{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:54:11Z","timestamp":1777373651831,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":2073,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1074\/jbc.m114.589762","type":"journal-article","created":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T01:08:09Z","timestamp":1420247289000},"page":"4512-4527","source":"Crossref","is-referenced-by-count":32,"title":["Synaptic Synthesis, Dephosphorylation, and Degradation"],"prefix":"10.1016","volume":"290","author":[{"given":"Paolo","family":"La Montanara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rusconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albina","family":"Locarno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Forti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Barbiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tramarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Chandola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Kilstrup-Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Landsberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.589762_bib1","doi-asserted-by":"crossref","first-page":"728267","DOI":"10.1155\/2012\/728267","article-title":"What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy","volume":"2012","author":"Kilstrup-Nielsen","year":"2012","journal-title":"Neural. Plast"},{"key":"10.1074\/jbc.M114.589762_bib2","first-page":"32048","article-title":"Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation","volume":"281","author":"Bertani","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.589762_bib3","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1074\/jbc.M804613200","article-title":"CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail","volume":"283","author":"Rusconi","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.589762_bib4","doi-asserted-by":"crossref","first-page":"12777","DOI":"10.1523\/JNEUROSCI.1102-10.2010","article-title":"CDKL5, a protein associated with Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling","volume":"30","author":"Chen","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.nbd.2010.02.014","article-title":"CDKL5 is a brain MeCP2 target gene regulated by DNA methylation","volume":"38","author":"Carouge","year":"2010","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M114.589762_bib6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ncb2566","article-title":"CDKL5 ensures excitatory synapse stability by reinforcing NGL-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC derived neurons","volume":"14","author":"Ricciardi","year":"2012","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.589762_bib7","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1073\/pnas.1300003110","article-title":"Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic development","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.589762_bib8","doi-asserted-by":"crossref","first-page":"21516","DOI":"10.1073\/pnas.1216988110","article-title":"Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice","volume":"109","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.589762_bib9","doi-asserted-by":"crossref","first-page":"e91613","DOI":"10.1371\/journal.pone.0091613","article-title":"Mapping pathological phenotypes in a mouse model of CDKL5 disorder","volume":"9","author":"Amendola","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.589762_bib10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/hmg\/ddq563","article-title":"Reduced AKT\/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model","volume":"20","author":"Ricciardi","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M114.589762_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.31.060407.125631","article-title":"Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system","volume":"31","author":"Flavell","year":"2008","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature11860","article-title":"Activity-dependent neuronal signalling and autism spectrum disorder","volume":"493","author":"Ebert","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.589762_bib13","doi-asserted-by":"crossref","first-page":"36550","DOI":"10.1074\/jbc.M111.235630","article-title":"Extrasynaptic N-methyl-d-aspartate (NMDA) receptor stimulation induces cytoplasmic translocation of the CDKL5 kinase and its proteasomal degradation","volume":"286","author":"Rusconi","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.589762_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1476-5381.1996.tb15173.x","article-title":"Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices","volume":"117","author":"Lombardi","year":"1996","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.M114.589762_bib15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.neuron.2013.06.039","article-title":"CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation","volume":"79","author":"De Rubeis","year":"2013","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.589762_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Depression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M114.589762_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.589762_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neures.2010.12.007","article-title":"Regulation and function of immediate early genes in the brain: beyond neuronal activity markers","volume":"69","author":"Okuno","year":"2011","journal-title":"Neurosci. Res"},{"key":"10.1074\/jbc.M114.589762_bib19","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1523\/JNEUROSCI.0119-10.2010","article-title":"Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis","volume":"30","author":"Verpelli","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00439-011-1058-x","article-title":"A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain","volume":"131","author":"Williamson","year":"2012","journal-title":"Hum. Genet"},{"key":"10.1074\/jbc.M114.589762_bib21","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1523\/JNEUROSCI.20-10-03529.2000","article-title":"Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons","volume":"20","author":"Sala","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib22","article-title":"Neurodevelopmental and neurobehavioral characteristics in males and females with CDKL5 duplications","author":"Szafranski","year":"2014","journal-title":"Eur. J. Hum Genet"},{"key":"10.1074\/jbc.M114.589762_bib23","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.5057-11.2012","article-title":"Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation","volume":"32","author":"Nalavadi","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.abb.2013.04.012","article-title":"Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder","volume":"535","author":"Sekiguchi","year":"2013","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M114.589762_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/88380","article-title":"A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication","volume":"4","author":"Hardingham","year":"2001","journal-title":"Nature Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn3192","article-title":"Mechanisms of CaMKII action in Long Term Potentiation","volume":"13","author":"Lisman","year":"2012","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/72915","article-title":"NMDA receptor-mediated control of protein synthesis at developing synapses","volume":"3","author":"Scheetz","year":"2000","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.M114.589762_bib28","doi-asserted-by":"crossref","first-page":"31913","DOI":"10.1074\/jbc.R110.154476","article-title":"Translational control mechanism in long-lasting synaptic plasticity and memory","volume":"285","author":"Gkogkas","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.589762_bib29","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/hmg\/ddi198","article-title":"CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome","volume":"14","author":"Mari","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M114.589762_bib30","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbrc.2008.10.113","article-title":"Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1","volume":"377","author":"Kameshita","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.589762_bib31","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1093\/hmg\/ddp426","article-title":"CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery","volume":"18","author":"Ricciardi","year":"2009","journal-title":"Hum. Mol. Genet"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819470348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819470348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.589762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T18:40:13Z","timestamp":1641148813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819470348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0021925819470348"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.589762","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}