{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:44:16Z","timestamp":1792453456514,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":2312,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01EY019320"],"award-info":[{"award-number":["R01EY019320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 091944"],"award-info":[{"award-number":["R01 091944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["C06RR015455"],"award-info":[{"award-number":["C06RR015455"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1074\/jbc.m114.564674","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:26:11Z","timestamp":1396916771000},"page":"14534-14546","source":"Crossref","is-referenced-by-count":142,"title":["Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation"],"prefix":"10.1016","volume":"289","author":[{"given":"Kannan","family":"Kunchithapautham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.564674_bib1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1074\/jbc.M114.564674_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0008-4182(05)80070-5","article-title":"Age-related macular degeneration: economic burden and value-based medicine analysis","volume":"40","author":"Brown","year":"2005","journal-title":"Can. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib3","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/IAE.0b013e3181e7976b","article-title":"Do we need a new classification for choroidal neovascularization in age-related macular degeneration?","volume":"30","author":"Freund","year":"2010","journal-title":"Retina"},{"key":"10.1074\/jbc.M114.564674_bib4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","article-title":"An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration","volume":"20","author":"Hageman","year":"2001","journal-title":"Prog. Retin. Eye Res"},{"key":"10.1074\/jbc.M114.564674_bib5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M114.564674_bib6","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.564674_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M114.564674_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M114.564674_bib9","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1097\/IAE.0b013e3181f57e30","article-title":"Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternatives","volume":"30","author":"Zarbin","year":"2010","journal-title":"Retina"},{"key":"10.1074\/jbc.M114.564674_bib10","first-page":"348092","article-title":"The role of the immune response in age-related macular degeneration","volume":"2013","author":"Whitcup","year":"2013","journal-title":"Int. J. Inflam"},{"key":"10.1074\/jbc.M114.564674_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.bi.57.070188.001541","article-title":"Molecular organization and function of the complement system","volume":"57","author":"M\u00fcller-Eberhard","year":"1988","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M114.564674_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI24521","article-title":"Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia\/reperfusion","volume":"116","author":"Thurman","year":"2006","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.564674_bib13","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1167\/iovs.08-3202","article-title":"Expression and modulation of RPE cell membrane complement regulatory proteins","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.thromres.2007.11.005","article-title":"Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress","volume":"122","author":"Yin","year":"2008","journal-title":"Thromb. Res"},{"key":"10.1074\/jbc.M114.564674_bib15","first-page":"357","article-title":"Immunohistochemical localization of complement regulatory proteins in the human retina","volume":"27","author":"Fett","year":"2012","journal-title":"Histol. Histopathol"},{"key":"10.1074\/jbc.M114.564674_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.exer.2011.06.002","article-title":"Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy","volume":"93","author":"Vogt","year":"2011","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.564674_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/path.4128","article-title":"Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration","volume":"229","author":"Ebrahimi","year":"2013","journal-title":"J. Pathol"},{"key":"10.1074\/jbc.M114.564674_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog. Retin. Eye Res"},{"key":"10.1074\/jbc.M114.564674_bib19","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bjo.2008.141168","article-title":"Environmental tobacco smoke exposure and eye disease","volume":"92","author":"Lois","year":"2008","journal-title":"Br. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib20","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.ophtha.2006.09.022","article-title":"Cigarette smoking and age-related macular degeneration in the EUREYE study","volume":"114","author":"Chakravarthy","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1074\/jbc.M114.564674_bib21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1001\/archopht.120.10.1357","article-title":"Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye Study","volume":"120","author":"Mitchell","year":"2002","journal-title":"Arch. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/bjo.2005.073643","article-title":"Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation","volume":"90","author":"Khan","year":"2006","journal-title":"Br. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/ehp.8564111","article-title":"Free-radical chemistry of cigarette smoke and its toxicological implications","volume":"64","author":"Church","year":"1985","journal-title":"Environ. Health Perspect"},{"key":"10.1074\/jbc.M114.564674_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/thx.2003.012468","article-title":"Acute effects of cigarette smoke on inflammation and oxidative stress: a review","volume":"59","author":"van der Vaart","year":"2004","journal-title":"Thorax"},{"key":"10.1074\/jbc.M114.564674_bib25","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI111760","article-title":"Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement","volume":"75","author":"Kew","year":"1985","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.564674_bib26","first-page":"19211","article-title":"Levels of inflammatory markers (complement C3, complement C4 and C-reactive protein) in smokers","volume":"10","author":"Sanai","year":"2011","journal-title":"Afr. J. Biotechnol"},{"key":"10.1074\/jbc.M114.564674_bib27","doi-asserted-by":"crossref","first-page":"e5304","DOI":"10.1371\/journal.pone.0005304","article-title":"Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M114.564674_bib28","doi-asserted-by":"crossref","first-page":"e67894","DOI":"10.1371\/journal.pone.0067894","article-title":"Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury","volume":"8","author":"Woodell","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M114.564674_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pupt.2012.07.005","article-title":"Respiratory epithelial cell responses to cigarette smoke: the unfolded protein response","volume":"25","author":"Kelsen","year":"2012","journal-title":"Pulm. Pharmacol. Ther"},{"key":"10.1074\/jbc.M114.564674_bib30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tem.2012.03.006","article-title":"The endocrine effects of nicotine and cigarette smoke","volume":"23","author":"Tweed","year":"2012","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.564674_bib31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1074\/jbc.M114.564674_bib32","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1091\/mbc.e08-11-1092","article-title":"Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection","volume":"20","author":"Ishida","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M114.564674_bib33","doi-asserted-by":"crossref","first-page":"F323","DOI":"10.1152\/ajprenal.00050.2008","article-title":"Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces","volume":"295","author":"Kitamura","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M114.564674_bib34","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb0805-766","article-title":"ERAD: the long road to destruction","volume":"7","author":"Meusser","year":"2005","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.564674_bib35","first-page":"45","article-title":"Endoplasmic reticulum stress and unfolded protein response pathways: potential for treating age-related retinal degeneration","volume":"7","author":"Haeri","year":"2012","journal-title":"J. Ophthalmic. Vis. Res"},{"key":"10.1074\/jbc.M114.564674_bib36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/BJ20101569","article-title":"Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting","volume":"434","author":"Ni","year":"2011","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M114.564674_bib37","first-page":"1592","article-title":"The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy","volume":"42","author":"Haimovici","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib38","doi-asserted-by":"crossref","first-page":"e10329","DOI":"10.1371\/journal.pone.0010329","article-title":"Abundant lipid and protein components of drusen","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M114.564674_bib39","first-page":"265","article-title":"Accumulation of cholesterol with age in human Bruch's membrane","volume":"42","author":"Curcio","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib40","doi-asserted-by":"crossref","first-page":"802059","DOI":"10.1155\/2011\/802059","article-title":"Lipids, lipoproteins, and age-related macular degeneration","volume":"2011","author":"Ebrahimi","year":"2011","journal-title":"J. Lipids"},{"key":"10.1074\/jbc.M114.564674_bib41","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1017\/S1462399410001742","article-title":"Endoplasmic reticulum stress and lipid dysregulation","volume":"13","author":"Colgan","year":"2011","journal-title":"Expert Rev. Mol. Med"},{"key":"10.1074\/jbc.M114.564674_bib42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/BJ20091827","article-title":"Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site","volume":"429","author":"Damiano","year":"2010","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M114.564674_bib43","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1073\/pnas.94.16.8720","article-title":"Abrogation of the alternative complement pathway by targeted deletion of murine factor B","volume":"94","author":"Matsumoto","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.564674_bib44","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.4049\/jimmunol.181.11.8068","article-title":"A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia\/reperfusion injury","volume":"181","author":"Huang","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.564674_bib45","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI65861","article-title":"Detection of complement activation using monoclonal antibodies against C3d","volume":"123","author":"Thurman","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.564674_bib46","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.564674_bib47","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.exer.2007.08.010","article-title":"VEGF modulation of retinal pigment epithelium resistance","volume":"85","author":"Ablonczy","year":"2007","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.564674_bib48","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2500\/ajra.2009.23.3400","article-title":"Cigarette smoke extract stimulates interleukin-8 production in human airway epithelium and is attenuated by superoxide dismutase in vitro","volume":"23","author":"Mulligan","year":"2009","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1074\/jbc.M114.564674_bib49","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1369\/jhc.2009.953448","article-title":"Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid","volume":"57","author":"Rudolf","year":"2009","journal-title":"J. Histochem. Cytochem"},{"key":"10.1074\/jbc.M114.564674_bib50","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.exer.2006.01.014","article-title":"Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death","volume":"83","author":"Lohr","year":"2006","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.564674_bib51","doi-asserted-by":"crossref","first-page":"830307","DOI":"10.1155\/2010\/830307","article-title":"Methods for monitoring endoplasmic reticulum stress and the unfolded protein response","volume":"2010","author":"Samali","year":"2010","journal-title":"Int. J. Cell Biol"},{"key":"10.1074\/jbc.M114.564674_bib52","first-page":"2035","article-title":"Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice","volume":"41","author":"Dithmar","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.otohns.2010.02.022","article-title":"Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage","volume":"143","author":"Davis","year":"2010","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"10.1074\/jbc.M114.564674_bib54","doi-asserted-by":"crossref","first-page":"18825","DOI":"10.1074\/jbc.270.32.18825","article-title":"Blue light-induced reactivity of retinal age pigment: in vitro generation of oxygen-reactive species","volume":"270","author":"R\u00f3zanowska","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.564674_bib55","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1001\/archopht.1991.01080090111033","article-title":"Antioxidant enzymes in the aging human retinal pigment epithelium","volume":"109","author":"Liles","year":"1991","journal-title":"Arch. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib56","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archopht.1993.01090070083023","article-title":"Age-dependent change in the hyaluronic acid content of the human chorioretinal complex","volume":"111","author":"Tate","year":"1993","journal-title":"Arch. Ophthalmol"},{"key":"10.1074\/jbc.M114.564674_bib57","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1074\/jbc.M112.421891","article-title":"Oxidative stress sensitizes RPE cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner","volume":"288","author":"Joseph","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.564674_bib58","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1167\/iovs.11-8638","article-title":"Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement","volume":"53","author":"Bandyopadhyay","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4419-5635-4_2","article-title":"The role of complement in AMD","volume":"703","author":"Zipfel","year":"2010","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M114.564674_bib60","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1167\/iovs.05-0719","article-title":"Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD","volume":"47","author":"Espinosa-Heidmann","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib61","doi-asserted-by":"crossref","first-page":"e48501","DOI":"10.1371\/journal.pone.0048501","article-title":"Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M114.564674_bib62","doi-asserted-by":"crossref","first-page":"C1200","DOI":"10.1152\/ajpcell.00126.2009","article-title":"Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration","volume":"297","author":"Bertram","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M114.564674_bib63","doi-asserted-by":"crossref","first-page":"16651","DOI":"10.1073\/pnas.0705079104","article-title":"Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction","volume":"104","author":"Coffey","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.564674_bib64","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.1167\/iovs.12-10069","article-title":"A novel role of complement in retinal degeneration","volume":"53","author":"Yu","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib65","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2353\/ajpath.2009.080927","article-title":"Complement factor H is critical in the maintenance of retinal perfusion","volume":"175","author":"Lundh von Leithner","year":"2009","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M114.564674_bib66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4614-0631-0_4","article-title":"Sublytic membrane-attack complex activation and VEGF secretion in retinal pigment epithelial cells","volume":"723","author":"Kunchithapautham","year":"2012","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M114.564674_bib67","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4419-1399-9_14","article-title":"Misfolded proteins and retinal dystrophies","volume":"664","author":"Lin","year":"2010","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M114.564674_bib68","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2119\/molmed.2010.00070","article-title":"Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization","volume":"16","author":"Salminen","year":"2010","journal-title":"Mol. Med"},{"key":"10.1074\/jbc.M114.564674_bib69","doi-asserted-by":"crossref","first-page":"14844","DOI":"10.1074\/jbc.M312948200","article-title":"Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4","volume":"279","author":"Roybal","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.564674_bib70","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1194\/jlr.M300306-JLR200","article-title":"Regulated expression of apolipoprotein E by human retinal pigment epithelial cells","volume":"45","author":"Ishida","year":"2004","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M114.564674_bib71","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1167\/iovs.08-2376","article-title":"Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile","volume":"50","author":"Wang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.564674_bib72","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1073\/pnas.1109703108","article-title":"Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration","volume":"108","author":"Johnson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.564674_bib73","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1124\/pr.111.005223","article-title":"International Union of Pharmacology. LXXXVII: complement peptide C5a, C4a, and C3a receptors","volume":"65","author":"Klos","year":"2013","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.M114.564674_bib74","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.1074\/jbc.M111.289322","article-title":"Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and Toll-like receptor 4 activation in human macrophages","volume":"287","author":"Mogilenko","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.564674_bib75","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1093\/ndt\/gfq717","article-title":"Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation","volume":"26","author":"Damman","year":"2011","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1074\/jbc.M114.564674_bib76","first-page":"405","article-title":"Human interleukin-6 acts as a co-factor for the up-regulation of C3 production by rat liver epithelial cells","volume":"5","author":"Platel","year":"1994","journal-title":"Eur. Cytokine Netw"},{"key":"10.1074\/jbc.M114.564674_bib77","first-page":"1588","article-title":"Complement gene expression and regulation in mouse retina and retinal pigment epithelium\/choroid","volume":"17","author":"Luo","year":"2011","journal-title":"Mol. Vis"},{"key":"10.1074\/jbc.M114.564674_bib78","series-title":"C53.COPD pathogenesis: in vitro and in vivo studies","first-page":"A4561","article-title":"Cigarette smoke-induced reactive oxygen species (ROS) production in human airway epithelial cells is calcium and NADPH-oxidase (NOX) dependent","author":"Yun","year":"2012"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820386592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820386592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.564674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T09:31:29Z","timestamp":1641288689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820386592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":78,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0021925820386592"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.564674","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}