{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:15:16Z","timestamp":1762157716142,"version":"3.37.3"},"reference-count":46,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":2310,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01CA140622","T32CA085183","CA016056"],"award-info":[{"award-number":["R01CA140622","T32CA085183","CA016056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1074\/jbc.m113.544320","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T02:37:02Z","timestamp":1398134222000},"page":"15642-15652","source":"Crossref","is-referenced-by-count":27,"title":["Regulation of the Interferon regulatory factor-8 (IRF-8) Tumor Suppressor Gene by the Signal Transducer and Activator of Transcription 5 (STAT5) Transcription Factor in Chronic Myeloid Leukemia"],"prefix":"10.1016","volume":"289","author":[{"given":"Jeremy D.","family":"Waight","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debarati","family":"Banik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott I.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M113.544320_bib1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M113.544320_bib2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","article-title":"Fused transcript of abl and bcr genes in chronic myelogenous leukaemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"key":"10.1074\/jbc.M113.544320_bib3","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.M113.544320_bib4","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M113.544320_bib5","doi-asserted-by":"crossref","first-page":"31704","DOI":"10.1074\/jbc.271.49.31704","article-title":"P210 and P190(BCR\/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members","volume":"271","author":"Ilaria","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.544320_bib6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1084\/jem.183.3.811","article-title":"Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr\/Abl","volume":"183","author":"Carlesso","year":"1996","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M113.544320_bib7","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1182\/blood-2009-10-248211","article-title":"High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia","volume":"117","author":"Warsch","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0168-9525(00)89000-9","article-title":"Jaks and Stats in signaling by the cytokine receptor superfamily","volume":"11","author":"Ihle","year":"1995","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.M113.544320_bib9","first-page":"247","article-title":"Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia","volume":"13","author":"Shuai","year":"1996","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M113.544320_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1074-7613(00)80025-4","article-title":"Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells","volume":"10","author":"Moriggl","year":"1999","journal-title":"Immunity"},{"key":"10.1074\/jbc.M113.544320_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-7613(00)80097-7","article-title":"Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells","volume":"11","author":"Moriggl","year":"1999","journal-title":"Immunity"},{"key":"10.1074\/jbc.M113.544320_bib12","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.4049\/jimmunol.164.5.2533","article-title":"The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5","volume":"164","author":"Lord","year":"2000","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M113.544320_bib13","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1182\/blood-2005-10-4110","article-title":"STAT5 signaling is required for the efficient induction and maintenance of CML in mice","volume":"107","author":"Ye","year":"2006","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/emmm.201000062","article-title":"Stat5 is indispensable for the maintenance of bcr\/abl-positive leukaemia","volume":"2","author":"Hoelbl","year":"2010","journal-title":"EMBO Mol. Med"},{"key":"10.1074\/jbc.M113.544320_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood.V91.1.22","article-title":"Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias","volume":"91","author":"Schmidt","year":"1998","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","article-title":"The IRF family transcription factors in immunity and oncogenesis","volume":"26","author":"Tamura","year":"2008","journal-title":"Annu Rev. Immunol"},{"key":"10.1074\/jbc.M113.544320_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81348-3","article-title":"Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene","volume":"87","author":"Holtschke","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M113.544320_bib18","first-page":"853","article-title":"Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia","volume":"118","author":"Konieczna","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.544320_bib19","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1182\/blood-2008-05-158485","article-title":"Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias","volume":"113","author":"Koenigsmann","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib20","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1128\/MCB.20.4.1149-1161.2000","article-title":"Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder","volume":"20","author":"Hao","year":"2000","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M113.544320_bib21","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1182\/blood-2003-08-2970","article-title":"Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR\/ABL and down-regulates bcl-2","volume":"103","author":"Burchert","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib22","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood.V97.11.3648","article-title":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-\u03b1","volume":"97","author":"Schmidt","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.immuni.2008.02.013","article-title":"The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8","volume":"28","author":"Esashi","year":"2008","journal-title":"Immunity"},{"key":"10.1074\/jbc.M113.544320_bib24","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1172\/JCI68189","article-title":"Myeloid-derived suppressor cell development is regulated by a STAT\/IRF-8 axis","volume":"123","author":"Waight","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M113.544320_bib25","doi-asserted-by":"crossref","first-page":"e45422","DOI":"10.1371\/journal.pone.0045422","article-title":"Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity","volume":"7","author":"Banik","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M113.544320_bib26","first-page":"3951","article-title":"The genomic structure of the murine ICSBP gene reveals the presence of the \u03b3 interferon-responsive element, to which an ISGF3 \u03b1 subunit (or similar) molecule binds","volume":"13","author":"Kanno","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M113.544320_bib27","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/leu.2010.131","article-title":"Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin","volume":"24","author":"Li","year":"2010","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M113.544320_bib28","doi-asserted-by":"crossref","first-page":"22925","DOI":"10.1016\/S0021-9258(17)31596-X","article-title":"Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia","volume":"269","author":"Oda","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M113.544320_bib29","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1182\/blood.V84.6.1731.1731","article-title":"Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia","volume":"84","author":"ten Hoeve","year":"1994","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib30","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1158\/0008-5472.CAN-10-0607","article-title":"A specific need for CRKL in p210BCR-ABL-induced transformation of mouse hematopoietic progenitors","volume":"70","author":"Seo","year":"2010","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.544320_bib31","doi-asserted-by":"crossref","first-page":"10602","DOI":"10.1073\/pnas.0404100101","article-title":"Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C","volume":"101","author":"Dechow","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M113.544320_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2141.2006.06161.x","article-title":"BCR-ABL activates STAT3 via JAK and MEK pathways in human cells","volume":"134","author":"Coppo","year":"2006","journal-title":"Br. J. Haematol"},{"key":"10.1074\/jbc.M113.544320_bib33","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1158\/0008-5472.CAN-06-4068","article-title":"Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.544320_bib34","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1182\/blood-2009-11-255232","article-title":"The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors","volume":"117","author":"Nelson","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib35","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/sj.leu.2403898","article-title":"Compensatory PI3-kinase\/Akt\/mTor activation regulates imatinib resistance development","volume":"19","author":"Burchert","year":"2005","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M113.544320_bib36","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1182\/blood-2003-01-0291","article-title":"ICSBP\/IRF-8 inhibits mitogenic activity of p210 Bcr\/Abl in differentiating myeloid progenitor cells","volume":"102","author":"Tamura","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib37","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1182\/blood-2003-01-0285","article-title":"The interferon regulatory factor ICSBP\/IRF-8 in combination with PU. 1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells","volume":"103","author":"Schmidt","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib38","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1158\/0008-5472.CAN-10-2493","article-title":"IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia","volume":"71","author":"Hu","year":"2011","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.544320_bib39","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","article-title":"Loss of \u03b2-catenin impairs the renewal of normal and CML stem cells in vivo","volume":"12","author":"Zhao","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M113.544320_bib40","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1128\/MCB.01595-09","article-title":"Interferon consensus sequence binding protein (ICSBP) decreases \u03b2-catenin activity in myeloid cells by repressing GAS2 transcription","volume":"30","author":"Huang","year":"2010","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M113.544320_bib41","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/leu.2010.33","article-title":"Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells","volume":"24","author":"Vidovic","year":"2010","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M113.544320_bib42","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1158\/0008-5472.CAN-06-1172","article-title":"Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor","volume":"66","author":"Rong","year":"2006","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M113.544320_bib43","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1182\/blood-2008-05-156422","article-title":"Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML","volume":"113","author":"Zhou","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib44","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood.V88.3.809.809","article-title":"Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines","volume":"88","author":"Weber-Nordt","year":"1996","journal-title":"Blood"},{"key":"10.1074\/jbc.M113.544320_bib45","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20101947","article-title":"Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia","volume":"208","author":"Heltemes-Harris","year":"2011","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M113.544320_bib46","doi-asserted-by":"crossref","first-page":"14925","DOI":"10.1073\/pnas.222491799","article-title":"Expression profiling of CD34+ hematopoietic stem\/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia","volume":"99","author":"Qian","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820386233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820386233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M113.544320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T09:29:46Z","timestamp":1641288586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820386233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":46,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0021925820386233"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m113.544320","relation":{},"ISSN":["0021-9258"],"issn-type":[{"type":"print","value":"0021-9258"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}