{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:29:19Z","timestamp":1780108159728,"version":"3.54.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":2135,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1074\/jbc.m114.599944","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:19:49Z","timestamp":1414714789000},"page":"36194-36203","source":"Crossref","is-referenced-by-count":37,"title":["Heparan Sulfate Inhibits Hematopoietic Stem and Progenitor Cell Migration and Engraftment in Mucopolysaccharidosis I"],"prefix":"10.1016","volume":"289","author":[{"given":"H. Angharad","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Holley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kia J.","family":"Langford-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona L.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toin H.","family":"van Kuppevelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Edmond","family":"Wraith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.R.","family":"Merry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Bigger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.599944_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1542\/peds.2008-0416","article-title":"Mucopolysaccharidosis I: Management and Treatment Guidelines","volume":"123","author":"Muenzer","year":"2009","journal-title":"Pediatrics"},{"key":"10.1074\/jbc.M114.599944_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1517\/14656566.6.3.489","article-title":"The first 5 years of clinical experience with laronidase enzyme replacement therapy for mucopolysaccharidosis I","volume":"6","author":"Wraith","year":"2005","journal-title":"Expert Opin. Pharmacother"},{"key":"10.1074\/jbc.M114.599944_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10545-006-0239-6","article-title":"Limitations of enzyme replacement therapy: current and future","volume":"29","author":"Wraith","year":"2006","journal-title":"J. Inherit. Metab. Dis"},{"key":"10.1074\/jbc.M114.599944_bib4","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/mt.2013.29","article-title":"Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation","volume":"21","author":"Wilkinson","year":"2013","journal-title":"Molecular Therapy"},{"key":"10.1074\/jbc.M114.599944_bib5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbmt.2009.01.020","article-title":"Risk factor analysis of outcomes after unrelated cord blood transplantation in patients with hurler syndrome","volume":"15","author":"Boelens","year":"2009","journal-title":"Biol. Blood Marrow Transplant"},{"key":"10.1074\/jbc.M114.599944_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.bmt.1705718","article-title":"Outcomes of hematopoietic stem cell transplantation for Hurler's syndrome in Europe: a risk factor analysis for graft failure","volume":"40","author":"Boelens","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1074\/jbc.M114.599944_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jpeds.2008.11.005","article-title":"Improved metabolic correction in patients with lysosomal storage disease treated with hematopoietic stem cell transplant compared with enzyme replacement therapy","volume":"154","author":"Wynn","year":"2009","journal-title":"J. Pediatr"},{"key":"10.1074\/jbc.M114.599944_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10545-012-9538-2","article-title":"Plasma and urinary levels of dermatan sulfate and heparan sulfate derived disaccharides after long-term enzyme replacement therapy (ERT) in MPS I: correlation with the timing of ERT and with total urinary excretion of glycosaminoglycans","volume":"36","author":"de Ru","year":"2013","journal-title":"J. Inherited Metabolic Disease"},{"key":"10.1074\/jbc.M114.599944_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/glycob\/cwh049","article-title":"Glycosaminoglycan degradation fragments in mucopolysaccharidosis I","volume":"14","author":"Fuller","year":"2004","journal-title":"Glycobiology"},{"key":"10.1074\/jbc.M114.599944_bib10","doi-asserted-by":"crossref","first-page":"37515","DOI":"10.1074\/jbc.M111.287474","article-title":"Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking \u03b1-l-iduronidase","volume":"286","author":"Holley","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib11","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1074\/jbc.M608796200","article-title":"Structural and functional basis of CXCL12 (stromal cell-derived factor-1\u03b1) binding to heparin","volume":"282","author":"Murphy","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1189\/jlb.72.2.353","article-title":"Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells","volume":"72","author":"Netelenbos","year":"2002","journal-title":"J. Leukocyte Biol"},{"key":"10.1074\/jbc.M114.599944_bib13","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1073\/pnas.0334864100","article-title":"Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines","volume":"100","author":"Proudfoot","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.599944_bib14","doi-asserted-by":"crossref","first-page":"12959","DOI":"10.1021\/bi990711d","article-title":"Glycosaminoglycans Interact Selectively with Chemokines and Modulate Receptor Binding and Cellular Responses","volume":"38","author":"Kuschert","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.599944_bib15","doi-asserted-by":"crossref","first-page":"18455","DOI":"10.1074\/jbc.274.26.18455","article-title":"Highly sensitive sequencing of the sulfated domains of heparan sulfate","volume":"274","author":"Merry","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.20011284","article-title":"Hematopoietic stem cells are uniquely selective in their migratory response to chemokines","volume":"195","author":"Wright","year":"2002","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M114.599944_bib17","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"10","author":"Ceradini","year":"2004","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M114.599944_bib18","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1172\/JCI10329","article-title":"Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function","volume":"106","author":"Ponomaryov","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.599944_bib19","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1096\/fj.09-134643","article-title":"Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12","volume":"23","author":"O'Boyle","year":"2009","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.599944_bib20","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.1074\/jbc.M008110200","article-title":"Characterization of the stromal cell-derived factor-1\u03b1-heparin complex","volume":"276","author":"Sadir","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/6.4.503","article-title":"Murine mucopolysaccharidosis type I: targeted disruption of the murine \u03b1-L-iduronidase gene","volume":"6","author":"Clarke","year":"1997","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M114.599944_bib22","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/mt.2012.82","article-title":"Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice","volume":"20","author":"Langford-Smith","year":"2012","journal-title":"Molecular Therapy"},{"key":"10.1074\/jbc.M114.599944_bib23","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/mt.2013.141","article-title":"Myeloid\/Microglial Driven Autologous Hematopoietic Stem Cell Gene Therapy Corrects a Neuronopathic Lysosomal Disease","volume":"21","author":"Sergijenko","year":"2013","journal-title":"Molecular Therapy"},{"key":"10.1074\/jbc.M114.599944_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ymthe.2005.01.022","article-title":"Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells","volume":"12","author":"Siapati","year":"2005","journal-title":"Molecular Therapy"},{"key":"10.1074\/jbc.M114.599944_bib25","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M114.599944_bib26","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1634\/stemcells.2008-0311","article-title":"A developmentally regulated heparan sulfate epitope defines a subpopulation with increased blood potential during mesodermal differentiation","volume":"26","author":"Baldwin","year":"2008","journal-title":"Stem cells"},{"key":"10.1074\/jbc.M114.599944_bib27","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1634\/stemcells.2006-0445","article-title":"Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells","volume":"25","author":"Johnson","year":"2007","journal-title":"Stem Cells"},{"key":"10.1074\/jbc.M114.599944_bib28","doi-asserted-by":"crossref","first-page":"e35787","DOI":"10.1371\/journal.pone.0035787","article-title":"Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB","volume":"7","author":"Wilkinson","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.599944_bib29","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s10545-005-0136-4","article-title":"Marrow stromal cells from patients affected by MPS I differentially support haematopoietic progenitor cell development","volume":"28","author":"Baxter","year":"2005","journal-title":"J. Inherit. Metab. Dis"},{"key":"10.1074\/jbc.M114.599944_bib30","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.exphem.2009.06.005","article-title":"Glycosaminoglycan mimetics-induced mobilization of hematopoietic progenitors and stem cells into mouse peripheral blood: structure\/function insights","volume":"37","author":"Albanese","year":"2009","journal-title":"Exp. Hematol"},{"key":"10.1074\/jbc.M114.599944_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1749-6632.2001.tb03573.x","article-title":"Increase in circulating SDF-1 after treatment with sulfated glycans. The role of SDF-1 in mobilization","volume":"938","author":"Sweeney","year":"2001","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.M114.599944_bib32","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1100\/tsw.2006.83","article-title":"Impairment of the activity of glycosaminoglycan-binding cytokines by functionally abnormal heparan sulfates: a novel mechanism underlying disease pathophysiology","volume":"6","author":"Gupta","year":"2006","journal-title":"Scientific World Journal"},{"key":"10.1074\/jbc.M114.599944_bib33","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1152\/ajpcell.00346.2007","article-title":"Endogenous Heparan Sulfate and Heparin Modulate Bone Morphogenetic Protein-4 (BMP-4) Signaling And Activity","volume":"294","author":"Khan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M114.599944_bib34","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1182\/blood-2005-02-0657","article-title":"Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells","volume":"106","author":"Pan","year":"2005","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.599944_bib35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/glycob\/cwn028","article-title":"A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin\/dermatan sulfates from biological samples","volume":"18","author":"Deakin","year":"2008","journal-title":"Glycobiology"},{"key":"10.1074\/jbc.M114.599944_bib36","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1681\/ASN.2004050413","article-title":"Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies","volume":"16","author":"Lensen","year":"2005","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M114.599944_bib37","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1074\/jbc.M506357200","article-title":"3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3","volume":"281","author":"Ten Dam","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib38","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1074\/jbc.273.21.12960","article-title":"Generation and Application of Type-specific Anti-Heparan Sulfate Antibodies Using Phage Display Technology. Further Evidence for Heparan Sulfate Heterogeneity in the Kidney","volume":"273","author":"van Kuppevelt","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.599944_bib39","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3324\/haematol.2011.058644","article-title":"Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler's syndrome after pharmacological enzyme replacement therapy","volume":"97","author":"Saif","year":"2012","journal-title":"Haematologica"},{"key":"10.1074\/jbc.M114.599944_bib40","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.119.4.961","article-title":"Developmental changes in heparan sulfate expression: in situ detection with mAbs","volume":"119","author":"David","year":"1992","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M114.599944_bib41","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.2353\/ajpath.2009.090211","article-title":"Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities","volume":"175","author":"Wilson","year":"2009","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M114.599944_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nchembio.766","article-title":"Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses","volume":"8","author":"Lawrence","year":"2012","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.M114.599944_bib43","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1161\/CIRCULATIONAHA.112.113290","article-title":"Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12\/proteoglycan interactions","volume":"126","author":"Rueda","year":"2012","journal-title":"Circulation"},{"key":"10.1074\/jbc.M114.599944_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ymgme.2009.10.175","article-title":"Evaluation of heparin cofactor II-thrombin complex as a biomarker on blood spots from mucopolysaccharidosis I, IIIA and IIIB mice","volume":"99","author":"Langford-Smith","year":"2010","journal-title":"Molecular Genetics Metabolism"},{"key":"10.1074\/jbc.M114.599944_bib45","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10545-010-9254-8","article-title":"Heparin cofactor II-thrombin complex and dermatan sulphate:chondroitin sulphate ratio are biomarkers of short- and long-term treatment effects in mucopolysaccharide diseases","volume":"34","author":"Langford-Smith","year":"2011","journal-title":"J. Inherited Metab. Dis"},{"key":"10.1074\/jbc.M114.599944_bib46","doi-asserted-by":"crossref","first-page":"e77632","DOI":"10.1371\/journal.pone.0077632","article-title":"Signal One and Two Blockade Are Both Critical for Non-Myeloablative Murine HSCT across a Major Histocompatibility Complex Barrier","volume":"8","author":"Langford-Smith","year":"2013","journal-title":"PloS one"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820580083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820580083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.599944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T18:37:28Z","timestamp":1689619048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820580083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":46,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0021925820580083"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.599944","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}