{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:38Z","timestamp":1792670858493,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1888,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AR059655"],"award-info":[{"award-number":["AR059655"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK011794"],"award-info":[{"award-number":["DK011794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK100215"],"award-info":[{"award-number":["DK100215"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1074\/jbc.m114.628313","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T02:12:54Z","timestamp":1431051174000},"page":"16744-16758","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":290,"title":["The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro"],"prefix":"10.1016","volume":"290","author":[{"given":"Jordan M.","family":"Spatz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc N.","family":"Wein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Gooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna L.","family":"Garr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Uda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forest","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dedic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Balcells-Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M.","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Babij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Divieti","family":"Pajevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.628313_bib1","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.3357\/ASEM.BR02.2009","article-title":"Skeletal effects of long-duration head-down bed rest","volume":"80","author":"Spector","year":"2009","journal-title":"Aviat. Space Environ. Med"},{"key":"10.1074\/jbc.M114.628313_bib2","first-page":"33","article-title":"Skeletal responses to space flight and the bed rest analog: a review","volume":"7","author":"LeBlanc","year":"2007","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"10.1074\/jbc.M114.628313_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jbmr.546","article-title":"Association between sclerostin and bone density in chronic spinal cord injury","volume":"27","author":"Morse","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib4","doi-asserted-by":"crossref","first-page":"A9","DOI":"10.3357\/ASEM.BR04.2009","article-title":"Dietary support of long-duration head-down bed rest","volume":"80","author":"Inniss","year":"2009","journal-title":"Aviat. Space Environ. Med"},{"key":"10.1074\/jbc.M114.628313_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1210\/jc.2012-2394","article-title":"Bariatric surgery results in cortical bone loss","volume":"98","author":"Stein","year":"2013","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.628313_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11695-010-0338-1","article-title":"Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up","volume":"21","author":"Vilarrasa","year":"2011","journal-title":"Obes. Surg"},{"key":"10.1074\/jbc.M114.628313_bib7","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/oby.2011.133","article-title":"Increased PTH and 1.25(OH)2D levels associated with increased markers of bone turnover following bariatric surgery","volume":"19","author":"Sinha","year":"2011","journal-title":"Obesity"},{"key":"10.1074\/jbc.M114.628313_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jbiomech.2009.09.016","article-title":"Boning up on Wolff's law: mechanical regulation of the cells that make and maintain bone","volume":"43","author":"Chen","year":"2010","journal-title":"J. Biomech"},{"key":"10.1074\/jbc.M114.628313_bib9","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M114.628313_bib10","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0273-1177(02)00393-9","article-title":"Ultrastructural changes in osteocytes in microgravity conditions","volume":"30","author":"Rodionova","year":"2002","journal-title":"Adv. Space Res"},{"key":"10.1074\/jbc.M114.628313_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","article-title":"Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction","volume":"5","author":"Tatsumi","year":"2007","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M114.628313_bib13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M114.628313_bib14","doi-asserted-by":"crossref","first-page":"26464","DOI":"10.1074\/jbc.M112.350108","article-title":"Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors","volume":"287","author":"Holdsworth","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib15","doi-asserted-by":"crossref","first-page":"26770","DOI":"10.1074\/jbc.M504308200","article-title":"SOST is a ligand for LRP5\/LRP6 and a Wnt signaling inhibitor","volume":"280","author":"Sem\u00ebnov","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib16","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/jbmr.161","article-title":"Sclerostin: a gem from the genome leads to bone-building antibodies","volume":"25","author":"Paszty","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib17","doi-asserted-by":"crossref","first-page":"E1736","DOI":"10.1210\/jc.2012-1579","article-title":"Serum sclerostin increases in healthy adult men during bed rest","volume":"97","author":"Spatz","year":"2012","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.628313_bib18","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/\u03b2-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.1807","article-title":"Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading","volume":"28","author":"Spatz","year":"2013","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib20","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/jbmr.1560","article-title":"Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training","volume":"27","author":"Armamento-Villareal","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib21","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1210\/jc.2010-0067","article-title":"Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss","volume":"95","author":"Gaudio","year":"2010","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.628313_bib22","doi-asserted-by":"crossref","first-page":"20880","DOI":"10.1074\/jbc.M111.231548","article-title":"Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region","volume":"286","author":"Bishop","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib23","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.3390\/nu4122047","article-title":"Space flight calcium: implications for astronaut health, spacecraft operations, and Earth","volume":"4","author":"Smith","year":"2012","journal-title":"Nutrients"},{"key":"10.1074\/jbc.M114.628313_bib24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0003-9993(99)90050-3","article-title":"Immobilization hypercalcemia treatment with pamidronate disodium after spinal cord injury","volume":"80","author":"Massagli","year":"1999","journal-title":"Arch. Phys. Med. Rehabil"},{"key":"10.1074\/jbc.M114.628313_bib25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1359\/jbmr.090730","article-title":"Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice","volume":"25","author":"Kramer","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib26","doi-asserted-by":"crossref","first-page":"e2942","DOI":"10.1371\/journal.pone.0002942","article-title":"Control of bone mass and remodeling by PTH receptor signaling in osteocytes","volume":"3","author":"O'Brien","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.628313_bib27","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1210\/jc.2011-0566","article-title":"Circulating sclerostin in disorders of parathyroid gland function","volume":"96","author":"Costa","year":"2011","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.628313_bib28","doi-asserted-by":"crossref","first-page":"E1848","DOI":"10.1210\/jc.2011-1534","article-title":"Acute decline in serum sclerostin in response to PTH infusion in healthy men","volume":"96","author":"Yu","year":"2011","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.628313_bib29","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1210\/en.2005-0239","article-title":"Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis","volume":"146","author":"Bellido","year":"2005","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M114.628313_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/JOE-10-0308","article-title":"Targeted ablation of the PTH\/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses","volume":"209","author":"Powell","year":"2011","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M114.628313_bib31","first-page":"128","article-title":"Biological underpinnings of Frost's mechanostat thresholds: the important role of osteocytes","volume":"10","author":"Hughes","year":"2010","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"10.1074\/jbc.M114.628313_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s007740050066","article-title":"Establishment and characterization of an osteocyte-like cell line, MLO-Y4","volume":"17","author":"Bonewald","year":"1999","journal-title":"J. Bone Miner. Metab"},{"key":"10.1074\/jbc.M114.628313_bib33","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbmr.465","article-title":"Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo","volume":"26","author":"Woo","year":"2011","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.bone.2011.08.016","article-title":"Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 element","volume":"49","author":"Yu","year":"2011","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib35","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/blood-2012-06-437160","article-title":"Myelopoiesis is regulated by osteocytes through Gs\u03b1-dependent signaling","volume":"121","author":"Fulzele","year":"2013","journal-title":"Blood"},{"key":"10.1074\/jbc.M114.628313_bib36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jbmr.2381","article-title":"HDAC5 controls MEF2C-driven sclerostin expression in osteocytes","volume":"30","author":"Wein","year":"2015","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bone.2004.03.006","article-title":"Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene","volume":"35","author":"Kalajzic","year":"2004","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib38","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1152\/ajprenal.2001.281.1.F12","article-title":"Optimized suspension culture: the rotating-wall vessel","volume":"281","author":"Hammond","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M114.628313_bib39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3233\/BIR-2009-0550","article-title":"Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells","volume":"46","author":"Papanicolaou","year":"2009","journal-title":"Biorheology"},{"key":"10.1074\/jbc.M114.628313_bib40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jbiomech.2011.10.037","article-title":"Effect of oscillating fluid flow stimulation on osteocyte mRNA expression","volume":"45","author":"Li","year":"2012","journal-title":"J. Biomech"},{"key":"10.1074\/jbc.M114.628313_bib41","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jor.20888","article-title":"Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes","volume":"27","author":"Santos","year":"2009","journal-title":"J. Orthop. Res"},{"key":"10.1074\/jbc.M114.628313_bib42","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/03008207.2010.546536","article-title":"Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation","volume":"52","author":"Igwe","year":"2011","journal-title":"Connect. Tissue Res"},{"key":"10.1074\/jbc.M114.628313_bib43","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bone.2009.06.010","article-title":"Identification of differentially expressed genes between osteoblasts and osteocytes","volume":"45","author":"Paic","year":"2009","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib44","doi-asserted-by":"crossref","first-page":"35939","DOI":"10.1074\/jbc.M109.060335","article-title":"The matricellular protein periostin is required for SOST inhibition and the anabolic response to mechanical loading and physical activity","volume":"284","author":"Bonnet","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib45","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib46","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1172\/JCI46406","article-title":"Gs\u03b1 enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice","volume":"121","author":"Wu","year":"2011","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.M114.628313_bib47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bone.2011.11.016","article-title":"TGF-\u03b2 regulates sclerostin expression via the ECR5 enhancer","volume":"50","author":"Loots","year":"2012","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib48","doi-asserted-by":"crossref","first-page":"e53813","DOI":"10.1371\/journal.pone.0053813","article-title":"Load regulates bone formation and Sclerostin expression through a TGF\u03b2-dependent mechanism","volume":"8","author":"Nguyen","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.628313_bib49","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jcb.22120","article-title":"Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a \u201cmechanoresponsive osteoblast gene signature\u201d","volume":"107","author":"Capulli","year":"2009","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M114.628313_bib50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12192-012-0370-2","article-title":"Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects","volume":"18","author":"Song","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1074\/jbc.M114.628313_bib51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10059-013-2310-0","article-title":"Pax6 expressed in osteocytes inhibits canonical Wnt signaling","volume":"35","author":"Jami","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1074\/jbc.M114.628313_bib52","doi-asserted-by":"crossref","first-page":"43146","DOI":"10.1074\/jbc.M302993200","article-title":"Effects of mechanical strain on the function of gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor","volume":"278","author":"Cherian","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.628313_bib53","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/MCB.02120-05","article-title":"E11\/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M114.628313_bib54","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.febslet.2011.06.019","article-title":"Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4","volume":"585","author":"Galea","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M114.628313_bib55","first-page":"43","article-title":"Changes in serum concentrations of calcium and its regulating hormones during tail suspension in rats","volume":"40","author":"Ito","year":"1996","journal-title":"Environ. Med"},{"key":"10.1074\/jbc.M114.628313_bib56","doi-asserted-by":"crossref","first-page":"e17772","DOI":"10.1371\/journal.pone.0017772","article-title":"Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression","volume":"6","author":"Genetos","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.628313_bib57","first-page":"P1","article-title":"Changes in gene expression and signal transduction in microgravity","volume":"8","author":"Hughes-Fulford","year":"2001","journal-title":"J. Gravit. Physiol"},{"key":"10.1074\/jbc.M114.628313_bib58","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1210\/en.2011-1128","article-title":"Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor","volume":"152","author":"Cohen-Kfir","year":"2011","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M114.628313_bib59","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbrc.2010.08.128","article-title":"Sclerostin is a direct target of osteoblast-specific transcription factor osterix","volume":"400","author":"Yang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.628313_bib60","doi-asserted-by":"crossref","first-page":"15048","DOI":"10.1073\/pnas.1203085109","article-title":"Regulation of \u03b2 catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin","volume":"109","author":"Bonnet","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.628313_bib61","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bone.2013.01.018","article-title":"Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone","volume":"53","author":"Macias","year":"2013","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"10.1074\/jbc.M114.628313_bib63","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1359\/jbmr.090517","article-title":"Human primary osteocyte differentiation in a 3D culture system","volume":"24","author":"Boukhechba","year":"2009","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M114.628313_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00774-013-0555-5","article-title":"Establishment of optimized in vitro assay methods for evaluating osteocyte functions","volume":"33","author":"Honma","year":"2015","journal-title":"J. Bone Miner. Metab"},{"key":"10.1074\/jbc.M114.628313_bib65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molonc.2007.02.004","article-title":"The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression","volume":"1","author":"Kenny","year":"2007","journal-title":"Mol. Oncol"},{"key":"10.1074\/jbc.M114.628313_bib66","doi-asserted-by":"crossref","first-page":"e50099","DOI":"10.1371\/journal.pone.0050099","article-title":"Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M114.628313_bib67","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M114.628313_bib68","doi-asserted-by":"crossref","first-page":"13849","DOI":"10.1074\/jbc.M306249200","article-title":"Cbfa1\/RUNX2 directs specific expression of the sclerosteosis gene (SOST)","volume":"279","author":"Sevetson","year":"2004","journal-title":"J. Biol. Chem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820402327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820402327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.628313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T05:53:11Z","timestamp":1616651591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820402327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":68,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0021925820402327"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.628313","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}