{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:39:31Z","timestamp":1762673971437},"reference-count":70,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2199,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1074\/jbc.m114.580365","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T06:02:13Z","timestamp":1406613733000},"page":"25509-25522","source":"Crossref","is-referenced-by-count":31,"title":["Protein Kinase C\u03b1 (PKC\u03b1) Regulates Bone Architecture and Osteoblast Activity"],"prefix":"10.1016","volume":"289","author":[{"given":"Gabriel L.","family":"Galea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee B.","family":"Meakin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Hulin-Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance E.","family":"Lanyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair W.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna S.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.580365_bib1","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1359\/jbmr.2001.16.11.1937","article-title":"Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis","volume":"16","author":"Lanyon","year":"2001","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"10.1074\/jbc.M114.580365_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/er.2003-0003","article-title":"Androgens and bone","volume":"25","author":"Vanderschueren","year":"2004","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M114.580365_bib4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","article-title":"Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study","volume":"375","author":"Zebaze","year":"2010","journal-title":"Lancet"},{"key":"10.1074\/jbc.M114.580365_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1474-9726.2011.00669.x","article-title":"Senescence-associated intrinsic mechanisms of osteoblast dysfunctions","volume":"10","author":"Kassem","year":"2011","journal-title":"Aging Cell"},{"key":"10.1074\/jbc.M114.580365_bib6","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jbmr.2222","article-title":"Age-related impairment of bones' adaptive response to loading in mice is associated with gender-related deficiencies in osteoblasts but no change in osteocytes","volume":"29","author":"Meakin","year":"2014","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib8","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00198-011-1656-4","article-title":"Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered","volume":"23","author":"Moustafa","year":"2012","journal-title":"Osteoporos. Int"},{"key":"10.1074\/jbc.M114.580365_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib11","first-page":"122","article-title":"One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture","volume":"6","author":"Skerry","year":"2006","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"10.1074\/jbc.M114.580365_bib12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jbmr.5650030610","article-title":"Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading","volume":"3","author":"Pead","year":"1988","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S8756-3282(98)00041-6","article-title":"Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine","volume":"22","author":"Turner","year":"1998","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.0.1820193","article-title":"The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-\u03b1 and -\u03b2","volume":"182","author":"Lee","year":"2004","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M114.580365_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jbmr.1754","article-title":"Estrogen receptor-\u03b1 is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2","volume":"28","author":"Windahl","year":"2013","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib16","doi-asserted-by":"crossref","first-page":"25501","DOI":"10.1074\/jbc.M702231200","article-title":"A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction","volume":"282","author":"Aguirre","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bone.2011.03.683","article-title":"Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V high bone mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it","volume":"49","author":"Saxon","year":"2011","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib18","doi-asserted-by":"crossref","first-page":"20715","DOI":"10.1074\/jbc.M703224200","article-title":"Wnt\/\u03b2-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor \u03b1","volume":"282","author":"Armstrong","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib19","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1074\/jbc.M112.405456","article-title":"Estrogen receptor \u03b1 mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor \u03b2","volume":"288","author":"Galea","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib20","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1158\/0008-5472.CAN-06-0268","article-title":"Protein kinase C \u03b1 but not PKC\u03b6 suppresses intestinal tumor formation in ApcMin\/+ mice","volume":"66","author":"Oster","year":"2006","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M114.580365_bib21","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1111\/j.1582-4934.2008.00683.x","article-title":"Stimulation of protein kinase C\u03b1 suppresses colon cancer cell proliferation by down-regulation of \u03b2-catenin","volume":"13","author":"Gwak","year":"2009","journal-title":"J. Cell Mol. Med"},{"key":"10.1074\/jbc.M114.580365_bib22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.steroids.2008.04.012","article-title":"Membrane ER\u03b1-dependent activation of PKC\u03b1 in endometrial cancer cells by estradiol","volume":"73","author":"Yang","year":"2008","journal-title":"Steroids"},{"key":"10.1074\/jbc.M114.580365_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bone.2003.09.007","article-title":"Interaction of estrogen receptor alpha with protein kinase C \u03b1 and c-Src in osteoblasts during differentiation","volume":"34","author":"Longo","year":"2004","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tips.2009.10.006","article-title":"Protein kinase C\u03b1: disease regulator and therapeutic target","volume":"31","author":"Konopatskaya","year":"2010","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1074\/jbc.M114.580365_bib25","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1002\/ijc.24633","article-title":"Protein kinase C \u03b1-dependent signaling mediates endometrial cancer cell growth and tumorigenesis","volume":"125","author":"Haughian","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M114.580365_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1677\/jme.1.02055","article-title":"Modulation of human estrogen receptor \u03b1 F promoter by a protein kinase C\/c-Src-dependent mechanism in osteoblast-like cells","volume":"37","author":"Longo","year":"2006","journal-title":"J. Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.580365_bib27","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1242\/jcs.03256","article-title":"Protein-kinase-C-mediated \u03b2-catenin phosphorylation negatively regulates the Wnt\/\u03b2-catenin pathway","volume":"119","author":"Gwak","year":"2006","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M114.580365_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.molcel.2009.12.022","article-title":"ROR\u03b1 attenuates Wnt\/\u03b2-catenin signaling by PKC\u03b1-dependent phosphorylation in colon cancer","volume":"37","author":"Lee","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.580365_bib29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jcp.10019","article-title":"Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells","volume":"189","author":"Geng","year":"2001","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.M114.580365_bib30","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.febslet.2011.06.019","article-title":"Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4","volume":"585","author":"Galea","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M114.580365_bib31","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1074\/jbc.M111.252742","article-title":"Loading-related regulation of transcription factor EGR2\/Krox-20 in bone cells is ERK1\/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent","volume":"287","author":"Zaman","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib32","doi-asserted-by":"crossref","first-page":"e13090","DOI":"10.1371\/journal.pone.0013090","article-title":"Mechanical stress activates Smad pathway through PKC\u03b4 to enhance interleukin-11 gene transcription in osteoblasts","volume":"5","author":"Kido","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.580365_bib33","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bone.2010.09.238","article-title":"PKC\u03b1 suppresses osteoblastic differentiation","volume":"48","author":"Nakura","year":"2011","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib34","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1073\/pnas.1003308107","article-title":"Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage","volume":"107","author":"Mistry","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.580365_bib35","doi-asserted-by":"crossref","first-page":"A2","DOI":"10.1259\/bjr.75.suppl_1.750002","article-title":"Skeletal aspects of Gaucher disease: a review","volume":"75","author":"Wenstrup","year":"2002","journal-title":"Br. J. Radiol"},{"key":"10.1074\/jbc.M114.580365_bib36","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.3101176","article-title":"Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses","volume":"235","author":"Hannun","year":"1987","journal-title":"Science"},{"key":"10.1074\/jbc.M114.580365_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm1000","article-title":"PKC-\u03b1 regulates cardiac contractility and propensity toward heart failure","volume":"10","author":"Braz","year":"2004","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M114.580365_bib38","doi-asserted-by":"crossref","first-page":"F233","DOI":"10.1152\/ajprenal.00484.2012","article-title":"Role of protein kinase C-\u03b1 in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts","volume":"304","author":"Wang","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M114.580365_bib39","first-page":"399","article-title":"PKC\u03b1 regulates platelet granule secretion and thrombus formation in mice","volume":"119","author":"Konopatskaya","year":"2009","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.580365_bib40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bone.2009.04.203","article-title":"Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro","volume":"45","author":"Wang","year":"2009","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/JBMR.041014","article-title":"Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44","volume":"20","author":"Cao","year":"2005","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/bonekey.2013.147","article-title":"Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling","volume":"2","author":"Galea","year":"2013","journal-title":"Bonekey Rep"},{"key":"10.1074\/jbc.M114.580365_bib43","doi-asserted-by":"crossref","first-page":"D792","DOI":"10.1093\/nar\/gkp1005","article-title":"PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification","volume":"38","author":"Spandidos","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.580365_bib44","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/jbmr.1599","article-title":"Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar\/woven bone transition","volume":"27","author":"Sugiyama","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib45","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib46","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1210\/en.2010-0645","article-title":"Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice","volume":"151","author":"Sugiyama","year":"2010","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M114.580365_bib47","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/jbmr.5650100813","article-title":"Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain","volume":"10","author":"Rawlinson","year":"1995","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib48","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5603\/FHC.2011.0048","article-title":"Gaucher disease diagnosed after bone marrow trephine biopsy: a report of two cases","volume":"49","author":"Sokolowska","year":"2011","journal-title":"Folia Histochem. Cytobiol"},{"key":"10.1074\/jbc.M114.580365_bib49","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bcmd.2009.08.002","article-title":"The clinical course of untreated Gaucher disease in 22 patients over 10 years: hematological and skeletal manifestations","volume":"43","author":"Piran","year":"2009","journal-title":"Blood Cells Mol. Dis"},{"key":"10.1074\/jbc.M114.580365_bib50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/09537104.2012.761686","article-title":"PKC\u03b1 negatively regulates in vitro proplatelet formation and in vivo platelet production in mice","volume":"25","author":"Williams","year":"2014","journal-title":"Platelets"},{"key":"10.1074\/jbc.M114.580365_bib51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1359\/jbmr.1999.14.7.1123","article-title":"Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes","volume":"14","author":"Zaman","year":"1999","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib52","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1074\/jbc.M109.027086","volume":"285","author":"Sunters","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/424389a","article-title":"Endocrinology: bone adaptation requires oestrogen receptor-\u03b1","volume":"424","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.580365_bib54","doi-asserted-by":"crossref","first-page":"e35726","DOI":"10.1371\/journal.pone.0035726","article-title":"Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner","volume":"7","author":"Javaheri","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.580365_bib55","doi-asserted-by":"crossref","first-page":"31720","DOI":"10.1016\/S0021-9258(19)84086-3","article-title":"Wnt\/\u03b2-catenin signaling is a normal physiological response to mechanical loading in bone","volume":"281","author":"Robinson","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1359\/jbmr.2002.17.4.593","article-title":"Human osteoblasts' proliferative responses to strain and 17\u03b2-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I","volume":"17","author":"Cheng","year":"2002","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib57","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency: macrophage-targeted glucocerebrosidase for Gaucher's disease","volume":"324","author":"Barton","year":"1991","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M114.580365_bib58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/(SICI)1096-8652(199906)61:2<103::AID-AJH5>3.0.CO;2-V","article-title":"Platelet function abnormalities in Gaucher disease patients","volume":"61","author":"Gillis","year":"1999","journal-title":"Am. J. Hematol"},{"key":"10.1074\/jbc.M114.580365_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/jme.0.0200245","article-title":"Modulation of mouse estrogen receptor transcription activity by protein kinase C \u03b4","volume":"20","author":"Lahooti","year":"1998","journal-title":"J. Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.580365_bib60","first-page":"1133","article-title":"Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels","volume":"7","author":"Migliaccio","year":"1993","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.580365_bib61","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1210\/en.2011-1977","article-title":"Estrogen receptors \u03b1 and \u03b2 have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone","volume":"153","author":"Saxon","year":"2012","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M114.580365_bib62","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1249\/MSS.0b013e31828d39bc","article-title":"\u03b2-1 adrenergic agonist mitigates unloading-induced bone loss by maintaining formation","volume":"45","author":"Swift","year":"2013","journal-title":"Med. Sci. Sports Exerc"},{"key":"10.1074\/jbc.M114.580365_bib63","doi-asserted-by":"crossref","first-page":"30192","DOI":"10.1074\/jbc.M504179200","article-title":"Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system","volume":"280","author":"Kondo","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib64","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bone.2007.04.184","article-title":"Blockade of \u03b2-adrenergic signaling does not influence the bone mechano-adaptive response in mice","volume":"41","author":"Marenzana","year":"2007","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.580365_bib65","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/\u03b2-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib66","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1359\/jbmr.091001","article-title":"Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice","volume":"25","author":"Callewaert","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.580365_bib67","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1302\/0301-620X.60B3.681422","article-title":"Bone loss in response to long-term immobilisation","volume":"60","author":"Uhthoff","year":"1978","journal-title":"J. Bone Joint Surg. Br"},{"key":"10.1074\/jbc.M114.580365_bib68","doi-asserted-by":"crossref","first-page":"e5438","DOI":"10.1371\/journal.pone.0005438","article-title":"Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner","volume":"4","author":"Noh","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.580365_bib69","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M500608200","article-title":"Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression","volume":"280","author":"Gaur","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.580365_bib70","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2011.08.020","article-title":"Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo","volume":"359","author":"Joeng","year":"2011","journal-title":"Dev. Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820315106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820315106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.580365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T04:31:14Z","timestamp":1641270674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820315106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":70,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0021925820315106"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.580365","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}