{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:57:59Z","timestamp":1758707879613},"reference-count":91,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":2471,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1074\/jbc.m113.514018","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T01:16:02Z","timestamp":1385082962000},"page":"2497-2514","source":"Crossref","is-referenced-by-count":15,"title":["Genetic Signatures of HIV-1 Envelope-mediated Bystander Apoptosis"],"prefix":"10.1016","volume":"289","author":[{"given":"Anjali","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael T.C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Mohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Sedano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Xin","family":"Khong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oon Tek","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Maurer-Stroh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.514018_bib1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.187.7.1113","article-title":"HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism","volume":"187","author":"Gandhi","year":"1998","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M113.514018_bib2","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3390\/v4113020","article-title":"HIV-1 induced bystander apoptosis","volume":"4","author":"Garg","year":"2012","journal-title":"Viruses"},{"key":"10.1074\/jbc.M113.514018_bib3","first-page":"114","article-title":"HIV disease progression. Immune activation, microbes, and a leaky gut","volume":"15","author":"Douek","year":"2007","journal-title":"Top. HIV Med"},{"key":"10.1074\/jbc.M113.514018_bib4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1128\/JVI.01715-08","article-title":"Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection","volume":"83","author":"Meythaler","year":"2009","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib5","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1128\/JVI.05214-11","article-title":"Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum","volume":"85","author":"van Gils","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib6","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1126\/science.8098552","article-title":"Apoptosis in AIDS","volume":"260","author":"Gougeon","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M113.514018_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4615-1995-9_9","article-title":"Mechanism of apoptosis in peripheral blood mononuclear cells of HIV-infected patients","volume":"374","author":"Oyaizu","year":"1995","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M113.514018_bib8","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1182\/blood.V82.11.3392.3392","article-title":"Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals","volume":"82","author":"Oyaizu","year":"1993","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.514018_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nm0295-129","article-title":"Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes","volume":"1","author":"Finkel","year":"1995","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M113.514018_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0684.2008.00323.x","article-title":"Kinetics of T lymphocyte apoptosis and the cellular immune response in SIVmac239-infected rhesus macaques","volume":"37","author":"Meythaler","year":"2008","journal-title":"J. Med. Primatol"},{"key":"10.1074\/jbc.M113.514018_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1743-422X-8-34","article-title":"Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice","volume":"8","author":"Garg","year":"2011","journal-title":"Virol. J"},{"key":"10.1074\/jbc.M113.514018_bib12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/sj.cdd.4401584","article-title":"Mechanisms of apoptosis induction by the HIV-1 envelope","volume":"12","author":"Perfettini","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M113.514018_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-4690-1-12","article-title":"Apoptosis of uninfected cells induced by HIV envelope glycoproteins","volume":"1","author":"Ahr","year":"2004","journal-title":"Retrovirology"},{"key":"10.1074\/jbc.M113.514018_bib14","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1128\/JVI.73.12.10489-10502.1999","article-title":"Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection","volume":"73","author":"Shankarappa","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.virol.2011.10.005","article-title":"The evolution of human immunodeficiency virus type-1 (HIV-1) envelope molecular properties and coreceptor use at all stages of infection in an HIV-1 donor-recipient pair","volume":"422","author":"Edo-Matas","year":"2012","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib16","doi-asserted-by":"crossref","first-page":"e2422","DOI":"10.1371\/journal.pone.0002422","article-title":"Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs","volume":"3","author":"Navis","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M113.514018_bib17","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1073\/pnas.82.14.4813","article-title":"Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III. Different viruses exhibit greatest divergence in their envelope genes","volume":"82","author":"Hahn","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.514018_bib18","doi-asserted-by":"crossref","first-page":"e1001228","DOI":"10.1371\/journal.ppat.1001228","article-title":"HIV-1 envelope subregion length variation during disease progression","volume":"6","author":"Curlin","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M113.514018_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/viro.1997.8996","article-title":"Evolution of human immunodeficiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles","volume":"241","author":"Shankarappa","year":"1998","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib20","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1128\/JVI.02648-08","article-title":"Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain","volume":"83","author":"Gray","year":"2009","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib21","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1479-5876-9-S1-S5","article-title":"Clinical significance of HIV-1 coreceptor usage","volume":"9","author":"Schuitemaker","year":"2011","journal-title":"J. Transl. Med"},{"key":"10.1074\/jbc.M113.514018_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.virol.2011.01.010","article-title":"Comparison of in vivo\nin vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants","volume":"412","author":"Edo-Matas","year":"2011","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib23","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/jvi.66.3.1354-1360.1992","article-title":"Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection. Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population","volume":"66","author":"Schuitemaker","year":"1992","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib24","first-page":"325","article-title":"Coreceptor usage and RANTES sensitivity of non-syncytium-inducing HIV-1 isolates obtained from patients with AIDS","volume":"2","author":"Jansson","year":"1999","journal-title":"J. Hum. Virol"},{"key":"10.1074\/jbc.M113.514018_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4690-7-23","article-title":"Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease. Indication of an evolving epidemic in West Africa","volume":"7","author":"Esbj\u00f6rnsson","year":"2010","journal-title":"Retrovirology"},{"key":"10.1074\/jbc.M113.514018_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virol.2006.08.027","article-title":"The envelope gene is a cytopathic determinant of CCR5 tropic HIV-1","volume":"358","author":"Olivieri","year":"2007","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.virol.2009.10.029","article-title":"Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection","volume":"396","author":"Wade","year":"2010","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/088922299310944","article-title":"Phenotypic characteristics of human immunodeficiency virus type 1 subtype C isolates of Ethiopian AIDS patients","volume":"15","author":"Bj\u00f6rndal","year":"1999","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M113.514018_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/QAD.0b013e328353bcaf","article-title":"CD8+ T cells in preventing HIV infection and disease","volume":"26","author":"McDermott","year":"2012","journal-title":"AIDS"},{"key":"10.1074\/jbc.M113.514018_bib30","doi-asserted-by":"crossref","first-page":"S302","DOI":"10.1086\/655652","article-title":"T cell immunity in acute HIV-1 infection","volume":"202","author":"Streeck","year":"2010","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.M113.514018_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/1568005054201553","article-title":"HIV-1 envelope evolution and vaccine efficacy","volume":"5","author":"Mosier","year":"2005","journal-title":"Curr. Drug Targets Infect. Disord"},{"key":"10.1074\/jbc.M113.514018_bib32","doi-asserted-by":"crossref","first-page":"e20135","DOI":"10.1371\/journal.pone.0020135","article-title":"Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge","volume":"6","author":"Borggren","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M113.514018_bib33","doi-asserted-by":"crossref","first-page":"9586","DOI":"10.1128\/JVI.00141-06","article-title":"Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity","volume":"80","author":"Sagar","year":"2006","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib34","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1128\/JVI.00268-11","article-title":"Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies","volume":"85","author":"van Gils","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature01470","article-title":"Antibody neutralization and escape by HIV-1","volume":"422","author":"Wei","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.514018_bib36","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1128\/JVI.73.12.9741-9755.1999","article-title":"Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates","volume":"73","author":"Li","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.virol.2005.04.034","article-title":"Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome","volume":"337","author":"Gray","year":"2005","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virol.2006.09.036","article-title":"Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion","volume":"360","author":"Thomas","year":"2007","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.virol.2010.12.010","article-title":"CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity","volume":"410","author":"Sterjovski","year":"2011","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib40","doi-asserted-by":"crossref","first-page":"16899","DOI":"10.1074\/jbc.M701701200","article-title":"Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion\/hemifusion","volume":"282","author":"Garg","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514018_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1189\/jlb.0805430","article-title":"HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir","volume":"79","author":"Garg","year":"2006","journal-title":"J. Leukoc. Biol"},{"key":"10.1074\/jbc.M113.514018_bib42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.virol.2005.03.032","article-title":"Thymic pathogenicity of an HIV-1 envelope is associated with increased CXCR4 binding efficiency and V5-gp41-dependent activity, but not V1\/V2-associated CD4 binding efficiency and viral entry","volume":"336","author":"Meissner","year":"2005","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.virol.2004.07.019","article-title":"Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor. Role of the envelope","volume":"328","author":"Meissner","year":"2004","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib44","doi-asserted-by":"crossref","first-page":"36404","DOI":"10.1074\/jbc.M111.281659","article-title":"HIV ENV glycoprotein-mediated bystander apoptosis depends on expression of the CCR5 co-receptor at the cell surface and ENV fusogenic activity","volume":"286","author":"Joshi","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514018_bib45","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1128\/JVI.72.4.2855-2864.1998","article-title":"Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1","volume":"72","author":"Platt","year":"1998","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.virol.2008.12.032","article-title":"Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India","volume":"385","author":"Kulkarni","year":"2009","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib47","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1128\/JVI.79.16.10108-10125.2005","article-title":"Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies","volume":"79","author":"Li","year":"2005","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib48","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1128\/AAC.46.6.1896-1905.2002","article-title":"Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy","volume":"46","author":"Wei","year":"2002","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1074\/jbc.M113.514018_bib49","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1126\/science.1093137","article-title":"Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission","volume":"303","author":"Derdeyn","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M113.514018_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/088922203762688649","article-title":"Characterization and selection of HIV-1 subtype C isolates for use in vaccine development","volume":"19","author":"Williamson","year":"2003","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M113.514018_bib51","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5. Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol"},{"key":"10.1074\/jbc.M113.514018_bib52","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.1145373","article-title":"Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4","volume":"317","author":"Huang","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M113.514018_bib53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1118398","article-title":"Structure of a V3-containing HIV-1 gp120 core","volume":"310","author":"Huang","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M113.514018_bib54","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10696","article-title":"Structure of HIV-1 gp120 V1\/V2 domain with broadly neutralizing antibody PG9","volume":"480","author":"McLellan","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.514018_bib55","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/prot.10104","article-title":"Increasing the precision of comparative models with YASARA NOVA. A self-parameterizing force field","volume":"47","author":"Krieger","year":"2002","journal-title":"Proteins"},{"key":"10.1074\/jbc.M113.514018_bib56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-60327-058-8_8","article-title":"Protein structure modeling with MODELLER","volume":"426","author":"Eswar","year":"2008","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.M113.514018_bib57","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.20660","article-title":"Very fast empirical prediction and rationalization of protein pKa values","volume":"61","author":"Li","year":"2005","journal-title":"Proteins"},{"key":"10.1074\/jbc.M113.514018_bib58","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/nar\/gki198","article-title":"MAFFT version 5. Improvement in accuracy of multiple sequence alignment","volume":"33","author":"Katoh","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.514018_bib59","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/viro.2002.1764","article-title":"Cell-surface-expressed HIV-1 envelope induces the death of CD4 T cells during GP41-mediated hemifusion-like events","volume":"305","author":"Blanco","year":"2003","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib60","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/viro.1999.0151","article-title":"Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120)","volume":"268","author":"Biard-Piechaczyk","year":"2000","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib61","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1089\/aid.2009.0010","article-title":"Altered bystander apoptosis induction and pathogenesis of enfuvirtide-resistant HIV type 1 Env mutants","volume":"25","author":"Garg","year":"2009","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M113.514018_bib62","doi-asserted-by":"crossref","first-page":"e1000955","DOI":"10.1371\/journal.pcbi.1000955","article-title":"Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies","volume":"6","author":"Gnanakaran","year":"2010","journal-title":"PLoS Comput. Biol"},{"key":"10.1074\/jbc.M113.514018_bib63","doi-asserted-by":"crossref","first-page":"e1000594","DOI":"10.1371\/journal.ppat.1000594","article-title":"Escape from autologous neutralizing antibodies in acute\/early subtype C HIV-1 infection requires multiple pathways","volume":"5","author":"Rong","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M113.514018_bib64","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/QAI.0b013e3181734f0e","article-title":"Performance of a population-based HIV-1 tropism phenotypic assay and correlation with V3 genotypic prediction tools in recent HIV-1 seroconverters","volume":"48","author":"de Mendoza","year":"2008","journal-title":"J. Acquir. Immune Defic. Syndr"},{"key":"10.1074\/jbc.M113.514018_bib65","first-page":"441","article-title":"Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest","volume":"45","author":"Xu","year":"2007","journal-title":"J. Microbiol"},{"key":"10.1074\/jbc.M113.514018_bib66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1742-4690-4-89","article-title":"Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS","volume":"4","author":"Sterjovski","year":"2007","journal-title":"Retrovirology"},{"key":"10.1074\/jbc.M113.514018_bib67","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1093\/nar\/gkl901","article-title":"Sequence comparison by sequence harmony identifies subtype-specific functional sites","volume":"34","author":"Pirovano","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.514018_bib68","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1007\/s00018-008-8147-6","article-title":"Role of HIV Gp41 mediated fusion\/hemifusion in bystander apoptosis","volume":"65","author":"Garg","year":"2008","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.M113.514018_bib69","doi-asserted-by":"crossref","first-page":"998","DOI":"10.4161\/auto.6880","article-title":"HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells","volume":"4","author":"Denizot","year":"2008","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M113.514018_bib70","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0952-7915(94)90149-X","article-title":"Indirect mechanisms of HIV pathogenesis. How does HIV kill T cells?","volume":"6","author":"Finkel","year":"1994","journal-title":"Curr. Opin. Immunol"},{"key":"10.1074\/jbc.M113.514018_bib71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1196\/annals.1299.004","article-title":"Mitochondrial apoptosis induced by the HIV-1 envelope","volume":"1010","author":"Castedo","year":"2003","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.M113.514018_bib72","first-page":"221","article-title":"Mechanisms of CD4 T-cell depletion triggered by HIV-1 viral proteins","volume":"8","author":"Varbanov","year":"2006","journal-title":"AIDS Rev"},{"key":"10.1074\/jbc.M113.514018_bib73","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4161\/auto.3275","article-title":"Autophagy and CD4+ T lymphocyte destruction by HIV-1","volume":"3","author":"Espert","year":"2007","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M113.514018_bib74","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1128\/JVI.02408-07","article-title":"Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus. Implications for AIDS pathogenesis","volume":"82","author":"Gordon","year":"2008","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib75","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/aid.1993.9.287","article-title":"New concepts in AIDS pathogenesis","volume":"9","author":"Gougeon","year":"1993","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M113.514018_bib76","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0923-2516(96)80585-1","article-title":"Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells","volume":"146","author":"Laurent-Crawford","year":"1995","journal-title":"Res. Virol"},{"key":"10.1074\/jbc.M113.514018_bib77","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.virol.2009.11.009","article-title":"Escape from autologous humoral immunity of HIV-1 is not associated with a decrease in replicative capacity","volume":"397","author":"Bunnik","year":"2010","journal-title":"Virology"},{"key":"10.1074\/jbc.M113.514018_bib78","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1128\/JVI.78.9.4541-4551.2004","article-title":"Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope\/receptor affinity and coreceptor binding site exposure","volume":"78","author":"Holm","year":"2004","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib79","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1128\/JVI.01382-06","article-title":"Fusion-induced apoptosis contributes to thymocyte depletion by a pathogenic human immunodeficiency virus type 1 envelope in the human thymus","volume":"80","author":"Meissner","year":"2006","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib80","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/infdis\/173.2.349","article-title":"Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection","volume":"173","author":"Koot","year":"1996","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.M113.514018_bib81","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1086\/515627","article-title":"Emergence of syncytium-inducing human immunodeficiency virus type 1 variants coincides with a transient increase in viral RNA level and is an independent predictor for progression to AIDS","volume":"178","author":"Spijkerman","year":"1998","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.M113.514018_bib82","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1172\/JCI7953C1","article-title":"Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1","volume":"106","author":"van Rij","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.514018_bib83","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.1128\/jvi.68.12.8188-8192.1994","article-title":"Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse","volume":"68","author":"Kaneshima","year":"1994","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib84","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1084\/jem.188.6.1159","article-title":"The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques","volume":"188","author":"Karlsson","year":"1998","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M113.514018_bib85","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1128\/JVI.73.2.976-984.1999","article-title":"Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)","volume":"73","author":"Cayabyab","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib86","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1128\/JVI.74.22.10690-10698.2000","article-title":"Importance of membrane fusion mediated by human immunodeficiency virus envelope glycoproteins for lysis of primary CD4-positive T cells","volume":"74","author":"LaBonte","year":"2000","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib87","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/JVI.74.9.4433-4440.2000","article-title":"Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivo","volume":"74","author":"Etemad-Moghadam","year":"2000","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib88","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1128\/JVI.75.12.5646-5655.2001","article-title":"Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus","volume":"75","author":"Etemad-Moghadam","year":"2001","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514018_bib89","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1182\/blood-2012-06-436345","article-title":"The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery. A randomized trial","volume":"121","author":"Hunt","year":"2013","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.514018_bib90","doi-asserted-by":"crossref","first-page":"e49538","DOI":"10.1371\/journal.pone.0049538","article-title":"A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia","volume":"7","author":"Holman","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M113.514018_bib91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-6405-7-43","article-title":"HIVBrainSeqDB. A database of annotated HIV envelope sequences from brain and other anatomical sites","volume":"7","author":"Holman","year":"2010","journal-title":"AIDS Res. Ther"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819747747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819747747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.514018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:41:15Z","timestamp":1641242475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819747747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0021925819747747"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.514018","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}