{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:05:43Z","timestamp":1771304743727,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":1996,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1074\/jbc.m114.626697","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T03:26:38Z","timestamp":1429673198000},"page":"14181-14191","source":"Crossref","is-referenced-by-count":7,"title":["Non-germ Line Restoration of Genomic Imprinting for a Small Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem Cells"],"prefix":"10.1016","volume":"290","author":[{"given":"Shankang","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pishun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieliu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiemin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.626697_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrg3032","article-title":"Genomic imprinting: the emergence of an epigenetic paradigm","volume":"12","author":"Ferguson-Smith","year":"2011","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M114.626697_bib2","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1242\/dev.101428","article-title":"Genomic imprinting in development, growth, behavior and stem cells","volume":"141","author":"Plasschaert","year":"2014","journal-title":"Development"},{"key":"10.1074\/jbc.M114.626697_bib3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00335-009-9229-y","article-title":"Imprinting evolution and human health","volume":"20","author":"Das","year":"2009","journal-title":"Mamm. Genome"},{"key":"10.1074\/jbc.M114.626697_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-genom-091212-153441","article-title":"Phenotypic outcomes of imprinted gene models in mice: elucidation of pre- and postnatal functions of imprinted genes","volume":"15","author":"Cleaton","year":"2014","journal-title":"Annu. Rev. Genomics Hum. Genet"},{"key":"10.1074\/jbc.M114.626697_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ccr.2005.09.007","article-title":"Global loss of imprinting leads to widespread tumorigenesis in adult mice","volume":"8","author":"Holm","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M114.626697_bib6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/cr.2011.15","article-title":"Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming","volume":"21","author":"Li","year":"2011","journal-title":"Cell Res"},{"key":"10.1074\/jbc.M114.626697_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/362751a0","article-title":"Parental-origin-specific epigenetic modification of the mouse H19 gene","volume":"362","author":"Ferguson-Smith","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib8","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/dev.121.12.4195","article-title":"Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos","volume":"121","author":"Sasaki","year":"1995","journal-title":"Development"},{"key":"10.1074\/jbc.M114.626697_bib9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02633","article-title":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting","volume":"429","author":"Kaneda","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2443.2009.01374.x","article-title":"Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation","volume":"15","author":"Kaneda","year":"2010","journal-title":"Genes Cell"},{"key":"10.1074\/jbc.M114.626697_bib11","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1093\/hmg\/ddm179","article-title":"Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse","volume":"16","author":"Kato","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M114.626697_bib12","doi-asserted-by":"crossref","first-page":"e1003873","DOI":"10.1371\/journal.pgen.1003873","article-title":"Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females","volume":"9","author":"McGraw","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.M114.626697_bib13","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1101\/gad.1667008","article-title":"Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development","volume":"22","author":"Hirasawa","year":"2008","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M114.626697_bib14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.devcel.2008.08.014","article-title":"A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints","volume":"15","author":"Li","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M114.626697_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.molcel.2011.08.032","article-title":"In embryonic stem cells, ZFP57\/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions","volume":"44","author":"Quenneville","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M114.626697_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ncb1519","article-title":"PGC7\/Stella protects against DNA demethylation in early embryogenesis","volume":"9","author":"Nakamura","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M114.626697_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature11093","article-title":"PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos","volume":"486","author":"Nakamura","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gad.10.8.1008","article-title":"Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes","volume":"10","author":"Tucker","year":"1996","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M114.626697_bib19","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1101\/gad.1841409","article-title":"Genomic imprinting: employing and avoiding epigenetic processes","volume":"23","author":"Bartolomei","year":"2009","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M114.626697_bib20","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/sj.emboj.7601513","article-title":"Differential histone modifications mark mouse imprinting control regions during spermatogenesis","volume":"26","author":"Delaval","year":"2007","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.626697_bib21","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/emboj.2011.425","article-title":"Transcription and histone methylation changes correlate with imprint acquisition in male germ cells","volume":"31","author":"Henckel","year":"2012","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.626697_bib22","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1093\/emboj\/cdf655","article-title":"Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes","volume":"21","author":"Fournier","year":"2002","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.626697_bib23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ygeno.2006.10.005","article-title":"Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain","volume":"89","author":"Carr","year":"2007","journal-title":"Genomics"},{"key":"10.1074\/jbc.M114.626697_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature08315","article-title":"KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints","volume":"461","author":"Ciccone","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib25","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.1163802","article-title":"The AIR noncoding RNA epigenetically silences transcription by targeting G9a to chromatin","volume":"322","author":"Nagano","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.M114.626697_bib26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/hmg\/ddi485","article-title":"Allele-specific deposition of macroH2A1 in imprinting control regions","volume":"15","author":"Choo","year":"2006","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M114.626697_bib27","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1038\/sj.onc.1208053","article-title":"ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain","volume":"23","author":"Unoki","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M114.626697_bib28","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M114.626697_bib29","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature06397","article-title":"The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA","volume":"450","author":"Sharif","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib30","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/ncomms2562","article-title":"UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9","volume":"4","author":"Liu","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M114.626697_bib31","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/cr.2011.176","article-title":"S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res"},{"key":"10.1074\/jbc.M114.626697_bib32","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1074\/jbc.M111.313965","article-title":"Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.626697_bib33","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/nar\/25.12.2532","article-title":"COBRA: a sensitive and quantitative DNA methylation assay","volume":"25","author":"Xiong","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M114.626697_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nature08829","article-title":"Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency","volume":"463","author":"Popp","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/oxfordjournals.jbchem.a022661","article-title":"Mechanisms of Igf2\/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation","volume":"127","author":"Sasaki","year":"2000","journal-title":"J. Biochem"},{"key":"10.1074\/jbc.M114.626697_bib36","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2144\/97225bm14","article-title":"Use of a single sequencing termination reaction to distinguish between cytosine and 5-methylcytosine in bisulfite-modified DNA","volume":"22","author":"Zhou","year":"1997","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.M114.626697_bib37","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature05987","article-title":"DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA","volume":"448","author":"Ooi","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib38","doi-asserted-by":"crossref","first-page":"22187","DOI":"10.1073\/pnas.0905767106","article-title":"The N-terminus of histone H3 is required for de novo DNA methylation in chromatin","volume":"106","author":"Hu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.626697_bib39","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/cr.2011.92","article-title":"Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase","volume":"21","author":"Li","year":"2011","journal-title":"Cell Res"},{"key":"10.1074\/jbc.M114.626697_bib40","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1101\/gad.9.17.2079","article-title":"An enhancer deletion affects both H19 and Igf2 expression","volume":"9","author":"Leighton","year":"1995","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M114.626697_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ygeno.2013.12.001","article-title":"Neuronatin gene: imprinted and misfolded: studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss","volume":"103","author":"Joseph","year":"2014","journal-title":"Genomics"},{"key":"10.1074\/jbc.M114.626697_bib42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature10229","article-title":"Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis","volume":"475","author":"Ferr\u00f3n","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.626697_bib43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/bfgp\/elq010","article-title":"Engineering mouse models to investigate the function of imprinting","volume":"9","author":"John","year":"2010","journal-title":"Brief. Funct. Genomics"},{"key":"10.1074\/jbc.M114.626697_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.devcel.2010.10.009","article-title":"Epigenetic transitions in germ cell development and meiosis","volume":"19","author":"Kota","year":"2010","journal-title":"Dev. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581880922X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581880922X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.626697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T03:03:34Z","timestamp":1641092614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192581880922X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":44,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S002192581880922X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.626697","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}