{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:44:25Z","timestamp":1792183465148,"version":"4.4.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2410,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1074\/jbc.m113.530006","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T04:19:24Z","timestamp":1387858764000},"page":"4180-4190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anthrax Lethal Toxin Inhibits Translation of Hypoxia-inducible Factor 1\u03b1 and Causes Decreased Tolerance to Hypoxic Stress"],"prefix":"10.1016","volume":"289","author":[{"given":"Weiming","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Torigoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Frucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.530006_bib1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1164\/rccm.201102-0209CI","article-title":"Anthrax infection","volume":"184","author":"Sweeney","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1074\/jbc.M113.530006_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","article-title":"Anthrax","volume":"55","author":"Mock","year":"2001","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1074\/jbc.M113.530006_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/20014091096738","article-title":"Anthrax toxin","volume":"27","author":"Bhatnagar","year":"2001","journal-title":"Crit. Rev. Microbiol"},{"key":"10.1074\/jbc.M113.530006_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/BJ20061891","article-title":"Manipulation of host signalling pathways by anthrax toxins","volume":"402","author":"Turk","year":"2007","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M113.530006_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0076-6879(07)38025-7","article-title":"Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways","volume":"438","author":"Bromberg-White","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M113.530006_bib6","doi-asserted-by":"crossref","first-page":"e1002659","DOI":"10.1371\/journal.ppat.1002659","article-title":"Proteolytic processing of Nlrp1b is required for inflammasome activity","volume":"8","author":"Frew","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M113.530006_bib7","doi-asserted-by":"crossref","first-page":"e1002638","DOI":"10.1371\/journal.ppat.1002638","article-title":"Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome","volume":"8","author":"Levinsohn","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M113.530006_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M113.530006_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1755-148X.2011.00942.x","article-title":"NLRP1, a regulator of innate immunity associated with vitiligo","volume":"25","author":"D'Osualdo","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1074\/jbc.M113.530006_bib10","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.2741\/3544","article-title":"Pathophysiology of anthrax","volume":"14","author":"Frankel","year":"2009","journal-title":"Front. Biosci"},{"key":"10.1074\/jbc.M113.530006_bib11","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2741\/3382","article-title":"Anthrax toxin: pathologic effects on the cardiovascular system","volume":"14","author":"Golden","year":"2009","journal-title":"Front. Biosci"},{"key":"10.1074\/jbc.M113.530006_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature12510","article-title":"Key tissue targets responsible for anthrax-toxin-induced lethality","volume":"501","author":"Liu","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.530006_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/toxins3060591","article-title":"The effects of anthrax lethal toxin on host barrier function","volume":"3","author":"Xie","year":"2011","journal-title":"Toxins"},{"key":"10.1074\/jbc.M113.530006_bib14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","article-title":"Bacillus anthracis lethal toxin induces TNF-\u03b1-independent hypoxia-mediated toxicity in mice","volume":"112","author":"Moayeri","year":"2003","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.530006_bib15","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1167\/iovs.11-7651","article-title":"Persistent inhibition of oxygen-induced retinal neovascularization by anthrax lethal toxin","volume":"52","author":"Bromberg-White","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M113.530006_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1556\/APhysiol.96.2009.1.2","article-title":"HIF-1: a key mediator in hypoxia","volume":"96","author":"Adams","year":"2009","journal-title":"Acta Physiol. Hung"},{"key":"10.1074\/jbc.M113.530006_bib17","article-title":"Hypoxia-inducible factor 1 (HIF-1) pathway","author":"Semenza","year":"2007","journal-title":"Sci STKE 2007"},{"key":"10.1074\/jbc.M113.530006_bib18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bcp.2004.02.040","article-title":"New anticancer strategies targeting HIF-1","volume":"68","author":"Yeo","year":"2004","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.M113.530006_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejmech.2012.01.033","article-title":"Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors","volume":"49","author":"Xia","year":"2012","journal-title":"Eur. J. Med. Chem"},{"key":"10.1074\/jbc.M113.530006_bib20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.tibs.2008.08.002","article-title":"HIF-1 regulation: not so easy come, easy go","volume":"33","author":"Yee Koh","year":"2008","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M113.530006_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-4757-3401-0_24","article-title":"The pVHL-hIF-1 system. A key mediator of oxygen homeostasis","volume":"502","author":"Maxwell","year":"2001","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M113.530006_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.530006_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.530006_bib24","doi-asserted-by":"crossref","first-page":"15498","DOI":"10.1074\/jbc.M700704200","article-title":"Constitutive\/hypoxic degradation of HIF-\u03b1 proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein","volume":"282","author":"Kong","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.530006_bib25","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1091\/mbc.e05-08-0770","article-title":"Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1\u03b1","volume":"17","author":"Zhou","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.530006_bib26","doi-asserted-by":"crossref","first-page":"48403","DOI":"10.1074\/jbc.M209114200","article-title":"Induction of hypoxia-inducible factor-1\u03b1 by transcriptional and translational mechanisms","volume":"277","author":"Pag\u00e9","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.530006_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3346\/jkms.2002.17.5.581","article-title":"Oxygen-dependent and -independent regulation of HIF-1\u03b1","volume":"17","author":"Chun","year":"2002","journal-title":"J. Korean Med. Sci"},{"key":"10.1074\/jbc.M113.530006_bib28","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.2174\/138161209789649420","article-title":"Regulation of HIF-1\u03b1 at the transcriptional level","volume":"15","author":"G\u00f6rlach","year":"2009","journal-title":"Curr. Pharm. Des"},{"key":"10.1074\/jbc.M113.530006_bib29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nature05029","article-title":"PML inhibits HIF-1\u03b1 translation and neoangiogenesis through repression of mTOR","volume":"442","author":"Bernardi","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.530006_bib30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/onc.2008.398","article-title":"Silibinin inhibits hypoxia-inducible factor-1\u03b1 and mTOR\/p70S6K\/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy","volume":"28","author":"Garc\u00eda-Maceira","year":"2009","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.530006_bib31","first-page":"299","article-title":"mTOR as a positive regulator of tumor cell responses to hypoxia","volume":"279","author":"Abraham","year":"2004","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"10.1074\/jbc.M113.530006_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1158\/1541-7786.MCR-08-0288","article-title":"Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability","volume":"7","author":"Knaup","year":"2009","journal-title":"Mol. Cancer Res"},{"key":"10.1074\/jbc.M113.530006_bib33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molcel.2010.10.030","article-title":"mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1\u03b1","volume":"40","author":"Cam","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M113.530006_bib34","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1091\/mbc.02-02-0017","article-title":"Hypoxia-inducible factor-1\u03b1 mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia","volume":"13","author":"Lang","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.530006_bib35","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1093\/nar\/gki1000","article-title":"The polypyrimidine tract-binding protein stimulates HIF-1\u03b1 IRES-mediated translation during hypoxia","volume":"33","author":"Schepens","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M113.530006_bib36","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.4049\/jimmunol.180.6.4139","article-title":"Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways","volume":"180","author":"Xu","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M113.530006_bib37","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1091\/mbc.e09-07-0550","article-title":"Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation","volume":"20","author":"Liu","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M113.530006_bib38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/BJ20110289","article-title":"Regulation and function of the RSK family of protein kinases","volume":"441","author":"Romeo","year":"2012","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M113.530006_bib39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.abb.2006.02.023","article-title":"The MAP kinase ERK5 binds to and phosphorylates p90 RSK","volume":"449","author":"Ranganathan","year":"2006","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M113.530006_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","author":"Sonenberg","year":"2009","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.530006_bib41","doi-asserted-by":"crossref","first-page":"e13910","DOI":"10.1371\/journal.pone.0013910","article-title":"Suppression of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) by tirapazamine is dependent on eIF2\u03b1 phosphorylation rather than the mTORC1\/4E-BP1 pathway","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M113.530006_bib42","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.4049\/jimmunol.174.8.4966","article-title":"Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells","volume":"174","author":"Fang","year":"2005","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M113.530006_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/hep.22928","article-title":"Hypoxia-inducible factor 1\u03b1 is up-regulated by oncostatin M and participates in oncostatin M signaling","volume":"50","author":"Vollmer","year":"2009","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M113.530006_bib44","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/cdd.2008.13","article-title":"Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion","volume":"15","author":"Loor","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M113.530006_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1752-8062.2008.00077.x","article-title":"In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1\u03b1 reduces myocardial infarct size","volume":"2","author":"Czibik","year":"2009","journal-title":"Clin. Transl. Sci"},{"key":"10.1074\/jbc.M113.530006_bib46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/mi.2013.29","article-title":"Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis","volume":"7","author":"Keely","year":"2014","journal-title":"Mucosal. Immunol"},{"key":"10.1074\/jbc.M113.530006_bib47","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI200421086","article-title":"Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis","volume":"114","author":"Karhausen","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.530006_bib48","first-page":"42","article-title":"Hypoxia, inflammation and phenotypic plasticity of macrophages: the central role of HIF-1 and NF\u03baB","volume":"3","author":"Malyshev","year":"2012","journal-title":"Patol. Fiziol. Eksp. Ter"},{"key":"10.1074\/jbc.M113.530006_bib49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1\u03b1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M113.530006_bib50","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.530006_bib51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2010.12.010","article-title":"Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease","volume":"25","author":"Olson","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M113.530006_bib52","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-\u03baB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1\u03b1","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.530006_bib53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biocel.2006.08.010","article-title":"Bacillus anthracis: a multi-faceted role for anthrax lethal toxin in thwarting host immune defenses","volume":"39","author":"Xu","year":"2007","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.M113.530006_bib54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4161\/cc.1.1.95","article-title":"Anthrax, MEK and cancer","volume":"1","author":"Bodart","year":"2002","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M113.530006_bib55","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/1535-7163.MCT-09-0694","article-title":"Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma","volume":"9","author":"Alfano","year":"2010","journal-title":"Mol. Cancer Ther"},{"key":"10.1074\/jbc.M113.530006_bib56","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1158\/1078-0432.CCR-06-2019","article-title":"Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice","volume":"12","author":"Abi-Habib","year":"2006","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/jbc.M113.530006_bib57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature11055","article-title":"An oxygen-regulated switch in the protein synthesis machinery","volume":"486","author":"Uniacke","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.530006_bib58","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/cid\/cis017","article-title":"Novel approaches to the treatment of systemic anthrax","volume":"54","author":"Artenstein","year":"2012","journal-title":"Clin. Infect. Dis"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820442024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820442024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.530006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T19:36:23Z","timestamp":1742499383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820442024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0021925820442024"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.530006","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anthrax Lethal Toxin Inhibits Translation of Hypoxia-inducible Factor 1\u03b1 and Causes Decreased Tolerance to Hypoxic Stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M113.530006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}