{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:37:13Z","timestamp":1792690633560,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1924,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1074\/jbc.m114.631697","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T02:12:38Z","timestamp":1430273558000},"page":"15121-15132","source":"Crossref","is-referenced-by-count":45,"title":["Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis"],"prefix":"10.1016","volume":"290","author":[{"given":"Marie E.","family":"Oskarsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Vlodavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla T.","family":"Westermark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.631697_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M114.631697_bib2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neurobiolaging.2005.04.017","article-title":"Common mechanisms of amyloid oligomer pathogenesis in degenerative disease","volume":"27","author":"Glabe","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M114.631697_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/13506129.2012.733741","article-title":"Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report","volume":"19","author":"Shin","year":"2012","journal-title":"Amyloid"},{"key":"10.1074\/jbc.M114.631697_bib4","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","article-title":"Pore formation by the cytotoxic islet amyloid peptide amylin","volume":"271","author":"Mirzabekov","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jmb.2004.06.086","article-title":"Phospholipid catalysis of diabetic amyloid assembly","volume":"341","author":"Knight","year":"2004","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.631697_bib6","doi-asserted-by":"crossref","first-page":"36086","DOI":"10.1074\/jbc.M111.240762","article-title":"Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol","volume":"286","author":"Trikha","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib7","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1039\/c3cc44880k","article-title":"Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy","volume":"49","author":"Bag","year":"2013","journal-title":"Chem. Commun"},{"key":"10.1074\/jbc.M114.631697_bib8","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00125-012-2451-2","article-title":"Deletion of Fas protects islet \u03b2 cells from cytotoxic effects of human islet amyloid polypeptide","volume":"55","author":"Park","year":"2012","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M114.631697_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/13506129.2014.964858","article-title":"Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis","volume":"21","author":"Sipe","year":"2014","journal-title":"Amyloid"},{"key":"10.1074\/jbc.M114.631697_bib10","first-page":"92","article-title":"Studies of amyloid: II: the isolation of a polysaccharide from amyloid-bearing tissue","volume":"34","author":"Hass","year":"1942","journal-title":"Arch. Pathol"},{"key":"10.1074\/jbc.M114.631697_bib11","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1177\/39.10.1940305","article-title":"A temporal and ultrastructural relationship between heparan sulfate proteoglycans and AA amyloid in experimental amyloidosis","volume":"39","author":"Snow","year":"1991","journal-title":"J. Histochem. Cytochem"},{"key":"10.1074\/jbc.M114.631697_bib12","first-page":"333","article-title":"Immunohistochemical identification of heparan sulphate proteoglycan in secondary systemic amyloidosis","volume":"73","author":"Norling","year":"1988","journal-title":"Clin. Exp. Immunol"},{"key":"10.1074\/jbc.M114.631697_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a004952","article-title":"Heparan sulfate proteoglycans","volume":"3","author":"Sarrazin","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"10.1074\/jbc.M114.631697_bib14","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2337\/diabetes.47.4.612","article-title":"Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation","volume":"47","author":"Castillo","year":"1998","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0003-9861(03)00116-4","article-title":"Proteoglycans synthesized and secreted by pancreatic islet \u03b2-cells bind amylin","volume":"413","author":"Potter-Perigo","year":"2003","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M114.631697_bib16","doi-asserted-by":"crossref","first-page":"16611","DOI":"10.1074\/jbc.M008423200","article-title":"Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide: implications for islet amyloid formation","volume":"276","author":"Park","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib17","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1021\/bi0510936","article-title":"Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation","volume":"45","author":"Abedini","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.631697_bib18","doi-asserted-by":"crossref","first-page":"31617","DOI":"10.1074\/jbc.272.50.31617","article-title":"Heparin-binding properties of the amyloidogenic peptides A\u03b2 and amylin: dependence on aggregation state and inhibition by Congo red","volume":"272","author":"Watson","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib19","doi-asserted-by":"crossref","first-page":"18770","DOI":"10.1074\/jbc.273.30.18770","article-title":"Substrate specificity of heparanases from human hepatoma and platelets","volume":"273","author":"Pikas","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib20","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1073\/pnas.0502287102","article-title":"In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad, Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631697_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1096\/fj.03-0572com","article-title":"Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior","volume":"18","author":"Zcharia","year":"2004","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M114.631697_bib22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/BF03402051","article-title":"Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP","volume":"6","author":"Westermark","year":"2000","journal-title":"Mol. Med"},{"key":"10.1074\/jbc.M114.631697_bib23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2337\/diab.21.2.S546","article-title":"Metabolic characteristics of isolated pancreatic islets in tissue culture","volume":"21","author":"Andersson","year":"1972","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib24","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1242\/jcs.01068","article-title":"Processing and activation of latent heparanase occurs in lysosomes","volume":"117","author":"Zetser","year":"2004","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M114.631697_bib25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","article-title":"Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in \u03b2 cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets","volume":"49","author":"Paulsson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M114.631697_bib26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0003-2697(82)90580-2","article-title":"N-[3H]acetyl-labeling, a convenient method for radiolabeling of glycosaminoglycans","volume":"119","author":"H\u00f6\u00f6k","year":"1982","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.M114.631697_bib27","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1073\/pnas.1101194108","article-title":"Heparan sulfate\/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein","volume":"108","author":"Noborn","year":"2011","journal-title":"Proc. Natl. Acad, Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631697_bib28","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1073\/pnas.89.6.2267","article-title":"A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis","volume":"89","author":"Lidholt","year":"1992","journal-title":"Proc. Natl. Acad, Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631697_bib29","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.2337\/diabetes.52.12.2943","article-title":"On-line monitoring of apoptosis in insulin-secreting cells","volume":"52","author":"K\u00f6hler","year":"2003","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib30","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.biocel.2008.02.014","article-title":"Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-aza-2\u2032-deoxycytidine","volume":"40","author":"Radhakrishnan","year":"2008","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.M114.631697_bib31","series-title":"Exp. Diab. Res","article-title":"Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation","author":"Paulsson","year":"2008"},{"key":"10.1074\/jbc.M114.631697_bib32","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/diabetes.54.7.2117","article-title":"Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation","volume":"54","author":"Paulsson","year":"2005","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1172\/JCI46177","article-title":"Heparan sulfate and heparanase play key roles in mouse \u03b2 cell survival and autoimmune diabetes","volume":"122","author":"Ziolkowski","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M114.631697_bib34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/glycob\/cwp205","article-title":"Heparan sulfate mediates amyloid-\u03b2 internalization and cytotoxicity","volume":"20","author":"Sandwall","year":"2010","journal-title":"Glycobiology"},{"key":"10.1074\/jbc.M114.631697_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0197-4580(89)90108-5","article-title":"Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses","volume":"10","author":"Snow","year":"1989","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M114.631697_bib36","first-page":"951","article-title":"Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus","volume":"116","author":"Young","year":"1992","journal-title":"Arch. Pathol. Lab. Med"},{"key":"10.1074\/jbc.M114.631697_bib37","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1074\/jbc.M114.600569","article-title":"Overexpression of heparanase lowers the amyloid burden in amyloid-\u03b2 precursor protein transgenic mice","volume":"290","author":"Jendresen","year":"2015","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib38","doi-asserted-by":"crossref","first-page":"C1586","DOI":"10.1152\/ajpcell.00208.2007","article-title":"Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro","volume":"293","author":"Hull","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M114.631697_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2009.03.140","article-title":"Important role of heparan sulfate in postnatal islet growth and insulin secretion","volume":"383","author":"Takahashi","year":"2009","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.631697_bib40","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nchembio.2007.41","article-title":"Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate","volume":"3","author":"Escobar Galvis","year":"2007","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.M114.631697_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2005.03.129","article-title":"Emergence of nuclear heparanase induces differentiation of human mammary cancer cells","volume":"331","author":"Nobuhisa","year":"2005","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.631697_bib42","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1021\/bi701427q","article-title":"Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR","volume":"46","author":"Luca","year":"2007","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.631697_bib43","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1110\/ps.036509.108","article-title":"Atomic structure of the cross-\u03b2 spine of islet amyloid polypeptide (amylin)","volume":"17","author":"Wiltzius","year":"2008","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M114.631697_bib44","doi-asserted-by":"crossref","first-page":"19285","DOI":"10.1073\/pnas.1314481110","article-title":"Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient \u03b2-sheet","volume":"110","author":"Buchanan","year":"2013","journal-title":"Proc. Natl. Acad, Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631697_bib45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmb.2005.02.029","article-title":"The parallel superpleated \u03b2-structure as a model for amyloid fibrils of human amylin","volume":"348","author":"Kajava","year":"2005","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M114.631697_bib46","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.1021\/bi020314u","article-title":"Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes","volume":"41","author":"Anguiano","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.631697_bib47","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/diabetes.53.6.1509","article-title":"Diabetes due to a progressive defect in \u03b2-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes","volume":"53","author":"Butler","year":"2004","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib48","doi-asserted-by":"crossref","first-page":"16284","DOI":"10.1021\/bi051432v","article-title":"The role of His-18 in amyloid formation by human islet amyloid polypeptide","volume":"44","author":"Abedini","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.631697_bib49","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","article-title":"Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus","volume":"368","author":"Lorenzo","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631697_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0014-5793(99)00894-7","article-title":"Induction of apoptosis by human amylin in RINm5F islet \u03b2-cells is associated with enhanced expression of p53 and p21WAF1\/CIP1","volume":"455","author":"Zhang","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M114.631697_bib51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","article-title":"The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles","volume":"48","author":"Janson","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib52","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/bi301525e","article-title":"Comparative molecular dynamics study of human islet amyloid polypeptide (IAPP) and rat IAPP oligomers","volume":"52","author":"Liang","year":"2013","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M114.631697_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jinorgbio.2014.07.002","article-title":"Cu(II) inhibits hIAPP fibrillation and promotes hIAPP-induced \u03b2 cell apoptosis through induction of ROS-mediated mitochondrial dysfunction","volume":"140","author":"Ma","year":"2014","journal-title":"J. Inorg. Biochem"},{"key":"10.1074\/jbc.M114.631697_bib54","doi-asserted-by":"crossref","first-page":"52810","DOI":"10.1074\/jbc.M308244200","article-title":"Fibrillogenic amylin evokes islet \u03b2-cell apoptosis through linked activation of a caspase cascade and JNK1","volume":"278","author":"Zhang","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631697_bib55","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00125-013-3152-1","article-title":"The role of caspase-8 in amyloid-induced \u03b2 cell death in human and mouse islets","volume":"57","author":"Park","year":"2014","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M114.631697_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/bip.22243","article-title":"New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity","volume":"100","author":"De Carufel","year":"2013","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M114.631697_bib57","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF00400722","article-title":"Rapid deposition of amyloid in human islets transplanted into nude mice","volume":"38","author":"Westermark","year":"1995","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M114.631697_bib58","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMc0802893","article-title":"Widespread amyloid deposition in transplanted human pancreatic islets","volume":"359","author":"Westermark","year":"2008","journal-title":"New Eng. J. Med"},{"key":"10.1074\/jbc.M114.631697_bib59","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/diabetes.48.10.1907","article-title":"Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?","volume":"48","author":"Bennet","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M114.631697_bib60","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.2337\/db07-0358","article-title":"Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation","volume":"56","author":"Cabric","year":"2007","journal-title":"Diabetes"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820443790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820443790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.631697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:38:43Z","timestamp":1639705123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820443790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":60,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0021925820443790"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.631697","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}