{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:23:36Z","timestamp":1781065416778,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"51","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":2144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS040408"],"award-info":[{"award-number":["NS040408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS066404"],"award-info":[{"award-number":["NS066404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1074\/jbc.m114.597575","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T06:09:12Z","timestamp":1413871752000},"page":"35409-35420","source":"Crossref","is-referenced-by-count":13,"title":["JAZ (Znf346), a SIRT1-interacting Protein, Protects Neurons by Stimulating p21 (WAF\/CIP1) Protein Expression"],"prefix":"10.1016","volume":"289","author":[{"given":"Sathi","family":"Mallick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh R.","family":"D'Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.597575_bib1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/emmm.201302451","article-title":"SIRT1 and SIRT2: emerging targets in neurodegeneration","volume":"5","author":"Donmez","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1074\/jbc.M114.597575_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tips.2012.05.007","article-title":"The neurobiology of sirtuins and their role in neurodegeneration","volume":"33","author":"Donmez","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M114.597575_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s40263-013-0055-0","article-title":"Targeting sirtuin-1 in Huntington's disease: rationale and current status","volume":"27","author":"Duan","year":"2013","journal-title":"CNS Drugs."},{"key":"10.1074\/jbc.M114.597575_bib4","doi-asserted-by":"crossref","first-page":"e4090","DOI":"10.1371\/journal.pone.0004090","article-title":"Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity","volume":"3","author":"Pfister","year":"2008","journal-title":"PLoS One."},{"key":"10.1074\/jbc.M114.597575_bib5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molcel.2011.07.038","article-title":"Peptide switch is essential for Sirt1 deacetylase activity","volume":"44","author":"Kang","year":"2011","journal-title":"Mol. Cell."},{"key":"10.1074\/jbc.M114.597575_bib6","doi-asserted-by":"crossref","first-page":"27399","DOI":"10.1074\/jbc.274.39.27399","article-title":"JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization","volume":"274","author":"Yang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M114.597575_bib7","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1128\/MCB.24.15.6608-6619.2004","article-title":"Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5","volume":"24","author":"Chen","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M114.597575_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1997.1177","article-title":"A Xenopus zinc finger protein that specifically binds dsRNA and RNA-DNA hybrids","volume":"271","author":"Finerty","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M114.597575_bib9","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1182\/blood-2006-06-029645","article-title":"JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity","volume":"108","author":"Yang","year":"2006","journal-title":"Blood."},{"key":"10.1074\/jbc.M114.597575_bib10","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4161\/cc.10.14.16587","article-title":"JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1","volume":"10","author":"Yang","year":"2011","journal-title":"Cell Cycle."},{"key":"10.1074\/jbc.M114.597575_bib11","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1073\/pnas.90.23.10989","article-title":"Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP","volume":"90","author":"D'Mello","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M114.597575_bib12","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1523\/JNEUROSCI.5704-10.2011","article-title":"Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3\u03b2","volume":"31","author":"Bardai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1523\/JNEUROSCI.2897-10.2011","article-title":"FoxG1 promotes the survival of postmitotic neurons","volume":"31","author":"Dastidar","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1523\/JNEUROSCI.3039-13.2014","article-title":"HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism","volume":"34","author":"Verma","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1523\/JNEUROSCI.3200-07.2008","article-title":"Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1\/cip1) in cell cycle-independent neuroprotection","volume":"28","author":"Langley","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib16","doi-asserted-by":"crossref","first-page":"17385","DOI":"10.1073\/pnas.1003996107","article-title":"Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway","volume":"107","author":"Haskew-Layton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M114.597575_bib17","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1523\/JNEUROSCI.14-07-04385.1994","article-title":"Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione","volume":"14","author":"Ratan","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib18","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/dneu.20637","article-title":"HDAC4 inhibits cell-cycle progression and protects neurons from cell death","volume":"68","author":"Majdzadeh","year":"2008","journal-title":"Dev. Neurobiol."},{"key":"10.1074\/jbc.M114.597575_bib19","doi-asserted-by":"crossref","first-page":"28623","DOI":"10.1074\/jbc.270.48.28623","article-title":"Functional analysis of the transforming growth factor \u03b2 responsive elements in the WAF1\/Cip1\/p21 promoter","volume":"270","author":"Datto","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M114.597575_bib20","doi-asserted-by":"crossref","first-page":"11258","DOI":"10.1074\/jbc.M109.073932","article-title":"Transcriptional regulation of p21\/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression","volume":"285","author":"Schaefer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M114.597575_bib21","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/nn.3460","article-title":"SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons","volume":"16","author":"Dobbin","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.mam.2007.02.001","article-title":"SIRT1 and neuronal diseases","volume":"29","author":"Tang","year":"2008","journal-title":"Mol. Aspects Med."},{"key":"10.1074\/jbc.M114.597575_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets","volume":"18","author":"Jiang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M114.597575_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-2236(00)01663-5","article-title":"Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?","volume":"24","author":"Copani","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2003.12.005","article-title":"Cell cycle regulation of neuronal apoptosis in development and disease","volume":"72","author":"Becker","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"10.1074\/jbc.M114.597575_bib26","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.0500989102","article-title":"Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury","volume":"102","author":"Di Giovanni","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M114.597575_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s13311-011-0095-4","article-title":"CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury","volume":"9","author":"Kabadi","year":"2012","journal-title":"Neurotherapeutics."},{"key":"10.1074\/jbc.M114.597575_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2006.01.120","article-title":"p21Cip1\/WAF1 regulates radial axon growth and enhances motor functional recovery in the injured peripheral nervous system","volume":"1081","author":"Tomita","year":"2006","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M114.597575_bib29","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1523\/JNEUROSCI.5110-06.2007","article-title":"Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1\/Cip1) as a novel mechanism of neuroprotection by glucocorticoids","volume":"27","author":"Harms","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M114.597575_bib30","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/MCB.16.4.1335","article-title":"The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells","volume":"16","author":"Poluha","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M114.597575_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/jcbfm.2012.213","article-title":"A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1\/CIP1)) for neuronal preconditioning","volume":"33","author":"Mergenthaler","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1074\/jbc.M114.597575_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2012.08.016","article-title":"A screen for inducers of p21(waf1\/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties","volume":"49","author":"Ma","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M114.597575_bib33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<134::AID-PATH960>3.0.CO;2-D","article-title":"Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1\/WAF1\/Sdi1","volume":"183","author":"Cox","year":"1997","journal-title":"J. Pathol."},{"key":"10.1074\/jbc.M114.597575_bib34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3181\/00379727-213-44046","article-title":"P21\u2013negative regulator of the cell cycle","volume":"213","author":"Gartel","year":"1996","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1074\/jbc.M114.597575_bib35","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/bi401675h","article-title":"Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids","volume":"53","author":"Burge","year":"2014","journal-title":"Biochemistry."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819560756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819560756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.597575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T22:10:58Z","timestamp":1641161458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819560756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":35,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0021925819560756"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.597575","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}