{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:44:34Z","timestamp":1768337074836,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":2197,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1074\/jbc.m114.577221","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T02:51:59Z","timestamp":1405997519000},"page":"24971-24979","source":"Crossref","is-referenced-by-count":21,"title":["Homer2 Protein Regulates Plasma Membrane Ca2+-ATPase-mediated Ca2+ Signaling in Mouse Parotid Gland Acinar Cells"],"prefix":"10.1016","volume":"289","author":[{"given":"Yu-Mi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soonhong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inik","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Muallem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Min","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.577221_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.physiol.70.113006.100618","article-title":"Polarized calcium signaling in exocrine gland cells","volume":"70","author":"Petersen","year":"2008","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.M114.577221_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0166-2236(99)01492-7","article-title":"Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons","volume":"23","author":"Fagni","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1074\/jbc.M114.577221_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.conb.2006.05.002","article-title":"Homer proteins: implications for neuropsychiatric disorders","volume":"16","author":"Szumlinski","year":"2006","journal-title":"Curr. Opin. Neurobiol"},{"key":"10.1074\/jbc.M114.577221_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0898-6568(02)00074-8","article-title":"Signalling specificity in GPCR-dependent Ca2+ signalling","volume":"15","author":"Kiselyov","year":"2003","journal-title":"Cell. Signal"},{"key":"10.1074\/jbc.M114.577221_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ceca.2007.05.007","article-title":"Homer proteins in Ca2+ signaling by excitable and non-excitable cells","volume":"42","author":"Worley","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M114.577221_bib8","first-page":"re8","article-title":"Homer as both a scaffold and transduction molecule","author":"Fagni","year":"2002","journal-title":"Sci. STKE 2002"},{"key":"10.1074\/jbc.M114.577221_bib9","doi-asserted-by":"crossref","first-page":"23969","DOI":"10.1074\/jbc.273.37.23969","article-title":"Novel members of the Vesl\/Homer family of PDZ proteins that bind metabotropic glutamate receptors","volume":"273","author":"Kato","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0896-6273(00)80589-9","article-title":"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors","volume":"21","author":"Tu","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.577221_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/386284a0","article-title":"Homer: a protein that selectively binds metabotropic glutamate receptors","volume":"386","author":"Brakeman","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.577221_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(03)00716-5","article-title":"Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors","volume":"114","author":"Yuan","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.577221_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0896-6273(00)80588-7","article-title":"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins","volume":"21","author":"Xiao","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.577221_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1083\/jcb.200210109","article-title":"Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLC\u03b2 GAP activities","volume":"162","author":"Shin","year":"2003","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib15","doi-asserted-by":"crossref","first-page":"44722","DOI":"10.1074\/jbc.M207675200","article-title":"Homer regulates gain of ryanodine receptor type 1 channel complex","volume":"277","author":"Feng","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0896-6273(00)80810-7","article-title":"Coupling of mGluR\/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins","volume":"23","author":"Tu","year":"1999","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.577221_bib17","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1523\/JNEUROSCI.4822-04.2005","article-title":"Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons","volume":"25","author":"Sala","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.577221_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0960-9822(03)00136-2","article-title":"Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer","volume":"13","author":"Gray","year":"2003","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.M114.577221_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1523\/JNEUROSCI.22-01-00167.2002","article-title":"Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression","volume":"22","author":"Bottai","year":"2002","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.577221_bib20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1151227","article-title":"NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins","volume":"319","author":"Huang","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.M114.577221_bib21","doi-asserted-by":"crossref","first-page":"C442","DOI":"10.1152\/ajpcell.1997.273.2.C442","article-title":"Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells","volume":"273","author":"Zeng","year":"1997","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M114.577221_bib22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.150.5.1101","article-title":"The mammalian Sec6\/8 complex interacts with Ca2+ signaling complexes and regulates their activity","volume":"150","author":"Shin","year":"2000","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib23","doi-asserted-by":"crossref","first-page":"32540","DOI":"10.1074\/jbc.M602496200","article-title":"Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane","volume":"281","author":"Kim","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib24","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1093\/emboj\/20.11.2680","article-title":"Plasticity and adaptation of Ca2+ signaling and Ca2+-dependent exocytosis in SERCA2+\/\u2212 mice","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.577221_bib25","doi-asserted-by":"crossref","first-page":"48172","DOI":"10.1074\/jbc.M208393200","article-title":"Ca2+-dependent protein kinase\u2013a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells","volume":"277","author":"Bruce","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00418-005-0100-2","article-title":"Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva","volume":"125","author":"Homann","year":"2006","journal-title":"Histochem. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/154405910508400604","article-title":"Parotid secretory granules: crossroads of secretory pathways and protein storage","volume":"84","author":"Gorr","year":"2005","journal-title":"J. Dent. Res"},{"key":"10.1074\/jbc.M114.577221_bib28","doi-asserted-by":"crossref","first-page":"21594","DOI":"10.1074\/jbc.M101448200","article-title":"Plasma membrane Ca2+-ATPase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95\/Dlg\/ZO-1) domain-containing proteins","volume":"276","author":"DeMarco","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib29","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1074\/jbc.M111616200","article-title":"Plasma membrane Ca2+ATPase isoform 2b interacts preferentially with Na+\/H+ exchanger regulatory factor 2 in apical plasma membranes","volume":"277","author":"DeMarco","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.200104131","article-title":"The plasma membrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I","volume":"155","author":"Schuh","year":"2001","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.577221_bib31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbrc.2006.03.020","article-title":"The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump","volume":"343","author":"Sgambato-Faure","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.577221_bib32","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1523\/JNEUROSCI.20-19-07238.2000","article-title":"Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels","volume":"20","author":"Kammermeier","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.577221_bib33","doi-asserted-by":"crossref","first-page":"15765","DOI":"10.1074\/jbc.272.25.15765","article-title":"Polarized expression of Ca2+ channels in pancreatic and salivary gland cells. Correlation with initiation and propagation of [Ca2+]i waves","volume":"272","author":"Lee","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0143-4160(97)90073-7","article-title":"Imaging of intracellular Ca2+ waves induced by muscarinic receptor stimulation in rat parotid acinar cells","volume":"22","author":"Tojyo","year":"1997","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M114.577221_bib35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/bj3400519","article-title":"Ryanodine and inositol trisphosphate receptors are differentially distributed and expressed in rat parotid gland","volume":"340","author":"Zhang","year":"1999","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M114.577221_bib36","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1006\/bbrc.1999.0818","article-title":"Millisecond analyses of Ca2+ initiation sites evoked by muscarinic receptor stimulation in exocrine acinar cells","volume":"259","author":"Takemura","year":"1999","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.577221_bib37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ceca.2007.05.011","article-title":"Calcium transporters and signalling in smooth muscles","volume":"42","author":"Floyd","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M114.577221_bib38","doi-asserted-by":"crossref","first-page":"37678","DOI":"10.1074\/jbc.M703416200","article-title":"Differential regulation of the apical plasma membrane Ca2+-ATPase by protein kinase A in parotid acinar cells","volume":"282","author":"Baggaley","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib39","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1074\/jbc.272.25.15771","article-title":"Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i waves","volume":"272","author":"Lee","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib40","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mcn.2006.10.010","article-title":"Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons","volume":"34","author":"Kurnellas","year":"2007","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1074\/jbc.M114.577221_bib41","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1023\/A:1024264025401","article-title":"Subcellular distribution of Homer 1b\/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons","volume":"28","author":"Sandon\u00e0","year":"2003","journal-title":"Neurochem. Res"},{"key":"10.1074\/jbc.M114.577221_bib42","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.96.10.5797","article-title":"Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons","volume":"96","author":"Genazzani","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.577221_bib43","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1074\/jbc.274.3.1667","article-title":"The expression of plasma membrane Ca2+ pump isoforms in cerebellar granule neurons is modulated by Ca2+","volume":"274","author":"Guerini","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.577221_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2012.06.069","article-title":"Homer proteins accelerate Ca2+ clearance mediated by the plasma membrane Ca2+ pump in hippocampal neurons","volume":"424","author":"Salm","year":"2012","journal-title":"Biochem. Biophys. Res. Commun"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820316525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820316525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.577221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T12:59:11Z","timestamp":1639832351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820316525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":44,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0021925820316525"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.577221","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}