcb.105.6.2771","article-title":"Incorporation of nascent myosin heavy chains into thick filaments of cardiac myocytes in thyroid-treated rabbits","volume":"105","author":"Wenderoth","year":"1987","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M113.513291_bib35","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1242\/jcs.00709","article-title":"Mutations in the motor domain modulate myosin activity and myofibril organization","volume":"116","author":"Wang","year":"2003","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M113.513291_bib36","doi-asserted-by":"crossref","first-page":"H869","DOI":"10.1152\/ajpheart.00452.2010","article-title":"Effects of low-level \u03b1-myosin heavy chain expression on contractile kinetics in porcine myocardium","volume":"300","author":"Locher","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M113.513291_bib37","doi-asserted-by":"crossref","first-page":"22193","DOI":"10.1073\/pnas.0909851106","article-title":"The SAH domain extends the functional length of the myosin lever","volume":"106","author":"Baboolal","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.513291_bib38","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1073\/pnas.0700321104","article-title":"Molecular basis of coiled-coil formation","volume":"104","author":"Steinmetz","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.513291_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/jmbi.2000.4351","article-title":"Are trigger sequences essential in the folding of two-stranded \u03b1-helical coiled-coils?","volume":"306","author":"Lee","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2013Alzheimer's disease of the heart?","volume":"368","author":"Willis","year":"2013","journal-title":"New Engl. J. Med"},{"key":"10.1074\/jbc.M113.513291_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/299226a0","article-title":"Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle","volume":"299","author":"McLachlan","year":"1982","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.513291_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/BJ20060500","article-title":"Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod","volume":"401","author":"Flashman","year":"2007","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M113.513291_bib43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/emboj\/16.2.211","article-title":"Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin","volume":"16","author":"Obermann","year":"1997","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M113.513291_bib44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1091\/mbc.9.4.829","article-title":"Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band","volume":"9","author":"Obermann","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.513291_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-2697(02)00253-1","article-title":"Measuring synthesis rates of muscle creatine kinase and myosin with stable isotopes and mass spectrometry","volume":"309","author":"Papageorgopoulos","year":"2002","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.M113.513291_bib46","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/cm.20365","article-title":"Myofibrillogenesis in skeletal muscle cells in zebrafish","volume":"66","author":"Sanger","year":"2009","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1074\/jbc.M113.513291_bib47","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1086\/424760","article-title":"Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause Laing early-onset distal myopathy (MPD1)","volume":"75","author":"Meredith","year":"2004","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M113.513291_bib48","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1091\/mbc.e08-02-0206","article-title":"Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells","volume":"19","author":"Jung","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.513291_bib49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0022-2836(76)80057-5","article-title":"Axial arrangement of crossbridges in thick filaments of vertebrate skeletal muscle","volume":"102","author":"Craig","year":"1976","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib50","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jmb.2011.11.042","article-title":"Effects of pathogenic proline mutations on myosin assembly","volume":"415","author":"Buvoli","year":"2012","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M113.513291_bib51","doi-asserted-by":"crossref","first-page":"H574","DOI":"10.1152\/ajpheart.00786.2009","article-title":"Gene transfer, expression, and sarcomeric incorporation of a headless myosin molecule in cardiac myocytes: evidence for a reserve in myofilament motor function","volume":"300","author":"Vandenboom","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M113.513291_bib52","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/01.RES.0000264102.00706.4e","article-title":"Calcium-independent negative inotropy by \u03b2-myosin heavy chain gene transfer in cardiac myocytes","volume":"100","author":"Herron","year":"2007","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.513291_bib53","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.137.1.131","article-title":"Point mutations in human \u03b2 cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly","volume":"137","author":"Becker","year":"1997","journal-title":"J. Cell Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820486697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820486697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.513291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T17:35:34Z","timestamp":1641317734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820486697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":53,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0021925820486697"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.513291","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}