{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:20:58Z","timestamp":1791159658782,"version":"4.1.0"},"reference-count":134,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":2232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA054559"],"award-info":[{"award-number":["R01 CA054559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AI077414"],"award-info":[{"award-number":["R01 AI077414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI078859"],"award-info":[{"award-number":["AI078859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI074410"],"award-info":[{"award-number":["AI074410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI043894"],"award-info":[{"award-number":["AI043894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1074\/jbc.m114.549659","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T02:57:16Z","timestamp":1403060236000},"page":"22284-22305","source":"Crossref","is-referenced-by-count":155,"title":["Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein"],"prefix":"10.1016","volume":"289","author":[{"given":"Elizabeth","family":"Jaworski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Van Duyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Shabbeer-Meyering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Iordanskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Saifuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe V.","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin C.","family":"Sampey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastas","family":"Popratiloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindesh","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Vertes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Mahieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatah","family":"Kashanchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.549659_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12185-011-0937-1","article-title":"Molecular mechanisms of HTLV-1 infection and pathogenesis","volume":"94","author":"Yasunaga","year":"2011","journal-title":"Int. J. Hematol"},{"key":"10.1074\/jbc.M114.549659_bib2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12185-011-0934-4","article-title":"Current status of HTLV-1 infection","volume":"94","author":"Watanabe","year":"2011","journal-title":"Int. J. Hematol"},{"key":"10.1074\/jbc.M114.549659_bib3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological Aspects and World Distribution of HTLV-1 Infection","volume":"3","author":"Gessain","year":"2012","journal-title":"Front. Microbiol"},{"key":"10.1074\/jbc.M114.549659_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fmicb.2012.00270","article-title":"HTLV-1 uveitis","volume":"3","author":"Kamoi","year":"2012","journal-title":"Front. Microbiol"},{"key":"10.1074\/jbc.M114.549659_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fmicb.2012.00389","article-title":"Clinical pathophysiology of human T-lymphotropic virus-type 1-associated myelopathy\/tropical spastic paraparesis","volume":"3","author":"Yamano","year":"2012","journal-title":"Front. Microbiol"},{"key":"10.1074\/jbc.M114.549659_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virol.2012.09.028","article-title":"HTLV-1: persistence and pathogenesis","volume":"435","author":"Cook","year":"2013","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib7","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I infection and associated diseases","volume":"24","author":"Proietti","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fmicb.2012.00406","article-title":"HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways","volume":"3","author":"Currer","year":"2012","journal-title":"Front. Microbiol"},{"key":"10.1074\/jbc.M114.549659_bib9","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","article-title":"Molecular mechanisms of cellular transformation by HTLV-1 Tax","volume":"24","author":"Grassmann","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib10","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1073\/pnas.86.9.3351","article-title":"Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector","volume":"86","author":"Grassmann","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.549659_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4161\/viru.1.1.9868","article-title":"Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells","volume":"1","author":"Norris","year":"2010","journal-title":"Virulence"},{"key":"10.1074\/jbc.M114.549659_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-4690-5-76","article-title":"The HTLV-1 Tax interactome","volume":"5","author":"Boxus","year":"2008","journal-title":"Retrovirology"},{"key":"10.1074\/jbc.M114.549659_bib13","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1128\/JVI.02331-07","article-title":"Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response","volume":"82","author":"Chandhasin","year":"2008","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/sj.onc.1208105","article-title":"The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation","volume":"24","author":"Kehn","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10495-008-0289-3","article-title":"HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis","volume":"14","author":"Vajente","year":"2009","journal-title":"Apoptosis"},{"key":"10.1074\/jbc.M114.549659_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2045-3701-2-15","article-title":"Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX","volume":"2","author":"Majone","year":"2012","journal-title":"Cell Biosci"},{"key":"10.1074\/jbc.M114.549659_bib17","doi-asserted-by":"crossref","first-page":"32897","DOI":"10.1074\/jbc.M110.146373","article-title":"The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin","volume":"285","author":"Belgnaoui","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib18","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1128\/JVI.02460-09","article-title":"Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker","volume":"84","author":"Kinjo","year":"2010","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib19","doi-asserted-by":"crossref","first-page":"36311","DOI":"10.1074\/jbc.M804931200","article-title":"HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase","volume":"283","author":"Durkin","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib20","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1128\/JVI.00086-10","article-title":"Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax","volume":"85","author":"Yang","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib21","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1038\/onc.2009.498","article-title":"The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription","volume":"29","author":"Kim","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib22","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1128\/JVI.00091-08","article-title":"Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle","volume":"82","author":"Liu","year":"2008","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cbi.2010.06.005","article-title":"HTLV-1 Tax: linking transformation, DNA damage and apoptotic T-cell death","volume":"188","author":"Chlichlia","year":"2010","journal-title":"Chem. Biol. Interact"},{"key":"10.1074\/jbc.M114.549659_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.virol.2010.04.018","article-title":"Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells","volume":"403","author":"Saito","year":"2010","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib25","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bcp.2011.12.037","article-title":"The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities","volume":"83","author":"Pant","year":"2012","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.M114.549659_bib26","doi-asserted-by":"crossref","first-page":"e49723","DOI":"10.1371\/journal.pone.0049723","article-title":"Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling","volume":"7","author":"Wahlgren","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib27","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/stem.1129","article-title":"Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth","volume":"30","author":"Xin","year":"2012","journal-title":"Stem Cells"},{"key":"10.1074\/jbc.M114.549659_bib28","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.4049\/jimmunol.1001768","article-title":"Exosome-driven antigen transfer for MHC class II presentation facilitated by the receptor binding activity of influenza hemagglutinin","volume":"185","author":"Testa","year":"2010","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib29","doi-asserted-by":"crossref","first-page":"21384","DOI":"10.1074\/jbc.M112.340513","article-title":"Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib30","doi-asserted-by":"crossref","first-page":"20370","DOI":"10.1073\/pnas.1014194107","article-title":"Human tumor virus utilizes exosomes for intercellular communication","volume":"107","author":"Meckes","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.549659_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1743-422X-7-271","article-title":"Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells","volume":"7","author":"Gourzones","year":"2010","journal-title":"Virol. J"},{"key":"10.1074\/jbc.M114.549659_bib32","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.549659_bib33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.addr.2012.07.019","article-title":"Roles of exosomes and microvesicles in disease pathogenesis","volume":"65","author":"Ohno","year":"2013","journal-title":"Adv. Drug Deliv. Rev"},{"key":"10.1074\/jbc.M114.549659_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1479-5876-9-86","article-title":"Body fluid derived exosomes as a novel template for clinical diagnostics","volume":"9","author":"Keller","year":"2011","journal-title":"J. Transl. Med"},{"key":"10.1074\/jbc.M114.549659_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis"},{"key":"10.1074\/jbc.M114.549659_bib36","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1021\/pr3008732","article-title":"Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients","volume":"11","author":"Chen","year":"2012","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.M114.549659_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-9-9","article-title":"Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages","volume":"9","author":"L\u00e4sser","year":"2011","journal-title":"J. Transl. Med"},{"key":"10.1074\/jbc.M114.549659_bib38","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/pmic.201200285","article-title":"Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling","volume":"13","author":"Dear","year":"2013","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/pros.20860","article-title":"Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen","volume":"69","author":"Poliakov","year":"2009","journal-title":"Prostate"},{"key":"10.1074\/jbc.M114.549659_bib40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1074\/mcp.M112.021303","article-title":"Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids","volume":"12","author":"Tauro","year":"2013","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib41","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib42","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1002\/pmic.200800109","article-title":"Proteomic profiling of exosomes: current perspectives","volume":"8","author":"Simpson","year":"2008","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","author":"Thery","year":"2006","journal-title":"Curr. Protoc. Cell Biol"},{"key":"10.1074\/jbc.M114.549659_bib44","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles","volume":"68","author":"Gy\u00f6rgy","year":"2011","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.M114.549659_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.97.2.329","article-title":"Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes","volume":"97","author":"Harding","year":"1983","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.549659_bib46","doi-asserted-by":"crossref","first-page":"767694","DOI":"10.1155\/2012\/767694","article-title":"Extracellular vesicles and their convergence with viral pathways","volume":"2012","author":"Wurdinger","year":"2012","journal-title":"Adv. Virol"},{"key":"10.1074\/jbc.M114.549659_bib47","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"Vlassov","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.549659_bib48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.chom.2012.08.010","article-title":"Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity","volume":"12","author":"Dreux","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1074\/jbc.M114.549659_bib49","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/cmi.12046","article-title":"Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes","volume":"15","author":"Columba Cabezas","year":"2013","journal-title":"Cell Microbiol"},{"key":"10.1074\/jbc.M114.549659_bib50","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1038\/cddis.2012.114","article-title":"Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction","volume":"3","author":"Hu","year":"2012","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.M114.549659_bib51","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/ni.1753","article-title":"HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits","volume":"10","author":"Xu","year":"2009","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-0854.2009.01006.x","article-title":"HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells","volume":"11","author":"Lenassi","year":"2010","journal-title":"Traffic"},{"key":"10.1074\/jbc.M114.549659_bib53","first-page":"678","article-title":"Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes","volume":"3","author":"Marriott","year":"1991","journal-title":"New Biol"},{"key":"10.1074\/jbc.M114.549659_bib54","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00705-004-0443-3","article-title":"Presence of HTLV-I Tax protein in cerebrospinal fluid from HAM\/TSP patients","volume":"150","author":"Cartier","year":"2005","journal-title":"Arch. Virol"},{"key":"10.1074\/jbc.M114.549659_bib55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s11373-005-9026-x","article-title":"HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease","volume":"12","author":"Alefantis","year":"2005","journal-title":"J. Biomed. Sci"},{"key":"10.1074\/jbc.M114.549659_bib56","doi-asserted-by":"crossref","first-page":"34581","DOI":"10.1074\/jbc.M707317200","article-title":"Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein","volume":"282","author":"Jain","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0042-6822(83)90395-1","article-title":"Restricted expression of human T-cell leukemia\u2013lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes","volume":"129","author":"Salahuddin","year":"1983","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib58","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1073\/pnas.80.17.5402","article-title":"Transformation of human umbilical cord blood T cells by human T-cell leukemia\/lymphoma virus","volume":"80","author":"Popovic","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.549659_bib59","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/10428194.2010.527406","article-title":"Senescence induction therapy for the treatment of adult T-cell leukemia","volume":"52","author":"Maeda","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"10.1074\/jbc.M114.549659_bib60","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1006\/viro.1994.1581","article-title":"Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones","volume":"204","author":"Kimata","year":"1994","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib61","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/20.17.4673","article-title":"Electroporation of viral transactivator proteins into lymphocyte suspension cells","volume":"20","author":"Kashanchi","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.549659_bib62","doi-asserted-by":"crossref","first-page":"e96778","DOI":"10.1371\/journal.pone.0096778","article-title":"The use of nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells","volume":"9","author":"Jaworski","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib63","doi-asserted-by":"crossref","first-page":"e12590","DOI":"10.1371\/journal.pone.0012590","article-title":"Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry","volume":"5","author":"Sripadi","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib64","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1039\/C2CC17225A","article-title":"Rapid, non-targeted discovery of biochemical transformation and biomarker candidates in oncovirus-infected cell lines using LAESI mass spectrometry","volume":"48","author":"Shrestha","year":"2012","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1074\/jbc.M114.549659_bib65","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/nar\/25.2.379","article-title":"HTLV-I Tax self-association in optimal trans-activation function","volume":"25","author":"Jin","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.549659_bib66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/13550280600614981","article-title":"Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells","volume":"12","author":"Ahuja","year":"2006","journal-title":"J. Neurovirol"},{"key":"10.1074\/jbc.M114.549659_bib67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.biopha.2007.02.006","article-title":"Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cells","volume":"61","author":"Ahuja","year":"2007","journal-title":"Biomed. Pharmacother"},{"key":"10.1074\/jbc.M114.549659_bib68","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1189\/jlb.0309172","article-title":"Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease","volume":"86","author":"Manuel","year":"2009","journal-title":"J. Leukoc. Biol"},{"key":"10.1074\/jbc.M114.549659_bib69","doi-asserted-by":"crossref","first-page":"e34490","DOI":"10.1371\/journal.pone.0034490","article-title":"HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter","volume":"7","author":"Rahman","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib70","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1074\/jbc.M112.438895","article-title":"Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA","volume":"288","author":"Narayanan","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib71","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.cell.2012.11.024","article-title":"Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration","volume":"151","author":"Luga","year":"2012","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.549659_bib72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1074\/mcp.M900152-MCP200","article-title":"Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature","volume":"9","author":"Mathivanan","year":"2010","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib73","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ki.2010.262","article-title":"Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome","volume":"78","author":"Rood","year":"2010","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.M114.549659_bib74","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v1i0.18397","article-title":"Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation","author":"Bobrie","year":"2012","journal-title":"J. Extracell. Vesicles"},{"key":"10.1074\/jbc.M114.549659_bib75","doi-asserted-by":"crossref","first-page":"e2461","DOI":"10.1371\/journal.pone.0002461","article-title":"Exosomes derived from M. Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo","volume":"3","author":"Giri","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib76","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1074\/mcp.M000063-MCP201","article-title":"Proteomics analysis of bladder cancer exosomes","volume":"9","author":"Welton","year":"2010","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib77","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/pmic.201200561","article-title":"In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine","volume":"13","author":"Principe","year":"2013","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M114.549659_bib78","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.1128\/JVI.05853-11","article-title":"Microvesicles and viral infection","volume":"85","author":"Meckes","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib79","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.549659_bib80","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3892\/or.2012.1967","article-title":"Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines","volume":"28","author":"Chiba","year":"2012","journal-title":"Oncol. Rep"},{"key":"10.1074\/jbc.M114.549659_bib81","doi-asserted-by":"crossref","first-page":"e46874","DOI":"10.1371\/journal.pone.0046874","article-title":"Identifying mRNA, microRNA and protein profiles of melanoma exosomes","volume":"7","author":"Xiao","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib82","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1681\/ASN.2012101031","article-title":"TGF-\u03b21-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis","volume":"24","author":"Borges","year":"2013","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M114.549659_bib83","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3390\/v3091532","article-title":"Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease","volume":"3","author":"Araya","year":"2011","journal-title":"Viruses"},{"key":"10.1074\/jbc.M114.549659_bib84","first-page":"926","article-title":"[HTLV-I-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)]","volume":"55","author":"Ijichi","year":"1997","journal-title":"Nihon Rinsho"},{"key":"10.1074\/jbc.M114.549659_bib85","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/0306-9877(93)90111-3","article-title":"An autoaggressive process against bystander tissues in HTLV-I-infected individuals: a possible pathomechanism of HAM\/TSP","volume":"41","author":"Ijichi","year":"1993","journal-title":"Med. Hypotheses"},{"key":"10.1074\/jbc.M114.549659_bib86","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actatropica.2012.09.012","article-title":"Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"125","author":"Starling","year":"2013","journal-title":"Acta Trop"},{"key":"10.1074\/jbc.M114.549659_bib87","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0022-510X(90)90217-B","article-title":"Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy\/tropical spastic paraparesis","volume":"97","author":"Nishimoto","year":"1990","journal-title":"J. Neurol. Sci"},{"key":"10.1074\/jbc.M114.549659_bib88","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/JVI.01513-06","article-title":"Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells","volume":"81","author":"Banerjee","year":"2007","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib89","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1096\/fj.08-122184","article-title":"Proteomic and immunologic analyses of brain tumor exosomes","volume":"23","author":"Graner","year":"2009","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.549659_bib90","first-page":"671","article-title":"Activation of the GM-CSF promoter by HTLV-I and -II tax proteins","volume":"4","author":"Nimer","year":"1989","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib91","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.V90.2.783","article-title":"Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"90","author":"Grossman","year":"1997","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.549659_bib92","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/ard.55.9.632","article-title":"Cytokine production by endothelial cells infected with human T cell lymphotropic virus type I","volume":"55","author":"Takashima","year":"1996","journal-title":"Ann. Rheum. Dis"},{"key":"10.1074\/jbc.M114.549659_bib93","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2249.2006.03150.x","article-title":"Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)\/tropical spastic paraparesis (HAM\/TSP) disease from HTLV-1 carrier state","volume":"145","author":"Guerreiro","year":"2006","journal-title":"Clin. Exp. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib94","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ijc.20266","article-title":"Elevated expression of CCL5\/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax","volume":"111","author":"Mori","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M114.549659_bib95","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jneuroim.2007.05.015","article-title":"High production of RANTES and MIP-1\u03b1 in the tropical spastic paraparesis\/HTLV-1-associated myelopathy (TSP\/HAM)","volume":"188","author":"Montanheiro","year":"2007","journal-title":"J. Neuroimmunol"},{"key":"10.1074\/jbc.M114.549659_bib96","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fphar.2012.00074","article-title":"The role of ATP-binding cassette transporters in neuro-inflammation: relevance for bioactive lipids","volume":"3","author":"Kooij","year":"2012","journal-title":"Front. Pharmacol"},{"key":"10.1074\/jbc.M114.549659_bib97","doi-asserted-by":"crossref","first-page":"e8212","DOI":"10.1371\/journal.pone.0008212","article-title":"P-glycoprotein acts as an immunomodulator during neuroinflammation","volume":"4","author":"Kooij","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.549659_bib98","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2443.2006.00927.x","article-title":"Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-\u03baB","volume":"11","author":"Okamoto","year":"2006","journal-title":"Genes Cells"},{"key":"10.1074\/jbc.M114.549659_bib99","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1182\/blood-2005-06-2567","article-title":"HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)","volume":"107","author":"Krueger","year":"2006","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.549659_bib100","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1182\/blood.V94.11.3847","article-title":"Inhibition of caspase cascade by HTLV-I tax through induction of NF-\u03baB nuclear translocation","volume":"94","author":"Kawakami","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.549659_bib101","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/JVI.73.2.1271-1277.1999","article-title":"Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line","volume":"73","author":"Iwanaga","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib102","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-4690-3-43","article-title":"Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach","volume":"3","author":"de la Fuente","year":"2006","journal-title":"Retrovirology"},{"key":"10.1074\/jbc.M114.549659_bib103","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1182\/blood-2008-01-134692","article-title":"Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells","volume":"112","author":"Bellon","year":"2008","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.549659_bib104","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.virol.2007.09.003","article-title":"PI3K\/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells","volume":"370","author":"Jeong","year":"2008","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib105","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1128\/JVI.73.12.9917-9927.1999","article-title":"Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1-infected cells","volume":"73","author":"Santiago","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib106","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1038\/sj.onc.1204304","article-title":"Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I","volume":"20","author":"Iwanaga","year":"2001","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib107","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1128\/MCB.22.10.3327-3338.2002","article-title":"Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein","volume":"22","author":"Haller","year":"2002","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.M114.549659_bib108","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1038\/sj.onc.1208825","article-title":"Activated AKT regulates NF-\u03baB activation, p53 inhibition and cell survival in HTLV-1-transformed cells","volume":"24","author":"Jeong","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.549659_bib109","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/JVI.72.1.633-640.1998","article-title":"Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia\/lymphotropic virus type 1 Tax protein","volume":"72","author":"Schmitt","year":"1998","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.addr.2012.08.007","article-title":"Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models","volume":"65","author":"Suetsugu","year":"2013","journal-title":"Adv. Drug. Deliv. Rev"},{"key":"10.1074\/jbc.M114.549659_bib111","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M114.549659_bib112","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/ijc.28164","article-title":"Silencing of human papillomavirus (HPV) E6\/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells","volume":"133","author":"Honegger","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M114.549659_bib113","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4049\/jimmunol.1102244","article-title":"Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages","volume":"189","author":"Kadiu","year":"2012","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib114","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1128\/JVI.01658-08","article-title":"Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells","volume":"83","author":"Khatua","year":"2009","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib115","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/ijc.22844","article-title":"Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes","volume":"121","author":"Ceccarelli","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M114.549659_bib116","first-page":"1034","article-title":"Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein","volume":"2","author":"Lindholm","year":"1990","journal-title":"New Biol"},{"key":"10.1074\/jbc.M114.549659_bib117","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1128\/JVI.71.9.6982-6989.1997","article-title":"Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax","volume":"71","author":"Cowan","year":"1997","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib118","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1128\/JVI.66.3.1294-1302.1992","article-title":"Extracellular Tax1 protein stimulates tumor necrosis factor-\u03b2 and immunoglobulin \u03ba light chain expression in lymphoid cells","volume":"66","author":"Lindholm","year":"1992","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib119","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/viro.1993.1450","article-title":"HTLV-1 gene expression by defective proviruses in an infected T-cell line","volume":"196","author":"Bhat","year":"1993","journal-title":"Virology"},{"key":"10.1074\/jbc.M114.549659_bib120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bbalip.2012.08.016","article-title":"Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells","volume":"1831","author":"Vance","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.549659_bib121","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1084\/jem.182.2.501","article-title":"Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1","volume":"182","author":"Saifuddin","year":"1995","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M114.549659_bib122","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.4049\/jimmunol.155.9.4376","article-title":"Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia\/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV)","volume":"155","author":"Spear","year":"1995","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib123","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1128\/JVI.02383-10","article-title":"Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag","volume":"85","author":"Inlora","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M114.549659_bib124","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.4049\/jimmunol.170.9.4840","article-title":"Phosphatidylserine on HIV envelope is a cofactor for infection of monocytic cells","volume":"170","author":"Callahan","year":"2003","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.549659_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00126334-200105010-00001","article-title":"Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors","volume":"27","author":"Carvalho","year":"2001","journal-title":"J. Acquir. Immune. Defic. Syndr"},{"key":"10.1074\/jbc.M114.549659_bib126","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1074\/jbc.M607122200","article-title":"The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles","volume":"282","author":"Islam","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib127","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ncomms1285","article-title":"Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells","volume":"2","author":"Mittelbrunn","year":"2011","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M114.549659_bib128","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/1439-7633(20010202)2:2<141::AID-CBIC141>3.0.CO;2-P","article-title":"Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase","volume":"2","author":"Arenz","year":"2001","journal-title":"Chembiochem"},{"key":"10.1074\/jbc.M114.549659_bib129","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/aid.1991.7.707","article-title":"Brefeldin A inhibits the processing and secretion of envelope glycoproteins of human immunodeficiency virus type 1","volume":"7","author":"Pal","year":"1991","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1074\/jbc.M114.549659_bib130","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbrc.2006.06.023","article-title":"Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity","volume":"346","author":"Macovei","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.549659_bib131","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-012-1428-2","article-title":"Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders","volume":"352","author":"Schneider","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1074\/jbc.M114.549659_bib132","doi-asserted-by":"crossref","first-page":"21357","DOI":"10.1074\/jbc.M112.340992","article-title":"Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells","volume":"287","author":"Macaire","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.549659_bib133","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s13238-012-2047-0","article-title":"New insight into the oncogenic mechanism of the retroviral oncoprotein Tax","volume":"3","author":"Cheng","year":"2012","journal-title":"Protein Cell"},{"key":"10.1074\/jbc.M114.549659_bib134","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/onc.2010.537","article-title":"Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy","volume":"30","author":"Matsuoka","year":"2011","journal-title":"Oncogene"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.549659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:05:54Z","timestamp":1689329154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820331641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":134,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0021925820331641"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.549659","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}