{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:51:04Z","timestamp":1790891464556,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":2232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RO1 EY013143"],"award-info":[{"award-number":["RO1 EY013143"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["EY018222"],"award-info":[{"award-number":["EY018222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1074\/jbc.m114.570143","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:44:36Z","timestamp":1403138676000},"page":"22172-22182","source":"Crossref","is-referenced-by-count":36,"title":["A Cleavage-potentiated Fragment of Tear Lacritin Is Bactericidal"],"prefix":"10.1016","volume":"289","author":[{"given":"Robert L.","family":"McKown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin V.","family":"Coleman Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneil K.","family":"Zadrozny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Deleault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.","family":"Raab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise S.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose K.","family":"Sia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon W.","family":"Laurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.570143_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.immunol.22.012703.104603","article-title":"Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense","volume":"22","author":"Yang","year":"2004","journal-title":"Annu. Rev. Immunol"},{"key":"10.1074\/jbc.M114.570143_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ni.1700","article-title":"Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis","volume":"10","author":"Zugasti","year":"2009","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M114.570143_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI115407","article-title":"Killing of Gram-negative bacteria by lactoferrin and lysozyme","volume":"88","author":"Ellison","year":"1991","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.570143_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s000110050561","article-title":"Synergistic actions of antibacterial neutrophil defensins and cathelicidins","volume":"49","author":"Nagaoka","year":"2000","journal-title":"Inflamm. Res"},{"key":"10.1074\/jbc.M114.570143_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.molimm.2007.06.001","article-title":"Porcine \u03b2-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria","volume":"45","author":"Veldhuizen","year":"2008","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M114.570143_bib6","doi-asserted-by":"crossref","unstructured":"Str\u00f6mstedt, A. A., Pasupuleti, M., Schmidtchen, A., Malmsten, M., Oligotryptophan-tagged antimicrobial peptides and the role of the cationic sequence. Biochim. Biophys. Acta 1788, 1916\u20131923,","DOI":"10.1016\/j.bbamem.2009.06.001"},{"key":"10.1074\/jbc.M114.570143_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exer.2013.07.014","article-title":"Antimicrobial compounds in tears","volume":"117","author":"McDermott","year":"2013","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.570143_bib8","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1529\/biophysj.108.133488","article-title":"Magainin 2 in action: distinct modes of membrane permeabilization in living bacterial and mammalian cells","volume":"95","author":"Imura","year":"2008","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M114.570143_bib9","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1073\/pnas.1101130108","article-title":"Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37","volume":"108","author":"Sochacki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.570143_bib10","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/ICO.0b013e31823f8bb9","article-title":"Antimicrobial susceptibility of nontuberculous mycobacteria from eye infections","volume":"31","author":"Brown-Elliott","year":"2012","journal-title":"Cornea"},{"key":"10.1074\/jbc.M114.570143_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2013.05.010","article-title":"Tear film lipids","volume":"117","author":"Butovich","year":"2013","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.570143_bib12","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1021\/pr2004874","article-title":"Characterization of the human tear metabolome by LC-MS\/MS","volume":"10","author":"Chen","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.M114.570143_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exer.2013.05.020","article-title":"Lacritin and the tear proteome as natural replacement therapy for dry eye","volume":"117","author":"Karnati","year":"2013","journal-title":"Exp. Eye Res"},{"key":"10.1074\/jbc.M114.570143_bib14","article-title":"Ueber die antisepsis des bindehautsackes und die bakterienfeindliche eigenschaft der tr\u00e4nen","author":"Bernheim","year":"1893","journal-title":"Beitr. z. Augenheilk. von Deutschmann. 1. Bd"},{"key":"10.1074\/jbc.M114.570143_bib15","first-page":"303","article-title":"On a remarkable bacteriolytic element found in tissues and secretions","volume":"93","author":"Fleming","year":"1922","journal-title":"Proc. R. Soc. London"},{"key":"10.1074\/jbc.M114.570143_bib16","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.570143_bib17","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1073\/pnas.0510847103","article-title":"Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury","volume":"103","author":"Berger","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.570143_bib18","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.4049\/jimmunol.0803282","article-title":"Lipocalin 2 is required for pulmonary host defense against Klebsiella infection","volume":"182","author":"Chan","year":"2009","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M114.570143_bib19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/35106587","article-title":"Innate antimicrobial peptide protects the skin from invasive bacterial infection","volume":"414","author":"Nizet","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.570143_bib20","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1128\/IAI.70.6.3068-3072.2002","article-title":"\u03b2-Defensin 1 contributes to pulmonary innate immunity in mice","volume":"70","author":"Moser","year":"2002","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.M114.570143_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jmbi.2001.4748","article-title":"cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland","volume":"310","author":"Sanghi","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.570143_bib22","doi-asserted-by":"crossref","first-page":"18146","DOI":"10.1074\/jbc.M112.436584","article-title":"Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib23","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1167\/iovs.10-6220","article-title":"Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated","volume":"52","author":"Samudre","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200605140","article-title":"Restricted epithelial proliferation by lacritin via PKC\u03b1-dependent NFAT and mTOR pathways","volume":"174","author":"Wang","year":"2006","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.570143_bib25","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1073\/pnas.1932980100","article-title":"A neural survival factor is a candidate oncogene in breast cancer","volume":"100","author":"Porter","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.570143_bib26","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1074\/jbc.M504670200","article-title":"Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L","volume":"281","author":"Baechle","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni732","article-title":"Dermcidin: a novel human antibiotic peptide secreted by sweat glands","volume":"2","author":"Schittek","year":"2001","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M114.570143_bib28","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1167\/iovs.11-8729","article-title":"Tear lacritin levels by age, sex, and time of day in healthy adults","volume":"53","author":"Seifert","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib29","doi-asserted-by":"crossref","first-page":"12090","DOI":"10.1074\/jbc.M112.422717","article-title":"Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity","volume":"288","author":"Zhang","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib30","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/cbic.200800476","article-title":"Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons","volume":"9","author":"Cerovsk\u00fd","year":"2008","journal-title":"ChemBioChem"},{"key":"10.1074\/jbc.M114.570143_bib31","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1167\/iovs.09-4573","article-title":"Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells","volume":"51","author":"Morimoto-Tochigi","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.jid.5700041","article-title":"Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites","volume":"126","author":"Rieg","year":"2006","journal-title":"J. Invest. Dermatol"},{"key":"10.1074\/jbc.M114.570143_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0002-9394(76)90188-4","article-title":"Identification of a nonlysozymal bactericidal factor (\u03b2 lysin) in human tears and aqueous humor","volume":"81","author":"Ford","year":"1976","journal-title":"Am. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.570143_bib34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0002-9394(72)91125-7","article-title":"Non-lysozyme antibacterial factor in human tears","volume":"74","author":"Friedland","year":"1972","journal-title":"Am. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.570143_bib35","first-page":"1156","article-title":"Nonlysozyme antibacterial factor in human tears. Fact or fiction?","volume":"25","author":"Janssen","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0002-9394(41)92140-2","article-title":"The antibacterial action of tears on staphylococci","volume":"24","author":"Thompson","year":"1941","journal-title":"Am. J. Ophthalmol"},{"key":"10.1074\/jbc.M114.570143_bib37","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1128\/IAI.71.7.3866-3874.2003","article-title":"Modification of Pseudomonas aeruginosa interactions with corneal epithelial cells by human tear fluid","volume":"71","author":"Fleiszig","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.M114.570143_bib38","first-page":"538","article-title":"Spectrum and antibiotic susceptibility pattern of bacterial isolates from conjunctival swabs","volume":"48","author":"Malhotra","year":"2005","journal-title":"Indian J. Pathol. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12348-011-0024-z","article-title":"Bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in Lagos, Nigeria","volume":"1","author":"Iwalokun","year":"2011","journal-title":"J. Ophthalmic Inflamm. Infect"},{"key":"10.1074\/jbc.M114.570143_bib40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/1097-0282(2000)55:1<4::AID-BIP30>3.0.CO;2-M","article-title":"Amphipathic, \u03b1-helical antimicrobial peptides","volume":"55","author":"Tossi","year":"2000","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M114.570143_bib41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/IAI.74.2.975-983.2006","article-title":"A live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infection","volume":"74","author":"Zaidi","year":"2006","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.M114.570143_bib42","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1167\/iovs.07-0588","article-title":"Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes","volume":"48","author":"Graham","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/ICO.0b013e3181e16f7c","article-title":"Microbiological evaluation of chronic blepharitis among Iranian veterans exposed to mustard gas: a case-controlled study","volume":"30","author":"Karimian","year":"2011","journal-title":"Cornea"},{"key":"10.1074\/jbc.M114.570143_bib44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1021\/pr0498133","article-title":"Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis","volume":"4","author":"Koo","year":"2005","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.M114.570143_bib45","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1128\/aem.63.6.2421-2431.1997","article-title":"Bacterial viability and antibiotic susceptibility testing with SYTOX green nucleic acid stain","volume":"63","author":"Roth","year":"1997","journal-title":"Appl. Environ. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib46","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.200511134","article-title":"Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin","volume":"174","author":"Ma","year":"2006","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.570143_bib47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archopht.1978.03910050373015","article-title":"Osmolarity of tear microvolumes in keratoconjunctivitis sicca","volume":"96","author":"Gilbard","year":"1978","journal-title":"Arch. Ophthalmol"},{"key":"10.1074\/jbc.M114.570143_bib48","first-page":"1624","article-title":"Human tears: osmotic characteristics","volume":"24","author":"Benjamin","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib49","first-page":"250","article-title":"Tear osmolarity variation in the dry eye","volume":"84","author":"Farris","year":"1986","journal-title":"Trans. Am. Ophthalmol. Soc"},{"key":"10.1074\/jbc.M114.570143_bib50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1110\/ps.0227803","article-title":"Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli","volume":"12","author":"O'Toole","year":"2003","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.570143_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.resmic.2011.10.009","article-title":"Polyamines reduce oxidative stress in Escherichia coli cells exposed to bactericidal antibiotics","volume":"163","author":"Tkachenko","year":"2012","journal-title":"Res. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib52","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1074\/jbc.M804482200","article-title":"Lipid-engineered Escherichia coli membranes reveal critical lipid headgroup size for protein function","volume":"284","author":"Wikstr\u00f6m","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib53","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.bbamem.2009.06.010","article-title":"Cardiolipin and the osmotic stress responses of bacteria","volume":"1788","author":"Romantsov","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.570143_bib54","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/msb.2010.18","article-title":"Metabolomic and transcriptomic stress response of Escherichia coli","volume":"6","author":"Jozefczuk","year":"2010","journal-title":"Mol. Syst. Biol"},{"key":"10.1074\/jbc.M114.570143_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jmb.2012.08.023","article-title":"Deactivation of the E. coli pH stress sensor CadC by cadaverine","volume":"424","author":"Haneburger","year":"2012","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.570143_bib56","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0923-2508(96)84015-0","article-title":"In vivo positive effects of exogenous pyrophosphate on Escherichia coli cell growth and stationary phase survival","volume":"147","author":"Biville","year":"1996","journal-title":"Res. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib57","first-page":"239","article-title":"HPLC analysis of closed, open, and reflex eye tear proteins","volume":"46","author":"Sitaramamma","year":"1998","journal-title":"Indian J. Ophthalmol"},{"key":"10.1074\/jbc.M114.570143_bib58","doi-asserted-by":"crossref","first-page":"33374","DOI":"10.1074\/jbc.M506047200","article-title":"The MUC1 SEA module is a self-cleaving domain","volume":"280","author":"Levitin","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib59","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1172\/JCI64416","article-title":"Cytokeratins mediate epithelial innate defense through their antimicrobial properties","volume":"122","author":"Tam","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.570143_bib60","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1128\/AAC.00181-06","article-title":"Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge","volume":"50","author":"Steffen","year":"2006","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1074\/jbc.M114.570143_bib61","doi-asserted-by":"crossref","first-page":"8434","DOI":"10.1074\/jbc.M111.332270","article-title":"Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat","volume":"287","author":"Paulmann","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.570143_bib62","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.vetmic.2014.01.034","article-title":"Polyamines are essential for virulence in Salmonella enterica serovar Gallinarum despite evolutionary decay of polyamine biosynthesis genes","volume":"170","author":"Schroll","year":"2014","journal-title":"Vet. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib63","doi-asserted-by":"crossref","first-page":"e1291","DOI":"10.1371\/journal.pone.0001291","article-title":"Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway","volume":"2","author":"Zhou","year":"2007","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.570143_bib64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2958.2011.07809.x","article-title":"Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines","volume":"82","author":"Joshi","year":"2011","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib65","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/JB.01201-13","article-title":"Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions","volume":"196","author":"Geiger","year":"2014","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.M114.570143_bib66","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1128\/AEM.00078-14","article-title":"Dimethylglycine provides salt and temperature stress protection to Bacillus subtilis","volume":"80","author":"Bashir","year":"2014","journal-title":"Appl. Environ. Microbiol"},{"key":"10.1074\/jbc.M114.570143_bib67","doi-asserted-by":"crossref","first-page":"e50300","DOI":"10.1371\/journal.pone.0050300","article-title":"PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.570143_bib68","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood.V97.12.3951","article-title":"Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3","volume":"97","author":"S\u00f8rensen","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.570143_bib69","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1167\/iovs.12-11488","article-title":"Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity","volume":"54","author":"Velez","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M114.570143_bib70","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.201008090","article-title":"Processing and turnover of the Hedgehog protein in the endoplasmic reticulum","volume":"192","author":"Chen","year":"2011","journal-title":"J. Cell Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820331550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.570143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:30:09Z","timestamp":1641256209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820331550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":70,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0021925820331550"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.570143","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}