{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:34:58Z","timestamp":1778553298251,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":2427,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1074\/jbc.m113.528273","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T02:11:33Z","timestamp":1386036693000},"page":"1580-1591","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins"],"prefix":"10.1016","volume":"289","author":[{"given":"Buxin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Siderovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Neubig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Trejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.528273_bib1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/j.1538-7836.2005.01377.x","article-title":"Protease-activated receptors in hemostasis, thrombosis and vascular biology","volume":"3","author":"Coughlin","year":"2005","journal-title":"J. Thromb. Haemost"},{"key":"10.1074\/jbc.M113.528273_bib2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0092-8674(91)90261-V","article-title":"Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation","volume":"64","author":"Vu","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.528273_bib3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0021-9258(17)42230-7","article-title":"Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G protein-coupled receptor kinases","volume":"269","author":"Ishii","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib4","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1074\/jbc.M109160200","article-title":"\u03b2-arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation","volume":"277","author":"Paing","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib5","doi-asserted-by":"crossref","first-page":"13698","DOI":"10.1073\/pnas.95.23.13698","article-title":"Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting","volume":"95","author":"Trejo","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.528273_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1128\/MCB.24.5.1990-1999.2004","article-title":"Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion","volume":"24","author":"Booden","year":"2004","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.528273_bib7","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1038\/onc.2008.84","article-title":"Persistent transactivation of EGFR and ErbB2\/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion","volume":"27","author":"Arora","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.528273_bib8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1600-0854.2007.00551.x","article-title":"Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis","volume":"8","author":"Wolfe","year":"2007","journal-title":"Traffic"},{"key":"10.1074\/jbc.M113.528273_bib9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200610154","article-title":"Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1","volume":"177","author":"Wolfe","year":"2007","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M113.528273_bib10","doi-asserted-by":"crossref","first-page":"40760","DOI":"10.1074\/jbc.M111.299776","article-title":"Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","article-title":"Signals for sorting of transmembrane proteins to endosomes and lysosomes","volume":"72","author":"Bonifacino","year":"2003","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M113.528273_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.pharmtox.48.113006.094646","article-title":"G protein-coupled receptor sorting to endosomes and lysosomes","volume":"48","author":"Marchese","year":"2008","journal-title":"Annu. Rev. Pharmcol. Toxicol"},{"key":"10.1074\/jbc.M113.528273_bib13","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/MCB.26.8.3231-3242.2006","article-title":"Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization","volume":"28","author":"Paing","year":"2006","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.528273_bib14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1124\/pr.110.003038","article-title":"Regulators of G-protein signaling and their G\u03b1 substrates. Promises and challenges in their use as drug discovery targets","volume":"63","author":"Kimple","year":"2011","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.M113.528273_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0076-6879(04)89005-0","article-title":"Application of RGS bos proteins to evaluate G-protein selectivity in receptor-promoted signaling","volume":"389","author":"Hains","year":"2004","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M113.528273_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.pharmtox.40.1.235","article-title":"The regulator of G protein signaling family","volume":"40","author":"De Vries","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1074\/jbc.M113.528273_bib17","doi-asserted-by":"crossref","first-page":"24949","DOI":"10.1074\/jbc.M203802200","article-title":"Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells","volume":"277","author":"Wang","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib18","doi-asserted-by":"crossref","first-page":"C654","DOI":"10.1152\/ajpcell.00441.2009","article-title":"RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling","volume":"299","author":"Laroche","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M113.528273_bib19","doi-asserted-by":"crossref","first-page":"21938","DOI":"10.1074\/jbc.M401672200","article-title":"A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1. Multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization","volume":"279","author":"Paing","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib20","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1074\/jbc.274.4.2216","article-title":"The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling","volume":"274","author":"Trejo","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1124\/mol.106.029397","article-title":"N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells","volume":"71","author":"Bodenstein","year":"2007","journal-title":"Mol. Pharm"},{"key":"10.1074\/jbc.M113.528273_bib22","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1073\/pnas.0810687106","article-title":"Caveolae are required for protease-selective signaling by protease-activated receptor-1","volume":"106","author":"Russo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.528273_bib23","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1074\/jbc.M310590200","article-title":"Termination of protease-activated receptor-1 signaling by \u03b2-arrestins is independent of receptor phosphorylation","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib24","doi-asserted-by":"crossref","first-page":"11203","DOI":"10.1074\/jbc.M112.439950","article-title":"Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits \u03b2-arrestin endosomal signaling","volume":"288","author":"Lin","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.528273_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/38284","article-title":"Defective platelet activation in G \u03b1 (q) -deficient mice","volume":"389","author":"Offermanns","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.528273_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-5793(95)00278-H","article-title":"The thrombin receptor in human platelets is coupled to a GTP binding protein of the G \u03b1 q family","volume":"363","author":"Benka","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M113.528273_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrd747","article-title":"Regulators of G-protein signalling as new central nervous system drug targets","volume":"1","author":"Neubig","year":"2002","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1074\/jbc.M113.528273_bib28","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1073\/pnas.0801508105","article-title":"Structural diversity in the RGS domain and its interaction with heterotrimeric G protein \u03b1-subunits","volume":"105","author":"Soundararajan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.528273_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tem.2006.03.008","article-title":"GRKs and \u03b2-arrestins. Roles in receptor silencing, trafficking and signaling","volume":"17","author":"Reiter","year":"2006","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1074\/jbc.M113.528273_bib30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrm2751","article-title":"Tickets to ride. Selecting cargo for clathrin-regulated internalization","volume":"10","author":"Traub","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M113.528273_bib31","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1073\/pnas.0510306103","article-title":"Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2\u03bc-cargo complexes","volume":"103","author":"Krauss","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.528273_bib32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1083\/jcb.201206096","article-title":"Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes","volume":"200","author":"Kim","year":"2013","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M113.528273_bib33","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/j.1600-0854.2009.00957.x","article-title":"Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis","volume":"10","author":"Wagener","year":"2009","journal-title":"Traffic"},{"key":"10.1074\/jbc.M113.528273_bib34","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1073\/pnas.1315110110","article-title":"Adaptor complex AP2\/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy","volume":"110","author":"Tian","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.528273_bib35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2004.12.018","article-title":"PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells","volume":"120","author":"Boire","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.528273_bib36","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nm958","article-title":"Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure","volume":"9","author":"Tang","year":"2003","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M113.528273_bib37","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1182\/blood-2011-10-387910","article-title":"A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling","volume":"119","author":"Ma","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.528273_bib38","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1182\/blood-2011-11-390369","article-title":"Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets","volume":"119","author":"Gegenbauer","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.528273_bib39","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1074\/jbc.274.13.8941","article-title":"Internalization of the TXA2 receptor \u03b1 and \u03b2 isoforms","volume":"274","author":"Parent","year":"1999","journal-title":"J. Biol. Chem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820336346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820336346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.528273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:58:51Z","timestamp":1639702731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820336346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0021925820336346"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.528273","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}