{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:58Z","timestamp":1787235718202,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":2232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1074\/jbc.m114.552679","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T22:43:14Z","timestamp":1403908994000},"page":"22183-22195","source":"Crossref","is-referenced-by-count":10,"title":["Anamorsin, a Novel Caspase-3 Substrate in Neurodegeneration"],"prefix":"10.1016","volume":"289","author":[{"given":"Nuri","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tanimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Hamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuru","family":"Kanakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Seon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areum","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Ho","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young J.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.552679_bib1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","article-title":"Apoptosis in the pathogenesis and treatment of disease","volume":"267","author":"Thompson","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M114.552679_bib2","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1038\/sj.onc.1207107","article-title":"A decade of caspases","volume":"22","author":"Degterev","year":"2003","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.552679_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1146\/annurev-biochem-061809-121639","article-title":"Caspase substrates and cellular remodeling","volume":"80","author":"Crawford","year":"2011","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M114.552679_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"Enari","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.552679_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35070009","article-title":"Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.552679_bib6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35070019","article-title":"Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing","volume":"3","author":"Sebbagh","year":"2001","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.552679_bib7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.cdd.4402103","article-title":"The CASBAH: a searchable database of caspase substrates","volume":"14","author":"L\u00fcthi","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M114.552679_bib8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.cell.2008.08.019","article-title":"Caspase cleavage is not for everyone","volume":"134","author":"Johnson","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.552679_bib9","doi-asserted-by":"crossref","first-page":"29449","DOI":"10.1074\/jbc.272.47.29449","article-title":"Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy","volume":"272","author":"Cryns","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib10","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.1073\/pnas.95.15.8532","article-title":"A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin","volume":"95","author":"Kamada","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.552679_bib11","doi-asserted-by":"crossref","first-page":"39018","DOI":"10.1074\/jbc.M006495200","article-title":"The Fas-induced apoptosis analyzed by high throughput proteome analysis","volume":"275","author":"Gerner","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.cdd.4401010","article-title":"Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation","volume":"9","author":"Gerner","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M114.552679_bib13","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1002\/pmic.200400979","article-title":"Identification of caspase-3 degradome by two-dimensional gel electrophoresis and matrix-assisted laser desorption\/ionization-time of flight analysis","volume":"4","author":"Lee","year":"2004","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M114.552679_bib14","doi-asserted-by":"crossref","first-page":"36321","DOI":"10.1074\/jbc.M708182200","article-title":"The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock","volume":"282","author":"Shao","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.cell.2004.05.008","article-title":"Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain","volume":"117","author":"Ricci","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.552679_bib16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nmeth792","article-title":"Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis","volume":"2","author":"Van Damme","year":"2005","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M114.552679_bib17","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.cell.2008.08.012","article-title":"Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini","volume":"134","author":"Mahrus","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.552679_bib18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0002-9440(10)63302-0","article-title":"Caspase-mediated degeneration in Alzheimer's disease","volume":"165","author":"Cribbs","year":"2004","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M114.552679_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2990.2000.00218.x","article-title":"Neuronal death in brain infarcts in man","volume":"26","author":"Love","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"10.1074\/jbc.M114.552679_bib20","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1073\/pnas.040556597","article-title":"Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease","volume":"97","author":"Hartmann","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.552679_bib21","doi-asserted-by":"crossref","first-page":"9986","DOI":"10.1074\/jbc.M800426200","article-title":"Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease","volume":"283","author":"Lee","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1292\/jvms.69.989","article-title":"Establishment of a novel equine cell line for isolation and propagation of equine herpesviruses","volume":"69","author":"Maeda","year":"2007","journal-title":"J. Vet. Med. Sci"},{"key":"10.1074\/jbc.M114.552679_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11626-007-9048-y","article-title":"Robertsonian translocation as a result of telomere shortening during replicative senescence and immortalization of bovine oviduct epithelial cells","volume":"43","author":"Murata","year":"2007","journal-title":"In Vitro Cell. Dev. Biol. Anim"},{"key":"10.1074\/jbc.M114.552679_bib24","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1046\/j.1471-4159.2001.00368.x","article-title":"Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2","volume":"77","author":"Choi","year":"2001","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.M114.552679_bib25","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/sj.cdd.4402221","article-title":"Intracellular K+ inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release","volume":"14","author":"Karki","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M114.552679_bib26","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.bbrc.2007.03.102","article-title":"Both dimerization and interdomain processing are essential for caspase-4 activation","volume":"356","author":"Karki","year":"2007","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.552679_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbapap.2004.03.008","article-title":"Rearrangement of tryptophan residues in caspase-3 active site upon activation","volume":"1700","author":"Park","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.552679_bib28","doi-asserted-by":"crossref","first-page":"25149","DOI":"10.1074\/jbc.M402395200","article-title":"Caspase-mediated cleavage of insulin receptor substrate","volume":"279","author":"Green","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1084\/jem.20031858","article-title":"Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis","volume":"199","author":"Shibayama","year":"2004","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M114.552679_bib30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2013.02.017","article-title":"Caspase-3-mediated cleavage of PICOT in apoptosis","volume":"432","author":"Yun","year":"2013","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.552679_bib31","doi-asserted-by":"crossref","first-page":"20451","DOI":"10.1074\/jbc.M311164200","article-title":"Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons","volume":"279","author":"Choi","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.nbd.2004.12.004","article-title":"Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease","volume":"18","author":"Kang","year":"2005","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M114.552679_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1\u03b1 contributes to neurodegeneration in Parkinson's disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.552679_bib34","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.3390\/molecules17067595","article-title":"Down regulation of CIAPIN1 reverses multidrug resistance in human breast cancer cells by inhibiting MDR1","volume":"17","author":"Lu","year":"2012","journal-title":"Molecules"},{"key":"10.1074\/jbc.M114.552679_bib35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2011.01.033","article-title":"A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK","volume":"405","author":"Saito","year":"2011","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.552679_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00702-010-0490-8","article-title":"Nuclear translocation of anamorsin during drug-induced dopaminergic neurodegeneration in culture and in rat brain","volume":"118","author":"Park","year":"2011","journal-title":"J. Neural. Transm"},{"key":"10.1074\/jbc.M114.552679_bib37","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1523\/JNEUROSCI.23-12-05069.2003","article-title":"Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment","volume":"23","author":"Han","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.552679_bib38","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","article-title":"A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis","volume":"272","author":"Thornberry","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib39","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1074\/jbc.272.15.9677","article-title":"Substrate specificities of caspase family proteases","volume":"272","author":"Talanian","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.552679_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1097-4547(19990701)57:1<86::AID-JNR9>3.0.CO;2-E","article-title":"Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK","volume":"57","author":"Choi","year":"1999","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M114.552679_bib41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2008.06.038","article-title":"Global mapping of the topography and magnitude of proteolytic events in apoptosis","volume":"134","author":"Dix","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.552679_bib42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0166-2236(99)01479-4","article-title":"Calpain and caspase: can you tell the difference?","volume":"23","author":"Wang","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1074\/jbc.M114.552679_bib43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/138920009788898028","article-title":"Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium","volume":"10","author":"Camins","year":"2009","journal-title":"Curr. Drug Metab"},{"key":"10.1074\/jbc.M114.552679_bib44","doi-asserted-by":"crossref","first-page":"a009365","DOI":"10.1101\/cshperspect.a009365","article-title":"Programmed cell death in Parkinson's disease","volume":"2","author":"Venderova","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.M114.552679_bib45","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1073\/pnas.1302378110","article-title":"Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis","volume":"110","author":"Banci","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.552679_bib46","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4161\/cbt.5.3.2381","article-title":"CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells","volume":"5","author":"Hao","year":"2006","journal-title":"Cancer Biol. Ther"},{"key":"10.1074\/jbc.M114.552679_bib47","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tibtech.2009.09.007","article-title":"Caspase substrates: easily caught in deep waters?","volume":"27","author":"Demon","year":"2009","journal-title":"Trends Biotechnol"},{"key":"10.1074\/jbc.M114.552679_bib48","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/j.1742-4658.2012.08597.x","article-title":"A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2","volume":"279","author":"Soler","year":"2012","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M114.552679_bib49","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1128\/MCB.00642-08","article-title":"Dre2, a conserved eukaryotic Fe\/S cluster protein, functions in cytosolic Fe\/S protein biogenesis","volume":"28","author":"Zhang","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M114.552679_bib50","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nchembio.432","article-title":"Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis","volume":"6","author":"Netz","year":"2010","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.M114.552679_bib51","doi-asserted-by":"crossref","first-page":"e4376","DOI":"10.1371\/journal.pone.0004376","article-title":"A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast","volume":"4","author":"Vernis","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.552679_bib52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2011.04.033","article-title":"PICOT is a molecule which binds to anamorsin","volume":"408","author":"Saito","year":"2011","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.552679_bib53","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.yjmcc.2008.09.124","article-title":"PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility","volume":"45","author":"Cha","year":"2008","journal-title":"J. Mol. Cell. Cardiol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.552679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:30:01Z","timestamp":1641256201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820331562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":53,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0021925820331562"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.552679","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}