{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:16:47Z","timestamp":1791350207294,"version":"4.3.1"},"reference-count":62,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":2315,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1074\/jbc.m113.538124","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T01:32:38Z","timestamp":1395192758000},"page":"12931-12945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4"],"prefix":"10.1016","volume":"289","author":[{"given":"Letta","family":"Argyri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Dafnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodossis A.","family":"Theodossiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios","family":"Stratikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Chroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.538124_bib1","series-title":"Molecular Mechanisms of Atherosclerosis","first-page":"111","author":"Zannis","year":"2004"},{"key":"10.1074\/jbc.M113.538124_bib2","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease","volume":"103","author":"Mahley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.538124_bib3","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1021\/bi00337a028","article-title":"Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues: time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages","volume":"24","author":"Zannis","year":"1985","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M113.538124_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1212\/WNL.46.3.673","article-title":"Apolipoprotein E \u03f54 association with dementia in a population-based study: The Framingham study","volume":"46","author":"Myers","year":"1996","journal-title":"Neurology"},{"key":"10.1074\/jbc.M113.538124_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(99)00129-9","article-title":"A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease","volume":"263","author":"Kamboh","year":"1999","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M113.538124_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0197-4580(02)00089-1","article-title":"Screening of two mutations at exon 3 of the apolipoprotein E gene (sites 28 and 42) in a sample of patients with sporadic late-onset Alzheimer's disease","volume":"24","author":"Scacchi","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M113.538124_bib8","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/j.1582-4934.2007.00130.x","article-title":"Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities","volume":"11","author":"Cedazo-M\u00ednguez","year":"2007","journal-title":"J. Cell Mol. Med"},{"key":"10.1074\/jbc.M113.538124_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1074\/jbc.M113.538124_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1471-4159.2010.06756.x","article-title":"An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide \u03b2 42","volume":"115","author":"Dafnis","year":"2010","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.M113.538124_bib11","article-title":"Human APOE genotype affects intraneuronal A\u03b21\u201342 accumulation in a lentiviral gene transfer model","author":"Zhao","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M113.538124_bib12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-\u03b2 in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.M113.538124_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1601-183X.2007.00372.x","article-title":"Review on the APP\/PS1KI mouse model: intraneuronal A\u03b2 accumulation triggers axonopathy, neuron loss and working memory impairment","volume":"7","author":"Bayer","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1074\/jbc.M113.538124_bib14","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.1434398100","article-title":"Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice","volume":"100","author":"Harris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.538124_bib15","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased Tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M113.538124_bib16","doi-asserted-by":"crossref","first-page":"18694","DOI":"10.1073\/pnas.0508254102","article-title":"Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity","volume":"102","author":"Chang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.538124_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2012.03.013","article-title":"An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines","volume":"210","author":"Dafnis","year":"2012","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M113.538124_bib18","doi-asserted-by":"crossref","first-page":"50380","DOI":"10.1074\/jbc.M204898200","article-title":"Apolipoprotein E4 forms a molten globule: a potential basis for its association with disease","volume":"277","author":"Morrow","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tibs.2006.06.008","article-title":"Apolipoprotein E structure: insights into function","volume":"31","author":"Hatters","year":"2006","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M113.538124_bib20","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.1106420108","article-title":"Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.538124_bib21","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1016\/S0021-9258(18)68778-2","article-title":"Human apolipoprotein E3 in aqueous solution: I: evidence for two structural domains","volume":"263","author":"Wetterau","year":"1988","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib22","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1016\/S0021-9258(18)68779-4","article-title":"Human apolipoprotein E3 in aqueous solution: II: properties of the amino- and carboxyl-terminal domains","volume":"263","author":"Aggerbeck","year":"1988","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib23","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1126\/science.2063194","article-title":"Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E","volume":"252","author":"Wilson","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M113.538124_bib24","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1194\/jlr.R800069-JLR200","article-title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS","volume":"50","author":"Mahley","year":"2009","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.538124_bib25","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1021\/bi800469r","article-title":"Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties","volume":"47","author":"Chroni","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib26","doi-asserted-by":"crossref","first-page":"40949","DOI":"10.1074\/jbc.M106337200","article-title":"Lipid binding-induced conformational change in human apolipoprotein E: evidence for two lipid-bound states on spherical particles","volume":"276","author":"Saito","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib27","doi-asserted-by":"crossref","first-page":"e27037","DOI":"10.1371\/journal.pone.0027037","article-title":"Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia","volume":"6","author":"Georgiadou","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.538124_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1194\/jlr.M030965","article-title":"Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy","volume":"54","author":"Georgiadou","year":"2013","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.538124_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pep.2011.06.011","article-title":"A simple approach for human recombinant apolipoprotein E4 expression and purification","volume":"79","author":"Argyri","year":"2011","journal-title":"Protein Expr. Purif"},{"key":"10.1074\/jbc.M113.538124_bib30","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/bi00838a031","article-title":"Computed circular dichroism spectra for the evaluation of protein conformation","volume":"8","author":"Greenfield","year":"1969","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib31","doi-asserted-by":"crossref","first-page":"15910","DOI":"10.1021\/bi0014406","article-title":"Probing the lipid-free structure and stability of apolipoprotein A-I by mutation","volume":"39","author":"Gorshkova","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bpc.2005.07.009","article-title":"The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure","volume":"119","author":"Cl\u00e9ment-Collin","year":"2006","journal-title":"Biophys. Chem"},{"key":"10.1074\/jbc.M113.538124_bib33","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1194\/jlr.M200157-JLR200","article-title":"Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization","volume":"43","author":"Segall","year":"2002","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M113.538124_bib34","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1074\/jbc.M511077200","article-title":"Structural and functional variations in human apolipoprotein E3 and E4","volume":"281","author":"Chou","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib35","series-title":"Electron Microscopy in Biology","first-page":"203","author":"Harris","year":"1991"},{"key":"10.1074\/jbc.M113.538124_bib36","first-page":"107","article-title":"The mounting of macromolecules for electron microscopy with particular reference to surface phenomena and the treatment of support films by glow discharge","volume":"8","author":"Dubochet","year":"1982","journal-title":"Adv. Opt. Electron Microsc"},{"key":"10.1074\/jbc.M113.538124_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/neu.10037","article-title":"Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death","volume":"51","author":"Lesuisse","year":"2002","journal-title":"J. Neurobiol"},{"key":"10.1074\/jbc.M113.538124_bib38","doi-asserted-by":"crossref","first-page":"44593","DOI":"10.1074\/jbc.M112.420224","article-title":"Differential regulation of amyloid-\u03b2 endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/abbi.1993.1311","article-title":"Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction","volume":"303","author":"Berridge","year":"1993","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M113.538124_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1074\/jbc.272.1.217","article-title":"Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: role in EGF receptor-mediated tyrosine phosphorylation","volume":"272","author":"Bae","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.538124_bib41","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics International"},{"key":"10.1074\/jbc.M113.538124_bib42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1529\/biophysj.104.046813","article-title":"Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution","volume":"88","author":"Chou","year":"2005","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M113.538124_bib43","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/bi060023b","article-title":"Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4","volume":"45","author":"Tanaka","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib44","doi-asserted-by":"crossref","first-page":"12644","DOI":"10.1021\/bi8015857","article-title":"Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia","volume":"47","author":"Gorshkova","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib45","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1021\/bi701923h","article-title":"Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms","volume":"47","author":"Sakamoto","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib46","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1021\/bi000099m","article-title":"Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain","volume":"39","author":"Morrow","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M113.538124_bib47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/089771503321532824","article-title":"Cerebrospinal fluid apolipoprotein E concentration decreases after traumatic brain injury","volume":"20","author":"Kay","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1074\/jbc.M113.538124_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.seizure.2009.12.001","article-title":"Cerebrospinal fluid apolipoprotein E concentration decreases after seizure","volume":"19","author":"Wang","year":"2010","journal-title":"Seizure"},{"key":"10.1074\/jbc.M113.538124_bib49","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"European Alzheimer's Disease Initiative (EADI), Genetic and Environmental Risk in Alzheimer's Disease, Alzheimer's Disease Genetic Consortium, and Cohorts for Heart and Aging Research in Genomic Epidemiology","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M113.538124_bib50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M113.538124_bib51","doi-asserted-by":"crossref","first-page":"e1002822","DOI":"10.1371\/journal.pcbi.1002822","article-title":"Chapter 11: Genome-wide association studies","volume":"8","author":"Bush","year":"2012","journal-title":"PLoS Comput. Biol"},{"key":"10.1074\/jbc.M113.538124_bib52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrg3118","article-title":"Rare and common variants: twenty arguments","volume":"13","author":"Gibson","year":"2011","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M113.538124_bib53","doi-asserted-by":"crossref","first-page":"e31039","DOI":"10.1371\/journal.pone.0031039","article-title":"Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families","volume":"7","author":"Cruchaga","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.538124_bib54","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1073\/pnas.151254698","article-title":"Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons","volume":"98","author":"Huang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.538124_bib55","doi-asserted-by":"crossref","first-page":"e14586","DOI":"10.1371\/journal.pone.0014586","article-title":"Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-\u03b2 in human Alzheimer brain","volume":"6","author":"Jones","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M113.538124_bib56","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.jnen.0000228136.58062.bf","article-title":"Involvement of oxidative stress in Alzheimer disease","volume":"65","author":"Nunomura","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1074\/jbc.M113.538124_bib57","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.bbamem.2007.02.002","article-title":"The redox chemistry of the Alzheimer's disease amyloid \u03b2 peptide","volume":"1768","author":"Smith","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M113.538124_bib58","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2012.5027","article-title":"Amyloid \u03b2-peptide (1\u201342)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression","volume":"19","author":"Butterfield","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"10.1074\/jbc.M113.538124_bib59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.freeradbiomed.2012.09.016","article-title":"Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis","volume":"62","author":"Dasuri","year":"2013","journal-title":"Free. Radic. Biol. Med"},{"key":"10.1074\/jbc.M113.538124_bib60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2012.11.014","article-title":"Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease","volume":"62","author":"Yan","year":"2013","journal-title":"Free. Radic. Biol. Med"},{"key":"10.1074\/jbc.M113.538124_bib61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0306-4522(00)00341-9","article-title":"Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R)","volume":"101","author":"Huber","year":"2000","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M113.538124_bib62","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1073\/pnas.95.18.10914","article-title":"Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females","volume":"95","author":"Raber","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820414759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820414759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.538124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T21:35:52Z","timestamp":1669152952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820414759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":62,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0021925820414759"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.538124","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M113.538124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}