{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:12:52Z","timestamp":1790233972065,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":1996,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K08HL097071"],"award-info":[{"award-number":["K08HL097071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL51670"],"award-info":[{"award-number":["HL51670"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL091842"],"award-info":[{"award-number":["HL091842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1074\/jbc.m114.611616","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T01:42:29Z","timestamp":1429321349000},"page":"14140-14153","source":"Crossref","is-referenced-by-count":8,"title":["Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia"],"prefix":"10.1016","volume":"290","author":[{"given":"Qian","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda S.","family":"Ostedgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viral S.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Ver Heul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph O.","family":"Randak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.611616_bib1","series-title":"ABC Proteins from Bacteria to Man","first-page":"589","article-title":"The cystic fibrosis transmembrane conductance regulator (ABCC7)","author":"Hanrahan","year":"2003"},{"key":"10.1074\/jbc.M114.611616_bib2","doi-asserted-by":"crossref","first-page":"a009498","DOI":"10.1101\/cshperspect.a009498","article-title":"The CFTR ion channel: gating, regulation, and anion permeation","volume":"3","author":"Hwang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.M114.611616_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biocel.2014.02.004","article-title":"CFTR structure and cystic fibrosis","volume":"52","author":"Cant","year":"2014","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.M114.611616_bib4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/j.1460-2075.1982.tb01276.x","article-title":"Distantly related sequences in the \u03b1- and \u03b2-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold","volume":"1","author":"Walker","year":"1982","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.611616_bib5","doi-asserted-by":"crossref","first-page":"18714","DOI":"10.1016\/S0021-9258(18)55121-8","article-title":"Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations","volume":"266","author":"Shyamala","year":"1991","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib6","first-page":"1","article-title":"Traffic ATPases: a superfamily of transport proteins operating from Escherichia coli to humans","volume":"65","author":"Ames","year":"1992","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1023\/A:1022443209010","article-title":"Modeling of nucleotide binding domains of ABC transporter proteins based on a F1-ATPase\/recA topology: structural model of the necleotide binding domains of the cystic fibrosis transmembrane conductance regulator (CFTR)","volume":"29","author":"Bianchet","year":"1997","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1074\/jbc.M114.611616_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/MMBR.00031-07","article-title":"Structure, function, and evolution of bacterial ATP-binding cassette systems","volume":"72","author":"Davidson","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"10.1074\/jbc.M114.611616_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0969-2126(01)00617-7","article-title":"Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter","volume":"9","author":"Karpowich","year":"2001","journal-title":"Structure"},{"key":"10.1074\/jbc.M114.611616_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1097-2765(02)00576-2","article-title":"ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer","volume":"10","author":"Smith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.611616_bib11","doi-asserted-by":"crossref","first-page":"15152","DOI":"10.1073\/pnas.1108858108","article-title":"Snapshots of the maltose transporter during ATP hydrolysis","volume":"108","author":"Oldham","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/25393","article-title":"Crystal structure of the ATP-binding subunit of an ABC transporter","volume":"396","author":"Hung","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.611616_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(00)80890-9","article-title":"Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily","volume":"101","author":"Hopfner","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.molcel.2003.08.004","article-title":"A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle","volume":"12","author":"Chen","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.611616_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(03)00983-8","article-title":"An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR","volume":"115","author":"Randak","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib16","doi-asserted-by":"crossref","first-page":"36105","DOI":"10.1074\/jbc.M112.408450","article-title":"Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity","volume":"287","author":"Randak","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib17","doi-asserted-by":"crossref","first-page":"27692","DOI":"10.1074\/jbc.M113.479675","article-title":"ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites","volume":"288","author":"Randak","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.molcel.2007.01.028","article-title":"Rad50 adenylate kinase activity regulates DNA tethering by Mre11\/Rad50 complexes","volume":"25","author":"Bhaskara","year":"2007","journal-title":"Mol Cell"},{"key":"10.1074\/jbc.M114.611616_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jmb.2010.06.029","article-title":"Structural basis for adenylate kinase activity in ABC ATPases","volume":"401","author":"Lammens","year":"2010","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib20","series-title":"The Enzymes","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1874-6047(08)60068-2","article-title":"Adenylate kinase","author":"Noda","year":"1973"},{"key":"10.1074\/jbc.M114.611616_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1039\/fd9929300085","article-title":"Induced-fit movements in adenylate kinases","volume":"93","author":"Schulz","year":"1992","journal-title":"Faraday Discuss"},{"key":"10.1074\/jbc.M114.611616_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/prot.340190304","article-title":"The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP","volume":"19","author":"Berry","year":"1994","journal-title":"Proteins"},{"key":"10.1074\/jbc.M114.611616_bib23","first-page":"103","article-title":"Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity","volume":"73","author":"Yan","year":"1999","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature04712","article-title":"The ABC protein turned chloride channel whose failure causes cystic fibrosis","volume":"440","author":"Gadsby","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.611616_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00424-006-0140-z","article-title":"CFTR (ABCC7) is a hydrolyzable-ligand-gated channel","volume":"453","author":"Aleksandrov","year":"2007","journal-title":"Pflugers Arch"},{"key":"10.1074\/jbc.M114.611616_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.abb.2008.03.033","article-title":"Molecular basis for the ATPase activity of CFTR","volume":"476","author":"Cheung","year":"2008","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M114.611616_bib27","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1113\/jphysiol.2009.171595","article-title":"Gating of the CFTR Cl\u2212 channel by ATP-driven nucleotide-binding domain dimerisation","volume":"587","author":"Hwang","year":"2009","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0021-9258(19)44380-9","article-title":"P1,P5-di(adenosine-5\u2032)pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase","volume":"248","author":"Lienhard","year":"1973","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0022-2836(92)90582-5","article-title":"Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 \u00c5 resolution. A model for a catalytic transition state","volume":"224","author":"M\u00fcller","year":"1992","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/jmbi.2000.4379","article-title":"Crystal structure of the SMC head domain: an ABC ATPase with 900 residues antiparallel coiled-coil inserted","volume":"306","author":"L\u00f6we","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/347382a0","article-title":"Expression and characterization of the cystic fibrosis transmembrane conductance regulator","volume":"347","author":"Gregory","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.611616_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0892-321","article-title":"Mislocalization of \u0394F508 CFTR in cystic fibrosis sweat gland","volume":"1","author":"Kartner","year":"1992","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M114.611616_bib33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jmb.2006.10.086","article-title":"Domain interdependence in the biosynthetic assembly of CFTR","volume":"365","author":"Cui","year":"2007","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1053\/j.gastro.2003.10.049","article-title":"The \u0394F508 mutation results in loss of CFTR function and mature protein in native human colon","volume":"126","author":"Mall","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M114.611616_bib35","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(90)90148-8","article-title":"Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis","volume":"63","author":"Cheng","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib36","doi-asserted-by":"crossref","first-page":"26142","DOI":"10.1016\/S0021-9258(18)35728-4","article-title":"Partial purification of the cystic fibrosis transmembrane conductance regulator","volume":"267","author":"Ostedgaard","year":"1992","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib37","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1529\/biophysj.108.140897","article-title":"A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating","volume":"95","author":"Dong","year":"2008","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M114.611616_bib38","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1073\/pnas.1120065109","article-title":"Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-\u0394F508 processing and alter its gating defect","volume":"109","author":"Dong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib39","doi-asserted-by":"crossref","first-page":"15370","DOI":"10.1073\/pnas.0706974104","article-title":"Processing and function of CFTR-\u0394F508 are species-dependent","volume":"104","author":"Ostedgaard","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib40","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1074\/jbc.270.4.1711","article-title":"The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity","volume":"270","author":"Carson","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib41","doi-asserted-by":"crossref","first-page":"31873","DOI":"10.1074\/jbc.273.48.31873","article-title":"Covalent modification of the nucleotide binding domains of cystic fibrosis transmembrane conductance regulator","volume":"273","author":"Cotten","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib42","series-title":"Epithelial Cell Culture Protocols","first-page":"115","article-title":"An in vitro model of differentiated human airway epithelia: methods and evaluation of primary cultures","author":"Karp","year":"2002"},{"key":"10.1074\/jbc.M114.611616_bib43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1097-2765(00)80284-1","article-title":"Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro","volume":"2","author":"Zabner","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.611616_bib44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cell.2010.11.029","article-title":"Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia","volume":"143","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/jbc.M114.611616_bib46","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1073\/pnas.261714599","article-title":"CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo","volume":"99","author":"Ostedgaard","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(95)90310-0","article-title":"Conformational states of CFTR associated with channel gating: the role of ATP binding and hydrolysis","volume":"82","author":"Gunderson","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1073\/pnas.0408575102","article-title":"Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain","volume":"102","author":"Berger","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib49","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1073\/pnas.91.11.4698","article-title":"Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis","volume":"91","author":"Hwang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib50","doi-asserted-by":"crossref","first-page":"19349","DOI":"10.1016\/S0021-9258(17)32174-9","article-title":"Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating","volume":"269","author":"Gunderson","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s002329900370","article-title":"The CFTR chloride channel: nucleotide interactions and temperature-dependent gating","volume":"163","author":"Mathews","year":"1998","journal-title":"J. Membr. Biol"},{"key":"10.1074\/jbc.M114.611616_bib52","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1074\/jbc.M109539200","article-title":"Mutations that change the position of the putative \u03b3-phosphate linker in the nucleotide binding domains of CFTR alter channel gating","volume":"277","author":"Berger","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib53","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10863-007-9119-5","article-title":"Role of CFTR's intrinsic adenylate kinase activity in gating of the Cl\u2212 channel","volume":"39","author":"Randak","year":"2007","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1074\/jbc.M114.611616_bib54","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0076-6879(83)91054-6","article-title":"Photoaffinity labeling of nucleotide binding sites with 8-azidopurine analogs: techniques and applications","volume":"91","author":"Potter","year":"1983","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M114.611616_bib55","doi-asserted-by":"crossref","first-page":"11241","DOI":"10.1021\/bi050859z","article-title":"Photoaffinity labeling with 8-azidoadenosine and its derivatives: chemistry of closed and opened adenosine diazaquinodimethanes","volume":"44","author":"Polshakov","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.611616_bib56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0092-8674(91)90072-7","article-title":"Nucleoside triphosphates are required to open the CFTR chloride channel","volume":"67","author":"Anderson","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib57","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1126\/science.1382316","article-title":"Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains","volume":"257","author":"Anderson","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M114.611616_bib58","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0092-8674(94)90385-9","article-title":"The amino-terminal portion of CFTR forms a regulated Cl\u2212 channel","volume":"76","author":"Sheppard","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.611616_bib59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1085\/jgp.105.3.329","article-title":"Regulation of CFTR Cl\u2212 channel gating by ADP and ATP analogues","volume":"105","author":"Schultz","year":"1995","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1085\/jgp.114.1.55","article-title":"Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites","volume":"114","author":"Weinreich","year":"1999","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib61","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1085\/jgp.200409227","article-title":"CFTR gating I: characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (\u0394R-CFTR)","volume":"125","author":"Bompadre","year":"2005","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib62","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1073\/pnas.0409787102","article-title":"ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity","volume":"102","author":"Randak","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib63","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1074\/jbc.M107128200","article-title":"The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart","volume":"277","author":"Frederich","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib64","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.1074\/jbc.274.19.13281","article-title":"Glucose generates sub-plasma membrane ATP microdomains in single islet \u03b2-cells","volume":"274","author":"Kennedy","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib65","first-page":"95","article-title":"Variations of adenine nucleotide levels in normal and pathologic human erythrocytes exposed to oxidattive stress","volume":"32","author":"Bozzi","year":"1994","journal-title":"Biochem. Mol. Biol. Int"},{"key":"10.1074\/jbc.M114.611616_bib66","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0167-4889(87)90134-0","article-title":"Glucose-induced changes in cytosolic ATP content in pancreatic islets","volume":"927","author":"Malaisse","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.611616_bib67","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1074\/jbc.271.28.16544","article-title":"Suppression of adenylate kinase catalyzed phosphotransfer precedes and is associated with glucose-induced insulin secretion in intact HIT-T15 cells","volume":"271","author":"Olson","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib68","doi-asserted-by":"crossref","first-page":"H776","DOI":"10.1152\/ajpheart.00116.2002","article-title":"Adenylate kinase AK1 knockout heart: energetics and functional performance under ischemia-reperfusion","volume":"283","author":"Pucar","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib69","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1074\/jbc.270.13.7311","article-title":"Adenylate kinase-catalyzed phosphoryl transfer couples ATP utilization with its generation by glycolysis in intact muscle","volume":"270","author":"Zeleznikar","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib70","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1085\/jgp.200409059","article-title":"Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy","volume":"124","author":"Muanprasat","year":"2004","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.611616_bib71","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.cub.2004.09.044","article-title":"Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases","volume":"14","author":"Lammens","year":"2004","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.M114.611616_bib72","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/bi0518592","article-title":"Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5\u2032-ATP, Ap3A, Ap4A, and Ap5A","volume":"45","author":"Baker","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.611616_bib73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0006-291X(02)02800-0","article-title":"Inhibition of mammalian ribonucleases by endogenous adenosine dinucleotides","volume":"300","author":"Kumar","year":"2003","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.611616_bib74","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1071142","article-title":"The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism","volume":"296","author":"Locher","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M114.611616_bib75","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1096\/fj.13-245639","article-title":"The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle","volume":"28","author":"Zolnerciks","year":"2014","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.611616_bib76","doi-asserted-by":"crossref","first-page":"11921","DOI":"10.1021\/bi001220s","article-title":"Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein","volume":"39","author":"Urbatsch","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.611616_bib77","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.bbamem.2011.02.004","article-title":"Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor","volume":"1808","author":"Yang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.611616_bib78","doi-asserted-by":"crossref","first-page":"14138","DOI":"10.1021\/bi001128w","article-title":"Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein","volume":"39","author":"Urbatsch","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.611616_bib79","doi-asserted-by":"crossref","first-page":"21111","DOI":"10.1074\/jbc.C200228200","article-title":"Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters","volume":"277","author":"Moody","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib80","doi-asserted-by":"crossref","first-page":"26862","DOI":"10.1074\/jbc.M301227200","article-title":"The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p","volume":"278","author":"Janas","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.611616_bib81","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nature03313","article-title":"CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains","volume":"433","author":"Vergani","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.611616_bib82","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1073\/pnas.0407459102","article-title":"The crystal structure of human adenylate kinase 6: an adenylate kinase localized to the cell nucleus","volume":"102","author":"Ren","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.611616_bib83","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/prot.23186","article-title":"hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies","volume":"80","author":"Drakou","year":"2012","journal-title":"Proteins"},{"key":"10.1074\/jbc.M114.611616_bib84","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00211022","article-title":"Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients","volume":"94","author":"D\u00f6rk","year":"1994","journal-title":"Hum. Genet"},{"key":"10.1074\/jbc.M114.611616_bib85","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/jmbi.1994.0104","article-title":"Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase","volume":"246","author":"M\u00fcller-Dieckmann","year":"1995","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.611616_bib86","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.1021\/bi960642s","article-title":"Crystal structure of the complex of UMP\/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5\u2032-adenosyl) P5-(5\u2032-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 \u00c5: implications for water-mediated specificity","volume":"35","author":"Scheffzek","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.611616_bib87","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1002\/j.1460-2075.1994.tb06954.x","article-title":"Conformational maturation of CFTR but not its mutant counterpart (\u0394F508) occurs in the endoplasmic reticulum and requires ATP","volume":"13","author":"Lukacs","year":"1994","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.611616_bib88","doi-asserted-by":"crossref","first-page":"25710","DOI":"10.1016\/S0021-9258(18)47306-1","article-title":"Intracellular turnover of cystic fibrosis transmembrane conductance regulator: inefficient processing and rapid degradation of wild-type and mutant proteins","volume":"269","author":"Ward","year":"1994","journal-title":"J. Biol. Chem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581880919X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581880919X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.611616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T03:03:42Z","timestamp":1641092622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192581880919X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":88,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S002192581880919X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.611616","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}