{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:00:34Z","timestamp":1788580834590,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":2025,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1074\/jbc.m114.592493","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T03:10:06Z","timestamp":1421809806000},"page":"7443-7451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fat\/Vessel-derived Secretory Protein (Favine)\/CCDC3 Is Involved in Lipid Accumulation"],"prefix":"10.1016","volume":"290","author":[{"given":"Sachiko","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Suganami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iichiro","family":"Shimomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.592493_bib1","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.592493_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.cellbio.16.1.145","article-title":"Molecular regulation of adipogenesis","volume":"16","author":"Rosen","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.M114.592493_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","article-title":"New developments in adipogenesis","volume":"20","author":"Lefterova","year":"2009","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.592493_bib4","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1242\/jcs.079699","article-title":"Adipogenesis at a glance","volume":"124","author":"Lowe","year":"2011","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M114.592493_bib5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1194\/jlr.R700005-JLR200","article-title":"Thematic review series: adipocyte biology-adipose tissue function and plasticity orchestrate nutritional adaptation","volume":"48","author":"Sethi","year":"2007","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M114.592493_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/embo-reports\/kve071","article-title":"Mechanisms of nutritional and hormonal regulation of lipogenesis","volume":"2","author":"Kersten","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M114.592493_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10409231003667500","article-title":"Genetic control of de novo lipogenesis: role in diet-induced obesity","volume":"45","author":"Strable","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.M114.592493_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/joim.12071","article-title":"Ectopic lipid storage and insulin resistance: a harmful relationship","volume":"274","author":"Bor\u00e9n","year":"2013","journal-title":"J. Intern. Med"},{"key":"10.1074\/jbc.M114.592493_bib9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","author":"Tchkonia","year":"2010","journal-title":"Aging Cell"},{"key":"10.1074\/jbc.M114.592493_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mad.2013.11.008","article-title":"Adipose tissue, diet and aging","volume":"136","author":"Zamboni","year":"2014","journal-title":"Mech. Ageing Dev"},{"key":"10.1074\/jbc.M114.592493_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2009.12.142","article-title":"Identification of a new secretory factor, CCDC3\/Favine, in adipocytes and endothelial cells","volume":"392","author":"Kobayashi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.592493_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbpb.2010.01.013","article-title":"Analysis of structure and gene expression of bovine CCDC3 gene indicates a function in fat metabolism","volume":"156","author":"Eberlein","year":"2010","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol"},{"key":"10.1074\/jbc.M114.592493_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/oby.20645","article-title":"CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity","volume":"22","author":"Ugi","year":"2014","journal-title":"Obesity"},{"key":"10.1074\/jbc.M114.592493_bib14","doi-asserted-by":"crossref","first-page":"25445","DOI":"10.1074\/jbc.M701549200","article-title":"Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy","volume":"282","author":"Ito","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.592493_bib15","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0301-472X(03)00260-1","article-title":"Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics","volume":"31","author":"Kitamura","year":"2003","journal-title":"Exp. Hematol"},{"key":"10.1074\/jbc.M114.592493_bib16","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1074\/jbc.270.7.3442","article-title":"Activation of mitogen-activated protein kinase and phosphatidylinositol 3\u2032-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes","volume":"270","author":"Wiese","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.592493_bib17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00316069","article-title":"Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O","volume":"97","author":"Ram\u00edrez-Zacar\u00edas","year":"1992","journal-title":"Histochemistry"},{"key":"10.1074\/jbc.M114.592493_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.592493_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0022-2275(20)41303-3","article-title":"Isolation and characterization of cells from rat adipose tissue developing into adipocytes","volume":"19","author":"Bj\u00f6rntorp","year":"1978","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M114.592493_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature10986","article-title":"A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism","volume":"484","author":"Herman","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.592493_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1210\/er.2010-0018","article-title":"Emerging roles for the transforming growth factor-\u03b2 superfamily in regulating adiposity and energy expenditure","volume":"32","author":"Zamani","year":"2011","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M114.592493_bib22","doi-asserted-by":"crossref","first-page":"C740","DOI":"10.1152\/ajpcell.00333.2007","article-title":"Connective tissue growth factor inhibits adipocyte differentiation","volume":"295","author":"Tan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M114.592493_bib23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1172\/JCI15924","article-title":"Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)","volume":"111","author":"Lee","year":"2003","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.592493_bib24","doi-asserted-by":"crossref","first-page":"E1291","DOI":"10.1152\/ajpendo.00654.2012","article-title":"Connective tissue growth factor\/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model","volume":"304","author":"Tan","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.592493_bib25","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1073\/pnas.82.24.8530","article-title":"Type \u03b2 transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts","volume":"82","author":"Ignotz","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.592493_bib26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.2527\/jas1989.6782171x","article-title":"Transforming growth factor type \u03b2 (TGF-\u03b2) and adipogenesis in pigs","volume":"67","author":"Richardson","year":"1989","journal-title":"J. Anim. Sci"},{"key":"10.1074\/jbc.M114.592493_bib27","doi-asserted-by":"crossref","first-page":"15712","DOI":"10.1073\/pnas.2536828100","article-title":"Adipose-specific peroxisome proliferator-activated receptor \u03b3 knockout causes insulin resistance in fat and liver but not in muscle","volume":"100","author":"He","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.592493_bib28","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1073\/pnas.0400356101","article-title":"Peroxisome proliferator-activated receptor \u03b3 is required in mature white and brown adipocytes for their survival in the mouse","volume":"101","author":"Imai","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.592493_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tem.2013.01.003","article-title":"Novel insights into ChREBP regulation and function","volume":"24","author":"Filhoulaud","year":"2013","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.592493_bib30","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0401516101","article-title":"Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis","volume":"101","author":"Iizuka","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.592493_bib31","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.1690453","article-title":"PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily","volume":"247","author":"Newman","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.M114.592493_bib32","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1016\/j.cellsig.2014.08.025","article-title":"Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-\u03b1\/nuclear factor \u03baB-induced endothelial inflammation","volume":"26","author":"Azad","year":"2014","journal-title":"Cell. Signal"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820648633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820648633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.592493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T18:54:05Z","timestamp":1689620045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820648633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0021925820648633"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.592493","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fat\/Vessel-derived Secretory Protein (Favine)\/CCDC3 Is Involved in Lipid Accumulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M114.592493","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}