{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:51:23Z","timestamp":1788403883103,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2410,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1074\/jbc.m113.514810","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T06:05:13Z","timestamp":1389247513000},"page":"5371-5385","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":13,"title":["Cytosolic Dynamics of Annexin A6 Trigger Feedback Regulation of Hypertrophy via Atrial Natriuretic Peptide in Cardiomyocytes"],"prefix":"10.1016","volume":"289","author":[{"given":"Priyam","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.514810_bib1","doi-asserted-by":"crossref","first-page":"R1014","DOI":"10.1016\/j.cub.2004.11.027","article-title":"How cells coordinate growth and division","volume":"14","author":"Jorgensen","year":"2004","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.M113.514810_bib2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.RES.0000077012.11088.BC","article-title":"Phenotyping hypertrophy. Eschew obfuscation","volume":"92","author":"Dorn","year":"2003","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.514810_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy. The good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.M113.514810_bib4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M113.514810_bib5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cardiores.2004.11.010","article-title":"Annexins and Ca2+ handling in the heart","volume":"65","author":"Camors","year":"2005","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M113.514810_bib6","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1038\/onc.2012.303","article-title":"Annexin A6 is a scaffold for PKC\u03b1 to promote EGFR inactivation","volume":"32","author":"Koese","year":"2013","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.514810_bib7","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1007\/s00018-009-0027-1","article-title":"The annexins. Spatial and temporal coordination of signaling events during cellular stress","volume":"66","author":"Monastyrskaya","year":"2009","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M113.514810_bib8","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cellbi.2008.08.009","article-title":"Annexin A6 at the cardiac myocyte sarcolemma. Evidence for self-association and binding to actin","volume":"32","author":"Locate","year":"2008","journal-title":"Cell Biol. Int"},{"key":"10.1074\/jbc.M113.514810_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s000180050068","article-title":"Annexins in the secretory pathway","volume":"53","author":"Donnelly","year":"1997","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M113.514810_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jcb.240460112","article-title":"Annexin VI is associated with calcium-sequestering organelles","volume":"46","author":"Hazarika","year":"1991","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M113.514810_bib11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0021-9258(17)42215-0","article-title":"Annexin VI, a marker protein of hepatocytic endosomes","volume":"269","author":"J\u00e4ckle","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514810_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-4157(94)90019-1","article-title":"Annexins. The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins","volume":"1197","author":"Raynal","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M113.514810_bib13","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1128\/MCB.19.12.8028","article-title":"Immunological development and cardiovascular function are normal in annexin VI null mutant mice","volume":"19","author":"Hawkins","year":"1999","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M113.514810_bib14","doi-asserted-by":"crossref","first-page":"e53774","DOI":"10.1371\/journal.pone.0053774","article-title":"Regulation of mitochondrial morphogenesis by annexin a6","volume":"8","author":"Chlystun","year":"2013","journal-title":"PloS One"},{"key":"10.1074\/jbc.M113.514810_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/jmcc.1997.0608","article-title":"Altered cardiac annexin mRNA and protein levels in the left ventricle of patients with end-stage heart failure","volume":"30","author":"Song","year":"1998","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M113.514810_bib16","first-page":"H1159","article-title":"Localization and quantitation of cardiac annexins II, V, and VI in hypertensive guinea pigs","volume":"276","author":"Trouv\u00e9","year":"1999","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M113.514810_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2121-12-7","article-title":"Interaction of annexin A6 with \u03b1 actinin in cardiomyocytes","volume":"12","author":"Mishra","year":"2011","journal-title":"BMC Cell Biol"},{"key":"10.1074\/jbc.M113.514810_bib18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1096\/fj.01-0892fje","article-title":"Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice","volume":"16","author":"Song","year":"2002","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M113.514810_bib19","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/01.RES.69.6.1476","article-title":"Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart","volume":"69","author":"Hescheler","year":"1991","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.514810_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11010-010-0565-8","article-title":"Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor","volume":"345","author":"Alkistis Frentzou","year":"2010","journal-title":"Mol. Cell. Biochem"},{"key":"10.1074\/jbc.M113.514810_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro","volume":"47","author":"Watkins","year":"2011","journal-title":"In Vitro Cell. Dev. Biol. Anim"},{"key":"10.1074\/jbc.M113.514810_bib22","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","article-title":"Mechanisms and models in heart failure. The biomechanical model and beyond","volume":"111","author":"Mann","year":"2005","journal-title":"Circulation"},{"key":"10.1074\/jbc.M113.514810_bib23","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI18389","article-title":"A friend within the heart. Natriuretic peptide receptor signaling","volume":"111","author":"Molkentin","year":"2003","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.514810_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1189\/jlb.1010567","article-title":"Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish","volume":"89","author":"Yoo","year":"2011","journal-title":"J. Leukoc. Biol"},{"key":"10.1074\/jbc.M113.514810_bib25","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1161\/hh1501.095715","article-title":"Acid prohormone sequence determines size, shape, and docking of secretory vesicles in atrial myocytes","volume":"89","author":"Baertschi","year":"2001","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M113.514810_bib26","doi-asserted-by":"crossref","first-page":"17464","DOI":"10.1074\/jbc.M414220200","article-title":"Nuclear factor-\u03baB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy","volume":"280","author":"Planavila","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514810_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-012-1424-6","article-title":"Tetrodotoxin attenuates isoproterenol-induced hypertrophy in H9c2 rat cardiac myocytes","volume":"371","author":"Chen","year":"2012","journal-title":"Mol. Cell. Biochem"},{"key":"10.1074\/jbc.M113.514810_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1677\/joe.0.1820303","article-title":"Analysis of differentially expressed genes in hyperthyroid-induced hypertrophied heart by cDNA microarray","volume":"182","author":"De","year":"2004","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M113.514810_bib29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Prot"},{"key":"10.1074\/jbc.M113.514810_bib30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2144\/000112470","article-title":"Using photoactivatable fluorescent protein Dendra2 to track protein movement","volume":"42","author":"Chudakov","year":"2007","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.M113.514810_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Bolte","year":"2006","journal-title":"J. Microsc"},{"key":"10.1074\/jbc.M113.514810_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-12-391857-4.00009-4","article-title":"Methods for cell and particle tracking","volume":"504","author":"Meijering","year":"2012","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M113.514810_bib33","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1128\/JVI.06003-11","article-title":"Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection","volume":"86","author":"Ma","year":"2012","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M113.514810_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.abb.2009.11.001","article-title":"Cholesterol as a factor regulating intracellular localization of annexin A6 in Niemann-Pick type C human skin fibroblasts","volume":"493","author":"Sztolsztener","year":"2010","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M113.514810_bib35","first-page":"H1091","article-title":"Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice","volume":"270","author":"Gunteski-Hamblin","year":"1996","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M113.514810_bib36","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0167-4889(94)90097-3","article-title":"Annexin VI isoforms are differentially expressed in mammalian tissues","volume":"1223","author":"Kaetzel","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M113.514810_bib37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jcb.22685","article-title":"Role of annexin A6 isoforms in catecholamine secretion by PC12 cells. Distinct influence on calcium response","volume":"111","author":"Podszywalow-Bartnicka","year":"2010","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M113.514810_bib38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.bbamcr.2010.09.015","article-title":"Annexin A6-linking Ca2+ signaling with cholesterol transport","volume":"1813","author":"Enrich","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M113.514810_bib39","doi-asserted-by":"crossref","first-page":"13795","DOI":"10.1021\/bi051160w","article-title":"Interactions of annexins with the \u03bc subunits of the clathrin assembly proteins","volume":"44","author":"Creutz","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.514810_bib40","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1021\/bi026742h","article-title":"Structural and dynamic changes in human annexin VI induced by a phosphorylation-mimicking mutation, T356D","volume":"42","author":"Freye-Minks","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.514810_bib41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrm3588","article-title":"Organization of the ER-Golgi interface for membrane traffic control","volume":"14","author":"Brandizzi","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.514810_bib42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00318402","article-title":"Co-distribution of annexin VI and actin in secretory ameloblasts and odontoblasts of rat incisor","volume":"263","author":"Goldberg","year":"1991","journal-title":"Cell Tissue Res"},{"key":"10.1074\/jbc.M113.514810_bib43","doi-asserted-by":"crossref","first-page":"33806","DOI":"10.1074\/jbc.M002662200","article-title":"Annexin VI stimulates endocytosis and is involved in the trafficking of low density lipoprotein to the prelysosomal compartment","volume":"275","author":"Grewal","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514810_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00395-010-0098-z","article-title":"Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide. Role of cGMP-dependent protein kinase and RGS2","volume":"105","author":"Klaiber","year":"2010","journal-title":"Basic Res. Cardiol"},{"key":"10.1074\/jbc.M113.514810_bib45","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/nm.2961","article-title":"The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun","volume":"18","author":"Sundaresan","year":"2012","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M113.514810_bib46","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1600-0854.2012.01328.x","article-title":"Regulated exocytosis. Novel insights from intravital microscopy","volume":"13","author":"Masedunskas","year":"2012","journal-title":"Traffic"},{"key":"10.1074\/jbc.M113.514810_bib47","doi-asserted-by":"crossref","first-page":"C907","DOI":"10.1152\/ajpcell.1992.262.4.C907","article-title":"Binding and aggregation of pro-atrial natriuretic factor by calcium","volume":"262","author":"Thibault","year":"1992","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M113.514810_bib48","doi-asserted-by":"crossref","first-page":"21594","DOI":"10.1074\/jbc.M501103200","article-title":"Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice","volume":"280","author":"Bubikat","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514810_bib49","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0008-6363(02)00667-3","article-title":"Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes. Importance of cyclic GMP","volume":"57","author":"Rosenkranz","year":"2003","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M113.514810_bib50","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/01.HYP.18.5.648","article-title":"Annexins V and VI. Major calcium-dependent atrial secretory granule-binding proteins","volume":"18","author":"Doubell","year":"1991","journal-title":"Hypertension"},{"key":"10.1074\/jbc.M113.514810_bib51","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1073\/pnas.93.18.9483","article-title":"Secretory granule targeting of atrial natriuretic peptide correlates with its calcium-mediated aggregation","volume":"93","author":"Canaff","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.514810_bib52","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-2828(03)00171-8","article-title":"Peptidylglycine-\u03b1-amidating monooxygenase and pro-atrial natriuretic peptide constitute the major membrane-associated proteins of rat atrial secretory granules","volume":"35","author":"O'Donnell","year":"2003","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M113.514810_bib53","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1242\/jcs.01245","article-title":"Annexins. Unique membrane binding proteins with diverse functions","volume":"117","author":"Rescher","year":"2004","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M113.514810_bib54","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins. Linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.514810_bib55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00109-011-0801-z","article-title":"Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides","volume":"90","author":"Calvieri","year":"2012","journal-title":"J. Mol. Med"},{"key":"10.1074\/jbc.M113.514810_bib56","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.200707101","article-title":"Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein","volume":"179","author":"Rybkin","year":"2007","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M113.514810_bib57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/bbrc.2001.4748","article-title":"Cholesterol enhances phospholipid binding and aggregation of annexins by their core domain","volume":"283","author":"Ayala-Sanmartin","year":"2001","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M113.514810_bib58","doi-asserted-by":"crossref","first-page":"32187","DOI":"10.1074\/jbc.M205499200","article-title":"Cholesterol modulates the membrane binding and intracellular distribution of annexin 6","volume":"277","author":"de Diego","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.514810_bib59","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-291X(92)91199-Z","article-title":"Differential recognition of secretory vesicles by annexins. European Molecular Biology Organization Course \u201cAdvanced Techniques for Studying Secretion\u201d","volume":"184","author":"Creutz","year":"1992","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M113.514810_bib60","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.devcel.2011.12.008","article-title":"In vivo imaging of molecular interactions at damaged sarcolemma","volume":"22","author":"Roostalu","year":"2012","journal-title":"Dev. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820440098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820440098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.514810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:54:01Z","timestamp":1639835641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820440098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0021925820440098"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.514810","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}