{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:52:53Z","timestamp":1782283973719,"version":"3.54.5"},"reference-count":99,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":2139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM080505"],"award-info":[{"award-number":["GM080505"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1074\/jbc.m114.597526","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T04:02:09Z","timestamp":1411704129000},"page":"32410-32429","source":"Crossref","is-referenced-by-count":16,"title":["Structure-Function Relationships in Human Testis-determining Factor SRY"],"prefix":"10.1016","volume":"289","author":[{"given":"Joseph D.","family":"Racca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Maloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalinda","family":"Wickramasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson B.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.597526_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/346240a0","article-title":"A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif","volume":"346","author":"Sinclair","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/351117a0","article-title":"Male development of chromosomally female mice transgenic for Sry","volume":"351","author":"Koopman","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.biocel.2009.12.005","article-title":"SRY: a transcriptional activator of mammalian testis determination","volume":"42","author":"Sekido","year":"2010","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.M114.597526_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature06944","article-title":"Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer","volume":"453","author":"Sekido","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib5","series-title":"Sex-determining Genes in Mice: Building Pathways","first-page":"4","author":"Lovell-Badge","year":"2002"},{"key":"10.1074\/jbc.M114.597526_bib6","first-page":"347","article-title":"Testicular anti-Mullerian hormone: history, genetics, regulation and clinical applications","volume":"3","author":"Josso","year":"2006","journal-title":"Pediatr. Endocrinol. Rev"},{"key":"10.1074\/jbc.M114.597526_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/aja.2011.169","article-title":"Male sex determination: insights into molecular mechanisms","volume":"14","author":"McClelland","year":"2012","journal-title":"Asian J. Androl"},{"key":"10.1074\/jbc.M114.597526_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrg1903","article-title":"The makings of maleness: towards an integrated view of male sexual development","volume":"7","author":"Wilhelm","year":"2006","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M114.597526_bib9","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/ejhg.2009.96","article-title":"A novel SRY missense mutation affecting nuclear import in a 46, XY female patient with bilateral gonadoblastoma","volume":"17","author":"Hersmus","year":"2009","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/jbc.M114.597526_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0960-9822(92)90541-H","article-title":"HMGs everywhere","volume":"2","author":"Ner","year":"1992","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.M114.597526_bib11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/364713a0","article-title":"Rapid sequence evolution of the mammalian sex-determining gene SRY","volume":"364","author":"Whitfield","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10577-011-9256-x","article-title":"SRY protein function in sex determination: thinking outside the box","volume":"20","author":"Zhao","year":"2012","journal-title":"Chromosome Res"},{"key":"10.1074\/jbc.M114.597526_bib13","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/j.1460-2075.1993.tb05776.x","article-title":"NMR structure of an HMG box","volume":"12","author":"Weir","year":"1993","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.597526_bib14","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1093\/emboj\/18.23.6610","article-title":"The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence-specific DNA recognition","volume":"18","author":"Murphy","year":"1999","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.597526_bib15","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/nar\/27.6.1409","article-title":"From head to toes: the multiple facets of Sox protein","volume":"6","author":"Wegner","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.597526_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0168-9525(99)01955-1","article-title":"Pairing SOX off: With partners in the regulation of embryonic development","volume":"16","author":"Kamachi","year":"2000","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.M114.597526_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/JOE-08-0447","article-title":"The role of SOX proteins in normal pituitary development","volume":"200","author":"Alatzoglou","year":"2009","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M114.597526_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tins.2005.08.008","article-title":"From stem cells to neurons and glia: a Soxist's view of neural development","volume":"28","author":"Wegner","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1074\/jbc.M114.597526_bib19","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1399-0004.2005.00518.x","article-title":"Bilateral anophthalmia and brain malformations caused by a 20-bp deletion in the SOX2 gene","volume":"68","author":"Zenteno","year":"2005","journal-title":"Clin. Genet"},{"key":"10.1074\/jbc.M114.597526_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0065-2660(07)00013-2","article-title":"Long-range gene control and genetic disease","volume":"61","author":"Kleinjan","year":"2008","journal-title":"Adv. Genet"},{"key":"10.1074\/jbc.M114.597526_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1159\/000078217","article-title":"Sox genes and cancer","volume":"105","author":"Dong","year":"2004","journal-title":"Cytogenet. Genome Res"},{"key":"10.1074\/jbc.M114.597526_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.stem.2012.12.007","article-title":"The sox family of transcription factors: versatile regulators of stem and progenitor cell fate","volume":"12","author":"Sarkar","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1074\/jbc.M114.597526_bib23","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/nar\/21.15.3427","article-title":"Solution structure of a DNA-binding domain from HMG1","volume":"21","author":"Read","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.597526_bib24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0969-2126(00)00063-0","article-title":"The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster","volume":"2","author":"Jones","year":"1994","journal-title":"Structure"},{"key":"10.1074\/jbc.M114.597526_bib25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(95)90532-4","article-title":"Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex","volume":"81","author":"Werner","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.597526_bib26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/376791a0","article-title":"Structural basis for DNA bending by the architectural transcription factor LEF-1","volume":"376","author":"Love","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/07391102.1997.10508185","article-title":"The SRY cantilever motif discriminates between sequence- and structure-specific DNA recognition: alanine mutagenesis of an HMG box","volume":"15","author":"Weiss","year":"1997","journal-title":"J. Biomol. Struct. Dyn"},{"key":"10.1074\/jbc.M114.597526_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1006\/jmbi.2001.4977","article-title":"Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occuring point mutation","volume":"312","author":"Murphy","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/BJ20111768","article-title":"The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition","volume":"443","author":"Jauch","year":"2012","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M114.597526_bib30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nsb0698-436","article-title":"The structure of PurR mutant L54M shows an alternative route to DNA kinking","volume":"5","author":"Arvidson","year":"1998","journal-title":"Nat. Struct. Biol"},{"key":"10.1074\/jbc.M114.597526_bib31","doi-asserted-by":"crossref","first-page":"11990","DOI":"10.1073\/pnas.90.24.11990","article-title":"The SRY high mobility group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity","volume":"90","author":"King","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0378-1119(89)90459-9","article-title":"Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector","volume":"85","author":"Kim","year":"1989","journal-title":"Gene"},{"key":"10.1074\/jbc.M114.597526_bib33","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.7985018","article-title":"Molecular basis of mammalian sexual determination: activation of M\u00fcllerian inhibiting substance gene expression by SRY","volume":"266","author":"Haqq","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M114.597526_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jmb.2006.01.060","article-title":"SRY and human sex determination: The basic tail of the HMG box functions as a kinetic clamp to augment DNA bending","volume":"358","author":"Phillips","year":"2006","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/(SICI)1098-1004(1997)9:5<388::AID-HUMU2>3.0.CO;2-0","article-title":"Mutations in SRY and SOX9: testis-determining genes","volume":"9","author":"Cameron","year":"1997","journal-title":"Hum. Mutat"},{"key":"10.1074\/jbc.M114.597526_bib36","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/nar\/21.10.2493","article-title":"Ancestry and diversity of the HMG box superfamily","volume":"21","author":"Laudet","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.597526_bib37","first-page":"359","article-title":"The SOX gene family: function and regulation in testis determination and male fertility maintenance","volume":"316","author":"Jiang","year":"2012","journal-title":"Mol. Biol. Rep"},{"key":"10.1074\/jbc.M114.597526_bib38","doi-asserted-by":"crossref","first-page":"E3567","DOI":"10.1073\/pnas.1300828110","article-title":"Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold","volume":"110","author":"Chen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1021\/bi971675q","article-title":"Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities","volume":"37","author":"Trimmer","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.597526_bib40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jmb.2006.04.048","article-title":"SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail","volume":"360","author":"Li","year":"2006","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib41","doi-asserted-by":"crossref","first-page":"36787","DOI":"10.1074\/jbc.M111.260091","article-title":"Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal","volume":"286","author":"Phillips","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1998.78.1.1","article-title":"Regulation of sexual dimorphism in mammals","volume":"78","author":"Haqq","year":"1998","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M114.597526_bib43","doi-asserted-by":"crossref","first-page":"27848","DOI":"10.1074\/jbc.272.44.27848","article-title":"Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9","volume":"272","author":"S\u00fcdbeck","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1097-0177(200003)217:3<293::AID-DVDY7>3.0.CO;2-P","article-title":"Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development","volume":"217","author":"de Santa Barbara","year":"2000","journal-title":"Dev. Dyn"},{"key":"10.1074\/jbc.M114.597526_bib45","doi-asserted-by":"crossref","first-page":"46480","DOI":"10.1074\/jbc.C100388200","article-title":"Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib46","doi-asserted-by":"crossref","first-page":"33839","DOI":"10.1074\/jbc.M302078200","article-title":"A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia\/autosomal sex reversal","volume":"278","author":"Argentaro","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200810106","article-title":"Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors","volume":"185","author":"Gontan","year":"2009","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.597526_bib48","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1210\/me.2004-0334","article-title":"Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal","volume":"19","author":"Sim","year":"2005","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.597526_bib49","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0168-9525(90)90253-3","article-title":"The structure of the homeodomain and its functional implications","volume":"6","author":"Gehring","year":"1990","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.M114.597526_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biophys.29.1.183","article-title":"DNA recognition by Cys2His2 zinc finger proteins","volume":"29","author":"Wolfe","year":"2000","journal-title":"Annu. Rev. Biophys. Biomol. Struct"},{"key":"10.1074\/jbc.M114.597526_bib51","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1373\/clinchem.2007.100156","article-title":"The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences","volume":"54","author":"de Ferranti","year":"2008","journal-title":"Clin. Chem"},{"key":"10.1074\/jbc.M114.597526_bib52","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1021\/bi049920a","article-title":"Sry-directed sex reversal in transgenic mice is robust to enhanced DNA bending: comparison of human and murine in HMG boxes","volume":"43","author":"Phillips","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.597526_bib53","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1006\/jmbi.1999.3285","article-title":"The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5","volume":"294","author":"Privalov","year":"1999","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib54","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1073\/pnas.81.1.130","article-title":"Two-dimensional 1H NMR study of the \u03bb operator site OL1: a sequential assignment strategy and its application","volume":"81","author":"Weiss","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib55","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1073\/pnas.94.7.2833","article-title":"A direct comparison of helix propensity in proteins and peptides","volume":"94","author":"Myers","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib56","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0960-9822(00)00141-X","article-title":"Protein Folding: Solid evidence for molten globules","volume":"4","author":"Dobson","year":"1994","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.M114.597526_bib57","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1096\/fasebj.10.1.8566530","article-title":"The molten globule state of \u03b1-lactalbumin","volume":"10","author":"Kuwajima","year":"1996","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.597526_bib58","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0076-6879(92)11021-A","article-title":"Circular dichroism spectroscopy of DNA","volume":"211","author":"Gray","year":"1992","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M114.597526_bib59","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/nar\/gkp026","article-title":"Circular dichroism and conformational polymorphism of DNA","volume":"37","author":"Kypr","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.597526_bib60","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1093\/nar\/22.16.3339","article-title":"DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5","volume":"22","author":"Connor","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.597526_bib61","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0092-8674(78)90335-5","article-title":"Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues","volume":"14","author":"Hiller","year":"1978","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.597526_bib62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpc.2013.08.006","article-title":"Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement","volume":"186","author":"Clore","year":"2014","journal-title":"Biophys. Chem"},{"key":"10.1074\/jbc.M114.597526_bib63","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.molcel.2009.11.018","article-title":"The incoherent feedforward loop can provide fold-change detection in gene regulation","volume":"36","author":"Goentoro","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.597526_bib64","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jez.1089","article-title":"Regulation of male sexual development by Sry and Sox9","volume":"290","author":"Koopman","year":"2001","journal-title":"J. Exp. Zool"},{"key":"10.1074\/jbc.M114.597526_bib65","doi-asserted-by":"crossref","first-page":"24813","DOI":"10.1016\/S0021-9258(19)74537-2","article-title":"The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein","volume":"268","author":"Dooijes","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib66","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/pro.5560041024","article-title":"Alignment of 700 globin sequences: extent of amino acid substitution and its correlation with variation in volume","volume":"4","author":"Kapp","year":"1995","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.597526_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1096\/fasebj.10.1.8566545","article-title":"Structural and genetic analysis of the folding and function of T4 lysozyme","volume":"10","author":"Matthews","year":"1996","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.597526_bib68","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biocel.2009.09.020","article-title":"Shuttling of SOX proteins","volume":"42","author":"Malki","year":"2010","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.M114.597526_bib69","doi-asserted-by":"crossref","first-page":"e25694","DOI":"10.1371\/journal.pone.0025694","article-title":"Exportin 4 interacts with Sox9 through the HMG box and inhibits the DNA binding of Sox9","volume":"6","author":"Tsuchiya","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.597526_bib70","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1128\/MCB.18.8.4819","article-title":"Differential importin-\u03b1 recognition and nuclear transport by nuclear localization signals within the high mobility group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1","volume":"18","author":"Prieve","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M114.597526_bib71","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0092-8674(91)90245-T","article-title":"Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence","volume":"64","author":"Robbins","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.597526_bib72","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/BST0340701","article-title":"Structural basis for the nuclear protein import cycle","volume":"34","author":"Stewart","year":"2006","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M114.597526_bib73","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1210\/en.2010-1475","article-title":"Inhibition of SRY-calmodulin complex formation induces ectopic expression of ovarian cell markers in developing XY gonads","volume":"152","author":"Sim","year":"2011","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M114.597526_bib74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/prot.1128","article-title":"Filling a cavity dramatically increases pressure stability of the c-Myb R2 subdomain","volume":"45","author":"Lassalle","year":"2001","journal-title":"Proteins"},{"key":"10.1074\/jbc.M114.597526_bib75","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/pro.61","article-title":"A review about nothing: are apolar cavities in proteins really empty?","volume":"18","author":"Matthews","year":"2009","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.597526_bib76","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1126\/science.1553543","article-title":"Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect","volume":"255","author":"Eriksson","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M114.597526_bib77","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1110\/ps.ps.32102","article-title":"A cavity-forming mutation in insulin induces segmental unfolding of a surrounding \u03b1-helix","volume":"11","author":"Xu","year":"2002","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.597526_bib78","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/pro.5560030413","article-title":"Protein folding dynamics: the diffusion-collision model and experimental data","volume":"3","author":"Karplus","year":"1994","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.597526_bib79","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-3233(08)60334-4","article-title":"Stability of \u03b1-helices","volume":"46","author":"Chakrabartty","year":"1995","journal-title":"Adv. Protein Chem"},{"key":"10.1074\/jbc.M114.597526_bib80","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1096\/fasebj.10.1.8566531","article-title":"The roles of partly folded intermediates in protein folding","volume":"10","author":"Creighton","year":"1996","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.597526_bib81","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/13318","article-title":"\u03b1-Lactalbumin forms a compact molten globule in the absence of disulfide bonds","volume":"6","author":"Redfield","year":"1999","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib82","doi-asserted-by":"crossref","first-page":"14700","DOI":"10.1021\/bi0202981","article-title":"A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers","volume":"41","author":"Hua","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.597526_bib83","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/353715a0","article-title":"A structural taxonomy of DNA-binding domains","volume":"353","author":"Harrison","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib84","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/347575a0","article-title":"Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA","volume":"347","author":"Weiss","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.597526_bib85","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0959-440X(94)90054-X","article-title":"Getting a grip on DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains","volume":"4","author":"Ellenberger","year":"1994","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1074\/jbc.M114.597526_bib86","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/mend.15.3.0617","article-title":"Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition","volume":"15","author":"Weiss","year":"2001","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.597526_bib87","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.1021\/bi049591m","article-title":"The LEF-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA","volume":"43","author":"Love","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.597526_bib88","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.3892686","article-title":"Aromatic-aromatic interaction: a mechanism of protein structure stabilization","volume":"229","author":"Burley","year":"1985","journal-title":"Science"},{"key":"10.1074\/jbc.M114.597526_bib89","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/pro.2443","article-title":"Advantages of proteins being disordered","volume":"23","author":"Liu","year":"2014","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.597526_bib90","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/mend.15.3.0621","article-title":"SRY and architectural gene regulation: the kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency","volume":"15","author":"Ukiyama","year":"2001","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M114.597526_bib91","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1006\/jmbi.1998.1895","article-title":"The energetics of HMG box interactions with DNA. Thermodynamic description of the box from mouse Sox-5","volume":"281","author":"Crane-Robinson","year":"1998","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib92","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jmb.2007.11.091","article-title":"Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog","volume":"376","author":"Jauch","year":"2008","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.597526_bib93","first-page":"25","author":"Weirauch","year":"2011"},{"key":"10.1074\/jbc.M114.597526_bib94","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1093\/emboj\/19.16.4362","article-title":"Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes","volume":"19","author":"Lipowsky","year":"2000","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.597526_bib95","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1073\/pnas.172383099","article-title":"A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination","volume":"99","author":"Gasca","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib96","doi-asserted-by":"crossref","first-page":"46575","DOI":"10.1074\/jbc.M101668200","article-title":"The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin \u03b21","volume":"276","author":"Forwood","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.597526_bib97","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1073\/pnas.1137864100","article-title":"Defective importin \u03b2 recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations","volume":"100","author":"Harley","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.597526_bib98","series-title":"The Perfect Storm: A True Story of Men Against the Sea","author":"Junger","year":"1997"},{"key":"10.1074\/jbc.M114.597526_bib99","doi-asserted-by":"crossref","first-page":"e17751","DOI":"10.1371\/journal.pone.0017751","article-title":"Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9, and SF1 mutations","volume":"6","author":"Knower","year":"2011","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820474472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820474472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.597526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T23:39:23Z","timestamp":1717371563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820474472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":99,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0021925820474472"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.597526","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}