{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:07:25Z","timestamp":1790100445843,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"45","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2138,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1074\/jbc.m114.572594","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T02:59:39Z","timestamp":1411095579000},"page":"31330-31340","source":"Crossref","is-referenced-by-count":35,"title":["Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with \u03b15\u03b21 Integrin"],"prefix":"10.1016","volume":"289","author":[{"given":"Hyo Seon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ja","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Sook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokkyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-In","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyeul","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.572594_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M114.572594_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M114.572594_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ccr.2011.03.016","article-title":"Multiple effects of angiopoietin-2 blockade on tumors","volume":"19","author":"Lewis","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M114.572594_bib4","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2013.03.011","article-title":"Angiopoietin signaling in the vasculature","volume":"319","author":"Eklund","year":"2013","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.M114.572594_bib5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1158\/0008-5472.CAN-12-2064","article-title":"Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition","volume":"73","author":"Daly","year":"2013","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M114.572594_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","article-title":"Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1","volume":"3","author":"Gale","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M114.572594_bib7","doi-asserted-by":"crossref","first-page":"23842","DOI":"10.1074\/jbc.M109.097543","article-title":"Angiopoietin-2 stimulation of endothelial cells induces \u03b1v\u03b23 integrin internalization and degradation","volume":"285","author":"Thomas","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.572594_bib8","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1083\/jcb.200507082","article-title":"Stable interaction between \u03b15\u03b21 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1","volume":"170","author":"Cascone","year":"2005","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.572594_bib9","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1158\/0008-5472.CAN-06-4100","article-title":"Angiopoietin-2 stimulates breast cancer metastasis through the \u03b15\u03b21 integrin-mediated pathway","volume":"67","author":"Imanishi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M114.572594_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1158\/0008-5472.CAN-05-1149","article-title":"Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the \u03b1v\u03b21 integrin and focal adhesion kinase signaling pathway","volume":"66","author":"Hu","year":"2006","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M114.572594_bib11","doi-asserted-by":"crossref","first-page":"29249","DOI":"10.1074\/jbc.M111.235689","article-title":"Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway","volume":"286","author":"Imanishi","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.572594_bib12","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI58832","article-title":"Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling","volume":"122","author":"Felcht","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.572594_bib13","doi-asserted-by":"crossref","first-page":"26516","DOI":"10.1074\/jbc.M100282200","article-title":"Direct cell adhesion to the angiopoietins mediated by integrins","volume":"276","author":"Carlson","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.572594_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.str.2005.03.009","article-title":"Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition","volume":"13","author":"Barton","year":"2005","journal-title":"Structure"},{"key":"10.1074\/jbc.M114.572594_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nsmb1101","article-title":"Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex","volume":"13","author":"Barton","year":"2006","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.M114.572594_bib16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbamcr.2009.01.018","article-title":"A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis","volume":"1793","author":"Kim","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.572594_bib17","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1073\/pnas.1533394100","article-title":"Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2","volume":"100","author":"Hu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.572594_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1126\/science.1069040","article-title":"Crystal structure of the extracellular segment of integrin \u03b1v\u03b23 in complex with an Arg-Gly-Asp ligand","volume":"296","author":"Xiong","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M114.572594_bib19","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1073\/pnas.0409493102","article-title":"Potentiation of the ligand-binding activity of integrin \u03b13\u03b21 via association with tetraspanin CD151","volume":"102","author":"Nishiuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.572594_bib20","first-page":"1321","article-title":"MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models","volume":"40","author":"Leow","year":"2012","journal-title":"Int. J. Oncol"},{"key":"10.1074\/jbc.M114.572594_bib21","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1158\/0008-5472.CAN-12-4697","article-title":"Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy","volume":"73","author":"Gerald","year":"2013","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M114.572594_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1200\/JCO.2011.38.7621","article-title":"Targeting the angiopoietin\/Tie2 pathway: cutting tumor vessels with a double-edged sword?","volume":"30","author":"Cascone","year":"2012","journal-title":"J. Clin. Oncol"},{"key":"10.1074\/jbc.M114.572594_bib23","series-title":"High Affinity Human Antibodies to Human Angiopoietin-2","author":"Thurston","year":"2011"},{"key":"10.1074\/jbc.M114.572594_bib24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ijc.10851","article-title":"Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival","volume":"103","author":"Sfiligoi","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M114.572594_bib25","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1096\/fj.11-182287","article-title":"Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer","volume":"25","author":"Schulz","year":"2011","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.572594_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M114.572594_bib27","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1083\/jcb.201212037","article-title":"Complete integrin headpiece opening in eight steps","volume":"201","author":"Zhu","year":"2013","journal-title":"J. Cell Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820333603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820333603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.572594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:38:42Z","timestamp":1641274722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820333603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":27,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0021925820333603"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.572594","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}